The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Ranibizumab for Neovascular Age-Related Macular Degeneration
Open accessAbstract
BACKGROUND: Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration. METHODS: In this multicenter, 2-year, double-blind, sham-controlled study, we randomly assigned patients with age-related macular degeneration with either minimally classic or occult (with no classic lesions) choroidal neovascularization to receive 24 monthly intravitreal injections of ranibizumab (either 0.3 mg or 0.5 mg) or sham injections. The primary end point was the proportion of patients losing fewer than 15 letters from baseline visual acuity at 12 months. RESULTS: We enrolled 716 patients in the study. At 12 months, 94.5% of the group given 0.3 mg of ranibizumab and 94.6% of those given 0.5 mg lost fewer than 15 letters, as compared with 62.2% of patients receiving sham injections (P<0.001 for both comparisons). Visual acuity improved by 15 or more letters in 24.8% of the 0.3-mg group and 33.8% of the 0.5-mg group, as compared with 5.0% of the sham-injection group (P<0.001 for both doses). Mean increases in visual acuity were 6.5 letters in the 0.3-mg group and 7.2 letters in the 0.5-mg group, as compared with a decrease of 10.4 letters in the sham-injection group (P<0.001 for both comparisons). The benefit in visual acuity was maintained at 24 months. During 24 months, presumed endophthalmitis was identified in five patients (1.0%) and serious uveitis in six patients (1.3%) given ranibizumab. CONCLUSIONS: Intravitreal administration of ranibizumab for 2 years prevented vision loss and improved mean visual acuity, with low rates of serious adverse events, in patients with minimally classic or occult (with no classic lesions) choroidal neovascularization secondary to age-related macular degeneration. (ClinicalTrials.gov number, NCT00056836 [ClinicalTrials.gov].).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ranibizumab anti-Fab immunoreactivity in treatment-naïve patients was between 0–0.9% in the MARINA and ANCHOR trials [30, 31].”
From Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review (2021) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The MARINA and ANCHOR trials with ranibizumab showed an incidence of 0.05% [30, 31], and a subsequent comparison study of ranibizumab and bevacizumab for neovascular AMD reported rates of 0.16% for ranibizumab and 0.5% for bevacizumab [32].”
From Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review (2021) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Regardless of anti-VEGF agent, pre-treatment ADA titers have not been shown to have any clinically relevant difference in BCVA outcomes [30, 33, 41, 43].”
From Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review (2021) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Repeated intravitreal (IVT) injections of anti-VEGF therapies effectively slow vision loss in the majority of treatment-compliant patients with wet AMD. 7 – 13”
From Design and Characterization of a Novel Intravitreal Dual-Transgene Genetic Medicine for Neovascular Retinopathies (2024) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the ANCHOR and MARINA studies, 8-14% of eyes gained 415 letters during months 4 to 12. [22][23][24]”
From Defining response to anti-VEGF therapies in neovascular AMD (2015) · cites this paper as [22]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It is now accepted that the best outcomes with anti-VEGF therapies in n-AMD are achieved with regular dosing at specific intervals, usually monthly, as demonstrated in the pivotal trials of ranibizumab, and sometimes two monthly in the first year with aflibercept after the ' three monthly initiation doses'.[22][23][24][25]”
From Defining response to anti-VEGF therapies in neovascular AMD (2015) · cites this paper as [22]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, this initial response at month 4 is not always predictive of long-term VA gains, as a proportion of such eyes continue to accrue gains in vision even after month 4 as in the ANCHOR and MARINA studies, 22,24 HARBOR study 30 and subsequent case series.31”
From Defining response to anti-VEGF therapies in neovascular AMD (2015) · cites this paper as [22]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Other major anti-VEGF clinical trials excluded such patients.18,19,20”
From Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials (2018) · cites this paper as [19]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“However, such lesions may be difficult to categorise as there are a group of 'delayed responders' who will not gain vision until well after 3 and sometimes not until after 12 months.22,24”
From Defining response to anti-VEGF therapies in neovascular AMD (2015) · cites this paper as [22]
Experimental — accuracy not yet measuredIn the citing paper
“In CATT and all randomized clinical trials of anti-VEGF treatment for neovascular AMD, most of the improvement in mean visual acuity from baseline occurred within the first 3 to 6 months with little erosion of the benefit through 2 years when a fixed schedule of monthly (ranibizumab, bevacizumab, aflibercept) or bi-monthly (aflibercept) treatment was maintained.1,7,9,17,34”
From Five-Year Outcomes with Anti–Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration (2016) · cites this paper as [1]
In the citing paper
“was associated with a remarkable proportion of patients with an improvement in vision”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“Ranibizumab is a fragment of a monoclonal antibody that binds to and inhibits all forms of VEGF-A.164,165”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“This drug, when injected intravitreally on a monthly basis, prevented vision loss”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“These benefits persisted through 24 months of follow-up.”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“Mean differences in visual acuity score in the treated and control groups were also impressive, with a mean increase of seven letters in the treated group compared with a mean decrease of 10 letters in the placebo group (p<0·001).”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“At 12 months, 95% of patients given ranibizumab 0·5 mg lost fewer than 15 letters (three lines of vision) compared with 62% of the placebo group (p<0·001).”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“for the first time with any treatment for age-related macular degeneration, was associated with a remarkable proportion of patients with an improvement in vision”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“Additionally, 34% of this group improved by 15 or more letters of vision compared with the 5% in the placebo group (p<0·001).”
