Informed consent, comparative effectiveness, and learning health care

An Ethics Framework for a Learning Health Care System: <i>A Departure from Traditional Research Ethics and Clinical Ethics</i>

Faden, R. R., Kass, N. E., Goodman, S. N., Pronovost, P., Tunis, S., & Beauchamp, T. L. (2013) · Hastings Center Report · doi:10.1002/hast.134 · Cited by 498 · see citing works

The Research‐Treatment Distinction: <i>A Problematic Approach for Determining Which Activities Should Have Ethical Oversight</i>

Kass, N. E., Faden, R. R., Goodman, S. N., Pronovost, P., Tunis, S., & Beauchamp, T. L. (2013) · Hastings Center Report · doi:10.1002/hast.133 · Cited by 235 · see citing works

Is Informed Consent Always Necessary for Randomized, Controlled Trials?

Truog, R. D., Robinson, W. M., Randolph, A. G., & Morris, A. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401013 · Cited by 192 · see citing works

Ethics and Informed Consent for Comparative Effectiveness Research With Prospective Electronic Clinical Data

Faden, R., KASS, N. E., Whicher, D. M., Stewart, W., & Tunis, S. (2013) · Medical Care · doi:10.1097/mlr.0b013e31829b1e4b · Cited by 75 · see citing works

Randomized, controlled trials as minimal risk: An ethical analysis*

Morris, M. C., & Nelson, R. M. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000257333.95528.b8 · Cited by 28 · see citing works

Time for united action on depression: a Lancet–World Psychiatric Association Commission

Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works

Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial

Paul, M., Daikos, G. L., Durante‐Mangoni, E., Yahav, D., Carmeli, Y., Benattar, Y. D., Skiada, A., Andini, R., Eliakim‐Raz, N., Nutman, A., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30099-9 · Cited by 626 · see citing works

Enduring and Emerging Challenges of Informed Consent

Grady, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1411250 · Cited by 477 · see citing works

Effect of an Enhanced Medical Home on Serious Illness and Cost of Care Among High-Risk Children With Chronic Illness

Mosquera, R. A., Avritscher, E. B. C., Samuels, C. L., Harris, T. S., Pedroza, C., Evans, P. W., Navarro, F., Wootton, S. H., Pacheco, S. E., Clifton, G. T., et al. (2014) · JAMA · doi:10.1001/jama.2014.16419 · Cited by 259 · see citing works

Primary care physicians and avoidable hospitalizations.

Parchman, M. L., & Culler, S. D. (1994) · PubMed · Cited by 218 · see citing works

Informed Consent

Grady, C., Cummings, S. R., Rowbotham, M. C., McConnell, M. V., Ashley, E. A., & Kang, G. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1603773 · Cited by 217 · see citing works

Reframing Consent for Clinical Research: A Function-Based Approach

Dickert, N. W., Eyal, N., Goldkind, S. F., Grady, C., Joffe, S., Lo, B., Miller, F. G., Pentz, R. D., Silbergleit, R., Weinfurt, K. P., et al. (2017) · The American Journal of Bioethics · doi:10.1080/15265161.2017.1388448 · Cited by 138 · see citing works

Massive transfusion policies at trauma centers participating in the American College of Surgeons Trauma Quality Improvement Program

Camazine, M. N., Hemmila, M. R., Leonard, J. C., Jacobs, R. A., Horst, J. A., Kozar, R. A., Bochicchio, G. V., Nathens, A. B., Cryer, H. M., & Spinella, P. C. (2015) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000641 · Cited by 127 · see citing works

Attitudes Toward Risk and Informed Consent for Research on Medical Practices

Cho, M. K., Magnus, D. C., Constantine, M. L., Lee, S. S., Kelley, M. C., Kraft, S. A., Korngiebel, D. M., James, C., Kuwana, E., Gallagher, T. H., et al. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0166 · Cited by 105 · see citing works

Transradial versus transfemoral approaches for diagnostic cerebral angiography: a prospective, single-center, non-inferiority comparative effectiveness study

