Cited by 4,685Cardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record, with a small difference in title or year; 40 of the 40 references it cites were found in a registry or an index.

Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults

Open access

O'Leary, Daniel H., Polak, Joseph F., Kronmal, Richard A., Manolio, Teri A., Burke, Gregory L., Wolfson, Sidney K.·1999·New England Journal of Medicine

DOI 10.1056/nejm199901073400103

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: The combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease. METHODS: Noninvasive measurements of the intima and media of the common and internal carotid artery were made with high-resolution ultrasonography in 5858 subjects 65 years of age or older. Cardiovascular events (new myocardial infarction or stroke) served as outcome variables in subjects without clinical cardiovascular disease (4476 subjects) over a median follow-up period of 6.2 years. RESULTS: The incidence of cardiovascular events correlated with measurements of carotid-artery intima-media thickness. The relative risk of myocardial infarction or stroke increased with intima-media thickness (P<0.001). The relative risk of myocardial infarction or stroke (adjusted for age and sex) for the quintile with the highest thickness as compared with the lowest quintile was 3.87 (95 percent confidence interval, 2.72 to 5.51). The association between cardiovascular events and intima-media thickness remained significant after adjustment for traditional risk factors, showing increasing risks for each quintile of combined intima-media thickness, from the second quintile (relative risk, 1.54; 95 percent confidence interval, 1.04 to 2.28), to the third (relative risk, 1.84; 95 percent confidence interval, 1.26 to 2.67), fourth (relative risk, 2.01; 95 percent confidence interval, 1.38 to 2.91), and fifth (relative risk, 3.15; 95 percent confidence interval, 2.19 to 4.52). The results of separate analyses of myocardial infarction and stroke paralleled those for the combined end point. CONCLUSIONS: Increases in the thickness of the intima and media of the carotid artery, as measured noninvasively by ultrasonography, are directly associated with an increased risk of myocardial infarction and stroke in older adults without a history of cardiovascular disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejm199901073400103

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Self-citation
Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens
Clauss, A. (2009) · Acta Haematologica · doi:10.1159/000205234 · Cited by 3,239
Coated Charcoal Immunoassay of Insulin
Herbert, V. D., Lau, K., Gottlieb, C. W., & Bleicher, S. J. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-10-1375 · Cited by 2,969
Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction
Bots, M. L., Hoes, A. W., Koudstaal, P. J., Albert Hofman, D., & Grobbee, D. E. (1997) · Circulation · doi:10.1161/01.cir.96.5.1432 · Cited by 2,333
Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993
Chambless, L. E., Heiss, G., Folsom, A. R., Rosamond, W., Szklo, M., Sharrett, A. R., & Clegg, L. X. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009302 · Cited by 1,990
An updated coronary risk profile. A statement for health professionals.
Anderson, K. M., Wilson, P. W., Odell, P. M., & Kannel, W. B. (1991) · Circulation · doi:10.1161/01.cir.83.1.356 · Cited by 1,834
Probability of stroke: a risk profile from the Framingham Study.
