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Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study
Abstract
Background Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. Methods We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication, we genotyped another 609 family trios, 2322 case subjects, and 789 control subjects and used genotyping data from two external control data sets. A joint analysis of data from 12,360 subjects was performed to estimate the overall significance and effect size of associations between alleles and the risk of multiple sclerosis. Results A transmission disequilibrium test of 334,923 single-nucleotide polymorphisms (SNPs) in 931 family trios revealed 49 SNPs having an association with multiple sclerosis (P Conclusions Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.
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“In 2007, the first GWAS in MS looked at 1540 parent‐affected offspring trios and identified two loci outside the MHC, encoding the interleukin‐2 receptor (IL‐2RA) and the interleukin‐7 receptor (IL‐7RA), respectively.30”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [30]
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“These validated the HLA association but showed no significant linkage to loci outside the MHC.”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [30]
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Metadata
- Authors
- The International Multiple Sclerosis Genetics Consortium
- Corresponding author
- The International Multiple Sclerosis Genetics Consortium
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-08-30
- Volume
- 357
- Issue
- 9
- Pages
- 851-862
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2164392039
- Cited by
- 1,746
- References
- 64
- Citations by year
- 2026: 26 · 2025: 38 · 2024: 40 · 2023: 32 · 2022: 55 · 2021: 49 · 2020: 57 · 2019: 53 · 2018: 66 · 2017: 74 · 2016: 75 · 2015: 97 · 2014: 109 · 2013: 112 · 2012: 145
- FWCI
- 132.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (076113)
- National Institutes of Health (6u54rr020278-06)
- National Institute of Allergy and Infectious Diseases (U19AI067152, AI-067152, P01AI039671)
- National Institute of Neurological Disorders and Stroke (NS26799, NS032830, NS049477, NS2427, R01NS032830, R01NS026799, R01NS049477)
- National Center for Research Resources (U54-RR020278-1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, genetic susceptibility, single nucleotide polymorphisms, family trios, transmission disequilibrium test, IL2RA, CD127, HLA-DRA, IL-2 receptor alpha, HLA locus, heritability
- MeSH terms
- Adolescent, Adult, Aged, Alleles, Female, HLA-DR Antigens, Humans, Male, Middle Aged, Multiple Sclerosis, Mutation, Risk Factors, Linkage Disequilibrium, Genome, Human, Genetic Predisposition to Disease, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Interleukin-2 Receptor alpha Subunit, Interleukin-7 Receptor alpha Subunit, HLA-DR alpha-Chains
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