The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Topical Treatment with Nerve Growth Factor for Corneal Neurotrophic Ulcers
Open accessAbstract
BACKGROUND: Corneal neurotrophic ulcers associated with impairment of sensory innervation of the cornea may lead to loss of vision, and there is no effective treatment for these ulcers. We evaluated the effects of nerve growth factor in patients with this disorder. METHODS: Twelve patients (14 eyes) with severe neurotrophic corneal ulcers associated with corneal anesthesia were treated with topical nerve growth factor 10 times daily for two days and then 6 times daily until the ulcers healed. Treatment continued for 2 weeks after the ulcers healed, and the patients were then followed for up to 12 months. The evolution of the corneal disease during treatment and follow-up was evaluated by slit-lamp examination, photography, fluorescein-dye testing, and tests of corneal sensitivity and best corrected visual acuity. RESULTS: Corneal healing began 2 to 14 days after the initiation of treatment with nerve growth factor, and all patients had complete healing of their corneal ulcers after 10 days to 6 weeks of treatment. Corneal sensitivity improved in 13 eyes, and returned to normal in 2 of the 13 eyes. Corneal integrity and sensitivity were maintained during the follow-up period (range, 3 to 12 months). Best corrected visual acuity increased progressively during treatment and follow-up in all patients. There were no systemic or local side effects of treatment. CONCLUSIONS: In this preliminary, uncontrolled study, topically applied exogenous nerve growth factor restored corneal integrity in patients with corneal neurotrophic ulcers.
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Cites
The Nerve Growth Factor 35 Years Later
Levi-Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,125
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THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN
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Donnerer, J., Schuligoi, R., & Stein, C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90237-v · Cited by 607
Nerve growth factor-induced hyperalgesia in the neonatal and adult rat
Lewin, G., Ritter, A., & Mendell, L. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02136.1993 · Cited by 563
Cytologlogic Evidence of Corneal Diseases with Limbal Stem Cell Deficiency
Puangsricharern, V., & Tseng, S. C. G. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30842-1 · Cited by 493
Petty, B. G., Cornblath, D. R., Adornato, B. T., Chaudhry, V., Flexner, C., Wachsman, M., Sinicropi, D., Burton, L. E., & Peroutka, S. J. (1994) · Annals of Neurology · doi:10.1002/ana.410360221 · Cited by 402
Function and evolution in the NGF family and its receptors
Ebendal, T. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320402 · Cited by 349
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Neurotrophic factor therapy for nervous system degenerative diseases
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Cited by
(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70081-2 · Cited by 3,267
Progress in corneal wound healing
Ljubimov, A. V., & Saghizadeh, M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.002 · Cited by 872
Dua, H. S., Said, D. G., Messmer, E. M., Rolando, M., Benitez-del-Castillo, J. M., Hossain, P. N., Shortt, A. J., Geerling, G., Nubile, M., Figueiredo, F. C., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.003 · Cited by 404
Self-citationTopical treatment with nerve growth factor for neurotrophic keratitis
Bonini, S. (2000) · Ophthalmology · doi:10.1016/s0161-6420(00)00163-9 · Cited by 320
Self-citationTopical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy
Pflugfelder, S. C., Massaro-Giordano, M., Perez, V. L., Hamrah, P., Deng, S. X., Espandar, L., Foster, C. S., Affeldt, J., Seedor, J. A., Afshari, N. A., et al. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2019.08.020 · Cited by 281
Metadata
- Authors
- Lambiase, A., Rama, P., Bonini, S., Caprioglio, G., & Aloe, L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1998-04-23
- Volume
- 338
- Issue
- 17
- Pages
- 1174-1180
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337729957
- Cited by
- 420
- References
- 22
- FWCI
- 18.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lambiase, A., Rama, P., Bonini, S., Caprioglio, G., & Aloe, L. (1998). Topical Treatment with Nerve Growth Factor for Corneal Neurotrophic Ulcers. New England Journal of Medicine. https://doi.org/10.1056/nejm199804233381702
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