Wolf, P. A., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.3.312 · Cited by 1,782
Is Relationship Between Serum Cholesterol and Risk of Premature Death From Coronary Heart Disease Continuous and Graded?: Findings in 356 222 Primary Screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
Stamler, J. (1986) · JAMA · doi:10.1001/jama.1986.03380200061022 · Cited by 1,318

Show all 40 references

Research works printed but not linked: 1

10.1001/jama.256.20.2823 · DOI · Paper page

Sorted by citations

Items 401–500 of 1,015

Carotid intima-media thickness in plaque-free site, carotid plaques and coronary heart disease risk prediction in older adults. The Three-City Study
Plichart, M., Celermajer, D. S., Zureik, M., Helmer, C., Jouven, X., Ritchie, K. A., Tzourio, C., Ducimetière, P., & Empana, J. P. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.09.024 · Cited by 144
Coronary calcification detected by electron-beam computed tomography and myocardial infarction. The Rotterdam Coronary Calcification Study
Vliegenthart, R. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3240 · Cited by 144
3D blood flow characteristics in the carotid artery bifurcation assessed by flow‐sensitive 4D MRI at 3T
Harloff, A., Albrecht, F., Spreer, J., Stalder, A. F., Bock, J., Frydrychowicz, A. P., Schöllhorn, J. S., Hetzel, A., Schumacher, M. C., Hennig, J., et al. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21774 · Cited by 143
Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes
Mita, T., Watada, H., Ogihara, T., Nomiyama, T., Ogawa, O., Kinoshita, J., Shimizu, T., Hirose, T., Tanaka, Y., & Kawamori, R. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.005 · Cited by 147
Aspirin for the prevention of cardiovascular events in patients without clinical cardiovascular disease: A meta-analysis of randomized trials
Berger, J. S., Lala, A., Krantz, M. J., Baker, G. S., & Hiatt, W. R. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.04.006 · Cited by 145
Elevated White Blood Cell Count and Carotid Plaque Thickness
Elkind, M. S. V., Cheng, J., Boden-Albala, B. M., Paik, M. C., & Sacco, R. L. (2001) · Stroke · doi:10.1161/01.str.32.4.842 · Cited by 144
Risk factors for cardiovascular event recurrence in the Atherosclerosis Risk in Communities (ARIC) study
Wattanakit, K., Folsom, A. R., Chambless, L. E., & Nieto, F. J. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.019 · Cited by 143
Correlation Between Flow-Mediated Vasodilatation of the Brachial Artery and Intima-Media Thickness in the Carotid Artery in Men
Hashimoto, M., Eto, M., Akishita, M., Kozaki, K., Ako, J., Iijima, K., Kim, S., Toba, K., Yoshizumi, M., & Ouchi, Y. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2795 · Cited by 142
Carotid Intima Media Thickness in Rheumatoid Arthritis as Compared to Control Subjects: A Meta-Analysis
van Sijl, A. M., Peters, M. J. L., Knol, D. L., de Vet, H. C. W., González-Gay, M. Á., Smulders, Y. M., Dijkmans, B. A. C., & Nurmohamed, M. T. (2010) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2010.06.006 · Cited by 143
Segment-Specific Associations of Carotid Intima-Media Thickness With Cardiovascular Risk Factors
Polak, J. F., Person, S. D., Wei, G. S., Godreau, A., Jacobs, D. R., Harrington, A. P., Sidney, S., & O’Leary, D. H. (2009) · Stroke · doi:10.1161/strokeaha.109.566596 · Cited by 142
Self-citation
Subclinical atherosclerosis in patients with rheumatoid arthritis
Ambrosino, P., Lupoli, R., Minno, A. D., Tasso, M., Peluso, R., & Minno, M. N. D. D. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-11-0921 · Cited by 141
Monocyte Count Is a Predictor of Novel Plaque Formation
Johnsen, S. H., Fosse, E., Joakimsen, O., Mathiesen, E. B., Stensland-Bugge, E., Njølstad, I., & Arnesen, E. (2005) · Stroke · doi:10.1161/01.str.0000158909.07634.83 · Cited by 143
Increased carotid intima media thickness and cardiac biomarkers in HIV infected children
McComsey, G. A., O’Riordan, M., Hazen, S. L., El‐Bejjani, D., Bhatt, S., Brennan, M., Storer, N. J., Adell, J., Nakamoto, D., & Dogra, V. S. (2007) · AIDS · doi:10.1097/qad.0b013e328133f29c · Cited by 142
Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan
Sun, Y., Lin, C.-H., Lu, C.-J., Yip, P., & Chen, R.-C. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00017-5 · Cited by 143
