The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Rosiglitazone and cardiotoxicity –weighing the evidence
Open accessAbstract
The recently published meta-analysis by Nissen and Wolski,1 which suggested a significant increase in the risk of myocardial infarction associated with treatment with rosiglitazone (Avandia) and an increase of similar magnitude, albeit nonsignificant, in the risk of death from cardiovascular causes, has created a furor in the press and a quandary for physicians and their patients. Given the vagaries of meta-analyses in general and of this meta-analysis in particular — owing to the absence of primary or time-to-event data, as acknowledged both in the article and in the accompanying editorial2 — clinicians have been left uncertain as to whether rosiglitazone . . .
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“Among the pharmacologic strategies, the thiazolidenidiones, also known as PPAR-gamma agonists, are powerful insulin sensitizers effective in lowering insulin resistance [66] and preventing T2D [67], with efficacy similar to lifestyle strategies and greater than metformin [68].”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [67]
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Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129
Rosiglitazone Evaluated for Cardiovascular Outcomes — An Interim Analysis
Home, P. D., Pocock, S. J., Beck-Nielsen, H., Gomis, R., Hanefeld, M., Jones, N. P., Komajda, M., & McMurray, J. J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073394 · Cited by 761
Choi, D., Kim, S., Choi, S. H., Ko, Y., Ahn, C. W., Jang, Y., Lim, S.-K., Lee, H., & Soo, B. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2654 · Cited by 243
Finding New Treatments for Diabetes — How Many, How Fast . . . How Good?
Nathan, D. M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068294 · Cited by 216
Rosiglitazone and Cardiovascular Risk
Psaty, B. M., & Furberg, C. D. (2007) · New England Journal of Medicine · doi:10.1056/nejme078099 · Cited by 179
Home, P. D., Pocock, S., Beck‐Nielsen, H., Gomis, R., Markolf Hanefeld, E., Dargie, H., Michel Komajda, N., Gubb, J., Biswas, N., & Jones, N. P. (2005) · Diabetologia · doi:10.1007/s00125-005-1869-1 · Cited by 149
Rosiglitazone RECORD study: glucose control outcomes at 18 months
Home, P., Jones, N. P., Pocock, S., Beck‐Nielsen, H., Gomis, R., Markolf Hanefeld, E., Michel Komajda, N., Curtis, P. S., & for the RECORD Study Group (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02160.x · Cited by 82
Research works printed but not linked: 1
- 10.1056/NEJMoa073394 · DOI · Paper page
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Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2009) · Diabetes Care · doi:10.2337/dc08-9025 · Cited by 3,834
Self-citationNathan, D. M., Buse, J. B., Davidson, M. B., Heine, R. J., Holman, R. R., Sherwin, R., & Zinman, B. (2006) · Diabetes Care · doi:10.2337/dc06-9912 · Cited by 1,205
Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2009) · Diabetologia · doi:10.1007/s00125-008-1157-y · Cited by 712
Self-citationReporting bias in medical research - a narrative review
McGauran, N., Wieseler, B., Kreis, J., Schüler, Y.-B., Kölsch, H., & Kaiser, T. (2010) · Trials · doi:10.1186/1745-6215-11-37 · Cited by 452
Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2007) · Diabetes Care · doi:10.2337/dc08-9016 · Cited by 324
Metadata
- Authors
- Nathan, D. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Nathan, David M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-07-05
- Volume
- 357
- Issue
- 1
- Pages
- 64-66
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2008001887
- Cited by
- 126
- References
- 10
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 1 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- rosiglitazone, cardiotoxicity, myocardial infarction risk, cardiovascular mortality, meta-analysis critique, time-to-event data, thiazolidinediones, type 2 diabetes
- MeSH terms
- Rosiglitazone, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Heart Failure, Humans, Hypoglycemic Agents, Metformin, Sulfonylurea Compounds, Thiazolidinediones
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