The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Open accessAbstract
BACKGROUND: There is evidence that medications or vitamins that increase the levels of brain catecholamines and protect against oxidative damage may reduce the neuronal damage and slow the progression of Alzheimer's disease. METHODS: We conducted a double-blind, placebo-controlled, randomized, multicenter trial in patients with Alzheimer's disease of moderate severity. A total of 341 patients received the selective monoamine oxidase inhibitor selegiline (10 mg a day), alpha-tocopherol (vitamin E, 2000 IU a day), both selegiline and alpha-tocopherol, or placebo for two years. The primary outcome was the time to the occurrence of any of the following: death, institutionalization, loss of the ability to perform basic activities of daily living, or severe dementia (defined as a Clinical Dementia Rating of 3). RESULTS: Despite random assignment, the baseline score on the Mini-Mental State Examination was higher in the placebo group than in the other three groups, and this variable was highly predictive of the primary outcome (P<0.001). In the unadjusted analyses, there was no statistically significant difference in the outcomes among the four groups. In analyses that included the base-line score on the Mini-Mental State Examination as a covariate, there were significant delays in the time to the primary outcome for the patients treated with selegiline (median time, 655 days; P=0.012), alpha-tocopherol (670 days, P=0.001) or combination therapy (585 days, P=0.049), as compared with the placebo group (440 days). CONCLUSIONS: In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“To date, none of the tested compounds have proven effective (Sano et al., 1997; Petersen et al., 2005; Pham and Plakogiannis, 2005; DeKosky et al., 2008).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Sano et al., 1997
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Following a report of success of high-dose vitamin E in keeping late-stage AD patients out of long-term care facilities longer than patients on a placebo81, other studies with vitamin E have been less impressive70,78,80.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [81]
Experimental — accuracy not yet measuredIn the citing paper
“there were no concerning safely signals or increased mortality with high-dose vitamin E. 127,128”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [127]
In the citing paper
“high-dose vitamin E (1000 IU twice daily was the regimen tested) may be considered based on results of 2 RCTs that supported approximately 20% lower rate of ADL decline over approximately 2 to 3 years; there were no concerning safely signals or increased mortality with high-dose vitamin E. 127,128”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [127]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Pryor, W. A. (1976) · Cited by 1,876
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296
Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease
The Parkinson Study Group (1993) · New England Journal of Medicine · doi:10.1056/nejm199301213280305 · Cited by 1,222
A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease
Knapp, M. J. (1994) · JAMA · doi:10.1001/jama.271.13.985 · Cited by 1,000
The Free Radical Theory of Aging
Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 935
Research works printed but not linked: 1
- Holm S, 1979, Scand J Stat, 6, 65
Cited by
Sorted by citations
Items 501–600 of 1,005
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N., Llewellyn, D., Isaac, M. G. E. K. N., & Tabet, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854.pub4 · Cited by 104
Antioxidant approaches for the treatment of Alzheimer’s disease
Lee, H. P., Zhu, X., Casadesús, G., Castellani, R. J., Nunomura, A., Smith, M. A., Lee, H., & Perry, G. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.74 · Cited by 104
Joseph, J. A., Denisova, N. A., Bielinski, D. F., Fisher, D. R., & Shukitt‐Hale, B. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00128-7 · Cited by 104
A healthy body, a healthy mind: long-term impact of diet on mood and cognitive function
Rogers, P. J. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200061 · Cited by 104
Hydroxynonenal, toxic carbonyls, and Alzheimer disease
Liu, Q., Raina, A. K., Smith, M. A., Sayre, L. M., & Perry, G. L. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00025-6 · Cited by 104
Dietary links to Alzheimer’s disease
Grant, W. B. (1997) · Cited by 104
Neuroprotective activities of estrogen: An update
Behl, C., & Manthey, D. (2000) · Journal of Neurocytology · doi:10.1023/a:1007109222673 · Cited by 104
Lezoualc’h, F., Sparapani, M., & Behl, C. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00530.x · Cited by 104
Kidd, P. M. (2005) · PubMed · Cited by 104
Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants
Domenico, F. D., Barone, E., Marzia Perluigi, A., & Butterfield, D. A. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.955853 · Cited by 103
Disentangling Mitochondria in Alzheimer’s Disease
Johri, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111520 · Cited by 103
Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats
Ohwada, K., Takeda, H., Yamazaki, M., Isogai, H., Nakano, M., Shimomura, M., Fukui, K., & Urano, S. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008005 · Cited by 103
Aliphatic propargylamines: New antiapoptotic drugs
Boulton, A. A., Davis, B. A., Durden, D. A., Dyck, L. E., Juorio, A. V., Li, X., Paterson, I. A., & Yu, P. H. (1997) · Drug Development Research · doi:10.1002/(sici)1098-2299(199711/12)42:3/4 · Cited by 103
Brigelius‐Flohé, R. (2006) · Nutrition Research Reviews · doi:10.1017/s0954422407202938 · Cited by 103
Nutritional factors, cognitive decline, and dementia
Parigi, A. D., Panza, F., Capurso, C. A., & Solfrizzi, V. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.09.020 · Cited by 103
Astrocytes protect neurons from ethanol‐induced oxidative stress and apoptotic death
Watts, L. T., Rathinam, M. L., Schenker, S., & Henderson, G. I. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20502 · Cited by 102
Neuronal and Vascular Oxidative Stress in Alzheimers Disease
Massaad, C. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376244 · Cited by 102
Nutrition and prevention of Alzheimer’s dementia
Swaminathan, A., & Jicha, G. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00282 · Cited by 102
Radial width of the temporal horn: a sensitive measure in Alzheimer disease.
