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Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
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The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Coagulopathy and antiphospholipid antibodies were seen in all three patients.
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“Multiple immunostaining studies reveal that ACE2 protein in the human brain is predominantly or exclusively expressed in vasculature (and specifically expressed within pericytes) (52, 53, 70), and many neurological symptoms associated with CoV-2 infection like stroke or altered consciousness are consistent with an underlying vasculopathy (71-76).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [71]
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Criado, P. R., Abdalla, B. M. Z., de Assis, I. C., Mello, C. V. B. D. G., Caputo, G. C., & Vieira, I. C. (2020) · Inflammation Research · doi:10.1007/s00011-020-01370-w · Cited by 142
COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations
Ho, D. C. W., Low, R., Tong, L. H. T., Gupta, V., Veeraraghavan, A., & Agrawal, R. V. (2020) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2020.1772313 · Cited by 134
The Role of Anticoagulation in COVID-19-Induced Hypercoagulability
Rico-Mesa, J. S., Rosas, D., Ahmadian-Tehrani, A., White, A., Anderson, A. S., & CHILTON, R. J. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01328-8 · Cited by 134
Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update
Gisondi, P., Piaserico, S., Bordin, C. R., Alaibac, M., Girolomoni, G., & Naldi, L. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16774 · Cited by 134
COVID‐19 coagulopathy: An in‐depth analysis of the coagulation system
Martín‐Rojas, R. M., Pérez‐Rus, G., Delgado‐Pinos, V. E., Domingo‐González, A., Regalado‐Artamendi, I., Alba‐Urdiales, N., Rodríguez, P. D., Monsalvo, S., Rodríguez‐Macías, G., Ballesteros, M., et al. (2020) · European Journal Of Haematology · doi:10.1111/ejh.13501 · Cited by 135
Vojdani, A., Vojdani, E., Saidara, E., & Maes, M. H. J. (2023) · Viruses · doi:10.3390/v15020400 · Cited by 138
Disseminated intravascular coagulation and its immune mechanisms
Popescu, N. I., Lupu, C., & Lupu, F. (2021) · Blood · doi:10.1182/blood.2020007208 · Cited by 140
Coagulopathy in COVID-19: Manifestations and management
Mucha, S. R., Dugar, S. P., McCrae, K. R., Joseph, D., Bartholomew, J. R., Sacha, G. L., & Militello, M. A. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.ccc024 · Cited by 130
Shah, S., Danda, D., Kavadichanda, C. G., Das, S., Adarsh, M. B., & Negi, V. S. (2020) · Rheumatology International · doi:10.1007/s00296-020-04639-9 · Cited by 130
Magro, G. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198070 · Cited by 131
Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis
Wu, T., Zuo, Z., Kang, S., Jiang, L., Luo, X., Xia, Z., Liu, J., Xiao, X., Ye, M., & Deng, M. (2020) · Aging and Disease · doi:10.14336/ad.2020.0520 · Cited by 126
Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients
Mouhat, B., Besutti, M., Bouiller, K., Grillet, F., Monnin, C., Ecarnot, F., Behr, J., Capellier, G., Soumagne, T., Pili‐Floury, S., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01811-2020 · Cited by 128
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Self-citationAdmission D-dimer levels, D-dimer trends, and outcomes in COVID-19
Naymagon, L., Zubizarreta, N. J., Feld, J., van Gerwen, M. A. G., Alsen, M., Thibaud, S., Kessler, A. J., Venugopal, S., Makki, I., Qin, Q., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.08.032 · Cited by 127
Central Nervous System Manifestations Associated with COVID-19
Divani, A. A., Andalib, S., Biller, J., Napoli, M. D., Moghimi, N., Rubiños, C., Nobleza, C. O., Sylaja, P. N., Toledano, M., Lattanzi, S., et al. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01079-7 · Cited by 129
Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far?
Tal, S., Spectre, G., Kornowski, R., & Perl, L. (2020) · Acta Haematologica · doi:10.1159/000508233 · Cited by 126
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Self-citationSkin manifestations of COVID‐19 in children: Part 1
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Metadata
- Authors
- Zhang, Y., Xiao, M., Zhang, S., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., Zhao, H., Zhang, H., Wang, C., Zhao, J., Sun, X., Tian, R., Wu, W., Wu, D., Ma, J., Chen, Y., Zhang, D., Xie, J., Yan, X., Zhou, X., Liu, Z., Wang, J., Du, B., Qin, Y., Gao, P., Qin, X., Xu, Y., Zhang, W., Li, T., Zhang, F., Zhao, Y., Li, Y., & Zhang, S.
- Affiliations
- Peking Union Medical College Hospital (CN)
- Peking Union Medical College Hospital, Beijing, China
- ORCID
- Zhang, Yan
- Xiao, Meng
- Zhang, Shulan
- Cao, Wei
- Jiang, Wei
- Chen, Huan
- Ding, Xin
- Zhao, Hua
- Zhang, Hongmin
- Wang, Chunyao
- Zhao, Jing
- Wu, Wei
- Wu, Dong
- Ma, Jie
- Zhang, Dong
- Xie, Jing
- Yan, Xiaowei
- Zhou, Xiang
- Du, Bin
- Qin, Yan
- Gao, Peng
- Qin, Xuzhen
- Xu, Yingchun
- Zhang, Wen
- Li, Taisheng
- Zhang, Fengchun
- Zhao, Yongqiang
- Li, Yongzhe
- Zhang, Shuyang
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-04-23
- Volume
- 382
- Issue
- 17
- Pages
- e38-e38
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7161262
- OpenAlex
- W3014573995
- Cited by
- 2,179
- References
- 1
- Citations by year
- 2026: 17 · 2025: 37 · 2024: 88 · 2023: 143 · 2022: 280 · 2021: 630 · 2020: 973
- FWCI
- 66.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- COVID-19 pandemic, coagulopathy, antiphospholipid antibodies, critically ill patients, intensive care unit, thrombosis, hypercoagulability
- MeSH terms
- COVID-19, Aged, Antibodies, Anti-Idiotypic, Blood Coagulation Disorders, Humans, Immunoglobulin A, Immunoglobulin G, Male, Pneumonia, Viral, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, Coronavirus Infections, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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