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Complement C3 Variant and the Risk of Age-Related Macular Degeneration
Open accessAbstract
BACKGROUND: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis. METHODS: We tested for an association between age-related macular degeneration and 13 single-nucleotide polymorphisms (SNPs) spanning the complement genes C3 and C5 in case subjects and control subjects from the southeastern region of England. All subjects were examined by an ophthalmologist and had independent grading of fundus photographs to confirm their disease status. To test for replication of the most significant findings, we genotyped a set of Scottish cases and controls. RESULTS: The common functional polymorphism rs2230199 (Arg80Gly) in the C3 gene, corresponding to the electrophoretic variants C3S (slow) and C3F (fast), was strongly associated with age-related macular degeneration in both the English group (603 cases and 350 controls, P=5.9x10(-5)) and the Scottish group (244 cases and 351 controls, P=5.0x10(-5)). The odds ratio for age-related macular degeneration in C3 S/F heterozygotes as compared with S/S homozygotes was 1.7 (95% confidence interval [CI], 1.3 to 2.1); for F/F homozygotes, the odds ratio was 2.6 (95% CI, 1.6 to 4.1). The estimated population attributable risk for C3F was 22%. CONCLUSIONS: Complement C3 is important in the pathogenesis of age-related macular degeneration. This finding further underscores the influence of the complement pathway in the pathogenesis of this disease.
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In the citing paper
“the fast migrating allotype (C3F), has been reported to be strongly associated with AMD in a study from English and Scottish populations (Yates et al., 2007).”
From Molecular pathology of age-related macular degeneration (2009) · cites this paper as Yates et al., 2007
In the citing paper
“We further confirmed the association with family history of AMD, consistent with the growing recognition of major genes involved in AMD (e.g., complement factor H and C3, LOCS 3877, HTRA 1) [21,83-86].”
From Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis (2010) · cites this paper as [86]
In the citing paper
“Genes in the complement pathway4–11 and a region of chromosome 10 12,13 have now been implicated as the major genetic contributors to disease.”
From Seven new loci associated with age-related macular degeneration (2013) · cites this paper as [7]
In the citing paper
“These include complement 2 (C2) and/or complement factor B (CFB) (56), complement 3 (C3) (170), and complement factor I (CFI) (44).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [170]
In the citing paper
“The complement system may indeed have an important role in the pathogenesis of age-related macular degeneration, since other factors such as factor B and complement components C2 and C3 are also associated with age-related macular degeneration.66,67”
From Age-related macular degeneration (2008) · cites this paper as [67]
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The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,969
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926
Self-citationThe AMD Genetics Clinical Study Group, Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1750 · Cited by 1,075
Mullins, R. F., Russell, S. R., Anderson, D. H., & Hageman, G. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.835 · Cited by 937
HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration
DeWan, A., Liu, M., Hartman, S., Zhang, S. S.-M., Liu, D. T. L., Zhao, C., Tam, P. O. S., Chan, W. M., Lam, D. S. C., Snyder, M., et al. (2006) · Science · doi:10.1126/science.1133807 · Cited by 876
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Research works printed but not linked: 2
- Rambausek M, 1987, Nephrol Dial Transplant, 2, 208
- Finn JE, 1994, Nephrol Dial Transplant, 9, 1564
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Tian, J., Qin, X., Fang, K., Chen, Q., Hou, J., Li, J., Yu, W., Chen, D., Hu, Y., & Li, X. (2012) · Pharmacogenomics · doi:10.2217/pgs.12.53 · Cited by 44
Spencer, K. L., Olson, L. M., Schnetz‐Boutaud, N. C., Gallins, P. J., Agarwal, A., Iannaccone, A., Kritchevsky, S. B., García, M., Nalls, M. A., Newman, A. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017784 · Cited by 44
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Edwards, A. O., Fridley, B. L., James, K. M., Sharma, A. K., Cunningham, J. M., & Tosakulwong, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003813 · Cited by 43