Frisoni, G. B., Geroldi, C., Beltramello, A., Bianchetti, A., Binetti, G. G., Bordiga, G., DeCarli, C. S., Laakso, M. P., Soininen, H. S., Testa, C., et al. (2002) · PubMed Central · Cited by 102
Huperzine A and tacrine attenuate ?-amyloid peptide-induced oxidative injury
Xiao, X., Wang, R., & Tang, X. C. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000901)61:5 · Cited by 101
Davies, S. S., Amarnath, V., Montine, K. S., Bernoud‐Hubac, N., Boutaud, O. G., Montine, T. J., & Roberts, L. J. (2002) · The FASEB Journal · doi:10.1096/fj.01-0696fje · Cited by 101
Bullock, R. A. (2005) · Psychiatry · doi:10.1383/psyt.4.1.64.58310 · Cited by 101
Subramaniam, R., Koppal, T., Green, M., Yatin, S. M., Jordan, B., Drake, J., & Butterfield, D. A. (1998) · Neurochemical Research · doi:10.1023/a:1020754807671 · Cited by 101
Coenzyme Q10:A Review of Its Promise as a Neuroprotectant
Young, A. J., Johnson, S., Steffens, D. C., & Doraiswamy, P. M. (2007) · CNS Spectrums · doi:10.1017/s1092852900020538 · Cited by 100
Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy
Behl, C. (2006) · Springer eBooks · doi:10.1007/0-387-23226-5_3 · Cited by 100
Chan, A. S.-Y., Cheung, M., Law, S. C. K., & Chan, J. (2004) · Cancer · doi:10.1002/cncr.11885 · Cited by 100
Arlt, S., Müller‐Thomsen, T., Beisiegel†, U., & Kontush, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0860-8 · Cited by 100
Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model
Garcia-Alloza, M., Dodwell, S. A., Meyer-Luehmann, M., Hyman, B. T., & Bacskai, B. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240468.12543.af · Cited by 99
Kölsch, H., Ludwig, M. Z., Lütjohann, D., & Rao, M. L. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170068 · Cited by 99
Zheng, H., Youdim, M. B. H., & Fridkin, M. (2010) · ACS Chemical Biology · doi:10.1021/cb900264w · Cited by 99
Recommendations for best practices in the treatment of Alzheimer's disease in managed care
Fillit, H. M., Doody, R. S., Binaso, K., Crooks, G. M., Ferris, S. H., Farlow, M. R., Leifer, B. P., Mills, C. S., Minkoff, N. B., Orland, B. I., et al. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.10.001 · Cited by 99
Advances and Challenges in the Prevention and Treatment of Alzheimer's Disease
Brinton, R. D., & Yamazaki, R. S. (1998) · Pharmaceutical Research · doi:10.1023/a:1011963929012 · Cited by 99
Butterfield, D. A., Yatin, S. M., Varadarajan, S., & Koppal, T. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)09050-3 · Cited by 99
Mediterranean Diet in Predementia and Dementia Syndromes
Solfrizzi, V., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., D’Onofrio, G., Addante, F., Sancarlo, D., Cascavilla, L., Pilotto, A., et al. (2011) · Current Alzheimer Research · doi:10.2174/156720511796391809 · Cited by 98
Treating Alzheimer's disease by targeting iron
Nikseresht, S., Bush, A. I., & Ayton, S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14567 · Cited by 98
Complementary medicines in psychiatry
Werneke, U., Turner, T. H., & Priebe, S. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.188.2.109 · Cited by 98
Baron, W., de Jonge, J. C., Vries, H. D., & Hoekstra, D. (1998) · Glia · doi:10.1002/(sici)1098-1136(199802)22:2 · Cited by 56
Natural Antioxidants for Neurodegenerative Diseases
Zhao, B. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:283 · Cited by 98
AGE–RAGE stress: a changing landscape in pathology and treatment of Alzheimer’s disease
Prasad, K. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03553-4 · Cited by 97
High doses of vitamin E in the treatment of disorders of the central nervous system in the aged
Vatassery, G. T., Bauer, T. A., & Dysken, M. W. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.793 · Cited by 97
Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs
Landsberg, G. M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.12.012 · Cited by 97
A practical algorithm for managing Alzheimer's disease: what, when, and why?
