Reduced Volume of the Nucleus Accumbens in Heroin Addiction
Abstract
The neural mechanisms of heroin addiction are still incompletely understood, even though modern neuroimaging techniques offer insights into disease-related changes in vivo. While changes on cortical structure have been reported in heroin addiction, evidence from subcortical areas remains underrepresented. Functional imaging studies revealed that the brain reward system and particularly the nucleus accumbens (NAcc) play a pivotal role in the pathophysiology of drug addiction. The aim of this study was to investigate whether there was a volume difference of the NAcc in heroin addiction in comparison to healthy controls. A further aim was to correlate subcortical volumes with clinical measurements on negative affects in addiction. Thirty heroin-dependent patients under maintenance treatment with diacetylmorphine and twenty healthy controls underwent structural MRI scanning at 3T. Subcortical segmentation analysis was performed using FMRIB's Integrated Registration and Segmentation Tool function of FSL. The State-Trait Anxiety Inventory and the Beck Depression Inventory were used to assess trait anxiety and depressive symptoms, respectively. A decreased volume of the left NAcc was observed in heroin-dependent patients compared to healthy controls. Depression score was negatively correlated with left NAcc volume in patients, whereas a positive correlation was found between the daily opioid dose and the volume of the right amygdala. This study indicates that there might be structural differences of the NAcc in heroin-dependent patients in comparison with healthy controls. Furthermore, correlations of subcortical structures with negative emotions and opioid doses might be of future relevance for the investigation of heroin addiction.
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Several other studies observed that lower gray matter volumes were associated with higher addictive tendencies.
“Additionally, several other studies observed that lower gray matter volumes were associated with higher addictive tendencies [77,78].”
From Addictive Features of Social Media/Messenger Platforms and Freemium Games against the Background of Psychological and Economic Theories (2019) · cites this paper as [78]
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- Authors
- Seifert, C. L., Magon, S., Sprenger, T., Lang, U. E., Huber, C. G., Denier, N., Vogel, M., Schmidt, A., Radue, E.-W., Borgwardt, S., & Walter, M.
- Affiliations
- TUM Klinikum (DE)
- University Hospital of Basel (CH)
- Universitäre Psychiatrische Kliniken Basel (CH)
- Corresponding author
- Seifert, Christian L.
- ORCID
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2014-12-03
- Volume
- 265
- Issue
- 8
- Pages
- 637-645
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2054646534
- Cited by
- 80
- References
- 62
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 5
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- RERO DOC (Universität Bern) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- heroin addiction, nucleus accumbens, brain volume, subcortical structures, amygdala, opioid use disorder, depression, trait anxiety, opioid dose, brain reward system
- MeSH terms
- Adult, Analysis of Variance, Female, Heroin Dependence, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nucleus Accumbens, Psychiatric Status Rating Scales, Statistics as Topic, Switzerland, Cross-Over Studies, Imaging, Three-Dimensional
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