Women’s sexual dysfunction associated with psychiatric disorders and their treatment
Open accessAbstract
Impairment of mental health is the most important risk factor for female sexual dysfunction. Women living with psychiatric illness, despite their frequent sexual difficulties, consider sexuality to be an important aspect of their quality of life. Antidepressant and antipsychotic medication, the neurobiology and symptoms of the illness, past trauma, difficulties in establishing relationships and stigmatization can all contribute to sexual dysfunction. Low sexual desire is strongly linked to depression. Lack of subjective arousal and pleasure are linked to trait anxiety: the sensations of physical sexual arousal may lead to fear rather than to pleasure. The most common type of sexual pain is 10 times more common in women with previous diagnoses of anxiety disorder. Clinicians often do not routinely inquire about their patients’ sexual concerns, particularly in the context of psychotic illness but careful assessment, diagnosis and explanation of their situation is necessary and in keeping with patients’ wishes. Evidence-based pharmacological and non-pharmacological interventions are available but poorly researched in the context of psychotic illness.
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A female brain cannot simultaneously turn off BT-related impulses and turn on sexual impulses.
“After all, a female brain cannot simultaneously turn off BT-related impulses and turn on sexual impulses (Basson & Gilks, 2018;Fleming, 2005;Nowak et al., 2023).”
From “Your Addiction, her Sexual Suffering”—A Qualitative Inquiry into the Effects of Compulsive Sexual Behaviors on Intimate Female Partners (2025) · cites this paper as Basson & Gilks, 2018
The Anxiety disorders section says nonsexual worries can distract women during sex and limit arousal and desire. It does not identify BT-related impulses or establish that a female brain cannot simultaneously suppress them and activate sexual impulses. No page number is available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredOne of the most important causes of sexual dysfunction in women is depression.
“One of the most important causes of sexual dysfunction in women is depression, which has been proven in various studies [40, 41].”
From Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial (2024) · cites this paper as [41]
The Introduction calls psychiatric disease the most important risk factor for women’s sexual dysfunction and identifies depression as strongly associated with it. But the Introduction also says the causal pathway is debated, so the source does not establish depression as a proven cause. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe greatest significant risk factor for female sexual dysfunction is mental health deterioration.
“The greatest significant risk factor for female sexual dysfunction is mental health deterioration (Basson & Gilks, 2018, Blycker, 2023;Leeners et al., 2014).”
From “Your Addiction, her Sexual Suffering”—A Qualitative Inquiry into the Effects of Compulsive Sexual Behaviors on Intimate Female Partners (2025) · cites this paper as Basson & Gilks, 2018
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Sexual desire, mood disorders and sleep disturbances in female BMS patients: A controlled study
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Associations of pelvic floor dysfunction and postnatal mental health: a systematic review
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Diseño y validación de la segunda edición del Cuestionario de Función Sexual de la Mujer, FSM-2
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Sexual dysfunction and quality of life in female patients with major depression disorder
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Female sexual function and distress and time-to-pregnancy in a prospective preconception cohort
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Sexual response in obsessive–compulsive disorder: the role of obsessive beliefs
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Sexuality, pelvic floor/vaginal health and contraception at menopause
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Is cognitive performance of women sensitive to the severity of menopausal symptoms?