Effect of glucocorticoids on the arteries in rheumatoid arthritis
del Rincón, I., O’Leary, D. H., Haas, R. W., & Escalante, A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20661 · Cited by 143
Self-citation
Clinical Utility of Endothelial Function Testing
Kuvin, J. T., & Karas, R. H. (2003) · Circulation · doi:10.1161/01.cir.0000075928.54461.33 · Cited by 143
High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects
Sesti, G., Andreozzi, F., Fiorentino, T. V., Mannino, G. C., Sciacqua, A., Marini, M. A., & Perticone, F. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0576-0 · Cited by 145
Manifestations and mechanisms of myocardial lipotoxicity in obesity
Sletten, A. C., Peterson, L. R., & Schaffer, J. E. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12728 · Cited by 148
Associations of Carotid Artery Intima-Media Thickness (IMT) With Risk Factors and Prevalent Cardiovascular Disease
Polak, J. F., Pencina, M. J., Meisner, A., Pencina, K. M., Brown, L. S., Wolf, P. A., & D’Agostino, R. B. (2010) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2010.29.12.1759 · Cited by 141
Self-citation
Genetics of Ischemic Stroke, Stroke-Related Risk Factors, Stroke Precursors and Treatments
Della‐Morte, D., Guadagni, F., Palmirotta, R., Testa, G., Caso, V., Paciaroni, M., Abete, P., Rengo, F., Ferroni, P., Sacco, R. L., et al. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.14 · Cited by 143
Cardiovascular risk in rheumatoid arthritis
Nurmohamed, M. T. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.02.015 · Cited by 143
Renovascular Disease and the Risk of Adverse Coronary Events in the Elderly
Edwards, M. S. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.2.207 · Cited by 140
Associations between markers of subclinical atherosclerosis and dietary patterns derived by principal components analysis and reduced rank regression in the Multi-Ethnic Study of Atherosclerosis (MESA)
Nettleton, J. A., Steffen, L. M., Schulze, M. B., Jenny, N. S., Barr, R. G., Bertoni, A. G., & Jacobs, D. R. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1615 · Cited by 140
Carotid Intima Media Thickness and Plaques Can Predict the Occurrence of Ischemic Cerebrovascular Events
Prati, P., Tosetto, A., Vanuzzo, D., Bader, G., Casaroli, M., Canciani, L., Castellani, S., & Touboul, P. (2008) · Stroke · doi:10.1161/strokeaha.107.511584 · Cited by 139
Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors
Mostafa, A., Mohamed, M. K., Saeed, M., Hasan, A., Fontanet, A. L., Godsland, I., Coady, E., Esmat, G., El‐Hoseiny, M., Abdul-Hamid, M., et al. (2010) · Gut · doi:10.1136/gut.2009.202317 · Cited by 139
Natural approaches in metabolic syndrome management
Patti, A. M., Al‐Rasadi, K., Giglio, R. V., Nikolić, D., Mannina, C. M., Castellino, G., Chianetta, R., Banach, M., Cicero, A. F. G., Lippi, G., et al. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.68717 · Cited by 141
Is There a Side Predilection for Cerebrovascular Disease?
Hernández, S. A. R., Kroon, A. A., van Boxtel, M. P. J., Mess, W. H., Lodder, J., Jolles, J., & de Leeuw, P. W. (2003) · Hypertension · doi:10.1161/01.hyp.0000077983.66161.6f · Cited by 138
Glycemic Control, Atherosclerosis, and Risk Factors for Cardiovascular Disease in Individuals With Diabetes
Selvin, E., Coresh, J., Golden, S. H., Boland, L. L., Brancati, F. L., & Steffes, M. W. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.1965 · Cited by 138
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
O’Donnell, C. J., Cupples, L. A., D’Agostino, R. B., Fox, C. S., Hoffmann, U., Hwang, S., Ingellson, E., Liu, C., Murabito, J. M., Polak, J. F., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s4 · Cited by 139
Self-citation
Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus
Kim, S. H., Lee, S. J., Kang, E. S., Kang, S., Hur, K. Y., Lee, H. J., Ahn, C. W., Cha, B. S., Yoo, J. S., & Lee, H. C. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.017 · Cited by 138
“A lower HbA1c is associated with a reduced risk of microvascular complications [24], and carotid IMT is commonly used as a surrogate marker for atherosclerotic diseases [6-10], although data on the relation of change in CIMT and risk of future events are limited at present [8].”
Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis
Lind, L., Ärnlöv, J., Lindahl, B., Siegbahn, A., Sundström, J., & Ingelsson, E. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.07.023 · Cited by 137
Relationship Between Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation in Middle-Aged Healthy Men
Yan, R. T., Anderson, T. J., Charbonneau, F., Title, L. M., Verma, S., & Lonn, E. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.079 · Cited by 138
High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes
Yoshida, N., Okumura, K.-I., & Aso, Y. (2005) · Metabolism · doi:10.1016/j.metabol.2004.09.014 · Cited by 138
Council on Nutrition, Physical Activity, and Metabolism Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Hypertension, and Obesity in the Young Committee of the Council on Scientific Statement From the American Heart Association Atherosclerosis, Progress and Challenges in Metabolic Syndrome in Children and Adolescents. A
McCrindle, B. W., Mietus‐Snyder, M., Steinberger, J., Daniels, S. R., Eckel, R. H., & Hayman, L. L. (2009) · Cited by 138
Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood
Urbina, E. M., Khoury, P. R., Bazzano, L., Burns, T. L., Daniels, S. R., Dwyer, T., Hu, T., Jacobs, D. R., Juonala, M., Prineas, R. J., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12334 · Cited by 138
Negative Emotions and 3-Year Progression of Subclinical Atherosclerosis
Stewart, J. C., Janicki, D. L., Muldoon, M. F., Sutton-Tyrrell, K., & Kamarck, T. W. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.225 · Cited by 137
Age-Related Macular Degeneration and Risk for Stroke
Wong, T. Y., Klein, R., Sun, C., Mitchell, P., Couper, D. J., Lai, H. C., Hubbard, L. D., Sharrett, A. R., & Study, F. T. A. R. I. C. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-2-200607180-00007 · Cited by 139
Obstructive Sleep Apnea and Carotid-Artery Intima-Media Thickness
Suzuki, T., Nakano, H., Maekawa, J., Okamoto, Y., Ohnishi, Y., Yamauchi, M., & Kimura, H. (2004) · SLEEP · doi:10.1093/sleep/27.1.129 · Cited by 136
Usefulness of Childhood Non–High Density Lipoprotein Cholesterol Levels Versus Other Lipoprotein Measures in Predicting Adult Subclinical Atherosclerosis: The Bogalusa Heart Study
Frontini, M., Srinivasan, S. R., Xu, J.-H., Tang, R., Bond, M. G., & Berenson, G. S. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1472 · Cited by 136
Hot flashes and carotid intima media thickness among midlife women
Thurston, R. C., Sutton-Tyrrell, K., Everson‐Rose, S. A., Hess, R., Powell, L. H., & Matthews, K. A. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181fa27fd · Cited by 135
Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study
Barr, R. G., Ahmed, F. S., Carr, J. J., Hoffman, E. A., Jiang, R., Kawut, S. M., & Watson, K. E. (2011) · European Respiratory Journal · doi:10.1183/09031936.00165410 · Cited by 135
Sex Differences in the Relationship of Risk Factors to Subclinical Carotid Atherosclerosis Measured 15 Years Later
Stensland-Bugge, E., Bønaa, K. H., Joakimsen, O., & Njølstad, I. (2000) · Stroke · doi:10.1161/01.str.31.3.574 · Cited by 137
Sex hormone levels and subclinical atherosclerosis in postmenopausal women: The Multi-Ethnic Study of Atherosclerosis
Ouyang, P., Vaidya, D. M., Dobs, A. S., Golden, S. H., Szklo, M., Heckbert, S. R., Kopp, P. A., & Gapstur, S. M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.037 · Cited by 136
Risk Factor Associations With the Presence of a Lipid Core in Carotid Plaque of Asymptomatic Individuals Using High-Resolution MRI
Wasserman, B. A., Sharrett, A. R., Lai, S., Gomes, A. S., Cushman, M., Folsom, A. R., Bild, D. E., Kronmal, R. A., Sinha, S., & Bluemke, D. A. (2008) · Stroke · doi:10.1161/strokeaha.107.498634 · Cited by 134
Self-citation
Obstructive Sleep Apnea and Atherosclerosis
Levy, P. A., Pépin, J., Arnaud, C., Baguet, J.-P., Demattéis, M., & Mach, F. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.03.001 · Cited by 146
Self‐Adjusting, Polymeric Multilayered Roll that can Keep the Shapes of the Blood Vessel Scaffolds during Biodegradation
