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Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

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Levy, Daniel, Garrison, Robert J., Savage, Daniel D., Kannel, William B., Castelli, William P.·1990·New England Journal of Medicine

DOI 10.1056/nejm199005313222203

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Abstract

A pattern of left ventricular hypertrophy evident on the electrocardiogram is a harbinger of morbidity and mortality from cardiovascular disease. Echocardiography permits the noninvasive determination of left ventricular mass and the examination of its role as a precursor of morbidity and mortality. We examined the relation of left ventricular mass to the incidence of cardiovascular disease, mortality from cardiovascular disease, and mortality from all causes in 3220 subjects enrolled in the Framingham Heart Study who were 40 years of age or older and free of clinically apparent cardiovascular disease, in whom left ventricular mass was determined echocardiographically. During a four-year follow-up period, there were 208 incident cardiovascular events, 37 deaths from cardiovascular disease, and 124 deaths from all causes. Left ventricular mass, determined echocardiographically, was associated with all outcome events. This relation persisted after we adjusted for age, diastolic blood pressure, pulse pressure, treatment for hypertension, cigarette smoking, diabetes, obesity, the ratio of total cholesterol to high-density lipoprotein cholesterol, and electrocardiographic evidence of left ventricular hypertrophy. In men, the risk factor-adjusted relative risk of cardiovascular disease was 1.49 for each increment of 50 g per meter in left ventricular mass corrected for the subject's height (95 percent confidence interval, 1.20 to 1.85); in women, it was 1.57 (95 percent confidence interval, 1.20 to 2.04). Left ventricular mass (corrected for height) was also associated with the incidence of death from cardiovascular disease (relative risk, 1.73 [95 percent confidence interval, 1.19 to 2.52] in men and 2.12 [95 percent confidence interval, 1.28 to 3.49] in women). Left ventricular mass (corrected for height) was associated with death from all causes (relative risk, 1.49 [95 percent confidence interval, 1.14 to 1.94] in men and 2.01 [95 percent confidence interval, 1.44 to 2.81] in women). We conclude that the estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors. An increase in left ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease.

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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
Value of Echocardiographic Measurement of Left Ventricular Mass in Predicting Cardiovascular Morbid Events in Hypertensive Men
Casale, P. N., Devereux, R. B., Milner, M. R., Zullo, G., Harshfield, G. A., Pickering, T. G., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-2-173 · Cited by 1,079
Echocardiographically Detected Left Ventricular Hypertrophy: Prevalence and Risk Factors
Levy, D. A., Anderson, K. M., SAVAGE, D. D., Kannel, W. B., Christiansen, J. C., & Castelli, W. P. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-1-7 · Cited by 819
Echocardiographic criteria for left ventricular hypertrophy: The Framingham heart study
Levy, D. A., Savage, D. D., Garrison, R. J., Anderson, K. M., Kannel, W. B., & Castelli, W. P. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91133-7 · Cited by 798
Left Ventricular Mass and Incidence of Coronary Heart Disease in an Elderly Cohort
Levy, D. A., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-2-101 · Cited by 700
Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease
Kannel, W. B., Gordon, T., Castelli, W. P., & MARGOLIS, J. R. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-6-813 · Cited by 638
Ventricular Arrhythmias in Patients with Hypertensive Left Ventricular Hypertrophy
McLenachan, J. M., Henderson, E., Morris, K. I., & Dargie, H. J. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709243171302 · Cited by 576