Stone, J. G., Zussman, B. M., Tonetti, D. A., Brown, M., Desai, S. M., Gross, B. A., Jadhav, A. P., Jovin, T. G., & Jankowitz, B. T. (2020) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2019-015642 · Cited by 104 · see citing works

Ethical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation

Goldstein, C. E., Weijer, C., Brehaut, J., Fergusson, D. A., Grimshaw, J., Horn, A. R., & Taljaard, M. (2018) · BMC Medical Ethics · doi:10.1186/s12910-018-0253-x · Cited by 96 · see citing works

Use of altered informed consent in pragmatic clinical research

McKinney, R. E., Beskow, L. M., Ford, D. E., Lantos, J. D., McCall, J., Patrick‐Lake, B., Pletcher, M. J., Rath, B., Schmidt, H. K., & Weinfurt, K. P. (2015) · Clinical Trials · doi:10.1177/1740774515597688 · Cited by 95 · see citing works

Building Learning Health Systems to Accelerate Research and Improve Outcomes of Clinical Care in Low- and Middle-Income Countries

English, M., Irimu, G., Agweyu, A., Gathara, D., Oliwa, J. N., Ayieko, P., Were, F., Paton, C., Tunis, S., & Forrest, C. B. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1001991 · Cited by 89 · see citing works

Objecting to experiments that compare two unobjectionable policies or treatments

Meyer, M. N., Heck, P. R., Holtzman, G. S., Anderson, S. M., Cai, W., Watts, D. J., & Chabris, C. F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820701116 · Cited by 87 · see citing works

Clinical research and medical care: towards effective and complete integration

Sacristán, J. A. (2015) · BMC Medical Research Methodology · doi:10.1186/1471-2288-15-4 · Cited by 85 · see citing works

The Integration of Clinical Trials With the Practice of Medicine

Angus, D. C., Huang, A. J., Lewis, R. J., Abernethy, A. P., Califf, R. M., Landray, M., KASS, N. E., Bibbins-Domingo, K. B., Abbasi, A. B., Abebe, K. Z., et al. (2024) · JAMA · doi:10.1001/jama.2024.4088 · Cited by 79 · see citing works

From Doxastic to Epistemic: A Typology and Critique of Qualitative Interview Styles

Berner-Rodoreda, A., Bärnighausen, T., Kennedy, C. E., Brinkmann, S., Sarker, M., Wikler, D. I., Eyal, N., & McMahon, S. A. (2018) · Qualitative Inquiry · doi:10.1177/1077800418810724 · Cited by 79 · see citing works

Brief Report

Young‐Afat, D. A., Verkooijen, H. M., van Gils, C. H., van der Velden, J. M., Burbach, J. P. M., Elias, S. G., van Delden, J. J., Relton, C., van Vulpen, M., & van der Graaf, R. (2016) · Epidemiology · doi:10.1097/ede.0000000000000435 · Cited by 76 · see citing works

The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials

Welch, M. J., Lally, R. C., Miller, J. E., Pittman, S., Brodsky, L., Caplan, A. L., Uhlenbrauck, G., Louzao, D. M., Fischer, J. H., & Wilfond, B. S. (2015) · Clinical Trials · doi:10.1177/1740774515597701 · Cited by 73 · see citing works

When and Why Is Research without Consent Permissible?

Gelinas, L. C., Wertheimer, A., & Miller, F. G. (2016) · The Hastings Center Report · doi:10.1002/hast.548 · Cited by 73 · see citing works

Telemedicine for Children With Medical Complexity: A Randomized Clinical Trial

Mosquera, R. A., Avritscher, E. B. C., Pedroza, C., Lee, K. H., Ramanathan, S., Harris, T. S., Eapen, J. C., Yadav, A., Caldas‐Vasquez, M., Poe, M., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2021-050400 · Cited by 66 · see citing works

The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry‐Based Randomized Trial: The EFFORT Trial

Heyland, D. K., Patel, J. J., Bear, D. E., Sacks, G. S., Nixdorf, H., Dolan, J., Aloupis, M., Licastro, K., Jovanović, V., Rice, T. W., et al. (2018) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1449 · Cited by 63 · see citing works