From Age-related macular degeneration (2008) · cites this paper as [164]
In the citing paper
“The adverse effects included endophthalmitis (1%) and serious uveitis (1%).”
From Age-related macular degeneration (2008) · cites this paper as [164]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · BMJ · doi:10.1136/bmj.308.6921.81 · Cited by 4,204
Global data on visual impairment in the year 2002.
(2004) · Europe PMC (PubMed Central) · Cited by 4,157
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
Ferrara, N. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0027 · Cited by 3,788
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718
Ranibizumab versus Verteporfin for Neovascular Age-Related Macular Degeneration
Brown, D. M., Kaiser, P. K., Michels, M., Soubrane, G., Heier, J. S., Kim, R. Y., Sy, J. P., & Schneider, S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062655 · Cited by 3,522
Self-citationAltman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · Cited by 3,322
Prevalence of Age-Related Macular Degeneration in the United States
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,774
Pegaptanib for neovascular age-related macular degeneration
Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337
Treatment of Age-related Macular Degeneration With Photodynamic Therapy (TAP) Study Group (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.10.1329 · Cited by 2,192
Flagged first, then by citations
Research works printed but not linked: 5
- Resnikoff S, 2004, Bull World Health Organ, 82, 844
- Bressler NM, 2001, Arch Ophthalmol, 119, 198
- Lopez PF, 1996, Invest Ophthalmol Vis Sci, 37, 855
- Kvanta A, 1996, Invest Ophthalmol Vis Sci, 37, 1929
- Grading of vitreous cells. In: Nussenblatt RB, Whitcup SM, Palestine AG. Uveitis: fundamentals and clinical practice. 2nd ed. New York: Mosby, 1996:64.
Cited by
Sorted by citations
Items 501–600 of 1,051
Cursiefen, C., Viaud, E., Bock, F., Geudelin, B., Ferry, A., Kadlecová, P., Lévy, M., Mahmood, S. A., Colin, S., Thorin, É., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.03.038 · Cited by 116
Ciulla, T. A., Huang, F., Westby, K., Williams, D. F., Zaveri, S., & Patel, S. C. (2018) · Ophthalmology Retina · doi:10.1016/j.oret.2018.01.006 · Cited by 115
Rayess, N., Houston, S. K. S., Gupta, O. P., Ho, A. C., & Regillo, C. D. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.09.011 · Cited by 115
Low-Level Laser Therapy Improves Vision in Patients with Age-Related Macular Degeneration
Ivandic, B., & Ivandić, T. (2008) · Photomedicine and Laser Surgery · doi:10.1089/pho.2007.2132 · Cited by 115
Digoxin inhibits retinal ischemia‐induced HIF‐1α expression and ocular neovascularization
Yoshida, T., Zhang, H., Iwase, T., Shen, J., Semenza, G. L., & Campochiaro, P. A. (2010) · The FASEB Journal · doi:10.1096/fj.09-145664 · Cited by 115
Orr, P. R., Rentz, A. M., Margolis, M. K., Revicki, D. A., Dolan, C., Colman, S. S., Fine, J. T., & Bressler, N. M. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5645 · Cited by 115
Combination therapy for the treatment of ocular neovascularization
Bradley, J. M. B., Ju, M., & Robinson, G. S. (2007) · Angiogenesis · doi:10.1007/s10456-007-9069-x · Cited by 115
Scheppke, L., Aguilar, E., Gariano, R. F., Jacobson, R., Hood, J. D., Doukas, J., Cao, J., Noronha, G., Yee, S., Weis, S. M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33361 · Cited by 115
Innovative therapies for neovascular age-related macular degeneration
Al-Khersan, H., Hussain, R. M., Ciulla, T. A., & Dugel, P. U. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1636031 · Cited by 114
Gharbiya, M., Allievi, F., Mazzeo, L., & Gabrieli, C. B. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2008.07.022 · Cited by 114
