Complement C3 Variant and the Risk of Age-Related Macular Degeneration

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  2. The complement cascade as a therapeutic target in intracerebral hemorrhage
    Andrew F. Ducruet, Brad E. Zacharia, Zachary L. Hickman, Bartosz T. Grobelny, Mason L. Yeh, Sergey A. Sosunov, Edward Sander Connolly · 2009 · Experimental Neurology
  3. Age-related macular degeneration and the role of the complement system
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  5. Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    Peter J. Francis, Sara Hamon, Jürg Ott, Richard G. Weleber, Michael L. Klein · 2008 · Journal of Medical Genetics
  6. Elevated membrane attack complex in human choroid with high risk complement factor H genotypes
    Robert F. Mullins, Aaron D. Dewald, Luan M. Streb, Kai Wang, Markus H. Kuehn, Edwin M. Stone · 2011 · Experimental Eye Research
  7. Genetic variants in the complement system predisposing to age-related macular degeneration: A review
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  8. Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-Related Macular Degeneration Using Multistate Markov Models
    Yi Yu, Robyn C Reynolds, BERNARD A. ROSNER, Mark J. Daly, Johanna M. Seddon · 2012 · Investigative Ophthalmology & Visual Science
  9. Association of Variants in the LIPC and ABCA1 Genes with Intermediate and Large Drusen and Advanced Age-Related Macular Degeneration
    Yi Yu, Robyn C Reynolds, Jesen A. Fagerness, BERNARD A. ROSNER, Mark J. Daly, Johanna M. Seddon · 2011 · Investigative Ophthalmology & Visual Science
  10. Elevated High-Density Lipoprotein Cholesterol and Age-Related Macular Degeneration: The Alienor Study
    Audrey Cougnard‐Grégoire, Marie‐Noëlle Delyfer, Jean‐François Korobelnik, Marie‐Bénédicte Rougier, Mélanie Le Goff, Jean‐François Dartigues, Pascale Barberger‐Gateau, Cécile Delcourt · 2014 · PLoS ONE
  11. Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
    Fernando Cruz‐Guilloty, Ali M. Saeed, Jose J. Echegaray, Stéphanie Duffort, Asha Ballmick, Yaohong Tan, Michel Betancourt, Eduardo J. Viteri, Ghansham C. Ramkhellawan, E. J. Ewald et al. · 2013 · International Journal of Inflammation
  12. Smoking, Dietary Betaine, Methionine, and Vitamin D in Monozygotic Twins with Discordant Macular Degeneration: Epigenetic Implications
    Johanna M. Seddon, Robyn C Reynolds, Heeral R. Shah, BERNARD A. ROSNER · 2011 · Ophthalmology
  13. Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration
    Zhenglin Yang, Zongzhong Tong, Yuhong Chen, Jiexi Zeng, Fang Lü, Xufang Sun, Chao Zhao, Kevin Wang, Lisa M Davey, Haoyu Chen et al. · 2010 · PLoS Genetics
  14. Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells
    Skeie, Jessica M., Fingert, John H., Russell, Stephen R., Stone, Edwin M., Mullins, Robert F. · 2010 · Investigative Opthalmology & Visual Science
  15. Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration
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  16. The complement system: a gateway to gene–environment interactions in schizophrenia pathogenesis
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  17. Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B
    Tamara Montes, Agustín Tortajada, B. Paul Morgan, Santiago Rodrı́guez de Córdoba, Claire Louise Harris · 2009 · Proceedings of the National Academy of Sciences
  18. Complement dysregulation and disease: From genes and proteins to diagnostics and drugs
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  19. Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
    Monte J. Radeke, Carolyn M. Radeke, Ying-Hsuan Shih, Jane G. Hu, Dean Bok, Lincoln V. Johnson, Peter J. Coffey · 2015 · Genome Medicine
  20. The challenges and promise of complement therapeutics for ocular diseases
    Park, Dong Ho, Connor, Kip M., Lambris, John D. · 2019 · Frontiers in Immunology
  21. Review of Genetics in Age Related Macular Degeneration
    Sandra Rocio Montezuma, Lucia Sobrin, Johanna M. Seddon · 2007 · Seminars in Ophthalmology
