Cited by 204Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersPituitary Gland Disorders and Treatments

Propranolol therapy for ectopic β-adrenergic receptors in adrenal Cushing's syndrome.

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Lacroix, André, Tremblay, Johanne, Rousseau, Guy, Bouvier, Michel, Hamet, Pavel·1997·New England Journal of Medicine

Abstract

Most patients with corticotropin-independent Cushing's syndrome have an adrenal adenoma or carcinoma,1 but a few have bilateral adrenal hyperplasia. Three patients with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia2–4 and two patients with adrenal adenomas5,6 in whom food stimulated cortisol secretion have been described; the abnormal adrenal tissues in these patients aberrantly overexpressed receptors for gastric inhibitory polypeptide.6,7 We describe a patient with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia in whom endogenous catecholamines, acting through an ectopic adrenal β-adrenergic receptor, stimulated cortisol secretion; the hyperadrenocorticism was inhibited by β-blockade. Case Report A 56-year-old man presented with . . .

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  • Somatostatin analogs have been used to control food-dependent cortisol hypersecretion due to aberrant glucose-dependent insulinotropic peptide receptors; propranolol has been proposed in adrenal hypercortisolism and leuprolide acetate in LH-dependent Cushing's syndrome.

    “Indeed, somatostatin analogs have been used to control food-dependent cortisol hypersecretion due to the presence of aberrant glucose-dependent insulinotropic peptide receptors (100, 101); propranolol has been proposed in patients with adrenal hypercortisolism (102) and leuprolide acetate in LH-dependent Cushing's syndrome (103).”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [102]

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  1. Archambeaud-Mouveroux F, Comas JM, Tessier MP, et al. Food- dependent Cushing's syndrome associated with the Carney complex. In: Proceedings of the 10th Meeting of the International Endocrine Society, San Francisco, June 12-15, 1996. Bethesda, Md.: Endocrine Society Press, 1996:899. abstract.
  2. Hieble JP, Ruffolo RR. Subclassification of the b-adrenoceptors. Phar- macol Commun 1995;6:183-93.
  3. Blin N, Camoin L, Maigret B, Strosberg AD. Structural and confor- mational features determining selective signal transduction in the b 3 -adre- nergic receptor. Mol Pharmacol 1993;44:1094-104.
  4. Hinshaw HT, Ney RL. Abnormal hormonal control in the neoplastic adrenal cortex. In: McKerns KW, ed. Hormones and cancer. New York: Ac- ademic Press, 1974:309-27.
  5. Mak JCW, Nishikawa M, Barnes PJ. Glucocorticoids increase b 2 -adre- nergic receptor transcription in human lung. Am J Physiol 1995;268:L41- L46.

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Authors
Lacroix, A., Tremblay, J., Rousseau, G., Bouvier, M., & Hamet, P.
Affiliations
  • Centre Hospitalier de l’Université de Montréal (CA)
  • Université de Montréal (CA)
Venue
New England Journal of Medicine
Published
1997-11-13
Volume
337
Issue
20
Pages
1429-1434
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2320000533
Cited by
204
References
24
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 6
FWCI
9.90
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sanofi
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
Cushing's syndrome, bilateral adrenal hyperplasia, propranolol, beta-adrenergic blockade, hyperadrenocorticism, catecholamines, cortisol secretion, adrenal adenoma
MeSH terms
Adrenal Glands, Adrenergic beta-Antagonists, Catecholamines, Cushing Syndrome, Humans, Hydrocortisone, Hyperplasia, Male, Middle Aged, Propranolol, Receptors, Adrenergic, beta

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