Cited by 126Prostate Cancer Treatment and ResearchCancer Genomics and DiagnosticsProstate Cancer Diagnosis and Treatment

Racial differences in genomic profiling of prostate cancer

Open access
Mahal, Brandon A., Alshalalfa, Mohammed, Kensler, Kevin H., Chowdhury-Paulino, Ilkania, Kantoff, Philip, Mucci, Lorelei A., Schaeffer, Edward M., Spratt, Daniel +3 more·2020·New England Journal of Medicine

Abstract

Genetic Alterations in Prostate Cancer Among nearly 2400 men with prostate cancer, next-generation sequencing of 474 genes showed differences among racial groups in the frequency of mutations in ce...

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Crossref · 10.1056/nejmc2000069

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  • Genetic ancestry may be causally related to some genetic traits and diseases, unlike the social construct of race.

    “Fairness and diversity have especially important considerations in such applications given that genetic ancestry may be causally related to some genetic traits and diseases (178, 183-186), as opposed to the social construct of race (173).”

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Authors
Mahal, B. A., Alshalalfa, M., Kensler, K. H., Chowdhury-Paulino, I., Kantoff, P., Mucci, L. A., Schaeffer, E. M., Spratt, D., Yamoah, K., Nguyen, P. L., & Rebbeck, T. R.
Affiliations
  • University of Miami (US)
  • Dana-Farber Cancer Institute (US)
  • Harvard University (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • Northwestern University (US)
  • University of Michigan (US)
  • Moffitt Cancer Center (US)
Venue
New England Journal of Medicine
Published
2020-09-10
Volume
383
Issue
11
Pages
1083-1085
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W3084287246
Cited by
126
References
5
Citations by year
2026: 13 · 2025: 14 · 2024: 15 · 2023: 25 · 2022: 38 · 2021: 20 · 2020: 1
FWCI
11.82
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Defense
  • Prostate Cancer Foundation
  • American Society for Radiation Oncology
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
Keywords
prostate cancer, racial disparities, genomic profiling, somatic mutations, genetic alterations, next-generation sequencing, genetic mutations
MeSH terms
Genetic Profile, Asian, Black or African American, Humans, Male, Mutation, Prostatic Neoplasms, White People

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