  22. Advances in understanding of pathogenesis of aHUS and HELLP
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    Cécile Delcourt, Jean‐François Korobelnik, Pascale Barberger‐Gateau, Marie‐Noëlle Delyfer, Marie‐Bénédicte Rougier, Mélanie Le Goff, Florence Malet, J. Colin, J.-F. Dartigues · 2010 · The journal of nutrition health & aging
  24. Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People
    McKay, G. J., Silvestri, G., Chakravarthy, U., Dasari, S., Fritsche, L. G., Weber, B. H., Keilhauer, C. N., Klein, M. L., Francis, P. J., Klaver, C. C. et al. · 2011 · American Journal of Epidemiology
  25. Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells
    Arije Ghannam, Martine Pernollet, Jean‐Luc Fauquert, Nicole Monnier, D. Ponard, Marie‐Bernadette Villiers, J. Navarro, Arlette Tridon, Joël Lunardi, Denis Gerlier et al. · 2008 · The Journal of Immunology
  26. CFH, C3 and ARMS2 Are Significant Risk Loci for Susceptibility but Not for Disease Progression of Geographic Atrophy Due to AMD
    Hendrik P. N. Scholl, Monika Fleckenstein, Lars G. Fritsche, Steffen Schmitz-Valckenberg, Arno P. Göbel, Christine Adrion, Christine Herold, Claudia N. Keilhauer, Friederike Mackensen, Andreas Mößner et al. · 2009 · PLoS ONE
  27. Lipids, Lipoproteins, and Age-Related Macular Degeneration
    Katayoon B. Ebrahimi, James T. Handa · 2011 · Journal of Lipids
  28. Functional modules, mutational load and human genetic disease
    Norann A. Zaghloul, Nicholas Katsanis · 2010 · Trends in Genetics
  29. REVIEW PAPER: Animals as Models of Age-Related Macular Degeneration
    Caroline J. Zeiss · 2010 · Veterinary Pathology
  30. The Proteomics of Drusen
    John W. Crabb · 2014 · Cold Spring Harbor Perspectives in Medicine
  31. Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
    Valentina Cipriani, Laura Lorés‐Motta, Fan He, Dina Fathalla, Viranga Tilakaratna, Selina McHarg, Nadhim Bayatti, İlhan E. Acar, Carel B. Hoyng, Sascha Fauser et al. · 2020 · Nature Communications
  32. Retinal pigment epithelium in the pathogenesis of age‐related macular degeneration and photobiomodulation as a potential therapy?
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  33. Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration
    Matt Rutar, Riccardo Natoli, Peter Kozulin, Krisztina Valter, Paul A. Gatenby, Jan M. Provis · 2011 · Investigative Ophthalmology & Visual Science
  34. The Role of Complement in AMD
    Peter F. Zipfel, Nadine Lauer, Christine Skerka · 2010 · Advances in experimental medicine and biology
  35. Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration
    Riccardo Natoli, Nilisha Fernando, Haihan Jiao, Tanja Racic, Michele C. Madigan, Nigel L. Barnett, Joshua A. Chu‐Tan, Krisztina Valter, Jan M. Provis, Matt Rutar · 2017 · Investigative Ophthalmology & Visual Science
  36. C2 and CFB Genes in Age-Related Maculopathy and Joint Action with CFH and LOC387715 Genes
    Jóhanna Jakobsdóttir, Yvette P. Conley, Daniel E. Weeks, Robert E. Ferrell, Michael B. Gorin · 2008 · PLoS ONE
  37. Inflammatory Mechanisms of Age-related Macular Degeneration
    Jared E. Knickelbein, Chi‐Chao Chan, Hatice Nida Sen, Frederick L. Ferris, Robert Burton Nussenblatt · 2015 · International Ophthalmology Clinics
  38. Age-Related Macular Degeneration
    Sam Khandhadia, Jocelyn Cherry, Andrew John Lotery · 2012 · Advances in experimental medicine and biology
  39. The molecular genetic basis of age-related macular degeneration: an overview
    Saritha Katta, Inderjeet Kaur, Subhabrata Chakrabarti · 2009 · Journal of Genetics
  40. Mitochondrial DNA Variants Mediate Energy Production and Expression Levels for CFH, C3 and EFEMP1 Genes: Implications for Age-Related Macular Degeneration
    M. Cristina Kenney, Marilyn Chwa, Shari R. Atilano, Janelle M. Pavlis, Payam Falatoonzadeh, Claudio Ramírez, Deepika Malik, Tiffany Hsu, Grace Woo, Kyaw Soe et al. · 2013 · PLoS ONE
  41. Complement Component C3 and Risk of Age-Related Macular Degeneration
