The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
HIV-Protease Inhibitors
Abstract
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.13 Recent guidelines recommend that initial treatment of all HIV-infected patients include the administration of an HIV-protease inhibitor.4 The HIV-Encoded ProteaseThe HIV protease, encoded in the 5' end of the pol gene, is expressed as part of the gag–pol polyprotein (Figure 1A, Figure 1B, and Figure 1C). This gene encodes a 99-amino-acid protein. Homodimers of this protein have the aspartyl protease activity that is typical of retroviral proteases; monomers . . .
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Cites
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., & Richman, D. D. (1997) · Science · doi:10.1126/science.278.5341.1291 · Cited by 2,186
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050
Cited by
Finzi, D., Blankson, J., Siliciano, J. D., Margolick, J. B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., et al. (1999) · Nature Medicine · doi:10.1038/8394 · Cited by 2,119
Self-citationIndinavir concentrations and St John's wort
Piscitelli, S. C., Burstein, A. H., Chaitt, D., Alfaro, R. M., & Falloon, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05712-8 · Cited by 874
The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy
Murata, H., Hruz, P. W., & Mueckler, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000228200 · Cited by 586
Dubé, M. P., Stein, J. H., Aberg, J. A., Fichtenbaum, C. J., Gerber, J. G., Tashima, K. T., Henry, W. K., Currier, J. S., Sprecher, D., Glesby, M. J., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/378131 · Cited by 580
Substrate Shape Determines Specificity of Recognition for HIV-1 Protease
Prabu-Jeyabalan, M., Nalivaika, E., & Schiffer, C. A. (2002) · Structure · doi:10.1016/s0969-2126(02)00720-7 · Cited by 331
Metadata
- Authors
- Flexner, C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1998-04-30
- Volume
- 338
- Issue
- 18
- Pages
- 1281-1293
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3026032990
- Cited by
- 852
- References
- 2
- FWCI
- 80.20
- Type
- journal article
- Language
- en
- Open access
- closed
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