Adherence to ranibizumab treatment for neovascular age-related macular degeneration in real life
Dröge, K., Muether, P. S., Hermann, M. M., Caramoy, A., Viebahn, U., Kirchhof, B., & Fauser, S. (2012) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-012-2177-3 · Cited by 114
Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases
Jones, M. K., Lü, B., Girman, S., & Wang, S. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.01.004 · Cited by 114
Visual Function Decline Resulting from Geographic Atrophy
Heier, J. S., Pieramici, D. J., Chakravarthy, U., Patel, S. S., Gupta, S. R., Lotery, A. J., Lad, E. M., Silverman, D. G., Henry, E. C., Anderesi, M., et al. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.01.019 · Cited by 114
Self-citationMelo, G. B., Cruz, N. F. S. D., Emerson, G. G., Rezende, F. A., Meyer, C. H., Uchiyama, S., Carpenter, J., Shiroma, H. F., Farah, M. E., Maia, M., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100862 · Cited by 114
de Vries, V. A., Bassil, F. L., & Ramdas, W. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-70269-7 · Cited by 114
Chang, W., Garg, S. J., Maturi, R. K., Hsu, J., Sivalingam, A., Gupta, S. A., Regillo, C. D., & Ho, A. C. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.02.007 · Cited by 114
Yadav, M., Schiavone, N., Guzmán‐Aránguez, A., Giansanti, F., Papucci, L., de Lara, M. J. P., Singh, M., & Kaur, I. P. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00733-4 · Cited by 113
Towards a better understanding of non-exudative choroidal and macular neovascularization
Sacconi, R., Fragiotta, S., Sarraf, D., Sadda, S. R., Freund, K. B., Parravano, M., Corradetti, G., Cabral, D., Capuano, V., Mière, A., et al. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101113 · Cited by 113
Efficacy of intravitreal bevacizumab in treating postoperative pseudophakic cystoid macular edema
Spitzer, M. S., Ziemssen, F., Yoeruek, E., Petermeier, K., Aisenbrey, S., & Szurman, P. (2008) · Journal of Cataract & Refractive Surgery · doi:10.1016/j.jcrs.2007.08.021 · Cited by 113
Bhavsar, A. R., Ip, M. S., & Glassman, A. R. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.04.011 · Cited by 113
Use of Retinal Procedures in Medicare Beneficiaries From 1997 to 2007
Ramulu, P. Y. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.224 · Cited by 113
Chong, E. W.-T., Kreis, A. J., Wong, T. Y., Simpson, J. A., & Guymer, R. H. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.12.005 · Cited by 112
Kiss, S., Liu, Y., Brown, J. G., Holekamp, N. M., Almony, A., Campbell, J. H., & Kowalski, J. W. (2014) · Clinical ophthalmology · doi:10.2147/opth.s60893 · Cited by 112
ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION
Chen, E., Lin, M., Cox, J., & Brown, D. M. (2011) · Retina · doi:10.1097/iae.0b013e318221594a · Cited by 112
Self-citationRayess, N., Rahimy, E., Storey, P. P., Shah, C. P., Wolfe, J. D., Chen, E., DeCroos, F. C., Garg, S. J., & Hsu, J. (2016) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2016.02.028 · Cited by 112
VEGF and Intraocular Neovascularization: From Discovery to Therapy
Ferrara, N. (2016) · Translational Vision Science & Technology · doi:10.1167/tvst.5.2.10 · Cited by 112
Anti-VEGF therapy: comparison of current and future agents
Pieramici, D. J., & Rabena, M. (2008) · Eye · doi:10.1038/eye.2008.88 · Cited by 112
Xu, M., Fan, R., Fan, X., Shao, Y., & Li, X. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s383101 · Cited by 111
Voleti, V. B., & Hubschman, J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.01.018 · Cited by 111
Intravitreal bevacizumab for surgical treatment of severe proliferative diabetic retinopathy
di Lauro, R., Ruggiero, P. D., di Lauro, R., di Lauro, M. T., & Romano, M. R. (2010) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-010-1303-3 · Cited by 111
