The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The Pathogenesis of Acute Pulmonary Edema Associated with Hypertension
Open accessAbstract
BACKGROUND: Patients with acute pulmonary edema often have marked hypertension but, after reduction of the blood pressure, have a normal left ventricular ejection fraction (> or =0.50). However, the pulmonary edema may not have resulted from isolated diastolic dysfunction but, instead, may be due to transient systolic dysfunction, acute mitral regurgitation, or both. METHODS: We studied 38 patients (14 men and 24 women; mean [+/-SD] age, 67+/-13 years) with acute pulmonary edema and systolic blood pressure greater than 160 mm Hg. We evaluated the ejection fraction and regional function by two-dimensional Doppler echocardiography, both during the acute episode and one to three days after treatment. RESULTS: The mean systolic blood pressure was 200+/-26 mm Hg during the initial echocardiographic examination and was reduced to 139+/-17 mm Hg (P< 0.01) at the time of the follow-up examination. Despite the marked difference in blood pressure, the ejection fraction was similar during the acute episode (0.50+/-0.15) and after treatment (0.50+/-0.13). The left ventricular regional wall-motion index (the mean value for 16 segments) was also the same during the acute episode (1.6+/-0.6) and after treatment (1.6+/-0.6). No patient had severe mitral regurgitation during the acute episode. Eighteen patients had a normal ejection fraction (at least 0.50) after treatment. In 16 of these 18 patients, the ejection fraction was at least 0.50 during the acute episode. CONCLUSIONS: In patients with hypertensive pulmonary edema, a normal ejection fraction after treatment suggests that the edema was due to the exacerbation of diastolic dysfunction by hypertension--not to transient systolic dysfunction or mitral regurgitation.
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Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
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Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study
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Self-citationDefining Diastolic Heart Failure: A Call for Standardized Diagnostic Criteria
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Self-citationDiagnosis and Treatment of Heart Failure Based on Left Ventricular Systolic or Diastolic Dysfunction
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Assessment of Cardiac Function
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Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883
Self-citationHeart Failure With Preserved Ejection Fraction In Perspective
Pfeffer, M. A., Shah, A. M., & Borlaug, B. A. (2019) · Circulation Research · doi:10.1161/circresaha.119.313572 · Cited by 837
Epidemiology of Diastolic Heart Failure
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Self-citationFlash pulmonary oedema and bilateral renal artery stenosis: the Pickering Syndrome
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Metadata
- Authors
- Gandhi, S. K., Powers, J. C., Nomeir, A.-M., Fowle, K., Kitzman, D. W., Rankin, K. M., & Little, W. C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-01-04
- Volume
- 344
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2323050154
- Cited by
- 733
- References
- 14
- FWCI
- 29.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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