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The role of personal factors in quality of life among Iranian women with vaginismus: a path analysis
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The impact of COVID-19 and long COVID on sexual function in cisgender women
Seehuus, M., Fertig, M. R., Handy, A. B., Clifton, J., & Stanton, A. M. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad155 · Cited by 11 · see citing works
Strizzi, J. M., Hald, G. M., Pavan, S., Heymann-Szlachcinska, A. M., Øllgaard, M., Winding, C., Dilling-Hansen, D., Jensen, A. M., Frøslev, M., Larsen, H., et al. (2024) · The Journal of Sex Research · doi:10.1080/00224499.2024.2432608 · Cited by 11 · see citing works
Mode of delivery and maternal sexual wellbeing: A longitudinal study
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Dinçer, B., Ayaz, E. Y., & Oğuz, A. (2021) · Sexuality and Disability · doi:10.1007/s11195-021-09693-0 · Cited by 11 · see citing works
Novick, A. M., Johnson, R. L., Lazorwitz, A. M., Belyavskaya, A., Berkowitz, L. N., Norton, A., Sammel, M. D., & Epperson, C. N. (2022) · The European Journal of Contraception & Reproductive Health Care · doi:10.1080/13625187.2022.2030702 · Cited by 10 · see citing works
Women’s sexual health in later life: Gaps and opportunities in research and practice
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Sexual functioning during the lockdown period in India
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Understanding Hypoactive Sexual Desire Disorder (HSDD) in Women: Etiology, Diagnosis, and Treatment
Ronghe, V., Pannase, K., Gomase, K., & Mahakalkar, M. (2023) · Cureus · doi:10.7759/cureus.49690 · Cited by 9 · see citing works
Evaluation of Sexual Function of Transgender Individuals
Barcelos, T. M. R., Brito, L. G. O., Ferreira, C. H. J., Franceschini, S. A., Troncon, J. K., Ferriani, R. A., & Lara, L. A. D. S. (2024) · International Urogynecology Journal · doi:10.1007/s00192-024-05857-6 · Cited by 9 · see citing works
Kashani, L., Aslzadeh, S., Shokraee, K., Shamabadi, A., Najafabadi, B. T., Jafarinia, M., Esalatmanesh, S., & Akhondzadeh, S. (2022) · PubMed Central · doi:10.22038/ajp.2022.19714 · Cited by 9 · see citing works
Sexual dysfunction, distress, and care-seeking among females during the preconception period
Bond, J. C., White, K. O., Abrams, J. A., Wesselink, A. K., & Wise, L. A. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.03.037 · Cited by 9 · see citing works
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Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in the United States
Shindel, A. W., & Rowen, T. S. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.05.011 · Cited by 9 · see citing works
Introducing sexual dysfunction in mental care
Gombert, M., Ballester, P., Segura, A., & Peiró, A. M. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1849135 · Cited by 9 · see citing works
Stroumsa, D., Raja, N. S., & Russell, C. B. (2024) · Reproduction · doi:10.1530/rep-24-0054 · Cited by 8 · see citing works
“Anger, embarrassment, less than a woman”: the emotional impact of Black women’s sexual pain
Malone, N. J., Thorpe, S. Y., Jester, J. K., Dogan, J. N., Stevens-Watkins, D. J., & Hargons, C. N. (2022) · Women & Health · doi:10.1080/03630242.2022.2155899 · Cited by 8 · see citing works
Managing antipsychotic-related sexual dysfunction in patients with schizophrenia
Silva, C. M., Rebelo, M., & Chendo, I. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2281399 · Cited by 8 · see citing works
Suanrueang, P., & Peltzer, K. (2024) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2024.2316127 · Cited by 8 · see citing works
Psychiatric Comorbidities and Sexual Health
Moghalu, O. I., Hotaling, J. M., & Pastuszak, A. W. (2020) · Current Sexual Health Reports · doi:10.1007/s11930-020-00264-6 · Cited by 8 · see citing works
Obstructive sleep apnea syndrome as a potential cause of sexual dysfunction in women
Kabak, M., & Akbudak, M. (2021) · Sleep And Breathing · doi:10.1007/s11325-020-02275-y · Cited by 8 · see citing works
Schizophrenia and Related Psychoses
(2021) · Wiley eBooks · doi:10.1002/9781119870203.mpg001 · Cited by 8 · see citing works
Perspectives of Mental Health Nurses About Sexual Safety in Acute Inpatient Mental Health Units
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Management of hypoactive sexual desire disorder in women in the gynecological setting
Lara, L. A. D. S., Scalco, S. C. P., Rufino, A. C., de Paula, S. R. C., Fernandes, E. S., Pereira, J. M. D. L., de França, S. S., Reis, S., de Almeida, S. B., Vale, F. B. C., et al. (2021) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0041-1731410 · Cited by 7 · see citing works
Do oral combined contraceptive pills modify body image and sexual function?
