Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome.
Open accessAbstract
Corticotropin-independent Cushing's syndrome is usually caused by cortisol-secreting adrenal adenomas, carcinomas, or (rarely) bilateral adrenal hyperplasia. In some patients with this syndrome, the excess secretion of cortisol is caused by abnormal adrenal expression and function of receptors for various hormones, including gastric inhibitory polypeptide,1–6 vasopressin,7–9 β-adrenergic agonists,10 and interleukin-1.11 These findings suggest that diverse other hormone receptors could be implicated in other patients.12 We describe a woman with bilateral adrenal hyperplasia and corticotropin-independent Cushing's syndrome that was clinically manifested transiently during her pregnancies and became constant only after menopause. The patient's cortisol secretion was stimulated by luteinizing hormone . . .
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Somatostatin analogs have been used to control food-dependent cortisol hypersecretion due to aberrant glucose-dependent insulinotropic peptide receptors; propranolol has been proposed in adrenal hypercortisolism and leuprolide acetate in LH-dependent Cushing's syndrome.
“Indeed, somatostatin analogs have been used to control food-dependent cortisol hypersecretion due to the presence of aberrant glucose-dependent insulinotropic peptide receptors (100, 101); propranolol has been proposed in patients with adrenal hypercortisolism (102) and leuprolide acetate in LH-dependent Cushing's syndrome (103).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [103]
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- Authors
- Lacroix, A., Hamet, P., & Boutin, J.-M.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-11-18
- Volume
- 341
- Issue
- 21
- Pages
- 1577-1581
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2317769924
- Cited by
- 244
- References
- 33
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 1 · 2022: 13 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 6 · 2012: 4
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- bilateral adrenal hyperplasia, leuprolide, luteinizing hormone, menopause, pregnancy, cortisol secretion, hormone receptors
- MeSH terms
- Adrenocorticotropic Hormone, Cushing Syndrome, Female, Humans, Hydrocortisone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Middle Aged, Leuprolide
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