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Health Effects of Overweight and Obesity in 195 Countries
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Health Effects of Overweight and Obesity in 195 CountriesTo the Editor: The Global Burden of Disease (GBD) collaborators (July 6 issue) 1 report that more than two thirds of deaths related to high body-mass index (BMI) were due to cardiovascular disease, which suggests that BMI-defined obesity has a major effect on cardiovascular disease.Some readers may wonder whether the perceived burden of obesity could have been even larger if an accurate measure of body fat, instead of BMI, had been used.Data from the Aerobics Center Longitudinal Study, involving 30,000 persons assessed with a state-of-the-art method to determine adiposity, suggest that this may not be the case. 2 We observed that BMI had a significantly higher discriminating capacity than bodyfat percentage or fat-mass index for predicting mortality from cardiovascular disease, and our study provided a physiological explanation for this finding.Our data also strongly support the use of BMI for defining obesity at an epidemiologic level, particularly in relation to mortality from cardiovascular disease.Furthermore, these findings suggest that obesity may be defined as an excess of body weight according to height (high BMI), rather than as an excess of body fat (high body-fat percentage or fat-mass index), as is generally stated.3
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“Although obesity is theoretically reversible28, 51, 52 and addressing it could provide the biggest opportunity to limit the advance of diabetes, current trends suggest that obesity rates are likely to continue to climb.45”
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Health effects of overweight and obesity in 195 countries over 25 years
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Metadata
- Authors
- Afshin, A., Reitsma, M. B., & Murray, C. J. L.
- Affiliations
- Institute for Health Metrics and Evaluation (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-10-12
- Volume
- 377
- Issue
- 15
- Pages
- 1495-1497
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2766120686
- Cited by
- 219
- References
- 12
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 29 · 2023: 38 · 2022: 31 · 2021: 21 · 2020: 35 · 2019: 26 · 2018: 7 · 2017: 2
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Licence
- other-oa
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- obesity, overweight, body mass index, cardiovascular mortality, body fat percentage, fat mass index, adiposity measurement, obesity definition, global burden of disease
- MeSH terms
- Cross-Sectional Studies, Developing Countries, Humans, Obesity, Body Mass Index, Prevalence, Overweight
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