Nowosielski, K. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00968-5 · Cited by 7 · see citing works
Gambrah, H. A., Hagedorn, J. C., Dmochowski, R. R., & Johnsen, N. V. (2022) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2022.08.198 · Cited by 9 · see citing works
Sexual dysfunction and associated factors in Behçet’s disease: a case–control study
Varkal, G., Türk, İ., Tüzün, Z., Agbuga, O. D., Mete, B., Coşkun, N. S. Ş., Evran, M., & Özbek, S. (2023) · Rheumatology International · doi:10.1007/s00296-023-05470-8 · Cited by 7 · see citing works
Mulvehill, S., & Tishler, J. (2024) · Sexual Medicine · doi:10.1093/sexmed/qfae023 · Cited by 7 · see citing works
What is the “weight” of body mass index on sexual functioning in women? A mediation model
Nardo, M. D., Conti, C. M., Francesco, G. D., Nicolardi, G., Guagnano, M. T., & Porcelli, P. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00995-4 · Cited by 7 · see citing works
Sha'ari, N., Woon, L. S., Sidi, H., Das, S., Bousman, C., & Saini, S. M. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153760 · Cited by 7 · see citing works
Mind-Body-Spirit Model for the Medical Management of Female Sexual Well-Being
Lorenz, T. K., & Finley, N. (2020) · Current Sexual Health Reports · doi:10.1007/s11930-020-00291-3 · Cited by 7 · see citing works
Parish, S. J., & Pope, R. (2024) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2024.03.002 · Cited by 6 · see citing works
Substance Abuse and Sexual Functioning: An Overview of Mechanisms
Soltaninejad, M., Naderi, Y., Rouhi, L., & Banazadeh, M. (2024) · Addiction and Health · doi:10.34172/ahj.1515 · Cited by 7 · see citing works
Premenstrual dysphoric disorder and sexual function: a narrative review
Susser, L., Parish, S. J., Dumas, E., & Nappi, R. E. (2023) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qead007 · Cited by 6 · see citing works
Mick, A., Wecker, H., Ziehfreund, S., Maul, J., Biedermann, T., & Zink, A. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-02841-4 · Cited by 6 · see citing works
The psychiatric impact of COVID-19 pandemic on sexual health
Paul, G. M., Nascimento, B., Afif‐Abdo, J., Coutinho, F., Miranda, E., & Abdo, C. H. N. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1197 · Cited by 6 · see citing works
Urrunaga‐Pastor, D., Mezones‐Holguín, E., Blümel, J. E., Apolaya-Segura, M., Barón, G., Belzares, E., Bencosme, A., Calle, A., Espinoza, M. T., Flores, D., et al. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001973 · Cited by 6 · see citing works
Double perinatal stress reduces the sexual response of adult female Wistar rats
Ferraz, M. R., Cavalheira, M. A., de Santana, A. O. M., Barboza, V. E., Nântua, M. D. S., Santos, L. N., & Pereira, S. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad036 · Cited by 6 · see citing works
Sexual health and emotional wellbeing of patients with haematological malignancies: general review.
Alsuliman, T., Rojas, R. M. M., Moukalled, N., Brissot, E., Quarez-Blaise, L., Marjanovic, Z., Blaise, D., Murphy, D., Logue, M., Savani, B., et al. (2024) · The Lancet Haematology · doi:10.1016/s2352-3026(24)00208-4 · Cited by 5 · see citing works
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Abstracts of III International Scientific and Practical Conference
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Luria, M., Park, K., Gewirtz‐Meydan, A., Arbanas, G., Ho, C. C. K., Ros, C. T. D., Srini, V. S., & Faubion, S. S. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf069 · Cited by 5 · see citing works
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Psychaesthenic Syndrome: A Review on its Implication in Female Sexual Arousal
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Endocrine disrupting chemicals and female sexual health: An emerging research priority
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Evidence for the Impact of Stress and Trauma on Sexual Function in Women
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- Authors
- Basson, R., & Gilks, T.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Basson, Rosemary
- ORCID
- Basson, Rosemary
- Venue
- Women's Health
- Publisher
- SAGE Publications
- Published
- 2018-01-01
- Volume
- 14
- Pages
- 1745506518762664-1745506518762664
- ISSN
- 1745-5057 (ISSN-L)
- 1745-5065
- PMC
- PMC5900810
- OpenAlex
- W2797764559
- Cited by
- 225
- References
- 156
- Citations by year
- 2026: 28 · 2025: 29 · 2024: 43 · 2023: 41 · 2022: 32 · 2021: 23 · 2020: 20 · 2019: 7 · 2018: 2
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Women s Health (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Social Sciences › Sociology and Political Science › Sex work and related issues
- Keywords
- female sexual dysfunction, mental illness, depression, anxiety disorders, antipsychotic drugs, antidepressant side effects, sexual desire, sexual arousal, sexual pain, psychosis, sexual health assessment, quality of life, stigma
- MeSH terms
- Anxiety, Arousal, Depression, Female, Humans, Libido, Sexual Behavior, Sexual Dysfunction, Physiological, Women's Health, Sexual Dysfunctions, Psychological
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