Qin, S., & Rodrigues, G. A. (2008) · Journal of Inflammation Research · doi:10.2147/jir.s4354 · Cited by 43
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Fritsche, L. G., Freitag‐Wolf, S., Bettecken, T., Meitinger, T., Keilhauer, C. N., Krawczak, M., & Weber, B. H. F. (2008) · Human Mutation · doi:10.1002/humu.20957 · Cited by 43
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Nguyen, Q. D., Agarwal, A. K., Rhoades, W. R., Hanout, M., Soliman, M. K., Sarwar, S., Sadiq, M. A., Sepah, Y. J., & Diana, V. (2015) · Clinical ophthalmology · doi:10.2147/opth.s74959 · Cited by 42
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Park, K. H., Ryu, E., Tosakulwong, N., Wu, Y., & Edwards, A. O. (2009) · PubMed Central · Cited by 40
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Rohrer, B., Coughlin, B. A., Bandyopadhyay, M., & Holers, V. M. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2011.0212 · Cited by 42
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Törn, C., Liu, X., Hagopian, W., Lernmark, Å., Simell, O., Rewers, M., Ziegler, A., Schatz, D., Akolkar, B., Önengüt-Gümüşcü, S., et al. (2016) · Scientific Reports · doi:10.1038/srep27887 · Cited by 39
Jensen, E. G., Jakobsen, T. S., Thiel, S., Askou, A. L., & Corydon, T. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249752 · Cited by 40
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Virgin, H. W. (2007) · Nature Immunology · doi:10.1038/ni1529 · Cited by 41
Sugino, I. K., Gullapalli, V. K., Sun, Q., Wang, J., Nunes, C. F., Cheewatrakoolpong, N., Johnson, A. C., Degner, B. C., Hua, J., Liu, T., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6112 · Cited by 39
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Ramo, K., Cashman, S. M., & Kumar-Singh, R. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2025 · Cited by 38
de Córdoba, S. R., Harris, C. L., Morgan, B. P., & Llorca, Ó. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.002 · Cited by 38
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Schnabolk, G., Coughlin, B., Joseph, K., Kunchithapautham, K., Bandyopadhyay, M., O'Quinn, E. C., Nowling, T., & Rohrer, B. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-15910 · Cited by 37
Scheetz, T. E., Fingert, J. H., Wang, K., Kuehn, M. H., Knudtson, K. L., Alward, W. L. M., Boldt, H. C., Russell, S. R., Folk, J. C., Casavant, T. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058657 · Cited by 39
Lee, A. S., Rusch, J., Lima, A. C., Usmani, A., Huang, N., Lepamets, M., Vigh‐Conrad, K. A., Worthington, R. E., Mägi, R., Wu, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12522-w · Cited by 42
Paun, C. C., Lechanteur, Y. T. E., Groenewoud, J. M. M., Altay, L., Schick, T., Daha, M. R., Fauser, S., Hoyng, C. B., den Hollander, A. I., & de Jong, E. K. (2016) · Scientific Reports · doi:10.1038/srep26568 · Cited by 37
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Peter, I., Huggins, G. S., Ordovás, J. M., Haan, M. N., & Seddon, J. M. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2011.05.016 · Cited by 34
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Saddala, M. S., Lennikov, A., Mukwaya, A., Fan, L., Hu, Z., & Hu, H. (2019) · Human Genomics · doi:10.1186/s40246-019-0199-1 · Cited by 33
Lederman, M., Weiss, A. T., & Chowers, I. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3019 · Cited by 32
Brandli, A. A., Vessey, K. A., & Fletcher, E. L. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03055-1 · Cited by 33
Jobling, A. I., Greferath, U., Dixon, M., Quiriconi, P., Eyar, B., van Koeverden, A. K., Mills, S. A., Vessey, K. A., Bui, B. V., & Fletcher, E. L. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101349 · Cited by 31
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Francis, P. J. (2011) · Clinical ophthalmology · doi:10.2147/opth.s11627 · Cited by 32
Common polymorphisms in the complement system and susceptiblity to bacterial meningitis
Adriani, K. S., Brouwer, M. C., Geldhoff, M., Baas, F., Zwinderman, A. H., Morgan, B. P., Harris, C. L., ENDE, A. V. D., & van de Beek, D. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.10.008 · Cited by 31
Increased Vitronectin Production by Complement-Stimulated Human Retinal Pigment Epithelial Cells
Wasmuth, S., Lueck, K., Baehler, H., Lommatzsch, A. P., & Pauleikhoff, D. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3326 · Cited by 31
Development of gene therapy for treatment of age‐related macular degeneration
Askou, A. L. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12452 · Cited by 32
Taking Complement to the Clinic – has the Time Finally Come?