Cummings, J. L., Isaacson, R., Schmitt, F. A., & Velting, D. M. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.166 · Cited by 97
Dependence as a unifying construct in defining Alzheimer's disease severity
McLaughlin, T. P., Feldman, H., Fillit, H. M., Sano, M. C., Schmitt, F. A., Aisen, P. S. S., Leibman, C. W., Mucha, L., Ryan, J. M., Sullivan, S. D., et al. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.09.004 · Cited by 97
Self-citationYatin, S. M., Yatin, M., Aulick, T., Ain, K. B., & Butterfield, D. A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00101-9 · Cited by 97
Schmidt, R., Hayn, M., Reinhart, B., Roob, G., Schmidt, H., Schumacher, M., Watzinger, N., & Launer, L. J. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb06008.x · Cited by 96
Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity
Klegeris, A., & MCGEER, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00021-0 · Cited by 96
Chodosh, J., Reuben, D. B., Albert, M., & Seeman, T. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50260.x · Cited by 96
Pharmacological activities of crocin in saffron
Soeda, S., Ochiai, T., Shimeno, H., Saito, H., Abe, K., Tanaka, H., & Shoyama, Y. (2007) · Journal of Natural Medicines · doi:10.1007/s11418-006-0120-9 · Cited by 96
Vitamin E for Alzheimer's disease and mild cognitive impairment
Isaac, M. G. E. K. N., Quinn, R., & Tabet, N. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002854 · Cited by 96
Disease-Modifying Therapies in Alzheimer???s Disease
ll, M. H., Berger, T., & Heneka, M. T. (2006) · Drugs · doi:10.2165/00003495-200666160-00004 · Cited by 95
Ben‐Shlomo, Y., Churchyard, A., Head, J. A., Hurwitz, B., Overstall, P. W., Ockelford, J., & Lees, A. J. (1998) · BMJ · doi:10.1136/bmj.316.7139.1191 · Cited by 95
Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
Cherubini, A., Martin, A., Andres-Lacueva, C., Di Iorio, A., Lamponi, M., Mecocci, P., Bartali, B., Corsi, A., Senin, U., & Ferrucci, L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.002 · Cited by 94
Role of iron in neurotoxicity: a cause for concern in the elderly?
Stankiewicz, J., & Brass, S. D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831ba07c · Cited by 94
Shores, M. M., Ryan‐Dykes, P., Williams, R. M., Mamerto, B., Sadak, T. I., Pascualy, M., Felker, B. L., Zweigle, M., Nichol, P., & Peskind, E. R. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1029 · Cited by 94
Nursing home placement is related to dementia progression
Knopman, D. S., Berg, J. D., Thomas, R. G., Grundman, M., Thal, L. J., Sano, M., & Study, F. M. O. T. A. D. C. (1999) · Neurology · doi:10.1212/wnl.52.4.714 · Cited by 94
Self-citationBrain Ageing in the New Millennium
Trollor, J. N., & Valenzuela, M. (2001) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.00969.x · Cited by 93
MAO-B inhibitors: multiple roles in the therapy of neurodegenerative disorders?
