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Propranolol therapy for ectopic β-adrenergic receptors in adrenal Cushing's syndrome.
Open accessAbstract
Most patients with corticotropin-independent Cushing's syndrome have an adrenal adenoma or carcinoma,1 but a few have bilateral adrenal hyperplasia. Three patients with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia2–4 and two patients with adrenal adenomas5,6 in whom food stimulated cortisol secretion have been described; the abnormal adrenal tissues in these patients aberrantly overexpressed receptors for gastric inhibitory polypeptide.6,7 We describe a patient with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia in whom endogenous catecholamines, acting through an ectopic adrenal β-adrenergic receptor, stimulated cortisol secretion; the hyperadrenocorticism was inhibited by β-blockade. Case Report A 56-year-old man presented with . . .
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“Indeed, somatostatin analogs have been used to control food-dependent cortisol hypersecretion due to the presence of aberrant glucose-dependent insulinotropic peptide receptors (100, 101); propranolol has been proposed in patients with adrenal hypercortisolism (102) and leuprolide acetate in LH-dependent Cushing's syndrome (103).”
From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [102]
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Lacroix, A., Feelders, R. A., Stratakis, C. A., & Nieman, L. K. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61375-1 · Cited by 1,777
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Metadata
- Authors
- Lacroix, A., Tremblay, J., Rousseau, G., Bouvier, M., & Hamet, P.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Université de Montréal (CA)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-11-13
- Volume
- 337
- Issue
- 20
- Pages
- 1429-1434
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320000533
- Cited by
- 204
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- Cushing's syndrome, bilateral adrenal hyperplasia, propranolol, beta-adrenergic blockade, hyperadrenocorticism, catecholamines, cortisol secretion, adrenal adenoma
- MeSH terms
- Adrenal Glands, Adrenergic beta-Antagonists, Catecholamines, Cushing Syndrome, Humans, Hydrocortisone, Hyperplasia, Male, Middle Aged, Propranolol, Receptors, Adrenergic, beta
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