Csaky, K. G., & Diana, V. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.06.014 · Cited by 111
Update on depression and age-related macular degeneration
Casten, R. J., & Rovner, B. W. (2013) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e32835f8e55 · Cited by 111
Monés, J., Singh, R. P., Bandello, F., Souied, E., Liu, X., & Gale, R. (2020) · Ophthalmologica · doi:10.1159/000502747 · Cited by 110
Overview of progress in the epidemiology of age-related macular degeneration
Klein, R. (2007) · Ophthalmic Epidemiology · doi:10.1080/09286580701344381 · Cited by 110
Ranibizumab for the treatment of neovascular age-related macular degeneration: A review
Kourlas, H., & ABRAMS, P. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.09.008 · Cited by 110
Waldstein, S. M., Philip, A.-M., Leitner, R., Simader, C., Langs, G., Gerendas, B. S., & Schmidt-Erfurth, U. M. (2015) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.4948 · Cited by 110
Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes
Ahn, S. J., Ahn, J., Park, S. Y., Kim, H., Hwang, D. D.-J., Park, J. H., Park, J. Y., Chung, J., Park, K. H., & Woo, S. J. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13054 · Cited by 110
Defining a Minimum Set of Standardized Patient-centered Outcome Measures for Macular Degeneration
Rodrigues, I. A. S., Sprinkhuizen, S. M., Barthelmes, D., Blumenkranz, M. S., Cheung, C. M. G., Haller, J. A., Johnston, R. L., Ramasamy, K., Klaver, C. C. W., McKibbin, M., et al. (2016) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2016.04.012 · Cited by 110
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery
Zierden, H. C., Josyula, A., Shapiro, R. L., Hsueh, H. T., Hanes, J. S., & Ensign, L. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.12.001 · Cited by 110
Jonas, J. B., Bourne, R., White, R. A., Flaxman, S. R., Keeffe, J. E., Leasher, J. L., Naidoo, K. S., Pesudovs, K., Price, H., Wong, T. Y., et al. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.06.012 · Cited by 109
Zhang, M., Zhang, J., Yan, M., Luo, D., Zhu, W., Kaiser, P. K., & Yu, D.-C. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.08.008 · Cited by 109
Self-citationThe potential of aptamers as anticoagulants
Nimjee, S. M., Rusconi, C. P., Harrington, R. A., & Sullenger, B. A. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.01.002 · Cited by 109
Goldstein, J. E., Massof, R. W., Deremeik, J. T., Braudway, S., Jackson, M. L., Kehler, K. B., Primo, S. A., & Sunness, J. S. (2012) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2012.1197 · Cited by 109
Mowat, F. M., Gornik, K. R., Dinculescu, A., Boye, S. L., Hauswirth, W. W., Petersen-Jones, S. M., & Bartoe, J. T. (2014) · Gene Therapy · doi:10.1038/gt.2013.64 · Cited by 108
Bacterial Dispersal Associated With Speech in the Setting of Intravitreous Injections
Wen, J. C. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.227 · Cited by 108
Sustained Visual Acuity Loss in the Comparison of Age-Related Macular Degeneration Treatments Trials
Ying, G., Kim, B. J., Maguire, M. G., Huang, J., Daniel, E., Jaffe, G. J., Grunwald, J. E., Blinder, K. J., Flaxel, C. J., Rahhal, F. M., et al. (2014) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2014.1019 · Cited by 108
Xu, D. N., Dávila, J. P., Rahimi, M., Rebhun, C. B., Alibhai, A. Y., Waheed, N. K., & Sarraf, D. (2017) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2017.12.005 · Cited by 108
RANIBIZUMAB TREATMENT IN TREATMENT-NAIVE NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Holz, F. G., Figueroa, M. S., Bandello, F. M., Yang, Y. C., Ohji, M., Dai, H., Wykrota, H., Sharma, S., Dunger‐Baldauf, C., Lacey, S., et al. (2019) · Retina · doi:10.1097/iae.0000000000002670 · Cited by 108
