Thyroiditis

Pearce, Elizabeth N.; Farwell, Alan P.; Braverman, Lewis E.

doi:10.1056/nejmra021194

Cited by 889Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentOphthalmology and Eye Disorders

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Thyroiditis

Pearce, Elizabeth N., Farwell, Alan P., Braverman, Lewis E.·2003·New England Journal of Medicine

DOI 10.1056/nejmra021194

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Abstract

This article summarizes the current understanding of the mechanisms of destruction in autoimmune thyroid disease. The authors explain the approach to the diagnosis and treatment of the most common types of thyroiditis, including Hashimoto's thyroiditis, painless postpartum thyroiditis, and painless sporadic thyroiditis. Thyroid dysfunction can also develop from treatment with medications such as amiodarone, lithium, interferon alfa, and interleukin-2.

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Painless thyroiditis classically presents with the same triphasic course described for subacute thyroiditis, but with no prodrome, neck pain, or elevated ESR, WBC count, or C-reactive protein.
“Painless or silent thyroiditis classically presents with the same triphasic course described for subacute thyroiditis, but with no prodrome, neck pain, or elevated ESR, WBC count, or C-reactive protein (625).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [625]

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Authors: Pearce, E. N., Farwell, A. P., & Braverman, L. E.
Affiliations: Boston University (US)
University of Massachusetts Chan Medical School (US)
ORCID: Pearce, Elizabeth N.
Farwell, Alan P.
Braverman, Lewis E.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2003-06-26
Volume: 348
Issue: 26
Pages: 2646-2655
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra021194
OpenAlex: W4250376568
Cited by: 878
References: 68
Citations by year: 2026: 25 · 2025: 31 · 2024: 62 · 2023: 59 · 2022: 71 · 2021: 56 · 2020: 52 · 2019: 40 · 2018: 44 · 2017: 36 · 2016: 41 · 2015: 54 · 2014: 43 · 2013: 40 · 2012: 43
FWCI: 3.09
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
Keywords: thyroiditis, autoimmune thyroid disease, Hashimoto's thyroiditis, postpartum thyroiditis, thyroid dysfunction, drug-induced thyroid dysfunction, amiodarone, lithium, interferon-alpha, interleukin-2, pathogenesis
MeSH terms: Female, Humans, Hypothyroidism, Male, Puerperal Disorders, Thyroid Gland, Thyroiditis, Thyrotoxicosis, Age of Onset

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