Ethical oversight in quality improvement and quality improvement research: new approaches to promote a learning health care system

Fiscella, K. A., Tobin, J. N., Carroll, J. K., He, H., & Ogedegbe, G. G. (2015) · BMC Medical Ethics · doi:10.1186/s12910-015-0056-2 · Cited by 62 · see citing works

The Heimdall framework for supporting characterisation of learning health systems

McLachlan, S., POTTS, H. W. W., Dube, K., Buchanan, D., Lean, S., Gallagher, T., Johnson, O. A., Daley, B. J., Marsh, W., & Fenton, N. (2018) · BMJ Health & Care Informatics · doi:10.14236/jhi.v25i2.996 · Cited by 57 · see citing works

Pragmatic Randomized Trials Without Standard Informed Consent?

Nayak, R., Wendler, D. S., Miller, F. G., & Kim, S. Y. H. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0817 · Cited by 56 · see citing works

No big data without small data: learning health care systems begin and end with the individual patient

Sacristán, J. A., & Dilla, T. (2015) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12350 · Cited by 53 · see citing works

Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19

Casey, J. D., Beskow, L. M., Brown, J., Brown, S. M., Gayat, É., Gong, M. N., Harhay, M. O., Jaber, S., Jentzer, J. C., Laterre, P., et al. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00044-3 · Cited by 52 · see citing works

Bringing cohort studies to the bedside: framework for a ‘green button’ to support clinical decision-making

Gallego, B., Walter, S. R., Day, R. O., Dunn, A. G., Sivaraman, V., Shah, N. H., Longhurst, C., & Coiera, E. W. (2015) · Journal of Comparative Effectiveness Research · doi:10.2217/cer.15.12 · Cited by 49 · see citing works

Hospital Consultation From Outpatient Clinicians for Medically Complex Children

Mosquera, R. A., Avritscher, E. B. C., Pedroza, C., Bell, C., Samuels, C. L., Harris, T. S., Eapen, J. C., Yadav, A., Poe, M., Parlar-Chun, R. L., et al. (2020) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.5026 · Cited by 46 · see citing works

Series: Pragmatic trials and real world evidence: Paper 4. Informed consent

Kalkman, S., van Thiel, G. J. M. W., Zuidgeest, M. G. P., GOETZ, I. A., Pfeiffer, B. M., Grobbee, D. E., & van Delden, J. J. M. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.03.019 · Cited by 44 · see citing works

Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness

Gobat, N., Gal, M., Francis, N. A., Hood, K., Watkins, A. K., Turner, J., Moore, R., Webb, S. A. R., Butler, C., & Nichol, A. (2015) · Trials · doi:10.1186/s13063-015-1110-6 · Cited by 43 · see citing works

Informed consent within a learning health system: A scoping review

Cumyn, A., Barton, A., Dault, R., Cloutier, A., Jalbert, R., & Éthier, J. (2019) · Learning Health Systems · doi:10.1002/lrh2.10206 · Cited by 42 · see citing works

Low risk pragmatic trials do not always require participants’ informed consent

Dal‐Ré, R., Avendaño, C., Bloechl‐Daum, B., de Boer, A., Eriksson, S., Fuhr, U., Holm, S., James, S. K., Mentz, R. J., Perucca, E., et al. (2019) · BMJ · doi:10.1136/bmj.l1092 · Cited by 39 · see citing works

Learning health care systems: Highly needed but challenging

Wouters, R. H. P., van der Graaf, R., Voest, E. E., & Bredenoord, A. L. (2020) · Learning Health Systems · doi:10.1002/lrh2.10211 · Cited by 39 · see citing works

Ethical and scientific considerations for patient enrollment into concurrent clinical trials

Myles, P. S., Williamson, E., Oakley, J. G., & Forbes, A. B. (2014) · Trials · doi:10.1186/1745-6215-15-470 · Cited by 38 · see citing works

Alternative consent models for comparative effectiveness studies: Views of patients from two institutions

KASS, N. E., Faden, R., FABI, R. E., Morain, S. R., Hallez, K., Whicher, D. M., Tunis, S., Moloney, R., Messner, D. A., & Pitcavage, J. M. (2016) · AJOB Empirical Bioethics · doi:10.1080/23294515.2016.1156188 · Cited by 38 · see citing works

