The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction
Open accessAbstract
BACKGROUND: Studies in Europe have suggested that injectable diacetylmorphine, the active ingredient in heroin, can be an effective adjunctive treatment for chronic, relapsing opioid dependence. METHODS: In an open-label, phase 3, randomized, controlled trial in Canada, we compared injectable diacetylmorphine with oral methadone maintenance therapy in patients with opioid dependence that was refractory to treatment. Long-term users of injectable heroin who had not benefited from at least two previous attempts at treatment for addiction (including at least one methadone treatment) were randomly assigned to receive methadone (111 patients) or diacetylmorphine (115 patients). The primary outcomes, assessed at 12 months, were retention in addiction treatment or drug-free status and a reduction in illicit-drug use or other illegal activity according to the European Addiction Severity Index. RESULTS: The primary outcomes were determined in 95.2% of the participants. On the basis of an intention-to-treat analysis, the rate of retention in addiction treatment in the diacetylmorphine group was 87.8%, as compared with 54.1% in the methadone group (rate ratio for retention, 1.62; 95% confidence interval [CI], 1.35 to 1.95; P<0.001). The reduction in rates of illicit-drug use or other illegal activity was 67.0% in the diacetylmorphine group and 47.7% in the methadone group (rate ratio, 1.40; 95% CI, 1.11 to 1.77; P=0.004). The most common serious adverse events associated with diacetylmorphine injections were overdoses (in 10 patients) and seizures (in 6 patients). CONCLUSIONS: Injectable diacetylmorphine was more effective than oral methadone. Because of a risk of overdoses and seizures, diacetylmorphine maintenance therapy should be delivered in settings where prompt medical intervention is available. (ClinicalTrials.gov number, NCT00175357.)
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Cites
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
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Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
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A Comparison of Levomethadyl Acetate, Buprenorphine, and Methadone for Opioid Dependence
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The Addiction Severity Index at 25: Origins, contributions, and transitions
McLellan, A. T., Cacciola, J. C., Alterman, A. I., Rikoon, S. H., & Carise, C. (2006) · The American Journal on Addictions · doi:10.1080/10550490500528316 · Cited by 450
Fortnightly Review: Methadone maintenance treatment in opiate dependence: a review
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Heroin-assisted treatment for opioid dependence: Randomised controlled trial
Haasen, C., Verthein, U., Degkwitz, P., Berger, J., Krausz, M., & Naber, D. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.026112 · Cited by 264
Cited by
Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B. D. L., Tyndall, M., & Walsh, S. L. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0137-5 · Cited by 639
Veilleux, J. C., Colvin, P. J., Anderson, J., York, C., & Heinz, A. J. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.10.006 · Cited by 336
Lingford-Hughes, A., Welch, S., Peters, L., Nutt, D., & With expert reviewers (in alphabetical order): Ball D, B. N. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112444324 · Cited by 332
The opioid overdose crisis as a global health challenge
Krausz, R. M., Westenberg, J. N., & Ziafat, K. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000712 · Cited by 91
Reduced Volume of the Nucleus Accumbens in Heroin Addiction
Seifert, C. L., Magon, S., Sprenger, T., Lang, U. E., Huber, C. G., Denier, N., Vogel, M., Schmidt, A., Radue, E.-W., Borgwardt, S., et al. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0564-y · Cited by 80
Metadata
- Authors
- Oviedo-Joekes, E., Brissette, S., Marsh, D. C., Lauzon, P., Guh, D., Anis, A., & Schechter, M. T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-08-20
- Volume
- 361
- Issue
- 8
- Pages
- 777-786
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2111198740
- Cited by
- 375
- References
- 19
- FWCI
- 26.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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