Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model

Structure-antioxidant activity relationships of flavonoids and phenolic acids

Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844 · see citing works

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Zhou, M., Diwu, Z. J., Panchuk-Voloshina, N., & Haugland, R. P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2391 · Cited by 1,400 · see citing works

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Huang, X., Atwood, C., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J. T., Moir, R. D., et al. (1999) · Biochemistry · doi:10.1021/bi990438f · Cited by 1,107 · see citing works

Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention

Bagchi, D., Bagchi, M., STOHS, S. J., Das, D. K., Ray, S. D., KUSZYNSKI, C. A., Joshi, S. S., & Pruess, H. G. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00210-9 · Cited by 1,068 · see citing works

Expression of Concern: Potent anti‐amyloidogenic and fibril‐destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

Ono, K., Yoshiike, Y., Takashima, A., Hasegawa, K., Naiki, H., & Yamada, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01976.x · Cited by 681 · see citing works

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · cited 3× · see citing works

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

Irizarry, M. C., Soriano, F., McNamara, M., Page, K. J., Schenk, D., Games, D., & Hyman, B. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07053.1997 · Cited by 497 · see citing works

Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

Walsh, D. M., & Selkoe, D. J. (2004) · Protein and Peptide Letters · doi:10.2174/0929866043407174 · Cited by 428 · see citing works

Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative

Klunk, W. E., Bacskai, B. J., Mathis, C. A., Kajdasz, S. T., McLellan, M. E., Frosch, M. P., Debnath, M. L., Holt, D. P., Wang, Y., & Hyman, B. T. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.9.797 · Cited by 412 · see citing works

Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach2 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Behl, C., & Moosmann, B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00883-3 · Cited by 301 · see citing works

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

Larson, J., LYNCH, G. S., Games, D., & Seubert, P. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01698-4 · Cited by 274 · see citing works

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

Knowles, R. B., Wyart, C., Buldyrev, S. V., Cruz, L., Urbanc, B., Hasselmo, M. E., Stanley, H. E., & Hyman, B. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5274 · Cited by 241 · see citing works

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer’s disease

Urbanc, B., Cruz, L., Le, R., Sanders, J., Ashe, K. H., Duff, K., Stanley, H. E., Irizarry, M. C., & Hyman, B. T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222433299 · Cited by 237 · see citing works

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment

Stackman, R. W., Eckenstein, F., Frei, B., Kulhanek, D., Nowlin, J., & Quinn, J. F. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00399-6 · Cited by 230 · see citing works

Cortical Synaptic Integration<i>In Vivo</i>Is Disrupted by Amyloid-β Plaques

Stern, E. A., Bacskai, B. J., Hickey, G. A., Attenello, F. J., Lombardo, J. A., & Hyman, B. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0462-04.2004 · Cited by 210 · see citing works

Natural extracts as possible protective agents of brain aging

Bastianetto, S., & Quirion, R. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00024-6 · Cited by 196 · see citing works

Antioxidant strategies for Alzheimer's disease

Grundman, M., & Delaney, P. (2002) · Proceedings of The Nutrition Society · doi:10.1079/pns2002146 · Cited by 193 · see citing works

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23269 · Cited by 190 · see citing works

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.008 · Cited by 189 · see citing works

Red Wine Ingredient Resveratrol Protects from β-Amyloid Neurotoxicity

Savaskan, E., Olivieri, G., Meier, F., Seifritz, E., Wirz‐Justice, A., & Müller-Spahn, F. (2003) · Gerontology · doi:10.1159/000073766 · Cited by 182 · see citing works

β-Amyloid Immunotherapy Prevents Synaptic Degeneration in a Mouse Model of Alzheimer's Disease

Buttini, M., Masliah, E., Barbour, R., Grajeda, H., Motter, R., Johnson-Wood, K., Khan, K., Seubert, P., Freedman, S., Schenk, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1697-05.2005 · Cited by 176 · see citing works

<i>In Vivo</i>Imaging of Reactive Oxygen Species Specifically Associated with Thioflavine S-Positive Amyloid Plaques by Multiphoton Microscopy

McLellan, M. E., Kajdasz, S. T., Hyman, B. T., & Bacskai, B. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02212.2003 · Cited by 174 · see citing works

Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease

Khoury, J. B. E., Hickman, S., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00036-0 · Cited by 157 · see citing works

Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations

Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10879.2003 · Cited by 149 · see citing works

Effects of coenzyme Q10 and α-tocopherol administration on their tissue levels in the mouse: elevation of mitochondrial α-tocopherol by coenzyme Q10

Lass, A., Forster, M. J., & Sohal, R. S. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00330-x · Cited by 148 · see citing works

Fibrillar β-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer’s disease

Matsuoka, Y., Picciano, M., LaFrancois, J. J., & Duff, K. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00115-4 · Cited by 147 · see citing works

Preparation and Definition of Ginkgo Biloba Extract

Drieu, K. (1988) · Springer eBooks · doi:10.1007/978-3-642-73686-5_3 · Cited by 139 · see citing works

Influence of the Severity of Cognitive Impairment on the Effect of the Ginkgo biloba Extract EGb 761® in Alzheimer’s Disease

Bars, P. L. L., Velasco, F. M., Ferguson, J. M., Dessain, E. C., Kieser, M., & Hoerr, R. (2002) · Neuropsychobiology · doi:10.1159/000048668 · Cited by 132 · see citing works

Ginkgo biloba Extract EGb 761® in Dementia: Intent-to-treat Analyses of a 24-week, Multi-center, Double-blind, Placebo-controlled, Randomized Trial

Kanowski, S., & Hoerr, R. (2003) · Pharmacopsychiatry · doi:10.1055/s-2003-45117 · Cited by 127 · see citing works

Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis.