Clinical Trials Infrastructure as a Quality Improvement Intervention in Low- and Middle-Income Countries

Denburg, A., Galindo, C. R., & Joffe, S. (2016) · The American Journal of Bioethics · doi:10.1080/15265161.2016.1170230 · Cited by 38 · see citing works

Proposals to Conduct Randomized Controlled Trials Without Informed Consent: a Narrative Review

Flory, J., Mushlin, A. I., & Goodman, Z. I. (2016) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3780-5 · Cited by 38 · see citing works

What the public think about participation in medical research during an influenza pandemic: an international cross-sectional survey.

Gobat, N., Butler, C. C., Mollison, J., Francis, N. A., Gal, M., Harris, V., Webb, S. A. R., Byrne, J.-P., Watkins, A., Sukumar, P., et al. (2019) · Public Health · doi:10.1016/j.puhe.2019.07.005 · Cited by 36 · see citing works

Generating and using real-world data: A worthwhile uphill battle

Verkerk, K., & Voest, E. E. (2024) · Cell · doi:10.1016/j.cell.2024.02.012 · Cited by 39 · see citing works

Electronic Health Record–Enabled Research in Children Using the Electronic Health Record for Clinical Discovery

Sutherland, S. M., Kaelber, D. C., Downing, N. L., Goel, V. V., & Longhurst, C. (2016) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.12.002 · Cited by 33 · see citing works

HEAT-PPCI sheds light on consent in pragmatic trials

Shaw, D. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61040-0 · Cited by 32 · see citing works

Needs and Challenges for Big Data in Radiation Oncology

McNutt, T., Moore, K. L., & Quon, H. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.11.032 · Cited by 32 · see citing works

The spectrum of ethical issues in a Learning Health Care System: a systematic qualitative review

McLennan, S., Kahrass, H., Wieschowski, S., Strech, D., & Langhof, H. (2018) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzy005 · Cited by 32 · see citing works

Sharing data under the 21st Century Cures Act

Majumder, M. A., Guerrini, C. J., Bollinger, J. M., Cook-Deegan, R. M., & McGuire, A. L. (2017) · Genetics in Medicine · doi:10.1038/gim.2017.59 · Cited by 31 · see citing works

Novel Methodology for Comparing Standard-of-Care Interventions in Patients With Cancer

Hilton, J. F., Mazzarello, S., Fergusson, D. A., Joy, A. A., Robinson, A. G., Arnaout, A., Hutton, B., Vandermeer, L., & Clemons, M. J. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2016.013474 · Cited by 30 · see citing works

Harms, benefits, and the nature of interventions in pragmatic clinical trials

Ali, J., Andrews, J. E., Somkin, C. P., & Rabinovich, C. E. (2015) · Clinical Trials · doi:10.1177/1740774515597686 · Cited by 30 · see citing works

A protocol for the 0.9% saline versus Plasma-Lyte 148 for intensive care fluid therapy (SPLIT) study

Reddy, S. K., Bailey, M., Beasley, R. W., Bellomo, R., Henderson, S. J., Mackle, D., McArthur, C. J., Mehrtens, J. E., Myburgh, J., McGuinness, S., et al. (2014) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01619-8 · Cited by 29 · see citing works

Informed Consent for Comparative Effectiveness Trials

Faden, R., Beauchamp, T. L., & Kass, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1403310 · Cited by 29 · see citing works

Pre-Visit Prioritization for complex patients with diabetes: Randomized trial design and implementation within an integrated health care system

Grant, R. W., Uratsu, C. S., Estacio, K. R., Altschuler, A., Kim, E. S., Fireman, B. H., Adams, A. S., Schmittdiel, J. A., & Heisler, M. (2016) · Contemporary Clinical Trials · doi:10.1016/j.cct.2016.01.012 · Cited by 29 · see citing works

The Views of Quality Improvement Professionals and Comparative Effectiveness Researchers on Ethics, IRBs, and Oversight