Xu, L., Mrejen, S., Jung, J. J., Gallego‐Pinazo, R., Thompson, D., Marsiglia, M., & Freund, K. B. (2014) · Retina · doi:10.1097/iae.0000000000000374 · Cited by 108
Protein delivery for retinal diseases: From basic considerations to clinical applications
Sanharawi, M. E., Kowalczuk, L., Touchard, E., Omri, S., de Kozak, Y., & Béhar‐Cohen, F. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.04.001 · Cited by 108
The anti-angiogenic isoforms of VEGF in health and disease
Qiu, Y., Hoareau‐Aveilla, C., Oltean, S., Harper, S. J., & Bates, D. O. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371207 · Cited by 108
Psychophysical Function in Age-related Maculopathy
Neelam, K., Nolan, J. M., Chakravarthy, U., & Beatty, S. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.12.003 · Cited by 108
Schmitz-Valckenberg, S., Fleckenstein, M., Göbel, A. P., Hohman, T. C., & Holz, F. G. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5619 · Cited by 108
Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema: A Prospective, Randomized Study
Jonas, J. B., Kamppeter, B. A., Harder, B., Vossmerbaeumer, U., Sauder, G., & Spandau, U. H. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.200 · Cited by 108
Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration
Gopinath, B., Flood, V. M., Rochtchina, E., Wang, J. J., & Mitchell, P. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.057091 · Cited by 108
Engelbert, M., Zweifel, S. A., & Freund, K. B. (2010) · Retina · doi:10.1097/iae.0b013e3181d50cbf · Cited by 107
Profile of conbercept in the treatment of neovascular age-related macular degeneration
Sun, X., & Lu, X. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s67536 · Cited by 107
Smailhodzic, D., Muether, P. S., Chen, J. L., Kwestro, A., Zhang, A. Y., Omar, A., van de Ven, J. P. H., KEUNEN, J. E. E., Kirchhof, B., Hoyng, C. B., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.05.040 · Cited by 107
Polat, O., İnan, S., Özcan, S., Doğan, M., Küsbeci, T., Yavaş, G. F., & İnan, Ü. U. (2017) · Turkish Journal of Ophthalmology · doi:10.4274/tjo.28003 · Cited by 107
Wong, T. Y., Ogura, Y., Lee, W. K., Iida, T., Chen, S., Mitchell, P., Cheung, C. M. G., Zhang, Z., Leal, S., & Ishibashi, T. (2019) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2019.02.027 · Cited by 107
Revicki, D. A., Rentz, A. M., Harnam, N., Thomas, V. S., & Lanzetta, P. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3766 · Cited by 107
Olsen, T. W., Feng, X., Wabner, K., Csaky, K., Pambuccian, S., & Cameron, J. D. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6291 · Cited by 106
Dawson, S. R., Mallen, C. D., Gouldstone, M. B., Yarham, R., & Mansell, G. (2014) · BMC Ophthalmology · doi:10.1186/1471-2415-14-78 · Cited by 106
Cell-Based Therapy for Degenerative Retinal Disease
Zarbin, M. A. (2019) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-05222-5 · Cited by 106
Dias, J. R. D. O., Rodrigues, E. B., Maia, M., Magalhães, O., Penha, F. M., & Farah, M. E. (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.186361 · Cited by 106
Li, M., Xu, Z., Zhang, L., Cui, M., Zhu, M., Guo, Y., Sun, R., Han, J., Song, E., He, Y., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c00680 · Cited by 106
Rahimi, N. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.03.019 · Cited by 106
Choi, D. Y., Ortube, M. C., McCannel, C. A., Sarraf, D., Hubschman, J., McCannel, T. A., & Gorin, M. B. (2011) · Retina · doi:10.1097/iae.0b013e318217ffde · Cited by 106
A systematic review on the effect of bevacizumab in exudative age-related macular degeneration
Schouten, J., Heij, E. C. L., Webers, C. A. B., Lundqvist, I. J., & Hendrikse, F. (2008) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-008-0952-y · Cited by 106