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  42. Genetics of age-related macular degeneration: current concepts, future directions
    DeAngelis, Margaret M., Silveira, Alexandra C., Carr, Elizabeth A., Kim, Ivana K. · 2011 · Seminars in Ophthalmology
  43. Developments in anti-complement therapy; from disease to clinical trial
    Claire Louise Harris, Richard B. Pouw, David Kavanagh, Ruyue Sun, Daniel Ricklin · 2018 · Molecular Immunology
  44. Blue light–filtering intraocular lenses: Review of potential benefits and side effects
    Fiona M. Cuthbertson, Stuart N. Peirson, Katharina Wulff, F. Foster, Susan M. Downes · 2009 · Journal of Cataract & Refractive Surgery
  45. Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
    Lei Wang, Naoshi Kondo, Marisol Cano, Katayoon B. Ebrahimi, Takeshi Yoshida, Brad P. Barnett, Shyam S. Biswal, James T. Handa · 2014 · Free Radical Biology and Medicine
  46. The spectrum of phenotypes caused by variants in the CFH gene
    Camiel J. F. Boon, Nicole C. A. J. van de Kar, B. Jeroen Klevering, JAN E. E. KEUNEN, Frans P.M. Cremers, Caroline C. W. Klaver, Carel B. Hoyng, Mohamed R. Daha, Anneke I. den Hollander · 2009 · Molecular Immunology
  47. Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions
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  48. Characterizing New-Onset Exudation in the Randomized Phase 2 FILLY Trial of Complement Inhibitor Pegcetacoplan for Geographic Atrophy
    Charles C. Wykoff, Philip J. Rosenfeld, Nadia Khalida Waheed, Rishi P. Singh, Nick Ronca, Jason S. Slakter, Giovanni Staurenghi, Jordi Monés, Caroline R. Baumal, Namrata Saroj et al. · 2021 · Ophthalmology
  49. Multiple Gene Polymorphisms in the Complement Factor H Gene Are Associated with Exudative Age-Related Macular Degeneration in Chinese
    Tsz Kin Ng, Li Jia Chen, David T.L. Liu, Pancy O. S. Tam, Wai Man Chan, Ke Liu, Yi Jun Hu, Kelvin Kam Lung Chong, Charles Sing Lok Lau, Sylvia W. Y. Chiang et al. · 2008 · Investigative Ophthalmology & Visual Science
  50. Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB–FKBPL–NOTCH4 region of chromosome 6p21.3
    Valentina Cipriani, Hin-Tak Leung, Vincent Plagnol, Catey Bunce, Jane C. Khan, Humma Shahid, Anthony T. Moore, Simon Peter Harding, Paul N. Bishop, Caroline Hayward et al. · 2012 · Human Molecular Genetics
  51. Measurement of Factor H Variants in Plasma Using Variant-Specific Monoclonal Antibodies: Application to Assessing Risk of Age-Related Macular Degeneration
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  53. Lysosomes: regulators of autophagy in the retinal pigmented epithelium
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  54. Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration
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  55. The significance of the complement system for the pathogenesis of age-related macular degeneration — current evidence and translation into clinical application
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  56. Functional and Structural Implications of the Complement Factor H Y402H Polymorphism Associated with Age-Related Macular Degeneration
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  58. Modelling the Genetic Risk in Age-Related Macular Degeneration
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  65. Assessing Susceptibility to Age-Related Macular Degeneration With Genetic Markers and Environmental Factors
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  66. Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular Degeneration
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  67. Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen
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  70. Genetics of Immunological and Inflammatory Components in Age-related Macular Degeneration
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  89. C-Reactive Protein and CFH, ARMS2/HTRA1 Gene Variants Are Independently Associated with Risk of Macular Degeneration
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