The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Severe Hypothyroidism Caused by Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas
Abstract
Hemangiomas are the most common tumors of infancy, with a prevalence of 5 to 10 percent among one-year-olds. They are characterized by rapid growth in the first year of life, followed by involution and gradual regression by adolescence.1,2 We recently treated a three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion. This finding suggested that the rate of degradation of thyroid hormone was accelerated. We subsequently identified high levels of type 3 iodothyronine deiodinase activity in the hemangioma tissue. This selenoenzyme, normally present in . . .
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“In that patient, the high serum levels of rT3 (413 ng/mL), followed by the demonstration of high expression of deiodinase type 3 (D3) in hemangioma tissue, were crucial to the diagnosis.”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [22]
In the citing paper
“Increased type 3 deiodinase activity in large hemangiomas can cause increased metabolic clearance of administered LT4 and, with that, necessitate a higher LT4 dose (120–122).”
Citations
Cites
Ingbar, S. H. (1965) · Archives of Internal Medicine · doi:10.1001/archinte.1965.03870060154035 · Cited by 1,745
Cellular markers that distinguish the phases of hemangioma during infancy and childhood.
Takahashi, K., Mulliken, J. B., Kozakewich, H. P., Rogers, R. A., Folkman, J., & Ezekowitz, R. A. B. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117241 · Cited by 644
Self-citationDrolet, B. A., Esterly, N. B., & Frieden, I. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410307 · Cited by 588
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy
Barlow, C. F., Priebe, C. J., Mulliken, J. B., Barnes, P. D., Donald, D. M., Folkman, J., & Ezekowitz, R. A. B. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70034-4 · Cited by 436
Levothyroxine Therapy in Patients with Thyroid Disease
Mandel, S. J., Brent, G. A., & Larsen, P. R. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-6-199309150-00009 · Cited by 324
Self-citationHemangiomas and Vascular Malformations of Infancy and Childhood
Fishman, S. J., & Mulliken, J. B. (1993) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)38656-4 · Cited by 308
Self-citationCongenital Hypothyroidism: Etiologies, Diagnosis, and Management
LAFRANCHI, S. H. (1999) · Thyroid · doi:10.1089/thy.1999.9.735 · Cited by 253
Salvatore, D., Low, S. C., Berry, M. J., Maia, A. L., Harney, J. W., Croteau, W., Germain, D. L. S., & Larsen, P. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118299 · Cited by 186
Self-citationKOH, L. K. H., GREENSPAN, F. S., & YEO, P. P. B. (1997) · Thyroid · doi:10.1089/thy.1997.7.891 · Cited by 185
Circulating 3,3', 5'-triiodothyronine (reverse T3) in the human newborn.
CHOPRA, I. J., Sack, J., & Fisher, D. A. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108030 · Cited by 123
Management of Congenital Hypothyroidism
Fisher, D. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-3-523 · Cited by 121
Pediatric Reference Intervals for Serum Thyroxine, Triiodothyronine, Thyrotropin, and Free Thyroxine
Zurakowski, D., Canzio, J. D., & Majzoub, J. A. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.7.1087 · Cited by 88
Primary haemostasis in thyroid disease
MYRUP, B., BREGENGÅRD, C., & FABER, J. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00899.x · Cited by 72
Interferon alpha-2a therapy in haemangiomas of infancy: spastic diplegia as a severe complication
Wörle, H., Maaß, E., Köhler, B., & Treuner, J. (1999) · European Journal of Pediatrics · doi:10.1007/s004310051089 · Cited by 66
Longitudinal assessment of l-thyroxine therapy for congenital hypothyroidism
Germak, J. A., & Foley, T. P. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80532-3 · Cited by 66
Courtin, F., Liva, P., Gavaret, J. M., Toru‐Delbauffe, D., & Pierre, M. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11399.x · Cited by 58
Pallud, S. E., Ramaugé, M., Gavaret, J., Lennon, A., Munsch, N., Germain, D. L. S., Pierre, M., & Courtin, F. (1999) · Endocrinology · doi:10.1210/endo.140.6.6834 · Cited by 53
Hernández, A., & Obregón, M.-J. (1995) · Endocrinology · doi:10.1210/endo.136.10.7664675 · Cited by 47
Hernández, A., Germain, D. L. S., & Obregón, M.-J. (1998) · Endocrinology · doi:10.1210/endo.139.2.5734 · Cited by 39
Rapid Pituitary and Peripheral Tissue Responses to Intravenous L-Triiodothyronine in Hypothyroidism*
Ladenson, P. W., Goldenheim, P. D., & Ridgway, E. C. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1252 · Cited by 30
Serum Thyroglobulin Levels: The Physiological Decrease in Infancy and the Absence in Athyroidism*
Ket, J. L., de Vijlder, J. J. M., Bikker, H., Gons, M. H., & Tegelaers, W. H. H. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-6-1301 · Cited by 30
Atrophic, Autoimmune Thyroiditis in Infancy
stergaard, G. Z. O., & Jacobsen, B. B. (2008) · Hormone Research · doi:10.1159/000181114 · Cited by 26
Pallud, S. (1999) · Endocrinology · doi:10.1210/en.140.6.2917 · Cited by 23
Hernandez, A. (1995) · Endocrinology · doi:10.1210/en.136.10.4543 · Cited by 20
Cardiac function in congenital hypothyroidism: Impairment and response to L-T4 therapy
Balducci, G., Acquafredda, A., Amendola, F., Natuzzi, M., Laforgia, N., & Cavallo, L. (1991) · Pediatric Cardiology · doi:10.1007/bf02238495 · Cited by 15
Spastic diplegia and interferon
Deb, G., Jenkner, A., & Donfrancesco, A. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70474-9 · Cited by 14
Hernández, A. (1998) · Endocrinology · doi:10.1210/en.139.2.634 · Cited by 12
Cited by
Sorted by citations
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Self-citationChaker, L., Bianco, A. C., Jonklaas, J., & Peeters, R. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30703-1 · Cited by 1,159
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Self-citationDeiodinases: implications of the local control of thyroid hormone action
Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845
Rastogi, M. V., & LAFRANCHI, S. H. (2010) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-5-17 · Cited by 601
Metadata
- Authors
- Huang, S. A., Tu, H. M., Harney, J. W., Venihaki, M., Butte, A. J., Kozakewich, H. P. W., Fishman, S. J., & Larsen, P. R.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Children's Hospital (TN)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-07-20
- Volume
- 343
- Issue
- 3
- Pages
- 185-189
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320158996
- Cited by
- 540
- References
- 27
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 12 · 2023: 5 · 2022: 17 · 2021: 30 · 2020: 22 · 2019: 27 · 2018: 22 · 2017: 32 · 2016: 28 · 2015: 20 · 2014: 31 · 2013: 23 · 2012: 26
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 07699, R01DK044128, DK-44128, T32DK007529, T32DK007699, DK-07529)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Vascular Malformations and Hemangiomas
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- type 3 iodothyronine deiodinase, infantile hemangioma, hepatic hemangioma, primary hypothyroidism, severe hypothyroidism, selenoenzymes, thyroid hormone replacement, thyrotropin secretion
- MeSH terms
- Hemangioma, Humans, Hypothyroidism, Infant, Iodide Peroxidase, Liver Neoplasms, Magnetic Resonance Imaging, Male, Neoplasms, Multiple Primary, Retrospective Studies, Thyrotropin
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