Lachmann, P. J., & Smith, R. A. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02258.x · Cited by 31
Proitsi, P., Lupton, M. K., Dudbridge, F., Tsolaki, M., Hamilton, G., Daniilidou, M., Pritchard, M., Lord, K., Martin, B. M., Craig, D., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.036 · Cited by 31
Genetic factors associated with the development of age-related macular degeneration
Sergejeva, O., Botov, R., Liutkevičienė, R., & Kriaučiūnienė, L. (2016) · Medicina · doi:10.1016/j.medici.2016.02.004 · Cited by 31
Lee, A., Kulkarni, M., Fang, A. M., Edelstein, S., Osborn, M. P., & Brantley, M. A. (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2009.172007 · Cited by 30
Genetic risk factors and age-related macular degeneration (AMD)
Mousavi, M., & Armstrong, R. A. (2013) · Journal of Optometry · doi:10.1016/j.optom.2013.07.002 · Cited by 32
Song, D., Sulewski, M. E., Wang, C., Song, J., Bhuyan, R., Sterling, J. K., Clark, E., Song, W.-C., & Dunaief, J. L. (2017) · Europe PMC (PubMed Central) · Cited by 30
Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size
Merle, B. M. J., ROSNER, B. A., & Seddon, J. M. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.5.17 · Cited by 31
Wu, L., Tao, Q., Chen, W., Wang, Z., Song, Y., Sheng, S.-Y., Li, P., & Zhou, J. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10453 · Cited by 30
Sofat, R., Casas, J. P., Meena Kumari, B., Talmud, P. J., Ireland, H., Mika Kivimaki, B., Marmot, M. G., Hughes, A. D., Thom, S., Ebrahim, S. B. J., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.021 · Cited by 30
Liu, K., Lai, T. Y. Y., Chiang, S. W. Y., Chan, V. C. K., Young, A. L., Tam, P. O. S., Pang, C. P., & Chen, L. J. (2014) · Scientific Reports · doi:10.1038/srep07018 · Cited by 30
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Dhillon, B., Wright, A. F., Tufail, A., Pappworth, I. Y., Hayward, C., Moore, I., Strain, L., Kavanagh, D., Barlow, P. N., Herbert, A. P., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5124 · Cited by 31
Self-citationWang, H., Jiang, Y., Shi, D., Quilliam, L. A., Chrzanowska‐Wodnicka, M., Wittchen, E. S., Li, D. Y., & Hartnett, M. E. (2013) · The FASEB Journal · doi:10.1096/fj.13-240028 · Cited by 30
Ghanbari, M., Erkeland, S. J., Xu, L., Colijn, J. M., Franco, O. H., Dehghan, A., Klaver, C. C. W., & Meester‐Smoor, M. A. (2017) · Human Mutation · doi:10.1002/humu.23226 · Cited by 30
Rohrer, B., Long, Q., Coughlin, B. A., Renner, B., Huang, Y. J., Kunchithapautham, K., Ferreira, V. P., Pangburn, M. K., Gilkeson, G. S., Thurman, J. M., et al. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5635-4_10 · Cited by 30
Estimated Prevalence and Risk Factor for Age-related Maculopathy
Roh, M., Kim, J. H., Byeon, S. H., Koh, H. J., Lee, S. C., & Kwon, O. W. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.6.931 · Cited by 31
The SERPING1 gene and age-related macular degeneration
Allikmets, R. L., Dean, M. C., Hageman, G. S., Baird, P. N., Klaver, C. C. W., Bergen, A. A. B., & Weber, B. H. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61618-4 · Cited by 30
Genetic Insights into Age-Related Macular Degeneration
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Gigante, P. R., Kotchetkov, I. S., Kellner, C. P., Haque, R. M., Ducruet, A. F., Hwang, B. Y., Solomon, R. A., Heyer, E. J., & Connolly, E. S. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.211144 · Cited by 29
Hautamäki, A., Seitsonen, S., Holopainen, J. M., Moilanen, J., Kivioja, J. L., Onkamo, P., Järvelä, I. E., & Immonen, I. (2015) · Acta Ophthalmologica · doi:10.1111/aos.12799 · Cited by 29
Lu, F., Liu, S., Hao, Q.-Y., Liu, L., Zhang, J., Chen, X., Wang, H., & Huang, P. (2018) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2018.0110 · Cited by 30
The Immunological Basis of Degenerative Diseases of the Eye
Nussenblatt, R. B., Liu, B., Wei, L., & Sen, H. N. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.740536 · Cited by 31
Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Chen, L. J. (2020) · Asia-Pacific Journal of Ophthalmology · doi:10.1097/01.apo.0000656976.47696.7d · Cited by 28
Metadata
- Authors
- Yates, J. R. W., Sepp, T., Matharu, B. K., Khan, J. C., Thurlby, D. A., Shahid, H., Clayton, D. G., Hayward, C., Morgan, J., Wright, A. F., Armbrecht, A. M., Dhillon, B., Deary, I. J., Redmond, E., Bird, A. C., & Moore, A. T.
- Affiliations
- University of Cambridge (GB)
- MRC Human Genetics Unit (GB)
- Princess Alexandra Eye Pavilion (GB)
- University of Edinburgh (GB)
- University College London (GB)
- Moorfields Eye Hospital (GB)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-08-09
- Volume
- 357
- Issue
- 6
- Pages
- 553-561
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2105479207
- Cited by
- 829
- References
- 41
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 30 · 2023: 22 · 2022: 27 · 2021: 30 · 2020: 28 · 2019: 25 · 2018: 25 · 2017: 33 · 2016: 36 · 2015: 52 · 2014: 57 · 2013: 66 · 2012: 81
- FWCI
- 63.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Pfizer
- Wellcome Trust
- Moorfields Eye Hospital NHS Foundation Trust
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- age-related macular degeneration, complement C3, single nucleotide polymorphisms, complement activation, genetic susceptibility, population attributable risk, pathogenesis
- MeSH terms
- Aged, Complement C3, Complement C5, Female, Genotype, Humans, Macular Degeneration, Male, Logistic Models, Odds Ratio, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Protein Structure, Quaternary
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