Eyeing central neurons in vascular growth and reparative angiogenesis
Sapieha, P. S. (2012) · Blood · doi:10.1182/blood-2012-04-396846 · Cited by 106
Ying, G., Maguire, M. G., Daniel, E., Ferris, F. L., Jaffe, G. J., Grunwald, J. E., Toth, C. A., Huang, J., & Martín, D. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.08.015 · Cited by 105
Jobling, A. I., Guymer, R. H., Vessey, K. A., Greferath, U., Mills, S. A., Brassington, K. H., Luu, C. D., Aung, K. Z., Trogrlic, L., Plunkett, M. J., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-262444 · Cited by 105
Cohen, E. J. (2010) · Yearbook of Ophthalmology · doi:10.1016/s0084-392x(10)79280-7 · Cited by 105
AI-based monitoring of retinal fluid in disease activity and under therapy
Schmidt-Erfurth, U. M., Reiter, G. S., Riedl, S., Seeböck, P., Vogl, W., Blodi, B. A., Domalpally, A., Fawzi, A. A., Jia, Y., Sarraf, D., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100972 · Cited by 105
Scholl, H. P. N., Fleckenstein, M., Fritsche, L. G., Schmitz-Valckenberg, S., Göbel, A. P., Adrion, C., Herold, C., Keilhauer, C. N., Mackensen, F., Mößner, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007418 · Cited by 105
Pechan, P., Rubin, H., Lukason, M., Ardinger, J., DuFresne, E., Hauswirth, W. W., Wadsworth, S. C., & Scaria, A. (2009) · Gene Therapy · doi:10.1038/gt.2008.115 · Cited by 104
Pegaptanib Sodium for Macular Edema Secondary to Central Retinal Vein Occlusion
Wroblewski, J. J. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.14 · Cited by 104
Pieramici, D. J., Rabena, M., CASTELLARIN, A. A., Nasir, M. A., See, R. F., Norton, T., Sánchez, A. I., Risard, S. M., & Avery, R. L. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.06.021 · Cited by 104
Talks, J. S., Lotery, A. J., Ghanchi, F. D., Sivaprasad, S., Johnston, R. L., Patel, N., McKibbin, M., Bailey, C., Mahmood, S., Lobo, A., et al. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.09.039 · Cited by 104
Daïen, V., Nguyen, V., Essex, R. W., Morlet, N., Barthelmes, D., Gillies, M. C., Gillies, M. C., Hunt, A., Essex, R. W., Dayajeewa, C., et al. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.07.005 · Cited by 104
Role of vascular endothelial growth factor in ocular angiogenesis.
Shams, N. K., & Ianchulev, T. (2006) · PubMed · doi:10.1016/j.ohc.2006.05.005 · Cited by 104
The Carmis Study Group, Piermarocchi, S., Saviano, S., Parisi, V., Tedeschi, M., Panozzo, G., Scarpa, G., Boschi, G., Giudice, G. L., The Carmis Study Group, et al. (2011) · European Journal of Ophthalmology · doi:10.5301/ejo.5000069 · Cited by 104
Bloch, S. B., Lund‐Andersen, H., Sander, B., & Larsen, M. (2013) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.02.012 · Cited by 104
The Neovascular Age-Related Macular Degeneration Database
Zarranz-Ventura, J., Liew, G., Johnston, R. L., Xing, W., Akerele, T., McKibbin, M., Downey, L., Natha, S., Chakravarthy, U., Bailey, C., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.04.026 · Cited by 103
Winnik, S. H., Lohmann, C., Siciliani, G., von Lukowicz, T., Kuschnerus, K., Kränkel, N., Brokopp, C. E., Enseleit, F., Michels, S., Ruschitzka, F. T., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.03.010 · Cited by 103
Holz, F. G., Bandello, F. M., Gillies, M. C., Mitchell, P. L. R., Osborne, A. R., Sheidow, T., Souied, E. H., & Figueroa, M. S. (2013) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2013-303232 · Cited by 103
Hata, M., Yamashiro, K., Ooto, S., Oishi, A., Tamura, H., Miyata, M., Ueda‐Arakawa, N., Takahashi, A., Tsujikawa, A., & Yoshimura, N. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20967 · Cited by 103
Intraocular inflammation following intravitreal injection of bevacizumab