Cheng, S., Yu, J., Wang, N., Cao, F., Zhang, W., Bai, W., Zheng, W., & Jiang, X. (2017) · Advanced Materials · doi:10.1002/adma.201700171 · Cited by 134
Incremental Predictive Value of Carotid Ultrasonography in the Assessment of Coronary Risk in a Cohort of Asymptomatic Type 2 Diabetic Subjects
Bernard, S., Sérusclat, A., Targe, F., Charrière, S., Roth, O., Beaune, J., Berthézène, F., & Moulin, P. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1158 · Cited by 131
Prediction of Mortality Risk in the Elderly
Störk, S., Feelders, R. A., van den Beld, A. W., Steyerberg, E. W., Savelkoul, H. F. J., Lamberts, S. W. J., Grobbee, D. E., & Bots, M. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.062 · Cited by 132
Fetal Growth and Preterm Birth Influence Cardiovascular Risk Factors and Arterial Health in Young Adults
Skilton, M. R., Viikari, J. S. A., Juonala, M., Laitinen, T. P., Lehtimäki, T. J., Taittonen, L. M., Kähönen, M. A. P., Celermajer, D. S., & Raitakari, O. T. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.234757 · Cited by 135
MRI of atherosclerosis in clinical trials
Yuan, C., Kerwin, W. S., Yarnykh, V. L., Cai, J., Saam, T., Chu, B., Takaya, N., Ferguson, M. S., Underhill, H. R., Xu, D., et al. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1065 · Cited by 133
Intimal medial thickness of the carotid artery in South Indian diabetic and non-diabetic subjects: the Chennai Urban Population Study (CUPS)
Mohan, V., Ravikumar, R., Rani, S. S., & Deepa, R. (2000) · Diabetologia · doi:10.1007/s001250051334 · Cited by 133
Apolipoprotein E Polymorphisms Predict Low Density Lipoprotein Cholesterol Levels and Carotid Artery Wall Thickness but Not Incident Coronary Heart Disease in 12,491 ARIC Study Participants
Volcik, K. A., Barkley, R. A., Hutchinson, R. G., Mosley, T. H., HEISS, G. M., Sharrett, A. R., Ballantyne, C. M., & Boerwinkle, E. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj202 · Cited by 135
Acceleration of atherosclerosis during the course of rheumatoid arthritis
del Rincón, I., O’Leary, D. H., Freeman, G. L., & Escalante, A. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.09.027 · Cited by 133
Self-citation
Cross-sectional analysis of baseline data to identify the major determinants of carotid intima–media thickness in a European population: the IMPROVE study
Baldassarre, D., Nyyssönen, K., Rauramaa, R., Fairé, U. D., Hamsten, A., Smit, A. J., Mannarino, E., Humphries, S. E., Giral, P., Grossi, E., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp496 · Cited by 130
Lycopene, Atherosclerosis, and Coronary Heart Disease
Rissanen, T. H., Voutilainen, S., Nyyssönen, K., & Salonen, J. T. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701010 · Cited by 132
Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension
Toikka, J., Laine, H. K., Ahotupa, M. O., Haapanen, A., Viikari, J. S. A., Hartiala, J., & Raitakari, O. T. (2000) · Hypertension · doi:10.1161/01.hyp.36.6.929 · Cited by 132
Cardiovascular risk factors and ultrasound evaluation of intima-media thickness at common carotids, carotid bulbs, and femoral and abdominal aorta arteries in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Sartorato, P., Zulian, E., Benedini, S., Mariniello, B., Schiavi, F., Bilora, F., Pozzan, G., Greggio, N., Pagnan, A., Mantero, F., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1711 · Cited by 132
Progression of Carotid Intima-Media Thickness and Plasma Antioxidants: The Los Angeles Atherosclerosis Study
Dwyer, J. H., Paul-Labrador, M. J., Fan, J., Shircore, A. M., Merz, C. N. B., & Dwyer, K. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000109955.80818.8a · Cited by 131
The association of personal and neighborhood socioeconomic indicators with subclinical cardiovascular disease in an elderly cohort. The cardiovascular health study
Nordstrom, C. K., Diez Roux, A. V., Jackson, S. A., & Gardin, J. M. (2004) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.03.017 · Cited by 131
Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification
