Zika Virus and Microcephaly
Abstract
Zika virus has been sweeping through South and Central America, with more than a million suspected cases during the past few months, along with a substantial increase in reporting of infants born with microcephaly.1,2 Thus far, the two outbreaks have largely been epidemiologically associated in time and geography. However, Mlakar and colleagues3 now report in the Journal molecular genetic and electron-microscopic data from a case that helps to strengthen the biologic association. This group cared for a pregnant European woman in whom a syndrome compatible with Zika virus infection developed at 13 weeks of gestation while she was working . . .
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Zika viral infection during pregnancy can cause microcephaly including severe structural damage to the prefrontal areas.
“Zika viral infection during pregnancy can cause microcephaly including severe structural damage to the prefrontal areas [338–340].”
From Development of prefrontal cortex (2022) · cites this paper as [339]
Cites
Zika Virus Outbreak on Yap Island, Federated States of Micronesia
Duffy, M. R., Chen, T.-H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805715 · Cited by 3,130 · see citing works
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884 · see citing works
Melo, A. S. O., Malinger, G., Ximenes, R., Szejnfeld, P. O., Sampaio, S. A., & de Filippis, A. M. B. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15831 · Cited by 1,180 · see citing works
Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015
Schüler‐Faccini, L., Ribeiro, E. M., Feitosa, I. M. L., Horovitz, D. D. G., Cavalcanti, D. P., Pessoa, A. L. S., Doriqui, M. J. R., Neri, J. I., Neto, J. M. D. P., Wanderley, H. Y. C., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6503e2 · Cited by 1,076 · see citing works
Zika Virus in the Americas — Yet Another Arbovirus Threat
Fauci, A. S., & Morens, D. M. (2016) · New England Journal of Medicine · doi:10.1056/nejmp1600297 · Cited by 1,075 · see citing works
The Neglected Dimension of Global Security — A Framework for Countering Infectious-Disease Crises
Sands, P., Mundaca-Shah, C. C., & Dzau, V. J. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1600236 · Cited by 215 · see citing works
Possible association between Zika virus infection and microcephaly
Ross, A. (2016) · Cited by 102 · see citing works
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Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292 · see citing works
Wells, M. F., Salick, M. R., Wiskow, O., Ho, D. J., Worringer, K. A., Ihry, R. J., Kommineni, S., Bilican, B., Klim, J. R., Hill, E. J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.011 · Cited by 269 · see citing works
Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes
Panchaud, A., Stojanov, M., Ammerdorffer, A., Vouga, M., & Baud, D. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-16 · Cited by 171 · see citing works
Duggal, N. K., Ritter, J. M., McDonald, E. M., Romo, H., Guirakhoo, F., Davis, B. S., Chang, G.-J. J., & Brault, A. C. (2017) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0263 · Cited by 52 · see citing works
- Authors
- Rubin, E. J., Greene, M. F., & Baden, L. R.
- Affiliations
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-03-10
- Volume
- 374
- Issue
- 10
- Pages
- 984-985
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2263516683
- Cited by
- 150
- References
- 7
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 12 · 2019: 8 · 2018: 15 · 2017: 27 · 2016: 56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- Zika virus, microcephaly, congenital Zika syndrome, pregnancy, viral infection in pregnancy, Zika virus outbreak, electron microscopy
- MeSH terms
- Zika Virus Infection, Zika Virus, Brain, Female, Fetal Diseases, Humans, Microcephaly, Pregnancy
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