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Cited by 804

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

Roberts, Jesse D., Fineman, Jeffrey R., Morin, Frederick C., Shaul, Philip W., Rimar, Stephen, Schreiber, Michael D., Polin, Richard A., Zwass, Maurice S., Zayek, Michael M., Gross, Ian, Heymann, Michael A., Zapol, Warren M., Thusu, Kajori G., Zellers, Thomas M., Wylam, Mark E., Zaslavsky, Alan·1997·New England Journal of Medicine
DOI 10.1056/nejm199702273360902
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Abstract

BACKGROUND: Persistent pulmonary hypertension of the newborn causes systemic arterial hypoxemia because of increased pulmonary vascular resistance and right-to-left shunting of deoxygenated blood. Inhaled nitric oxide decreases pulmonary vascular resistance in newborns. We studied whether inhaled nitric oxide decreases severe hypoxemia in infants with persistent pulmonary hypertension. METHODS: In a prospective, multicenter study, 58 full-term infants with severe hypoxemia and persistent pulmonary hypertension were randomly assigned to breathe either a control gas (nitrogen) or nitric oxide (80 parts per million), mixed with oxygen from a ventilator. If oxygenation increased after 20 minutes and systemic blood pressure did not decrease, the treatment was considered successful and was continued at lower concentrations. Otherwise, it was discontinued and alternative therapies, including extracorporeal membrane oxygenation, were used. RESULTS: Inhaled nitric oxide successfully doubled systemic oxygenation in 16 of 30 infants (53 percent), whereas conventional therapy without inhaled nitric oxide increased oxygenation in only 2 of 28 infants (7 percent). Long-term therapy with inhaled nitric oxide sustained systemic oxygenation in 75 percent of the infants who had initial improvement. Extracorporeal membrane oxygenation was required in 71 percent of the control group and 40 percent of the nitric oxide group (P=0.02). The number of deaths was similar in the two groups. Inhaled nitric oxide did not cause systemic hypotension or increase methemoglobin levels. CONCLUSIONS: Inhaled nitric oxide improves systemic oxygenation in infants with persistent pulmonary hypertension and may reduce the need for more invasive treatments.

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Metadata

Authors
Roberts, J. D., Fineman, J. R., Morin, F. C., Shaul, P. W., Rimar, S., Schreiber, M. D., Polin, R. A., Zwass, M. S., Zayek, M. M., Gross, I., Heymann, M. A., Zapol, W. M., Thusu, K. G., Zellers, T. M., Wylam, M. E., & Zaslavsky, A.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1997-02-27
Volume
336
Issue
9
Pages
605-610
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199702273360902
OpenAlex
W2324162185
Cited by
804
References
10
FWCI
64.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. https://app.cochat.ai/papers/10.1056/nejm199702273360902
The paper
Roberts, J. D., Fineman, J. R., Morin, F. C., Shaul, P. W., Rimar, S., Schreiber, M. D., Polin, R. A., Zwass, M. S., Zayek, M. M., Gross, I., Heymann, M. A., Zapol, W. M., Thusu, K. G., Zellers, T. M., Wylam, M. E., & Zaslavsky, A. (1997). Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal of Medicine. https://doi.org/10.1056/nejm199702273360902

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.