Whicher, D. M., KASS, N. E., Saghai, Y., Faden, R., Tunis, S., & Pronovost, P. J. (2015) · Journal of Empirical Research on Human Research Ethics · doi:10.1177/1556264615571558 · Cited by 28 · see citing works

Ethics Issues Arising in the Transition to Learning Health Care Systems: Results from Interviews with Leaders from 25 Health Systems

Morain, S. R., & KASS, N. E. (2016) · eGEMs (Generating Evidence & Methods to improve patient outcomes) · doi:10.13063/2327-9214.1212 · Cited by 28 · see citing works

Development of the National Network of Depression Centers Mood Outcomes Program: A Multisite Platform for Measurement-Based Care

Zandi, P. P., Wang, Y., Patel, P. D., Katzelnick, D. J., Turvey, C., Wright, J. H., Ajilore, O., Coryell, W. H., Schneck, C. D., Guille, C., et al. (2020) · Psychiatric Services · doi:10.1176/appi.ps.201900481 · Cited by 27 · see citing works

User Experience and Usability of Voice User Interfaces: A Systematic Literature Review

Deshmukh, A. M., & Chalmeta, R. (2024) · Information · doi:10.3390/info15090579 · Cited by 26 · see citing works

Anticipated Ethics and Regulatory Challenges in PCORnet: The National Patient-Centered Clinical Research Network

Ali, J., Califf, R. M., & Sugarman, J. (2015) · Accountability in Research · doi:10.1080/08989621.2015.1023951 · Cited by 26 · see citing works

Coverage With Evidence Development and Managed Entry in the Funding of Personalized Medicine: Practical and Ethical Challenges for Oncology

Lewis, J., Kerridge, I., & Lipworth, W. L. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.2838 · Cited by 26 · see citing works

Creating a pragmatic trials program for breast cancer patients: Rethinking Clinical Trials (REaCT)

Basulaiman, B. M., Awan, A. A., Fergusson, D. A., Vandermeer, L., Arnaout, A., Hilton, J. F., Hutton, B., Joy, A. A., Robinson, A. G., Califaretti, N., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05274-0 · Cited by 25 · see citing works

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol

Taljaard, M., Weijer, C., Grimshaw, J., Ali, A., Brehaut, J., Campbell, M., Carroll, K. A., Edwards, S., Eldridge, S. M., Forrest, C. B., et al. (2018) · Trials · doi:10.1186/s13063-018-2895-x · Cited by 24 · see citing works

Living laboratory: whole‐genome sequencing as a learning healthcare enterprise

Angrist, M. H., & Jamal, L. (2014) · Clinical Genetics · doi:10.1111/cge.12461 · Cited by 23 · see citing works

Patients' views concerning research on medical practices: Implications for consent

Weinfurt, K. P., Bollinger, J. M., Brelsford, K. M., Crayton, T. J., Topazian, R. J., KASS, N. E., Beskow, L. M., & Sugarman, J. (2015) · AJOB Empirical Bioethics · doi:10.1080/23294515.2015.1117536 · Cited by 24 · see citing works

External validity of a randomised controlled trial on the treatment of severe infections caused by MRSA

Paul, M., Bronstein, E., Yahav, D., Goldberg, E., Bishara, J., & Leibovici, L. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008838 · Cited by 23 · see citing works

What gives them the right? Legal privilege and waivers of consent for research

Baker, F. X., & Merz, J. F. (2018) · Clinical Trials · doi:10.1177/1740774518803122 · Cited by 22 · see citing works

Care and research concepts should be revised to practice outcome-based medical care

Raymond, J., Darsaut, T. E., & Roy, D. J. (2019) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.05.025 · Cited by 22 · see citing works

Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program

Reddy, S. K., Young, P. J., Beasley, R. W., Mackle, D., McGuinness, S., McArthur, C. J., Henderson, S. J., Weinberg, L., French, C., Orford, N. R., et al. (2015) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01524-7 · Cited by 21 · see citing works

Can informed consent to research be adapted to risk?