Foley, P., Gerlach, M., Youdim, M. B. H., & Riederer, P. F. (2000) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(99)00043-7 · Cited by 93
Kowalik-Jankowska, T., Ruta, M., Wiśniewska, K., Łankiewicz, L., & Dyba, M. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.03.001 · Cited by 92
Kumar, B., Dwivedi, A. R., Sarkar, B., Gupta, S. K., Krishnamurthy, S., Mantha, A. K., Parkash, J., & Kumar, V. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00220 · Cited by 92
Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease
Collins, A. E., Saleh, T. M., & Kalisch, B. E. (2022) · Antioxidants · doi:10.3390/antiox11020213 · Cited by 93
Rota, C., Rimbach, G. H., Minihane, A. M., Stoecklin, E., & Barella, L. (2005) · Nutritional Neuroscience · doi:10.1080/10284150400027123 · Cited by 92
Song, J., Hur, B. E., Bokara, K. K., Yang, W., Cho, H. J., Park, K. A., Lee, W. T., Lee, K. M., & Lee, J. E. (2014) · Yonsei Medical Journal · doi:10.3349/ymj.2014.55.3.689 · Cited by 92
Deschamps, V., Barberger‐Gateau, P., Peuchant, E., & Orgogozo, J. M. (2001) · Neuroepidemiology · doi:10.1159/000054752 · Cited by 92
Um, M. Y., Choi, W.-H., Aan, J.-Y., Kim, S.-R., & Ha, T. Y. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.08.054 · Cited by 91
Borroni, E., Bohrmann, B., Grueninger, F., Prinssen, E. P. M., Navé, S., Loetscher, H., Chinta, S. J., Rajagopalan, S., Rane, A., Siddiqui, A., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.241653 · Cited by 90
Alzheimer's Disease: Cerebrovascular Dysfunction, Oxidative stress, and Advanced Clinical Therapies
Marlatt, M. W., Lucassen, P. J., Perry, G. L., Smith, M. A., & Zhu, X. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15206 · Cited by 90
Cognitive Function in Elderly People Is Influenced by Vitamin E Status
Ortega, R. M., Requejo, A. M., López-Sobaler, A. M., Navia, B., Perea, J. M., Andrés, P., & Robles, F. J. B. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.2065 · Cited by 90
Liu, A., Zhao, X. D., Li, H., Liu, Z., Liu, B., Mao, X., Guo, L., Bi, K., & Jia, Y. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.10.028 · Cited by 89
Role of the antioxidant ascorbate in hibernation and warming from hibernation
Drew, K. L., Tøien, Ø., Rivera, P., Smith, M. A., Perry, G. L., & Rice, M. E. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00118-7 · Cited by 89
Percy, M. E., Kruck, T. P. A., Pogue, A. I., & Lukiw, W. J. (2011) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2011.08.001 · Cited by 89
Huang, Q., Aluise, C. D., Gururaj Joshi, A., Rukhsana Sultana, A., Clair, D. K. S., Markesbery, W. R., & Butterfield, D. A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22422 · Cited by 89
Dietary patterns and cognitive function in elderly men in Finland, Italy and the Netherlands
Huijbregts, P., Feskens, E. J. M., Räsänen, L., Fidanza, F., Alberti-Fidanza, A., Nissinen, A. M., Giampaoli, S., & Kromhout, D. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600654 · Cited by 89
Chiba, T., Yamada, M., Hashimoto, Y., Sato, M., Sasabe, J., Kita, Y. A., Terashita, K., Aiso, S., Nishimoto, I., & Matsuoka, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3348-05.2005 · Cited by 89
Sang, Z., Wang, K., Zhang, P., Shi, J., Liu, W., & Tan, Z. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.021 · Cited by 89
Topic, B., Tani, E., Tsiakitzis, K. C., Kourounakis, P. N., Dere, E., Hasenöhrl, R. U., Häcker, R., Mattern, C., & Huston, J. P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00241-x · Cited by 89
Tocopherol (Vitamin E) in Alzheimer???s Disease and Other Neurodegenerative Disorders
Berman, K., & Brodaty, H. (2004) · CNS Drugs · doi:10.2165/00023210-200418120-00005 · Cited by 89
Vegetarian diet: panacea for modern lifestyle diseases?
Segasothy, M., & Phillips, P. A. (1999) · QJM · doi:10.1093/qjmed/92.9.531 · Cited by 89
Mendelsohn, A. B., Belle, S. H., Stoehr, G. P., & Ganguli, M. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009556 · Cited by 88
Loeffler, D. A. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230025 · Cited by 90
How do AD patients and their caregivers decide whether to enroll in a clinical trial?
