Microvascular injury in the brains of patients with Covid-19
Open accessAbstract
Microvascular Changes in the Brain in Covid-19 High-resolution MRI and histopathological study of the brains of patients who had died from Covid-19 showed punctate hyperintensities and punctate or ...
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The human COVID cases examined cannot be considered 'mild' because each individual died for reasons that were or may have been related to COVID.
“As each of these individuals died for reasons that were or may have been related to COVID (Lee et al., 2021), these cases cannot be considered “mild.””
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Lee et al., 2021
These additional neuropathological consequences of severe COVID include microvascular thrombi, neuron loss, cortical inflammation, and even direct brain infection in some cases.
“These include microvascular thrombi, neuron loss, cortical inflammation, and even direct brain infection in some cases (Lee et al., 2021; Remsik et al., 2021; Song et al., 2021; Yang et al., 2021).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Lee et al., 2021
Human brain tissue samples were prepared and analyzed as previously described.
“Human brain tissue samples were prepared and analyzed as previously described (Lee et al., 2021).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Lee et al., 2021
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Cites
Endothelial cell infection and endotheliitis in COVID-19
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358 · see citing works
Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
Matschke, J., Lütgehetmann, M., Hagel, C., Sperhake, J. P., Schröder, A. S., Edler, C., Mushumba, H., Fitzek, A., Allweiss, L., Dandri, M., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30308-2 · Cited by 1,300 · see citing works
Neuropathological features of Covid-19
Solomon, I. H., Normandin, E., Bhattacharyya, S., Mukerji, S. S., Keller, K., Ali, A. S., Adams, G., Hornick, J. L., Padera, R. F., & Sabeti, P. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2019373 · Cited by 815 · see citing works
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Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., O’Dea, M. R., Dutton, S., Shamardani, K., Nwangwu, K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.008 · Cited by 521 · see citing works
Self-citationGreene, C., Connolly, R., Brennan, D., Laffan, A., O’Keeffe, E., Zaporojan, L., O’Callaghan, J., Thomson, B., Connolly, E., Argue, R., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01576-9 · Cited by 429 · see citing works
The neurobiology of long COVID
Monje, M., & Iwasaki, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.006 · Cited by 415 · see citing works
Tropism of SARS-CoV-2 for human cortical astrocytes
Andrews, M. G., Mukhtar, T., Eze, U. C., Simoneau, C. R., Ross, J., Parikshak, N., Wang, S., Zhou, L., Koontz, M., Velmeshev, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122236119 · Cited by 159 · see citing works
Immunological defense of CNS barriers against infections
Ampie, L., & McGavern, D. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.012 · Cited by 63 · see citing works
COVID-19 as a Risk Factor for Alzheimer’s Disease
Golzari-Sorkheh, M., Weaver, D. F., & Reed, M. A. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-220800 · Cited by 39 · see citing works
Poloni, T. E., Moretti, M., Medici, V., Turturici, E., Belli, G., Cavriani, E., Visonà, S. D., Rossi, M., Fantini, V., Ferrari, R. R., et al. (2022) · Cells · doi:10.3390/cells11193124 · Cited by 24 · see citing works
- Authors
- Lee, M.-H., Perl, D. P., Nair, G., Li, W., Maric, D., Murray, H., Dodd, S. J., Koretsky, A. P., Watts, J. A., Cheung, V., Masliah, E., Horkayne-Szakaly, I., Jones, R., Stram, M. N., Moncur, J., Hefti, M., Folkerth, R. D., & Nath, A.
- Affiliations
- National Institute of Neurological Disorders and Stroke (US)
- Uniformed Services University of the Health Sciences (US)
- University of Michigan (US)
- National Institutes of Health (US)
- Defense Health Agency, Silver Spring, MD
- Defense Health Agency (US)
- Office of Chief Medical Examiner (US)
- University of Iowa (US)
- Corresponding author
- Nath, Avindra
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-02-04
- Volume
- 384
- Issue
- 5
- Pages
- 481-483
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7787217
- OpenAlex
- W3114155216
- Cited by
- 562
- References
- 3
- Citations by year
- 2026: 25 · 2025: 42 · 2024: 86 · 2023: 107 · 2022: 147 · 2021: 152 · 2020: 3
- FWCI
- 45.22
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- New England Journal of Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (Division of Intramural Research)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, microvascular damage, brain, cerebral microvasculature, brain histopathology, post-mortem brain imaging, SARS-CoV-2
- MeSH terms
- COVID-19, SARS-CoV-2, Autopsy, Brain, Humans, Magnetic Resonance Imaging, Middle Aged, Microvessels
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