Racial differences in genomic profiling of prostate cancer
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Genetic Alterations in Prostate Cancer Among nearly 2400 men with prostate cancer, next-generation sequencing of 474 genes showed differences among racial groups in the frequency of mutations in ce...
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Genetic ancestry may be causally related to some genetic traits and diseases, unlike the social construct of race.
“Fairness and diversity have especially important considerations in such applications given that genetic ancestry may be causally related to some genetic traits and diseases (178, 183-186), as opposed to the social construct of race (173).”
From Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions (2024) · cites this paper as [184]
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- Authors
- Mahal, B. A., Alshalalfa, M., Kensler, K. H., Chowdhury-Paulino, I., Kantoff, P., Mucci, L. A., Schaeffer, E. M., Spratt, D., Yamoah, K., Nguyen, P. L., & Rebbeck, T. R.
- Affiliations
- University of Miami (US)
- Dana-Farber Cancer Institute (US)
- Harvard University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Northwestern University (US)
- University of Michigan (US)
- Moffitt Cancer Center (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-09-10
- Volume
- 383
- Issue
- 11
- Pages
- 1083-1085
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8971922
- OpenAlex
- W3084287246
- Cited by
- 126
- References
- 5
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 15 · 2023: 25 · 2022: 38 · 2021: 20 · 2020: 1
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- Prostate Cancer Foundation
- American Society for Radiation Oncology
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Keywords
- prostate cancer, racial disparities, genomic profiling, somatic mutations, genetic alterations, next-generation sequencing, genetic mutations
- MeSH terms
- Genetic Profile, Asian, Black or African American, Humans, Male, Mutation, Prostatic Neoplasms, White People
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