Yao, Y., Chinnici, C. M., Tang, H., Trojanowski, J. Q., Lee, V. M. ‐., & Praticò, D. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-21 · Cited by 90 · see citing works

In Vivo Multiphoton Imaging of a Transgenic Mouse Model of Alzheimer Disease Reveals Marked Thioflavine-S-Associated Alterations in Neurite Trajectories

D'Amore, J. D., Kajdasz, S. T., McLellan, M. E., Bacskai, B. J., Stern, E. A., & Hyman, B. T. (2003) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/62.2.137 · Cited by 89 · see citing works

Plaques and tangles and the pathogenesis of Alzheimer's disease.

Armstrong, R. A. (2006) · PubMed · Cited by 87 · see citing works

Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells.

Smith, J. V., Burdick, A. J., Golik, P., Khan, I. A., Wallace, D. C., & Luo, Y. (2002) · PubMed · Cited by 84 · see citing works

Pycnogenol® protects neurons from amyloid-β peptide-induced apoptosis

Peng, Q. L., Buz'Zard, A. R., & Lau, B. H. S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00263-2 · Cited by 84 · see citing works

Rodent Aβ(1–42) exhibits oxidative stress properties similar to those of human Aβ(1–42): Implications for proposed mechanisms of toxicity

Boyd-Kimball, D., Sultana, R., Abdul, H. M., & Butterfield, D. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6509 · Cited by 83 · see citing works

Combination Therapy of Donepezil and Vitamin E in Alzheimer Disease

Klatte, E. T., Scharre, D. W., Nagaraja, H. N., Davis, R. A., & Beversdorf, D. Q. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200304000-00010 · Cited by 81 · see citing works

Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy Bodies

Hashimoto, M., & Masliah, E. (2003) · Neurochemical Research · doi:10.1023/a:1026073324672 · Cited by 78 · see citing works

Small non-fibrillar assemblies of amyloid β-protein bearing the Arctic mutation induce rapid neuritic degeneration

Whalen, B. M., Selkoe, D. J., & Hartley, D. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.007 · Cited by 75 · see citing works

Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations

Martin, A., Janigian, D., Shukitt‐Hale, B., Prior, R. L., & Joseph, J. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01923-x · Cited by 61 · see citing works

Oxidative stress induced by beta-amyloid peptide1–42 is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells

Qi, X., Xiu, J., Shan, K.-R., Xiao, Y. C., Gu, R., Liu, R., & Guan, Z.-Z. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.02.007 · Cited by 56 · see citing works

The effect of Ginkgo extract EGb761 in cisplatin-induced peripheral neuropathy in mice

Öztürk, G., Anlar, Ö., Erdoğan, E., et al. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.12.006 · Cited by 38 · see citing works

EGb 761 is a neuroprotective agent against beta-amyloid toxicity.

Bastianetto, S., & Quirion, R. (2002) · PubMed · Cited by 35 · see citing works

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729 · see citing works

Amyloid toxicity in Alzheimer’s disease

Reiss, A. B., Arain, H. A., Stecker, M. M., Siegart, N. M., & Kasselman, L. J. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0063 · Cited by 447 · see citing works

Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures

Galasko, D. R., Peskind, E., Clark, C. M., Quinn, J. F., Ringman, J. M., Jicha, G. A., Cotman, C., Cottrell, B., Montine, T. J., Thomas, R. G., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.85 · Cited by 377 · see citing works

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221 · see citing works

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

Tong, X.-K., Nicolakakis, N., Fernandes, P., Ongali, B., Brouillette, J., Quirion, R., & Hamel, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.003 · Cited by 122 · see citing works

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

Rozkalne, A., Hyman, B. T., & Spires-Jones, T. L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.11.014 · Cited by 103 · see citing works

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseases

Golde, T. E., & Miller, V. M. (2009) · Alzheimer's Research &amp; Therapy · doi:10.1186/alzrt5 · Cited by 98 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works

Traditional used Plants against Cognitive Decline and Alzheimer Disease

Eckert, G. P. (2010) · Frontiers in Pharmacology · doi:10.3389/fphar.2010.00138 · Cited by 47 · see citing works

Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging

Spires-Jones, T. L., Calignon, A. D., Meyer-Luehmann, M., Bacskai, B. J., & Hyman, B. T. (2011) · Methods · doi:10.1016/j.ymeth.2010.12.009 · Cited by 24 · see citing works

Aluminum neurotoxicity involves oxidative stress, inflammation and apoptosis : implications for neurodegeneration

Johnson, V. J. (2002)

The inhibitory effect of neuropathic organophosphate esters on neurite outgrowth in cell cultures: A basis for screening for delayed neurotoxicity

Henschler, D., Schmuck, G., van Aerssen, M., & Schiffmann, D. (1992) · Toxicology in Vitro · doi:10.1016/0887-2333(92)90022-j · Cited by 46 · see citing works

The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition

Tabaton, M., Mandybur, T. I., Perry, G. L., Onorato, M., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260614 · Cited by 80 · see citing works

Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles

Feng, C., Liu, S., Zhou, F., Gao, Y., Li, Y., Du, G., Chen, Y., Jiao, H., Feng, J., Zhang, Y., et al. (2018) · Toxicology · doi:10.1016/j.tox.2018.11.003 · Cited by 43 · see citing works

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer’s amyloid β-peptide 1–42

Butterfield, D. A., & Kański, J. (2002) · Peptides · doi:10.1016/s0196-9781(02)00066-9 · Cited by 151 · see citing works