The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Effects on Plasma Lipoproteins of a Prudent Weight-Reducing Diet, with or without Exercise, in Overweight Men and Women
Open accessAbstract
BACKGROUND: The National Cholesterol Education Program (NCEP) recommends a low-saturated-fat, low-cholesterol diet, with weight loss if indicated, to correct elevated plasma cholesterol levels. Weight loss accomplished by simple caloric restriction or increased exercise typically increases the level of high-density lipoprotein (HDL) cholesterol. Little is known about the effects on plasma lipoproteins of a hypocaloric NCEP diet with or without exercise in overweight people. METHODS: We tested the hypothesis that exercise (walking or jogging) will increase HDL cholesterol levels in moderately overweight, sedentary people who adopt a hypocaloric NCEP diet. We randomly assigned 132 men and 132 women 25 to 49 years old to one of three groups: control, hypocaloric NCEP diet, or hypocaloric NCEP diet with exercise. One hundred nineteen of the men and 112 of the women returned for testing after one year. RESULTS: After one year, the subjects in both intervention groups had reached or closely approached NCEP Step 1 dietary goals and reduced their mean body fat significantly (range of reduction in mean fat weight, 4.0 to 7.8 kg). Weight loss on the NCEP diet alone did not significantly change HDL cholesterol levels in either the men or the women as compared with the subjects in the control group. Plasma levels of HDL cholesterol increased significantly more in the men who exercised and dieted (mean [+/- SE] change, +13 +/- 3 percent) than in the men who only dieted (+2 +/- 3 percent, P less than 0.01) or the men who acted as controls (-4 +/- 2 percent, P less than 0.001). HDL cholesterol levels remained about the same in the women who exercised and dieted (+1 +/- 2 percent); they were higher than in the women who only dieted (-10 +/- 3 percent, P less than 0.01), but not higher than in the controls (-3 +/- 3 percent). CONCLUSIONS: Regular exercise in overweight men and women enhances the improvement in plasma lipoprotein levels that results from the adoption of a low-saturated-fat, low-cholesterol diet.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Several exercise trials combined with weight loss reported larger improvements in CVD risk factors.21,40,41”
From Aerobic, resistance, or combined exercise training and cardiovascular risk profile in overweight or obese adults: the CardioRACE trial (2024) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Enzymatic determination of total serum cholesterol.
Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W., & Fu, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.4.470 · Cited by 9,845
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Blair, S. N. (1989) · JAMA · doi:10.1001/jama.1989.03430170057028 · Cited by 2,658
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,154
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931
An updated coronary risk profile. A statement for health professionals.
Anderson, K. M., Wilson, P. W., Odell, P. M., & Kannel, W. B. (1991) · Circulation · doi:10.1161/01.cir.83.1.356 · Cited by 1,834
Lapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657
Physical Activity and the Incidence of Coronary Heart Disease
Powell, K. E., Thompson, P. D., Caspersen, C. J., & Kendrick, J. S. (1987) · Annual Review of Public Health · doi:10.1146/annurev.pu.08.050187.001345 · Cited by 1,457
Research works printed but not linked: 6
- 10.1001/jama.251.3.351 · DOI · Paper page
- 1959, Stat Bull Metrop Life Insur Co, 40, 1
- Warnick, 1982, Clin Chem, 28, 1574
- 1990, MMWR, 39, 541
- 10.1001/jama.262.17.2395 · DOI · Paper page
- Bush, 1988, Clin Chem, 34, B60
Cited by
Sorted by citations
Items 501–520 of 520
Reimers, C. D., & Knapp, G. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-24285-4.00003-3
(1997) · Primary Care Update for OB/GYNS · doi:10.1016/s1068-607x(97)00010-3
Nutrition and cardiovascular health.
Kotchen, T., Kotchen, J., & Bronner, F. (2002) · Modern nutrition · doi:10.1201/9781420041286.ch2 · Cited by 2
Walker, C. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-76606-5_3
White, J. (1991) · The Physician and Sportsmedicine · doi:10.1080/00913847.1991.11704882
Efficacy of Different Antiobesity Interventions
Keller, U. B., & Stoeckli, R. (2004) · CRC Press eBooks · doi:10.1201/9780203508756.ch22
Katsagoni, C. N., Kokkinos, P. F., & Sidossis, L. S. (2023) · doi:10.1002/9781119833475.ch17
Holloszy, J. O., & Kohrt, W. M. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01696.x
Asterino, W., & Campbell, K. (2020) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-64802-145-920251009
Women’s Health and Health Behaviors
Cornell, C. E., Gilliland, M. J., & Lewis, C. E. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4789-1_26
Mukhtar, R. (2013) · The University of Bath Online Publications Store (The University of Bath)
Symposium on obesity (Second Part).
Bastarrachea, R. A., Rolls, B. J., Hill, J. O., Pi‐Sunyer, F. X., Després, J., & Campfield, L. A. (1999) · REVISTA BIOMÉDICA · doi:10.32776/revbiomed.v10i2.194
Self-efficacy, decision making, and the stages of exercise behavior change
Haas, J. C. (1996) · Montana State University ScholarWorks (Montana State University)
Bewegung und Sport, Herzinfarkt und Cholesterin
Schürch, P. M. (1992) · pharma-kritik · doi:10.37667/pk.1992.531
López, Á., & Jesús, M. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Barrile, S. R. (2003) · Americanae (AECID Library)
Approach to the Patient with Hyperlipidemia
Stone, N. J. (2001) · doi:10.1007/978-1-4615-6601-4_14
Osborn, R., Psota, T., Sa, J., & Sbrocco, T. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1348-7_4
Metadata
- Authors
- Wood, P. D., Stefanick, M. L., Williams, P. T., & Haskell, W. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-08-15
- Volume
- 325
- Issue
- 7
- Pages
- 461-466
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2013899239
- Cited by
- 520
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 5 · 2016: 8 · 2015: 19 · 2014: 12 · 2013: 11 · 2012: 12
- FWCI
- 25.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k04hl002183-05, 5r01hl024462-10)
- National Heart, Lung, and Blood Institute (HL-24462, HL-02183)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- serum lipoproteins, HDL cholesterol, weight loss, hypocaloric diet, low saturated fat diet, cholesterol-lowering diet, physical activity, overweight adults, sex differences, fat loss, caloric restriction
- MeSH terms
- Adult, Energy Intake, Cholesterol, Dietary, Coronary Disease, Diet, Reducing, Dietary Fats, Female, Humans, Lipoproteins, Cholesterol, HDL, Male, Middle Aged, Obesity, Triglycerides, Exercise
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