Show all 28 references

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Levy, 1987, Circulation, 76, IV-143
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Cittadini, A., Grossman, J. D., Napoli, R., Katz, S. E., Strömer, H., Smith, R. J., CLARK, R. G., Morgan, J. P., & Douglas, P. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00010-7 · Cited by 160
Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes
Huynh, K., Kiriazis, H., Du, X., Love, J. E., Jandeleit-Dahm, K. A. M., Forbes, J. M., McMullen, J. R., & Ritchie, R. H. (2012) · Diabetologia · doi:10.1007/s00125-012-2495-3 · Cited by 162
Comparison of enalapril versus nifedipine to decrease left ventricular hypertrophy in systemic hypertension (the PRESERVE trial)
Devereux, R. B., Dahlöf, B., Levy, D. A., & Pfeffer, M. A. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00228-7 · Cited by 162
Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive
Greenwood, J. P., Scott, E. M., Stoker, J. B., & Mary, D. A. S. G. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01600-x · Cited by 161
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Chami, H. A., Devereux, R. B., Gottdiener, J. S., Mehra, R., Roman, M. J., Benjamin, E. J., & Gottlieb, D. J. (2008) · Circulation · doi:10.1161/circulationaha.107.717892 · Cited by 167
Extreme sacrifice: sudden cardiac death in the US Fire Service
Smith, D. L., Barr, D. A., & Kales, S. N. (2013) · Extreme Physiology & Medicine · doi:10.1186/2046-7648-2-6 · Cited by 180
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Tanabe, A., Naruse, M., Naruse, K., Mitsuyasu, H. A. S. E., Yoshimoto, T., Tanaka, M., Seki, T., Demura, R., & Demura, H. (1997) · Hypertension Research · doi:10.1291/hypres.20.85 · Cited by 161
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Cheung, N., Bluemke, D. A., Klein, R., Sharrett, A. R., Islam, A. F. M., Cotch, M. F., Klein, R., Criqui, M. H., & Wong, T. Y. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.029 · Cited by 161
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Lieb, W., Gona, P. N., Larson, M. G., Aragam, J. R., Zile, M. R., Cheng, S. C., Benjamin, E. J., & Vasan, R. S. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.05.008 · Cited by 160
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Roh, J. D., Rhee, J., Chaudhari, V., & Rosenzweig, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.305250 · Cited by 161
Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Shah, R. V., Murthy, V. L., Colangelo, L. A., Reis, J., Venkatesh, B. A., Sharma, R., Abbasi, S. A., Goff, D. C., Carr, J. J., Rana, J. S., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.6309 · Cited by 158
Left ventricular abnormalities in children, adolescents and young adults with renal disease
Johnstone, L. M., Jones, C. L., Grigg, L., Wilkinson, J. L., Walker, R. G., & Powell, H. R. (1996) · Kidney International · doi:10.1038/ki.1996.401 · Cited by 159
Prevention of Cardiac Hypertrophy by Atorvastatin in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy
Senthil, V., Chen, S. N., Tsybouleva, N., Halder, T., Nagueh, S. F., Willerson, J. T., Roberts, R., & Marian, A. J. (2005) · Circulation Research · doi:10.1161/01.res.0000177090.07296.ac · Cited by 159
Mechanisms of target organ damage caused by hypertension: Therapeutic potential
Cohuet, G., & Struijker-Boudier, H. A. J. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.002 · Cited by 162
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Asghar, O., Alsunni, A. A., Khavandi, K., Khavandi, A., Withers, S., Greenstein, A. S., Heagerty, A. M., & Malik, R. A. (2009) · Clinical Science · doi:10.1042/cs20080500 · Cited by 162
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Lim, H. W., Windt, L. J. D., Steinberg, L. A., Taigen, T. L., Witt, S. A., Kimball, T. R., & Molkentin, J. D. (2000) · Circulation · doi:10.1161/01.cir.101.20.2431 · Cited by 158
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Völkers, M., Salz, M., Herzog, N., Frank, D., Dolatabadi, N., Frey, N., Gude, N. A., Friedrich, O., Koch, W. J., Katus, H. A., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.01.020 · Cited by 157
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Hunton, D. L., Lucchesi, P. A., Pang, Y., Cheng, X., Dell’Italia, L. J., & Marchase, R. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107167200 · Cited by 157
The associations of body size and body composition with left ventricular mass: impacts for indexation in adults