Karlawish, J. H., Casarett, D., Klocinski, J., & Sankar, P. L. (2001) · Neurology · doi:10.1212/wnl.56.6.789 · Cited by 88
Efficient Synthesis of Chiral β‐Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation
Chen, J., Zhang, W., Geng, H., Li, W., Hou, G., Lei, A., & Zhang, X. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200805058 · Cited by 88
Oxidative Stress and the Aging Brain
Vila, J., Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2007) · Frontiers in neuroscience · doi:10.1201/9781420005523.ch15 · Cited by 88
Mitochondrial therapeutic interventions in Alzheimer’s disease
Giau, V. V., An, S. S. A., & Hulme, J. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.09.033 · Cited by 87
Conforti, F., Marrelli, M., Colica, C., Menichini, F., Perri, V., Uzunov, D., Statti, G. A., Duez, P., & Menichini, F. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.05.085 · Cited by 87
Aruoma, O. I., Sun, B., Fujii, H., Neergheen, V. S., Bahorun, T., Kang, K., & Sung, M. (2006) · BioFactors · doi:10.1002/biof.5520270121 · Cited by 87
Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline
Basambombo, L. L., Carmichael, P., Côté, S., & Laurin, D. (2016) · Annals of Pharmacotherapy · doi:10.1177/1060028016673072 · Cited by 87
Schubert, M., Kluge, S., Schmölz, L., Wallert, M., Galli, F., Birringer, M., & Lorkowski, S. (2018) · Antioxidants · doi:10.3390/antiox7010010 · Cited by 87
Mitochondrial Abnormalities in Alzheimer’s Disease
Silva, D. F., Selfridge, J. E., Lu, J., E, L., Cardoso, S. M., & Swerdlow, R. H. (2012) · Advances in Pharmacology · doi:10.1016/b978-0-12-394816-8.00003-9 · Cited by 86
Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder
Barbagallo, M., Marotta, F., & Dominguez, L. J. (2015) · Mediators of Inflammation · doi:10.1155/2015/624801 · Cited by 86
Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities
Caldwell, C. C., Yao, J., & Brinton, R. D. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0324-8 · Cited by 86
Song, F., Poljak, A., Kochan, N. A., Raftery, M. J., Brodaty, H., Smythe, G. A., & Sachdev, P. S. (2014) · Proteome Science · doi:10.1186/1477-5956-12-5 · Cited by 86
A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment
Schifitto, G., Zhang, J., Evans, S. R., Sacktor, N. C., Simpson, D. M., Millar, L., Hung, V., Miller, E. N., Smith, E. V., Ellis, R. J., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000268487.78753.0f · Cited by 86
Behl, C. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070082 · Cited by 86
Presenile dementia syndromes: an update on taxonomy and diagnosis
Greicius, M. D. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.691 · Cited by 86
Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease
Dumont, M., Lin, M. T. S., & Beal, M. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100507 · Cited by 85
Health economic evaluation of treatments for Alzheimer′s disease: impact of new diagnostic criteria
Wimo, A. B., Ballard, C. G., Brayne, C., Gauthier, S. G., Handels, R. L. H., Jones, R. W., Jönsson, L., Khachaturian, A. S., & Kramberger, M. G. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12167 · Cited by 85
Management of mild to moderate Alzheimer's disease and dementia
Hogan, D. B., Bailey, P., Carswell, A., Clarke, B., Cohen, C. A., Forbes, D. A., Man‐Son‐Hing, M., Lanctôt, K. L., Morgan, D., & Thorpe, L. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.07.006 · Cited by 85
Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1
Ahmed, M., Hung, W.-Y., Zu, J. S., Hockberger, P. E., & Siddique, T. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00317-8 · Cited by 85
Wenk, G. L., McGann-Gramling, K. R., Hauss‐Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L., & Ongini, E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02359.x · Cited by 85
Pycnogenol® protects neurons from amyloid-β peptide-induced apoptosis
Peng, Q. L., Buz'Zard, A. R., & Lau, B. H. S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00263-2 · Cited by 85
Metadata
- Authors
- Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S., & Thal, L. J.
- Affiliations
- University of California San Diego (US)
- Harvard University (US)
- University of California, Irvine (US)
- University of South Florida (US)
- University of Southern California (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-04-24
- Volume
- 336
- Issue
- 17
- Pages
- 1216-1222
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2326200998
- Cited by
- 2,380
- References
- 36
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 39 · 2023: 39 · 2022: 41 · 2021: 38 · 2020: 44 · 2019: 43 · 2018: 44 · 2017: 47 · 2016: 55 · 2015: 54 · 2014: 72 · 2013: 62 · 2012: 82
- FWCI
- 118.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (U01‐AG10483, U01AG010483, U19AG010483)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, selegiline, alpha-tocopherol, vitamin E, monoamine oxidase inhibitors, combination therapy, disease progression, dementia, activities of daily living, Mini-Mental State Examination, oxidative stress, catecholamines
- MeSH terms
- Activities of Daily Living, Aged, Alzheimer Disease, Cognition, Double-Blind Method, Drug Combinations, Female, Humans, Institutionalization, Male, Mental Status Schedule, Monoamine Oxidase Inhibitors, Selegiline, Vitamin E, Proportional Hazards Models, Treatment Outcome, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
