Neutralization Profile after Recovery from SARS-CoV-2 Omicron Infection
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To the Editor: In the Food and Drug Administration (FDA)-mandated safety trial by Ytterberg et al., patients who were treated with tofacitinib had a higher incidence of cancer than those treated with a tumor necrosis factor (TNF)
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Omicron does not induce relevant cross-protective neutralizing antibody titres in SARS-CoV-2 naïve populations.
“Unfortunately, while Omicron appears to cause less severe disease than other variants4, it does not induce relevant cross-protective neutralizing antibody (nAb) titres in SARS-CoV-2 naïve populations, meaning they may be less protected against future infection compared with those previously exposed to other variants or vaccinated5.”
From Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models (2023) · cites this paper as [5]
These two population groups primed by different antigens will likely have different antibody responses as the sera of individuals primed by pre-Omicron variants or vaccines poorly neutralize the Omicron BA.1/2 variant and vice versa.
“These two population groups primed by different antigens will likely have different antibody responses as the sera of individuals primed by pre-Omicron variants or vaccines poorly neutralize the Omicron BA.1/2 variant and vice versa 26,27 .”
From Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa (2023) · cites this paper as [26]
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Machine Learning to Identify Critical Biomarker Profiles in New SARS-CoV-2 Variants
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Self-citationSARS-CoV-2-Neutralizing Antibodies
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- Authors
- Rössler, A., Knabl, L., von Laer, D., & Kimpel, J.
- Affiliations
- Innsbruck Medical University (AT)
- Tyrolpath Obrist Brunhuber, Zams, Austria
- Medical University of Innsbruck, Innsbruck, Austria
- Corresponding author
- Kimpel, Janine
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2022-05-05
- Volume
- 386
- Issue
- 18
- Pages
- 1764-1766
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC9006769
- OpenAlex
- W4220704112
- Cited by
- 95
- References
- 7
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 26 · 2022: 54
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- www.nejmgroup.org/legal/terms-of-use.htm (vor)
- Locations
- New England Journal of Medicine (publishedVersion, public-domain)
- medRxiv (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute of Virology, Medical University of Innsbruck
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- Omicron variant, neutralizing antibodies, COVID-19 recovery, tofacitinib, cancer incidence
- MeSH terms
- COVID-19, SARS-CoV-2, Antibodies, Viral, Humans, Antibodies, Neutralizing
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