Hense, H., Gneiting, B., Muscholl, M. W., Broeckel, U., Kuch, B., Doering, A., Riegger, G. A. J., & Schunkert, H. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00240-x · Cited by 157
Congestive heart failure, coronary events and atherothrombotic brain infarction in elderly blacks and whites with systemic hypertension and with and without echocardiographic and electrocardiographic evidence of left ventricular hypertrophy
Aronow, W. S., Ahn, C. W., Kronzon, I., & Koenigsberg, M. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90562-y · Cited by 157
The 1993 Guidelines for the Management of Mild Hypertension: Memorandum from a WHO/ISH Meeting
Zanchetti, A., Chalmers, J. P., Arakawa, K., Gyarfas, I., Hamet, P., Hansson, L., Julius, S., MacMahon, S. W., Mancia, G., Ménard, J., et al. (1993) · Blood Pressure · doi:10.3109/08037059309077535 · Cited by 157
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Pluim, B. M., Lamb, H. J., Kayser, H. W. M., Leujes, F., Beyerbacht, H. P., Zwinderman, A. H., van der Laarse, A., Vliegen, H. W., Roos, A., & van der Wall, E. E. (1998) · Circulation · doi:10.1161/01.cir.97.7.666 · Cited by 153
Association of Atrial Natriuretic Peptide and Type A Natriuretic Peptide Receptor Gene Polymorphisms With Left Ventricular Mass in Human Essential Hypertension
Rubattu, S., Bigatti, G. G. O., Evangelista, A., Lanzani, C. L., Stanzione, R., Zagato, L., Manunta, P., Marchitti, S., Venturelli, V., Bianchi, G., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.12.081 · Cited by 156
Left Ventricular Hypertrophy in Hypertension: Stimuli, Patterns, and Consequences.
Devereux, R. B., & Roman, M. J. (1999) · Hypertension Research · doi:10.1291/hypres.22.1 · Cited by 156
Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension
Aeschbacher, B. C. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01245-0 · Cited by 156
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence
Selvetella, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.031 · Cited by 159
Cardiac Hypertrophy in Obstructive Sleep Apnea Syndrome
Noda, A., Okada, T., Yasuma, F., Nakashima, N., & Yokota, M. (1995) · Chest · doi:10.1378/chest.107.6.1538 · Cited by 155
Biomarkers of Chronic Cardiac Injury and Hemodynamic Stress Identify a Malignant Phenotype of Left Ventricular Hypertrophy in the General Population
Neeland, I. J., Drazner, M. H., Berry, J. D., Ayers, C. R., deFilippi, C. R., Seliger, S. L., Nambi, V., McGuire, D. K., Omland, T., & de Lemos, J. A. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.10.012 · Cited by 155
Associations of Late Adolescent or Young Adult Cardiovascular Health With Premature Cardiovascular Disease and Mortality
Perak, A. M., Ning, H., Khan, S. S., Bundy, J. D., Allen, N. B., Lewis, C. E., Jacobs, D. R., Horn, L. V., & Lloyd‐Jones, D. M. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.002 · Cited by 156
Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart
Pan, J., Fukuda, K., Kodama, H., Makino, S., Takahashi, T., Sano, M., Hori, S., & Ogawa, S. (1997) · Circulation Research · doi:10.1161/01.res.81.4.611 · Cited by 155

Authors: Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P.
Affiliations: National Heart, Lung, and Blood Institute (US)
National Center for Health Statistics (US)
Boston University (US)
ORCID: Levy, Daniel
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1990-05-31
Volume: 322
Issue: 22
Pages: 1561-1566
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199005313222203
OpenAlex: W2334499091
Cited by: 5,699
References: 28
Citations by year: 2026: 77 · 2025: 76 · 2024: 85 · 2023: 100 · 2022: 117 · 2021: 124 · 2020: 156 · 2019: 142 · 2018: 134 · 2017: 170 · 2016: 189 · 2015: 211 · 2014: 215 · 2013: 199 · 2012: 215
FWCI: 76.54
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: left ventricular mass, left ventricular hypertrophy, cardiovascular disease incidence, cardiovascular mortality, all-cause mortality, echocardiography, cardiovascular risk factors, hypertension, sex differences, Framingham Heart Study
MeSH terms: Blood Pressure, Echocardiography, Female, Follow-Up Studies, Cardiomegaly, Humans, Lipids, Male, Middle Aged, Prognosis, Risk Factors, Smoking, Multivariate Analysis, Diabetes Complications

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Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

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