Kullo, I. J., & Malik, A. R. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.11.039 · Cited by 133
Study of Cardiovascular Health Outcomes in the Era of Claims Data
Psaty, B. M., Delaney, J. A., Arnold, A. M., Curtis, L. H., Fitzpatrick, A. L., Heckbert, S. R., McKnight, B., Ives, D. G., Gottdiener, J. S., Kuller, L. H., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.018610 · Cited by 131
Elevated fibrinogen levels and subsequent subclinical atherosclerosis: The CARDIA Study
Green, D., Foiles, N., Chan, C., Schreiner, P. J., & Liu, K. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.039 · Cited by 133
Association of Multiple Inflammatory Markers with Carotid Intimal Medial Thickness and Stenosis (from the Framingham Heart Study)
Thakore, A. H., Guo, C., Larson, M. G., Corey, D., Wang, T. J., Vasan, R. S., D’Agostino, R. B., Lipinska, I., Keaney, J. F., Benjamin, E. J., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.01.036 · Cited by 131
Using MRI to Assess Aortic Wall Thickness in the Multiethnic Study of Atherosclerosis: Distribution by Race, Sex, and Age
Li, A. E., Kamel, I. R., Rando, F., Anderson, M. L., Kumbasar, B., Lima, J. A. C., & Bluemke, D. A. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.182.3.1820593 · Cited by 131
Baseline Values but Not Treatment-Induced Changes in Carotid Intima-Media Thickness Predict Incident Cardiovascular Events in Treated Hypertensive Patients
Zanchetti, A., Hennig, M., Hollweck, R., Bond, G., Tang, R., Cuspidi, C., Parati, G., Facchetti, R., & Mancia, G. (2009) · Circulation · doi:10.1161/circulationaha.108.773119 · Cited by 128
Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans
Calabresi, L., Baldassarre, D., Castelnuovo, S., Conca, P., Bocchi, L., Candini, C., Frigerio, B., Amato, M., Sirtori, C. R., Alessandrini, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.848143 · Cited by 130
Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans
Calabresi, L., Baldassarre, D., Castelnuovo, S., Conca, P., Bocchi, L., Candini, C., Frigerio, B., Amato, M., Sirtori, C. R., Alessandrini, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.818143 · Cited by 130
Circulating CD4 + CD25 hi CD127 lo Regulatory T-Cell Levels Do Not Reflect the Extent or Severity of Carotid and Coronary Atherosclerosis
Ammirati, E., Cianflone, D., Banfi, M., Vecchio, V., Palini, A. G., Metrio, M. D., Marenzi, G., Panciroli, C., Tumminello, G., Anzuini, A., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.206813 · Cited by 130
Metabolic syndrome is associated with early signs of organ damage in nondiabetic, hypertensive patients
Leoncini, G., Ratto, E., Viazzi, F. C., VACCARO, V., Parodi, D., Parodi, A., Falqui, V., Tomolillo, C., Deferrari, G., & Pontremoli, R. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01468.x · Cited by 130
Westernization of Chinese Adults and Increased Subclinical Atherosclerosis
Woo, K. S., Chook, P., Raitakari, O. T., McQuillan, B., Feng, J. Z., & Celermajer, D. S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.10.2487 · Cited by 130
Carotid Artery Wall Thickness in Patients With Obstructive Sleep Apnea Syndrome
Silvestrini, M., Rizzato, B., Placidi, F., Baruffaldi, R., Bianconi, A., & Diomedi, M. (2002) · Stroke · doi:10.1161/01.str.0000019123.47840.2d · Cited by 129
American Society of Echocardiography Report
Roman, M. J., Naqvi, T. Z., Gardin, J. M., Gerhard‐Herman, M. D., Jaff, M. R., & Mohler, E. R. (2006) · Vascular Medicine · doi:10.1177/1358863x06070511 · Cited by 129
Elevated C-Reactive Protein Associates With Early-Stage Carotid Atherosclerosis in Young Subjects With Type 1 Diabetes
Hayaishi-Okano, R., Yamasaki, Y., Katakami, N., Ohtoshi, K., Gorogawa, S.-I., Kuroda, A., Matsuhisa, M., Kosugi, K., Nishikawa, N., Kajimoto, Y., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1432 · Cited by 130
Radiation-Induced Carotid Artery Stenosis: A Comprehensive Review of the Literature
Xu, J., & Cao, Y. (2013) · Interventional Neurology · doi:10.1159/000363068 · Cited by 128
Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome
