The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Ethical Problems with Sham Surgery in Clinical Research
Abstract
The recent use of sham surgery in randomized, controlled trials raises three critical questions about research involving human subjects. The first question concerns the tension between the highest standard of research design and the highest standard of ethics.1 When these two standards come into conflict and researchers cannot simultaneously meet both, which should prevail, and how should a balance be struck? The second question points to ongoing uncertainties and disagreements in assessing the risks and benefits of research protocols. When reasonable people — the members of well-established institutional review boards or the sponsors of research — disagree in their risk–benefit . . .
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Cites
(2003) · Manual for Research Ethics Committees · doi:10.1017/cbo9780511550089.028 · Cited by 3,413
Lurie, P., & Wolfe, S. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709183371212 · Cited by 882
The Ethics of Clinical Research in the Third World
Angell, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709183371209 · Cited by 863
The therapeutic misconception: Informed consent in psychiatric research
Appelbaum, P. S., Roth, L. H., & Lidz, C. (1982) · International Journal of Law and Psychiatry · doi:10.1016/0160-2527(82)90026-7 · Cited by 688
The Continuing Unethical Use of Placebo Controls
Rothman, K. J., & Michels, K. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408113310611 · Cited by 663
An Evaluation of Internal-Mammary-Artery Ligation by a Double-Blind Technic
Cobb, L. A., Thomas, G. I., Dillard, D. H., Merendino, K. A., & Bruce, R. A. (1959) · New England Journal of Medicine · doi:10.1056/nejm195905282602204 · Cited by 534
Ethical Complexities of Conducting Research in Developing Countries
Varmus, H., & Satcher, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710023371411 · Cited by 424
Research involving persons with mental disorders that may affect decisionmaking capacity.
(2002) · PubMed · Cited by 160
Johnson, A. G. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90637-8 · Cited by 155
Placebo-Controlled Trials and the Logic of Clinical Purpose
Freedman, B. (1990) · IRB Ethics and Human Research · doi:10.2307/3564541 · Cited by 137
Cited by
Deconstructing the Placebo Effect and Finding the Meaning Response
Moerman, D. E., & Jonas, W. B. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-6-200203190-00011 · Cited by 745
Kaptchuk, T. J. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-11-200206040-00011 · Cited by 616
Azizi, M., Sapoval, M., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Midulla, M., Mounier-Véhier, C., Courand, P.-Y., Lantelme, P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61942-5 · Cited by 519
Watts, N. B., Harris, S. T., & Genant, H. K. (2001) · Osteoporosis International · doi:10.1007/s001980170086 · Cited by 314
Laparoscopy and Reported Pain among Patients with Endometriosis
Jarrell, J., Mohindra, R., Ross, S., Taenzer, P., & Brant, R. (2005) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)30531-x · Cited by 83
Metadata
- Authors
- Macklin, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-09-23
- Volume
- 341
- Issue
- 13
- Pages
- 992-996
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2047668071
- Cited by
- 340
- References
- 21
- FWCI
- 16.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
