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Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
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The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Coagulopathy and antiphospholipid antibodies were seen in all three patients.
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“Multiple immunostaining studies reveal that ACE2 protein in the human brain is predominantly or exclusively expressed in vasculature (and specifically expressed within pericytes) (52, 53, 70), and many neurological symptoms associated with CoV-2 infection like stroke or altered consciousness are consistent with an underlying vasculopathy (71-76).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [71]
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Viral infections and antiphospholipid antibodies
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Chang, J. C. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s299357 · Cited by 37
Primary Adrenal Insufficiency Due to Bilateral Adrenal Infarction in COVID-19
Machado, I. F. R., Menezes, I. Q., de Figueiredo, S. R., Coelho, F. M. A., Terrabuio, D. R. B., Ramos, D. V., Fagundes, G. F. C., Maciel, A. A. W., Latronico, A. C., Fragoso, M. C. B. V., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab557 · Cited by 39
Berkman, S. A., & Song, S. S. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211002274 · Cited by 38
Acute stroke care during the COVID-19 pandemic. Ictus Madrid Program recommendations
Rodríguez‐Pardo, J., Fuentes, B., de Leciñana, M. A., Campollo, J., Castaño, P. C., Ruiz, J. C., Herrero, J. E., Leal, R. G., Núñez, A. G., Cerezo, J. F. G., et al. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2020.04.007 · Cited by 36
Ischaemic stroke in the time of coronavirus disease 2019
Meza, H. T., Gil, Á. L., Saldaña, A. S., Yus, C., Baron, B., Mur, D. S., Moreno, J. M., & Aragón, G. D. S. Y. M. D. P. D. A. A. I. E. (2020) · European Journal of Neurology · doi:10.1111/ene.14327 · Cited by 36
Gül, Ü. (2020) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2005-182 · Cited by 36
COVID-19 Severity and Stroke: Correlation of Imaging and Laboratory Markers
Katz, J. M., Libman, R., WANG, J. J., Filippi, C. G., Sanelli, P. C., Zlochower, A. B., Gribko, M., Pacia, S. V., Kuzniecky, R., Najjar, S., et al. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6920 · Cited by 36
Self-citationLeveraging the Electronic Health Record to Address the COVID-19 Pandemic
Satterfield, B. A., Dikilitas, O., & Kullo, I. J. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.04.008 · Cited by 42
Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection
Savelieff, M. G., Feldman, E. L., & Stino, A. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105715 · Cited by 37
Metadata
- Authors
- Zhang, Y., Xiao, M., Zhang, S., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., Zhao, H., Zhang, H., Wang, C., Zhao, J., Sun, X., Tian, R., Wu, W., Wu, D., Ma, J., Chen, Y., Zhang, D., Xie, J., Yan, X., Zhou, X., Liu, Z., Wang, J., Du, B., Qin, Y., Gao, P., Qin, X., Xu, Y., Zhang, W., Li, T., Zhang, F., Zhao, Y., Li, Y., & Zhang, S.
- Affiliations
- Peking Union Medical College Hospital (CN)
- Peking Union Medical College Hospital, Beijing, China
- ORCID
- Zhang, Yan
- Xiao, Meng
- Zhang, Shulan
- Cao, Wei
- Jiang, Wei
- Chen, Huan
- Ding, Xin
- Zhao, Hua
- Zhang, Hongmin
- Wang, Chunyao
- Zhao, Jing
- Wu, Wei
- Wu, Dong
- Ma, Jie
- Zhang, Dong
- Xie, Jing
- Yan, Xiaowei
- Zhou, Xiang
- Du, Bin
- Qin, Yan
- Gao, Peng
- Qin, Xuzhen
- Xu, Yingchun
- Zhang, Wen
- Li, Taisheng
- Zhang, Fengchun
- Zhao, Yongqiang
- Li, Yongzhe
- Zhang, Shuyang
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-04-23
- Volume
- 382
- Issue
- 17
- Pages
- e38-e38
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7161262
- OpenAlex
- W3014573995
- Cited by
- 2,179
- References
- 1
- Citations by year
- 2026: 17 · 2025: 37 · 2024: 88 · 2023: 143 · 2022: 280 · 2021: 630 · 2020: 973
- FWCI
- 66.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- COVID-19 pandemic, coagulopathy, antiphospholipid antibodies, critically ill patients, intensive care unit, thrombosis, hypercoagulability
- MeSH terms
- COVID-19, Aged, Antibodies, Anti-Idiotypic, Blood Coagulation Disorders, Humans, Immunoglobulin A, Immunoglobulin G, Male, Pneumonia, Viral, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, Coronavirus Infections, Pandemics
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