Hamczyk, M. R., del Campo, L., & Andrés, V. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121454 · Cited by 134
Associations of Serum IL-18 Levels With Carotid Intima-Media Thickness
Yamagami, H., Kitagawa, K., Hoshi, T., Furukado, S., Hougaku, H., Nagai, Y., & Hori, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000168417.52486.56 · Cited by 129
Maximum Value of Home Blood Pressure: A Novel Indicator of Target Organ Damage in Hypertension
Matsui, Y., Ishikawa, J., Eguchi, K., Shibasaki, S., Shimada, K., & Kario, K. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.171645 · Cited by 127
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors
Barbieri, M., Rizzo, M. R., Marfella, R., Boccardi, V., Esposito, A., Pansini, A., & Paolisso, G. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.12.018 · Cited by 127
The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes
Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., & Stevenson, W. G. (2006) · Circulation · doi:10.1161/circulationaha.106.655761 · Cited by 130
Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD
Polak, J. F., & O’Leary, D. H. (2016) · Global Heart · doi:10.1016/j.gheart.2016.08.006 · Cited by 130
Self-citation
Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes
Sun, J., Zhao, X.-Q., Balu, N., Neradilek, M. B., Isquith, D. A., Yamada, K., Cantón, G., Crouse, J. R., Anderson, T. J., Huston, J., et al. (2017) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.06.017 · Cited by 127
Increased High-Density Lipoprotein Cholesterol Predicts the Pioglitazone-Mediated Reduction of Carotid Intima-Media Thickness Progression in Patients With Type 2 Diabetes Mellitus
Davidson, M., Meyer, P., Haffner, S. M., Feinstein, S. B., D’Agostino, R. B., Kondos, G. T., Pérez, A., Chen, Z., & Mazzone, T. (2008) · Circulation · doi:10.1161/circulationaha.107.746610 · Cited by 126
Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: assessment of patients with suspected coronary artery disease.
Berman, D. S., Hachamovitch, R., Shaw, L. J., Friedman, J. D., Hayes, S. W., Thomson, L., Fieno, D. S., Germano, G., Slomka, P. J., Wong, N. D., et al. (2006) · PubMed · Cited by 126
Assessment of atherosclerosis using carotid ultrasonography in a cohort of HIV-positive patients treated with protease inhibitors☆☆☆★
Seminari, E. M., Pan, A., Voltini, G., Carnevale, G., Maserati, R., Minoli, L., Meneghetti, G., Tinelli, C., & Testa, S. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00736-5 · Cited by 127
Phosphorus levels are associated with subclinical atherosclerosis in the general population
Onufrak, S. J., Bellasi, A., Shaw, L. J., Herzog, C. A., Cardarelli, F., Wilson, P. W. F., Vaccarino, V., & Raggi, P. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.004 · Cited by 126
Tumor Necrosis Factor Receptor Levels Are Associated With Carotid Atherosclerosis
Elkind, M. S. V., Cheng, J., Boden-Albala, B. M., Rundek, T., Thomas, J. A., Chen, H., Rabbani, L. E., & Sacco, R. L. (2002) · Stroke · doi:10.1161/hs0102.100531 · Cited by 126
Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease
Rohani, M., Jogestrand, T., Ekberg, M., van der Linden, J., Källner, G., Jussila, R., & Agewall, S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.10.012 · Cited by 126
Childhood risk factors for adult cardiovascular disease and primary prevention in childhood
Celermajer, D. S., & Ayer, J. G. (2006) · Heart · doi:10.1136/hrt.2005.081760 · Cited by 126
Human cartilage gp‐39+,CD16+ monocytes in peripheral blood and synovium: Correlation with joint destruction in rheumatoid arthritis
Baeten, D., Boots, A. M. H., Steenbakkers, P. G. A., Elewaut, D. S., Bos, E. S., Verheijden, G. F. M., Verbruggen, G., Miltenburg, A. M. M., Rijnders, A. W. M., VEYS, E. M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200006)43:6 · Cited by 198
Pediatric Precursors of Adult Cardiovascular Disease: Noninvasive Assessment of Early Vascular Changes in Children and Adolescents
Groner, J. A., Joshi, M. S., & Bauer, J. A. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2992 · Cited by 122
Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study
Desvarieux, M., Demmer, R. T., Jacobs, D. R., Papapanou, P. N., Sacco, R. L., & Rundek, T. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000254 · Cited by 131
Carotid Artery Plaque Morphology and Composition in Relation to Incident Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis (MESA)
Zavodni, A. E. H., Wasserman, B. A., McClelland, R. L., Gomes, A. S., Folsom, A. R., Polak, J. F., Lima, J. A. C., & Bluemke, D. A. (2014) · Radiology · doi:10.1148/radiol.14131020 · Cited by 125
Self-citation
Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Polak, J. F., Backlund, J. C., Cleary, P. A., Harrington, A. P., O’Leary, D. H., Lachin, J. M., & Nathan, D. M. (2011) · Diabetes · doi:10.2337/db10-0296 · Cited by 124
Self-citation
Relationships of surrogate indexes of insulin resistance with insulin sensitivity assessed by euglycemic hyperinsulinemic clamp and subclinical vascular damage
Fiorentino, T. V., Marini, M. A., Succurro, E., Andreozzi, F., & Sesti, G. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000911 · Cited by 126
Associations between IgG antibody to oral organisms and carotid intima–medial thickness in community-dwelling adults
BECK, J., Eke, P. I., LIN, D., Madianos, P. N., Couper, D. J., MOSS, K. L., Elter, J. R., HEISS, G. M., & Offenbacher, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.017 · Cited by 125
Associations of Acculturation and Socioeconomic Status With Subclinical Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis
Lutsey, P. L., Roux, A. V. D., Jacobs, D. R., Burke, G. L., Harman, J. L., Shea, S., & Folsom, A. R. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.123844 · Cited by 125
Self-citation
Apolipoprotein B/Apolipoprotein A-I in Relation to the Metabolic Syndrome and Change in Carotid Artery Intima-Media Thickness During 3 Years in Middle-Aged Men
Wallenfeldt, K., Bokemark, L., Wikstrand, J., Hulthe, J., & Fagerberg, B. (2004) · Stroke · doi:10.1161/01.str.0000140629.65145.3c · Cited by 126
Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis
Hamed, S. A., Hamed, E. A., Eldin, A. M. E., & Mahmoud, N. M. (2010) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2009.04.007 · Cited by 125
A stroke prediction score in the elderly
Lumley, T., Kronmal, R. A., Cushman, M., Manolio, T. A., & Goldstein, S. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00434-6 · Cited by 124
Self-citation
Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly
Lind, P., van Bavel, B., Salihović, S., & Lind, L. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103563 · Cited by 124

Authors: O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K.
Affiliations: Brigham and Women's Hospital (US)
University of Washington (US)
National Heart, Lung, and Blood Institute (US)
Atrium Health Wake Forest Baptist (US)
ORCID: Polak, Joseph F.
Kronmal, Richard A.
Manolio, Teri A.
Burke, Gregory L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-01-07
Volume: 340
Issue: 1
Pages: 14-22
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199901073400103
OpenAlex: W2316167515
Cited by: 4,685
References: 40
Citations by year: 2026: 33 · 2025: 66 · 2024: 61 · 2023: 77 · 2022: 84 · 2021: 103 · 2020: 123 · 2019: 130 · 2018: 149 · 2017: 150 · 2016: 177 · 2015: 210 · 2014: 191 · 2013: 251 · 2012: 231
FWCI: 99.83
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc085081-021, n01hc085079-024, n01hc085080-026)
National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85080, N01-HC85079)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: carotid intima-media thickness, myocardial infarction, stroke, cardiovascular risk factors, older adults, carotid artery, atherosclerosis, high-resolution ultrasound
MeSH terms: Aged, Carotid Arteries, Cerebrovascular Disorders, Female, Humans, Male, Myocardial Infarction, Prospective Studies, Risk Factors, Ultrasonography, Incidence, Proportional Hazards Models, Tunica Intima, Tunica Media, Disease-Free Survival

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks