Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

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A haplotype map of the human genome

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The Future of Genetic Studies of Complex Human Diseases

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Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

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Axonal transection in the lesions of multiple sclerosis

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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A genome-wide association study identifies novel risk loci for type 2 diabetes

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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Revised diagnostic criteria for neuromyelitis optica

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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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CD4+CD25high Regulatory Cells in Human Peripheral Blood

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Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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Diagnostic criteria for multiple sclerosis

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Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

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Genome-wide association studies: theoretical and practical concerns

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Pedigree disequilibrium tests for multilocus haplotypes.

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Environmental risk factors for multiple sclerosis. Part I: The role of infection

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Identification of autoantibodies associated with myelin damage in multiple sclerosis

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Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

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McAlpine's Multiple Sclerosis

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A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

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Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Smyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O. S., Smink, L. J., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, D. B., et al. (2006) · Nature Genetics · doi:10.1038/ng1800 · Cited by 694

A full genome search in multiple sclerosis

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Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

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A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

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A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

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Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

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The Codon 620 Tryptophan Allele of the Lymphoid Tyrosine Phosphatase (LYP) Gene Is a Major Determinant of Graves’ Disease

Velaga, M., Wilson, V., Jennings, C., Owen, C. J., Herington, S. D., Donaldson, P. T., Ball, S. G., James, R. A., Quinton, R., Perros, P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1108 · Cited by 464

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450

Three functional variants of IFN regulatory factor 5 ( IRF5 ) define risk and protective haplotypes for human lupus

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Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis.

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CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

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Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

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Multiple sclerosis

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Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β

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A High-Density Screen for Linkage in Multiple Sclerosis

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Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

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Evaluating and improving power in whole-genome association studies using fixed marker sets

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A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

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Human regulatory T cells and their role in autoimmune disease

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Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

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A second major histocompatibility complex susceptibility locus for multiple sclerosis

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Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein

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Treatment of multiple sclerosis with an anti–interleukin‐2 receptor monoclonal antibody

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Association of the interleukin‐2 receptor alpha (IL‐2Rα)/CD25 gene region with Graves’ disease using a multilocus test and tag SNPs

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Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

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Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis

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The R620W Polymorphism of the Protein Tyrosine Phosphatase PTPN22 Is Not Associated with Multiple Sclerosis

Begovich, A. B., Caillier, S. J., Alexander, H. C., Penko, J. M., Hauser, S. L., Barcellos, L. F., & Oksenberg, J. R. (2004) · The American Journal of Human Genetics · doi:10.1086/427244 · Cited by 114

Gaining insight into PTPN22 and autoimmunity

Gregersen, P. K. (2005) · Nature Genetics · doi:10.1038/ng1205-1300 · Cited by 100

Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-α gene and their associations with multiple sclerosis

Teutsch, S. M., Booth, D. R., Bennetts, B., Heard, R. N., & Stewart, G. J. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200994 · Cited by 99

Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Bielekova, B., Muraro, P. A., Golestaneh, L., Pascal, J., McFarland, H. F., & Martinꝉ, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00200-3 · Cited by 73

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells

Yu, A., & Malek, T. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5115 · Cited by 56

IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility

Matesanz, F., Caro‐Maldonado, A., Fedetz, M., Fernández, Ó., Milne, R. L., Guerrero, M., Delgado, C., & Alcina, A. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0416-4 · Cited by 50

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

Jager, P. L. D., Sawcer, S. J., Waliszewska, A., Farwell, L. M., Wild, G., Cohen, A., Langelier, D., Bitton, A., Compston, A., Hafler, D. A., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201548 · Cited by 38

Association of Fcγ receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family‐based association study in Caucasians

Kyogoku, C., Tsuchiya, N., Wu, H. L., Tsao, B. P., & Tokunaga, K. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20029 · Cited by 36

Current understanding of the genetic aetiology of rheumatoid arthritis and likely future developments

Criswell, L. A., & Gregersen, P. K. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/kei054 · Cited by 16

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697

Multiple sclerosis

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Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

International Multiple Sclerosis Genetics Consortium, Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., et al. (2019) · Science · doi:10.1126/science.aav7188 · Cited by 1,471

News in brief

(2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70214-4

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 62

Decoding multiple sclerosis: an update on genomics and future directions

Oksenberg, J. R. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865867 · Cited by 66

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 65