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Cited by 479

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

Open access
Davis, Susan R., Moreau, Michele, Kroll, Robin, Bouchard, Céline, Panay, Nick, Gass, Margery, Braunstein, Glenn D., Hirschberg, Angelica Linden, Rodenberg, Cynthia, Pack, Simon, Koch, Helga, Moufarege, Alain, Studd, John·2008·New England Journal of Medicine
DOI 10.1056/nejmoa0707302
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Abstract

BACKGROUND: The efficacy and safety of testosterone treatment for hypoactive sexual desire disorder in postmenopausal women not receiving estrogen therapy are unknown. METHODS: We conducted a double-blind, placebo-controlled, 52-week trial in which 814 women with hypoactive sexual desire disorder were randomly assigned to receive a patch delivering 150 or 300 microg of testosterone per day or placebo. Efficacy was measured to week 24; safety was evaluated over a period of 52 weeks, with a subgroup of participants followed for an additional year. The primary end point was the change from baseline to week 24 in the 4-week frequency of satisfying sexual episodes. RESULTS: At 24 weeks, the increase in the 4-week frequency of satisfying sexual episodes was significantly greater in the group receiving 300 microg of testosterone per day than in the placebo group (an increase of 2.1 episodes vs. 0.7, P<0.001) but not in the group receiving 150 microg per day (1.2 episodes, P=0.11). As compared with placebo, both doses of testosterone were associated with significant increases in desire (300 microg per day, P<0.001; 150 microg per day, P=0.04) and decreases in distress (300 microg per day, P<0.001; 150 microg per day, P=0.04). The rate of androgenic adverse events - primarily unwanted hair growth - was higher in the group receiving 300 microg of testosterone per day than in the placebo group (30.0% vs. 23.1%). Breast cancer was diagnosed in four women who received testosterone (as compared with none who received placebo); one of the four received the diagnosis in the first 4 months of the study period, and one, in retrospect, had symptoms before undergoing randomization. CONCLUSIONS: In postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 microg of testosterone per day resulted in a modest but meaningful improvement in sexual function. The long-term effects of testosterone, including effects on the breast, remain uncertain. (ClinicalTrials.gov number, NCT00131495.)

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Metadata

Authors
Davis, S. R., Moreau, M., Kroll, R., Bouchard, C., Panay, N., Gass, M., Braunstein, G. D., Hirschberg, A. L., Rodenberg, C., Pack, S., Koch, H., Moufarege, A., & Studd, J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-11-06
Volume
359
Issue
19
Pages
2005-2017
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0707302
OpenAlex
W2090105521
Cited by
479
References
11
FWCI
25.70
Type
journal article
Language
en
Open access
bronze

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