SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons
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Abstract
Abstract Recently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B.1.1.529 (Omicron) has been described. Here, we analyze titers of neutralizing antibodies of sera from convalescent or vaccinated individuals against the new B.1.1.529 variant and compared them with titers against other Variants of Concern (B.1.1.7, B.1.351, B.1617.2) using replication competent SARS-CoV-2 variants. We found that sera from vaccinated individuals neutralized the B.1.1.529 variant to a much lesser extent than any other variant analyzed. Neutralization capacity against B.1.1.529 was maintained best against sera from super immune individuals (infected and vaccinated or vaccinated and infected).
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Omicron BA.1 possesses a greater capacity of immune escape.
“This is different with Omicron BA.1 which possesses a greater capacity of immune escape [29-31];”
From Vaccine effectiveness and duration of protection of COVID-19 mRNA vaccines against Delta and Omicron BA.1 symptomatic and severe COVID-19 outcomes in adults aged 50 years and over in France (2023) · cites this paper as [29]
In the main text (page not specified), the paper reports that vaccinated persons’ serum neutralized Omicron much less effectively than alpha, beta, or delta, supporting greater immune escape. It identifies the variant as B.1.1.529 but does not specify BA.1, so the sublineage-specific wording is not established by our copy. (LLM, conf=0.80)
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Cites
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“This is different with Omicron BA.1 which possesses a greater capacity of immune escape [29–31]; which when coupled to a decay of neutralizing antibodies further reduces VE against this variant.”
Post-Vaccination Neutralization Responses to Omicron Sub-Variants
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- Authors
- Rössler, A., Riepler, L., Bante, D., von Laer, D., & Kimpel, J.
- Affiliations
- Innsbruck Medical University (AT)
- Medical University of Innsbruck, Innsbruck, Austria
- Corresponding author
- Kimpel, Janine
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2022-02-17
- Volume
- 386
- Issue
- 7
- Pages
- 698-700
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8781314
- OpenAlex
- W4206275144
- Cited by
- 466
- References
- 3
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 30 · 2023: 102 · 2022: 292 · 2021: 18
- FWCI
- 54.14
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- SARS-CoV-2, Omicron variant, neutralizing antibodies, serum neutralization, COVID-19 vaccination, convalescent serum, vaccine-induced immunity, natural immunity
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Viral, Convalescence, Humans, Immunity, Active, Vaccination, Antibodies, Neutralizing
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