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Cited by 2,499

The DOI matches its Crossref record.

Eosinophilic Inflammation in Asthma

Open access
Bousquet, Jean, Chanez, Pascal, Lacoste, Jean Yves, Barnéon, Gilbert, Ghavanian, Nouchine, Enander, Ingrid, Venge, Per, Ahlstedt, Staffan, Simony-Lafontaine, Joelle, Godard, Philippe, Michel, François-Bernard·1990·New England Journal of Medicine
DOI 10.1056/nejm199010113231505
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Abstract

BACKGROUND AND METHODS: The importance of eosinophils in the pathogenesis of bronchial asthma is not established. In an attempt to evaluate the role of eosinophilic inflammation in asthma, we compared 10 normal subjects with 43 patients with chronic asthma, 19 of whom had severe disease as assessed by a clinical scoring method described by Aas and by pulmonary-function tests. Eosinophils were counted in peripheral blood and bronchoalveolar-lavage fluid, and in biopsy specimens obtained from the patients and post mortem from 8 subjects without asthma, but not from the 10 normal controls. Eosinophil cationic protein was titrated by radioimmunoassay in the bronchoalveolar-lavage fluid from all subjects and studied by immunohistochemistry in the biopsy specimens. RESULTS: There was a significant increase in the number of peripheral-blood eosinophils in the patients that was correlated with the clinical severity of asthma (P less than 0.001) and pulmonary function (P less than 0.03). Levels of eosinophils and eosinophil cationic protein were increased in the bronchoalveolar-lavage fluid from the patients and were also correlated with the severity of asthma (P less than 0.001 and P less than 0.002, respectively). Hematoxylin-eosin staining of bronchial-biopsy specimens showed that intraepithelial eosinophils were present only in patients with asthma. Immunohistochemical analysis of eosinophil cationic protein revealed that normal subjects had only a few nondegranulated eosinophils deep in the submucosa, whereas all the patients had degranulated eosinophils beneath the basement membrane and among epithelial cells. In some patients there was a relation between the presence of degranulated eosinophils and epithelial damage. CONCLUSIONS: Eosinophilic inflammation of the airways is correlated with the severity of asthma. These cells are likely to play a part in the epithelial damage seen in this disease.

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Metadata

Authors
Bousquet, J., Chanez, P., Lacoste, J. Y., Barnéon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P., & Michel, F.-B.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1990-10-11
Volume
323
Issue
15
Pages
1033-1039
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199010113231505
OpenAlex
W2312870247
Cited by
2,499
References
0
FWCI
51.63
Type
journal article
Language
en
Open access
bronze

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