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Cited by 259

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Aggressive vs. Conservative Phototherapy for Infants with Extremely Low Birth Weight

Open access
Morris, Brenda H., Oh, William, Tyson, Jon E., Stevenson, David K., Phelps, Dale L., O'Shea, T. Michael, McDavid, Georgia E., Perritt, Rebecca L., Van Meurs, Krisa P., Vohr, Betty R., Grisby, Cathy, Yao, Qing, Pedroza, Claudia, Das, Abhik, Poole, W. Kenneth, Carlo, Waldemar A., Duara, Shahnaz, Laptook, Abbot R., Salhab, Walid A., Shankaran, Seetha, Poindexter, Brenda B., Fanaroff, Avroy A., Walsh, Michele C., Rasmussen, Maynard R., Stoll, Barbara J., Cotten, C. Michael, Donovan, Edward F., Ehrenkranz, Richard A., Guillet, Ronnie, Higgins, Rosemary D.·2008·New England Journal of Medicine
DOI 10.1056/nejmoa0803024
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Abstract

BACKGROUND: It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less). METHODS: We randomly assigned 1974 infants with extremely low birth weight at 12 to 36 hours of age to undergo either aggressive or conservative phototherapy. The primary outcome was a composite of death or neurodevelopmental impairment determined for 91% of the infants by investigators who were unaware of the treatment assignments. RESULTS: Aggressive phototherapy, as compared with conservative phototherapy, significantly reduced the mean peak serum bilirubin level (7.0 vs. 9.8 mg per deciliter [120 vs. 168 micromol per liter], P<0.01) but not the rate of the primary outcome (52% vs. 55%; relative risk, 0.94; 95% confidence interval [CI], 0.87 to 1.02; P=0.15). Aggressive phototherapy did reduce rates of neurodevelopmental impairment (26%, vs. 30% for conservative phototherapy; relative risk, 0.86; 95% CI, 0.74 to 0.99). Rates of death in the aggressive-phototherapy and conservative-phototherapy groups were 24% and 23%, respectively (relative risk, 1.05; 95% CI, 0.90 to 1.22). In preplanned subgroup analyses, the rates of death were 13% with aggressive phototherapy and 14% with conservative phototherapy for infants with a birth weight of 751 to 1000 g and 39% and 34%, respectively (relative risk, 1.13; 95% CI, 0.96 to 1.34), for infants with a birth weight of 501 to 750 g. CONCLUSIONS: Aggressive phototherapy did not significantly reduce the rate of death or neurodevelopmental impairment. The rate of neurodevelopmental impairment alone was significantly reduced with aggressive phototherapy. This reduction may be offset by an increase in mortality among infants weighing 501 to 750 g at birth. (ClinicalTrials.gov number, NCT00114543.)

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Metadata

Authors
Morris, B. H., Oh, W., Tyson, J. E., Stevenson, D. K., Phelps, D. L., O'Shea, T. M., McDavid, G. E., Perritt, R. L., Van Meurs, K. P., Vohr, B. R., Grisby, C., Yao, Q., Pedroza, C., Das, A., Poole, W. K., Carlo, W. A., Duara, S., Laptook, A. R., Salhab, W. A., Shankaran, S., Poindexter, B. B., Fanaroff, A. A., Walsh, M. C., Rasmussen, M. R., Stoll, B. J., Cotten, C. M., Donovan, E. F., Ehrenkranz, R. A., Guillet, R., & Higgins, R. D.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2008-10-30
Volume
359
Issue
18
Pages
1885-1896
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0803024
OpenAlex
W1976451021
Cited by
259
References
23
FWCI
12.29
Type
journal article
Language
en
Open access
bronze

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