Chronic Autoimmune Thyroiditis

Dayan, Colin M.; Daniels, Gilbert H.

doi:10.1056/nejm199607113350206

Cited by 904Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

Chronic Autoimmune Thyroiditis

Dayan, Colin M., Daniels, Gilbert H.·1996·New England Journal of Medicine

DOI 10.1056/nejm199607113350206

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Abstract

In 1912, Hashimoto described four women in whom the thyroid gland was enlarged and appeared to have been transformed into lymphoid tissue (“struma lymphomatosa”).1 Although the patients were not initially hypothyroid, they became so after thyroid surgery. Over 40 years later, the presence of antithyroid antibodies was reported in patients with this disorder.2 Hashimoto's disease, or Hashimoto's thyroiditis, is now recognized as a form of chronic autoimmune thyroiditis.There is no internationally accepted classification of autoimmune thyroid diseases.3 Some investigators consider autoimmune thyroiditis a histologic diagnosis that can be subdivided into lymphocytic thyroiditis, if only lymphocytic infiltration is present, and . . .

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Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages, and the prevalence of thyroid autoimmunity increases with aging.
“Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages and the prevalence of thyroid autoimmunity increases with aging (23, 26, 27).”
From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [23]

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Thyroiditis
Pearce, E. N., Farwell, A. P., & Braverman, L. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021194 · Cited by 878 · see citing works
Hypothyroidism
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Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis
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Antibody interference in thyroid assays: a potential for clinical misinformation
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Amiodarone-Induced Thyrotoxicosis
Daniels, G. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7119 · Cited by 159 · see citing works
Self-citation
Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort
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Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial
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Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study
Okada, N., Iwama, S., Okuji, T., Kobayashi, T., Yasuda, Y., Wada, E., Onoue, T., Goto, M., Sugiyama, M., Tsunekawa, T., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0736-7 · Cited by 78 · see citing works
Thyroxine replacement: a clinical endocrinologist’s viewpoint
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Self-citation
Levothyroxine therapy in elderly patients with hypothyroidism
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“Autoimmune hypothyroidism is the most common cause of hypothyroidism at all ages and the prevalence of thyroid autoimmunity increases with aging (23, 26, 27).”
Background
Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years
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Self-citation
Atrophic Body Gastritis in Patients With Autoimmune Thyroid Disease: An Underdiagnosed Association
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Incidence of Antibodies Blocking Thyrotropin EffectIn Vitroin Patients with Euthyroid or Hypothyroid Autoimmune Thyroiditis*
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Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases.
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Abstract #571 Association Between Anti-Thyroid Antibody Levels and Sense of Wellbeing in Patients with Hashimoto’s Thyroiditis (HT)
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Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis
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Authors: Dayan, C. M., & Daniels, G. H.
Affiliations: Bristol Royal Infirmary (GB)
Massachusetts General Hospital (US)
ORCID: Dayan, Colin M.
Daniels, Gilbert H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1996-07-11
Volume: 335
Issue: 2
Pages: 99-107
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199607113350206
OpenAlex: W2314357784
Cited by: 904
References: 113
Citations by year: 2026: 11 · 2025: 18 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 28 · 2020: 28 · 2019: 22 · 2018: 36 · 2017: 18 · 2016: 41 · 2015: 29 · 2014: 50 · 2013: 34 · 2012: 43
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: chronic autoimmune thyroiditis, Hashimoto's thyroiditis, thyroid autoantibodies, lymphocytic thyroiditis, hypothyroidism
MeSH terms: Humans, Thyroiditis, Autoimmune, Thyroxine, Prevalence

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Chronic Autoimmune Thyroiditis

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