The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Is Insulin-Dependent Diabetes Mellitus Environmentally Induced?
Abstract
Insulin-dependent diabetes mellitus (IDDM) remains an enigmatic disease despite a number of spectacular research discoveries during the past two decades that relate to its underlying genetics and pathogenesis.1 Many investigators are convinced that an environmental factor must be involved in the pathogenesis of this disorder. If so, the inability to identify this factor has been remarkable. The two most compelling pieces of evidence that nurture as well as nature is involved are the facts that only one in every three pairs of identical twins affected by IDDM becomes concordant for the disease and that the incidence of IDDM is increasing. . . .
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“A plethora of environmental influences have been purported to affect the epidemiology of type 1 diabetes,25 with infant and adolescent diets,26 vitamin D and vitamin D pathway constituents,27–29 and viruses receiving the most focus.30,31”
From Type 1 diabetes (2014) · cites this paper as [25]
Citations
Cites
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Kaufman, D. L., Erlander, M. G., Clare-Salzler, M., Atkinson, M. A., Maclaren, N. K., & Tobin, A. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115573 · Cited by 490
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,931
Self-citationBody temperature regulation in diabetes
Kenny, G. P., Sigal, R. J., & McGinn, R. (2016) · Temperature · doi:10.1080/23328940.2015.1131506 · Cited by 297
“Although the causes of type 1 diabetes remain to be elucidated, it is probably caused by a combination of genetic predisposition (with >40 loci known to affect susceptibility)(3) and various environmental factors including stress and viruses.(4) On the other hand, type 2 diabetes is most often diagnosed in adults and…”
BackgroundIslet cell autoantigens in insulin-dependent diabetes
Atkinson, M. A., & Maclaren, N. K. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116745 · Cited by 129
Self-citation
Metadata
- Authors
- Maclaren, N., & Atkinson, M.
- ORCID
- Atkinson, Mark
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-07-30
- Volume
- 327
- Issue
- 5
- Pages
- 348-349
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2010284257
- Cited by
- 41
- References
- 1
- Citations by year
- 2022: 1 · 2017: 1 · 2016: 4 · 2014: 1 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- type 1 diabetes, environmental factors, pathogenesis, twin concordance, incidence trends, diabetes genetics
- MeSH terms
- Animals, Antibodies, Diabetes Mellitus, Type 1, HLA Antigens, Humans, Islets of Langerhans, Milk, Milk Proteins, Peptide Fragments, Serum Albumin, Bovine, Mice, Inbred NOD, Mice
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