Bromwich, D., & Rid, A. (2014) · Journal of Medical Ethics · doi:10.1136/medethics-2013-101912 · Cited by 21 · see citing works

Patient Perspectives on the Ethical Implementation of a Rapid Learning System for Oncology Care

Jones, R. D., Sabolch, A. N., Aakhus, E., Spence, R., Bradbury, A. R., & Jagsi, R. (2017) · Journal of Oncology Practice · doi:10.1200/jop.2016.016782 · Cited by 21 · see citing works

Kenyan health stakeholder views on individual consent, general notification and governance processes for the re-use of hospital inpatient data to support learning on healthcare systems

Mbuthia, D., Molyneux, S. C., Njue, M., Mwalukore, S., & Marsh, V. (2019) · BMC Medical Ethics · doi:10.1186/s12910-018-0343-9 · Cited by 20 · see citing works

The ethics of ‘Trials within Cohorts’ (TwiCs): 2nd international symposium

the SPIN investigators, Relton, C., Burbach, M., Collett, C., Flory, J., Gerlich, S., Holm, S., Hunn, A., Kim, S., Kwakkenbos, L., et al. (2017) · Trials · doi:10.1186/s13063-017-1961-0 · Cited by 20 · see citing works

Methods for the Watch the Spot Trial. A Pragmatic Trial of More- versus Less-Intensive Strategies for Active Surveillance of Small Pulmonary Nodules

Gould, M. K., Smith‐Bindman, R., Kelly, K. L., Altman, D. E., Barjaktarević, I., Creekmur, B., de Bie, E., Dyer, D. S., Barbosa, E. J. M., Mularski, R. A., et al. (2019) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201903-268sd · Cited by 20 · see citing works

Antiplatelet Therapy May Be Continued After Intracerebral Hemorrhage

Salman, R. A., & Dennis, M. S. (2014) · Stroke · doi:10.1161/strokeaha.114.005786 · Cited by 19 · see citing works

Evolution of medical ethics in resuscitation and end of life

Mentzelopoulos, S. D., Haywood, K. L., Cariou, A., Mantzanas, M., & Bossaert, L. L. (2016) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.tacc.2016.08.001 · Cited by 19 · see citing works

Determinants of Patient and Surrogate Experiences With Acute Care Research Consent: A Key Informant Interview Study

Scicluna, V. M., Goldkind, S. F., Mitchell, A. R., Pentz, R. D., Speight, C. D., Silbergleit, R., & Dickert, N. W. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012599 · Cited by 19 · see citing works

Alternative Consent Models in Pragmatic Palliative Care Clinical Trials

Carpenter, J. G., Ulrich, C. M., Hodgson, N. A., Hanson, L. C., & Ersek, M. T. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.09.044 · Cited by 17 · see citing works

Pragmatic randomized trials in drug development pose new ethical questions: a systematic review

Kalkman, S., van Thiel, G. J. M. W., Grobbee, D. E., & van Delden, J. J. M. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.03.005 · Cited by 17 · see citing works

Ethics of Informed Consent for Pragmatic Trials with New Interventions

Kalkman, S., Kim, S. Y. H., van Thiel, G. J. M. W., Grobbee, D. E., & van Delden, J. J. M. (2017) · Value in Health · doi:10.1016/j.jval.2017.04.005 · Cited by 17 · see citing works

Public Attitudes toward Consent When Research Is Integrated into Care—Any “Ought” from All the “Is”?

Morain, S. R., & Largent, E. A. (2021) · The Hastings Center Report · doi:10.1002/hast.1242 · Cited by 17 · see citing works

Personalized prescription feedback to reduce antibiotic overuse in primary care: rationale and design of a nationwide pragmatic randomized trial

Hemkens, L. G., Saccilotto, R. T., Reyes, S. L., Glinz, D., Zumbrunn, T., Grolimund, O., Gloy, V., Raatz, H., Widmer, A. F., Zeller, A., et al. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1739-0 · Cited by 17 · see citing works

New modes of engagement for big data research

Winickoff, D. E., Jamal, L., & Anderson, N. (2016) · Journal of Responsible Innovation · doi:10.1080/23299460.2016.1190443 · Cited by 17 · see citing works

Patients’ beliefs regarding informed consent for low-risk pragmatic trials

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