The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Subclinical Hyperthyroidism
Abstract
Persons with subclinical hyperthyroidism are at increased risk for cardiovascular and skeletal conditions. Decisions regarding treatment depend on age, menopausal status in women, and the presence of symptoms of and risk factors for cardiovascular disease or bone loss.
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In the citing paper
“LT4 over-treated patients are exposed to a chronic state of excess iodothyronines in the more sensitive target tissues, mainly the heart and bones (5)”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
In the citing paper
“Analyses of real-world data from patient registries have demonstrated that the levels of serum TSH outside the reference intervals, in patients with LT4-treated hypothyroidism, are associated with adverse health outcomes, including ischemic heart disease events, cardiac dysrhythmias, fractures, and heart failure (5, 72, 73).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
In the citing paper
“These risks were particularly more pronounced in those with serum TSH levels that are consistently at the extremes (<0.1 or >10.0 mU/L).”
From ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism (2025) · cites this paper as [5]
Citations
Cites
1 retracted
Yang, R., Yao, L., Fang, Y., Sun, J., Guo, T., Yang, K., & Tian, L. (2017) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-017-0828-5 · Cited by 35
RetractedRoss, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
Self-citationThe Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Self-citationCooper, D. S., & Biondi, B. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60276-6 · Cited by 1,039
Self-citationCooper, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmra042972 · Cited by 1,008
Self-citationThyroid Status, Cardiovascular Risk, and Mortality in Older Adults
Cappola, A. R., Fried, L. P., Arnold, A. M., Danese, M. D., Kuller, L. H., Burke, G. L., Tracy, R. P., & Ladenson, P. W. (2006) · JAMA · doi:10.1001/jama.295.9.1033 · Cited by 862
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
Collet, T.-H., Gussekloo, J., Bauer, D. C., den Elzen, W. P. J., Cappola, A. R., Balmer, P., Iervasi, G., Åsvold, B. O., Sgarbi, J. A., Völzke, H., et al. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.402 · Cited by 572
Gencer, B., Collet, T.-H., Virgini, V., Bauer, D. C., Gussekloo, J., Cappola, A. R., Nanchen, D., den Elzen, W. P. J., Balmer, P., Luben, R. N., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.096024 · Cited by 517
Flynn, R. W., Bonellie, S. R., Jung, R. T., MacDonald, T. M., Morris, A. D., & Leese, G. P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1625 · Cited by 415
Biondi, B. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4701 · Cited by 356
Self-citation
Cited by
Sorted by citations
Thyroid dysfunction and diabetes mellitus: two closely associated disorders
Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00163 · Cited by 598
Self-citationLee, S. Y., & Pearce, E. N. (2023) · JAMA · doi:10.1001/jama.2023.19052 · Cited by 364
Thyroid cancer, recent advances in diagnosis and therapy
Nabhan, F. A., Dedhia, P. H., & Ringel, M. D. (2021) · International Journal of Cancer · doi:10.1002/ijc.33690 · Cited by 228
Thayakaran, R., Adderley, N. J., Sainsbury, C., Torlinska, B., Boelaert, K., Šumilo, D., Price, M., Thomas, G. N., Toulis, K. A., & Nirantharakumar, K. (2019) · BMJ · doi:10.1136/bmj.l4892 · Cited by 138
Chaker, L., Cooper, D. S., Walsh, J. P., & Peeters, R. P. (2024) · The Lancet · doi:10.1016/s0140-6736(23)02016-0 · Cited by 143
Self-citation
Metadata
- Authors
- Biondi, B., & Cooper, D. S.
- Affiliations
- Johns Hopkins University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-06-21
- Volume
- 378
- Issue
- 25
- Pages
- 2411-2419
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4246335980
- Semantic Scholar
- d89d164d3bdb8cfd7d1e88a1593ecc89aec5dbe3
- Cited by
- 135
- References
- 44
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 18 · 2023: 20 · 2022: 24 · 2021: 20 · 2020: 19 · 2019: 9 · 2018: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- subclinical hyperthyroidism, cardiovascular risk, bone loss, osteoporosis, menopause, treatment decision-making, age, cardiovascular risk factors
- MeSH terms
- Aged, Female, Humans, Hyperthyroidism, Iodine Radioisotopes, Methimazole, Reference Values, Antithyroid Agents, Thyroid Hormones, Thyrotropin, Thyroxine, Disease Progression
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