Drug Addiction
Abstract
The neuropsychiatric mechanisms of drug addiction are complex, fascinating, and clinically important. This article reviews the genetic factors, receptor-mediated processes, and anatomical structures involved in drug addiction.
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Substance use causes biological changes to the brain's reward system, requiring repeated and/or increased doses to maintain allostasis and prevent unpleasant withdrawal symptoms.
“Substance use causes biological changes to the brain’s reward system, requiring repeated and/or increased doses to maintain allostasis and prevent unpleasant withdrawal symptoms (Cami & Farre, 2003).”
From “I don’t want to take buprenorphine for the rest of my life”: Acceptance and Commitment Therapy for a Client Struggling to Reduce Low-Dose Buprenorphine (a Hermeneutic Single-Case Efficacy Design) (2023) · cites this paper as Cami & Farre, 2003
It may be that, while opioid-substitution medication is required to manage the acute difficulties of withdrawal, ACT addresses the underlying psychological difficulties perpetuating substance misuse.
“It may be that, while opioid-substitution medication is required to manage the acute difficulties of withdrawal, ACT addresses the underlying psychological difficulties perpetuating substance misuse (Cami & Farre, 2003; Smout et al., 2010).”
From “I don’t want to take buprenorphine for the rest of my life”: Acceptance and Commitment Therapy for a Client Struggling to Reduce Low-Dose Buprenorphine (a Hermeneutic Single-Case Efficacy Design) (2023) · cites this paper as Cami & Farre, 2003
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- Authors
- Camí, J., & Farré, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-09-04
- Volume
- 349
- Issue
- 10
- Pages
- 975-986
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4244161634
- Cited by
- 477
- References
- 89
- Citations by year
- 2026: 3 · 2025: 19 · 2024: 16 · 2023: 13 · 2022: 20 · 2021: 29 · 2020: 19 · 2019: 12 · 2018: 21 · 2017: 20 · 2016: 25 · 2015: 15 · 2014: 24 · 2013: 28 · 2012: 14
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- drug addiction, genetic factors, neuroanatomy, addiction genetics, neurotransmitter receptors
- MeSH terms
- Ethanol, Animals, Cannabinoids, Cocaine, Disease Models, Animal, Dopamine, Humans, Narcotics, Nicotine, Recurrence, Reinforcement, Psychology, Substance Withdrawal Syndrome, Substance-Related Disorders
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