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Cited by 112Retinal Diseases and TreatmentsAlcohol Consumption and Health EffectsRetinal Imaging and Analysis

Alcohol Consumption and the Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

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Chong, Elaine W.-T., Kreis, Andreas J., Wong, Tien Y., Simpson, Julie A., Guymer, Robyn H.·2008·American Journal of Ophthalmology
DOI 10.1016/j.ajo.2007.12.005
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Abstract

Purpose To review systematically the evidence currently available on alcohol consumption and the risk of age-related macular degeneration (AMD).Design Systematic review and meta-analysis of observational studies.Methods Seven databases were searched systematically with no limits on the year or language of publication for prospective cohort studies. References identified from pertinent reviews and articles also were retrieved. Two reviewers independently searched the above databases and selected the studies using prespecified standardized criteria. These criteria included appropriate adjustment for age and smoking in the analysis. Of the 441 studies identified initially, five cohort studies met the selection criteria. Data extraction and study quality evaluation were performed independently by two reviewers and results were pooled quantitatively using meta-analytic methods.Results The five cohort studies included 136,946 people, among whom AMD developed in 1923 (1,513 early and 410 late). Pooled results showed that heavy alcohol consumption was associated with an increased risk of early AMD (pooled odds ratio, 1.47; 95% confidence interval, 1.10 to 1.95), whereas the association between heavy alcohol consumption and risk of late AMD was inconclusive. There were insufficient data to evaluate a dose-response association between alcohol consumption and AMD or the association between moderate alcohol consumption and AMD.Conclusions Heavy alcohol consumption (more than three standard drinks per day) is associated with an increased risk of early AMD. Although this association seems to be independent of smoking, residual confounding effects from smoking cannot be excluded completely.

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Authors
Chong, E. W.-T., Kreis, A. J., Wong, T. Y., Simpson, J. A., & Guymer, R. H.
Affiliations
The University of Melbourne (AU)
Corresponding author
Wong, Tien Y.
ORCID
Venue
American Journal of Ophthalmology
Publisher
Elsevier BV
Published
2008-04
Volume
145
Issue
4
Pages
707-715.e2
ISSN
0002-9394 (ISSN-L)
DOI
10.1016/j.ajo.2007.12.005
OpenAlex
W2082032407
Cited by
112
References
66
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 10 · 2013: 5 · 2012: 9
FWCI
1.27
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
alcohol consumption, age-related macular degeneration, heavy drinking, early AMD, late AMD, risk factors, smoking confounding, dose-response relationship, moderate drinking
MeSH terms
Alcohol Drinking, Humans, Macular Degeneration, Risk Factors, Odds Ratio, Databases, Factual

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