Bakri, S. J., Larson, T. A., & Edwards, A. O. (2008) · Graefe's Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0754-7 · Cited by 102
Mitchell, P. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.585394 · Cited by 102
Koizumi, H., Kano, M., Yamamoto, A., Saito, M., Maruko, I., Kawasaki, R., Sekiryu, T., Okada, A. A., & Iida, T. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.12.025 · Cited by 102
Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides
de Cogan, F., Hill, L. J., Lynch, A., Morgan-Warren, P. J., Lechner, J., Berwick, M. R., Peacock, A. F. A., Chen, M., Scott, R. A. H., Xu, H., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20072 · Cited by 102
Mackensen, F., Heinz, C., Becker, M. D., & Heiligenhaus, A. (2008) · Retina · doi:10.1097/iae.0b013e318156db75 · Cited by 102
Hudson, H. L., Lane, S. S., Heier, J. S., Stulting, R. D., Singerman, L. J., Lichter, P. R., Sternberg, P., & Chang, D. F. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.07.010 · Cited by 102
Self-citationHomma, K., Okamoto, S., Mandai, M., Gotoh, N., Rajasimha, H. K., Chang, Y.-S., Chen, S., Li, W., Cogliati, T., Swaroop, A., et al. (2013) · Stem Cells · doi:10.1002/stem.1372 · Cited by 101
Stangos, A. N., Gandhi, J. S., Sahni, J., Heimann, H., Pournaras, C. J., & Harding, S. P. (2010) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.05.035 · Cited by 101
“The patient is speaking”: discovering the patient voice in ophthalmology
Dean, S., Mathers, J. M., Calvert, M., Kyte, D. G., Conroy, D. M., Folkard, A., Southworth, S., Murray, P. I., & Denniston, A. K. (2017) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-309955 · Cited by 101
Surgery for cataracts in people with age-related macular degeneration
Casparis, H., Lindsley, K. B., Kuo, I. C., Sikder, S., & Bressler, N. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006757.pub4 · Cited by 101
Adult Retinal Pigment Epithelial Transplantation in Exudative Age-related Macular Degeneration
Tezel, T. H., Priore, L. V. D., Berger, A. S., & Kaplan, H. J. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.12.007 · Cited by 101
Reducing the Risk of Endophthalmitis Following Intravitreal Injections
Scott, I. U., & Flynn, H. W. (2007) · Retina · doi:10.1097/iae.0b013e3180307271 · Cited by 101
Metadata
- Authors
- Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., & Kim, R. Y.
- Affiliations
- University of Miami (US)
- Houston Methodist (US)
- Ophthalmic Consultants of Boston (US)
- Retina Vitreous Associates Medical Group (US)
- Cleveland Clinic (US)
- Genentech (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-10-05
- Volume
- 355
- Issue
- 14
- Pages
- 1419-1431
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2124415048
- Cited by
- 5,886
- References
- 25
- Citations by year
- 2026: 179 · 2025: 231 · 2024: 207 · 2023: 198 · 2022: 242 · 2021: 324 · 2020: 311 · 2019: 259 · 2018: 286 · 2017: 325 · 2016: 313 · 2015: 356 · 2014: 358 · 2013: 371 · 2012: 371
- FWCI
- 240.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- Pennsylvania State University
- University of South Florida
- Towson University
- Genentech
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- ranibizumab, neovascular age-related macular degeneration, choroidal neovascularization, intravitreal injection, anti-VEGF therapy, VEGF-A, visual acuity, blindness prevention, endophthalmitis, uveitis, adverse events, long-term follow-up, dose comparison, occult choroidal neovascularization, anti-angiogenic therapy, VEGF inhibitors
- MeSH terms
- Ranibizumab, Aged, Aged, 80 and over, Antibodies, Monoclonal, Double-Blind Method, Female, Humans, Injections, Macular Degeneration, Male, Middle Aged, Optic Disk, Visual Acuity, Choroidal Neovascularization, Angiogenesis Inhibitors, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
