The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
A Randomized Study of the Effect of Withdrawing Hydroxychloroquine Sulfate in Systemic Lupus Erythematosus
Open accessAbstract
BACKGROUND: The antimalarial drug hydroxychloroquine is thought to be effective in controlling some of the manifestations of systemic lupus erythematosus, but its effectiveness has not been demonstrated conclusively. METHODS: We conducted a six-month, randomized, double-blind, placebo-controlled study of the effect of discontinuing hydroxychloroquine sulfate treatment in 47 patients with clinically stable systemic lupus erythematosus. The patients were randomly assigned to continue their same dose of hydroxychloroquine (n = 25) or to receive placebo (n = 22) for 24 weeks. Ten patients in each group were also taking prednisone. RESULTS: The relative risk of a clinical flare-up, defined as the development of specific clinical manifestations of systemic lupus erythematosus or an increase in their severity, was 2.5 times higher (95 percent confidence interval, 1.08 to 5.58) in the patients taking placebo than in those continuing to take hydroxychloroquine (16 of 22 patients vs. 9 of 25 had flare-ups), and the time to a flare-up was shorter (P = 0.02). The relative risk of a severe exacerbation of disease that required withdrawal from the study was 6.1 times higher (95 percent confidence interval, 0.72 to 52.44) for the patients taking placebo (5 of 22 patients vs. 1 of 25 had severe exacerbations of disease). Changes in the dose of prednisone were not different in the two groups. CONCLUSIONS: Patients with quiescent systemic lupus erythematosus who are taking hydroxychloroquine are less likely to have a clinical flare-up if they are maintained on the drug.
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Cites
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
The statistical analysis of failure time data
Herson, J. (1981) · Controlled Clinical Trials · doi:10.1016/0197-2456(81)90009-x · Cited by 1,380
The arthritis impact measurement scales. further investigations of a health status measure
Meenan, R. F., Gertman, P. M., Mason, J. H., & Dunaif, R. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780250903 · Cited by 383
Antimalarials in the management of discoid and systemic lupus erythematosus
L. Dubois, E. (1978) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(78)90033-1 · Cited by 189
Tett, S., Cutler, D., Day, R., & Brown, K. (1988) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1988.tb05281.x · Cited by 177
SYSTEMIC LUPUS ERYTHEMATOSUS: RECENT ADVANCES IN ITS DIAGNOSIS AND TREATMENT
Dubois, E. L. (1956) · Annals of Internal Medicine · doi:10.7326/0003-4819-45-2-163 · Cited by 137
Ophthalmologic considerations and testing in patients receiving long-term antimalarial therapy
Bernstein, H. N. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91267-6 · Cited by 130
Antimalarials in rheumatology: Efficacy and safety
Maksymowych, W. P., & RUSSELL, A. S. (1987) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(87)90023-0 · Cited by 82
Antimalarial drugs for rheumatoid arthritis
Mackenzie, A. H. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90474-6 · Cited by 73
The Use of Amsler Grids in Early Chloroquin Retinopathy
Easterbrook, M. (1984) · Ophthalmology · doi:10.1016/s0161-6420(84)34139-2 · Cited by 47
Cited by
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette, B. C., Shlomchik, M. J., & Marshak-Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,900
Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P., & Khamashta, M. A. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.101766 · Cited by 978
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Means, T. K., Latz, E., Hayashi, F., Murali, M. R., Golenbock, D. T., & Luster, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523025 · Cited by 849
Bertsias, G., Ioannidis, J. P. A., Boletis, J., Bombardieri, S., Cervera, R., Dostal, C., Font, J., Gilboe, I. M., Houssiau, F., Huizinga, T., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.070367 · Cited by 762
Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus
Ruiz-Irastorza, G., Egurbide, M.-V., Pijoan, J.-I., Garmendia, M., Villar, I., Martinez-Berriotxoa, A., Erdozain, J.-G., & Aguirre, C. (2006) · Lupus · doi:10.1177/0961203306071872 · Cited by 411
Metadata
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-01-17
- Volume
- 324
- Issue
- 3
- Pages
- 150-154
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4242308600
- Cited by
- 677
- References
- 13
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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