The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Identification of a Novel Antibody Associated with Autoimmune Pancreatitis
Open accessAbstract
BACKGROUND: Autoimmune pancreatitis is characterized by an inflammatory process that leads to organ dysfunction. The cause of the disease is unknown. Its autoimmune origin has been suggested but never proved, and little is known about the pathogenesis of this condition. METHODS: To identify pathogenetically relevant autoantigen targets, we screened a random peptide library with pooled IgG obtained from 20 patients with autoimmune pancreatitis. Peptide-specific antibodies were detected in serum specimens obtained from the patients. RESULTS: Among the detected peptides, peptide AIP(1-7) was recognized by the serum specimens from 18 of 20 patients with autoimmune pancreatitis and by serum specimens from 4 of 40 patients with pancreatic cancer, but not by serum specimens from healthy controls. The peptide showed homology with an amino acid sequence of plasminogen-binding protein (PBP) of Helicobacter pylori and with ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), an enzyme highly expressed in acinar cells of the pancreas. Antibodies against the PBP peptide were detected in 19 of 20 patients with autoimmune pancreatitis (95%) and in 4 of 40 patients with pancreatic cancer (10%). Such reactivity was not detected in patients with alcohol-induced chronic pancreatitis or intraductal papillary mucinous neoplasm. The results were validated in another series of patients with autoimmune pancreatitis or pancreatic cancer: 14 of 15 patients with autoimmune pancreatitis (93%) and 1 of 70 patients with pancreatic cancer (1%) had a positive test for anti-PBP peptide antibodies. When the training and validation groups were combined, the test was positive in 33 of 35 patients with autoimmune pancreatitis (94%) and in 5 of 110 patients with pancreatic cancer (5%). CONCLUSIONS: The antibody that we identified was detected in most patients with autoimmune pancreatitis but also in some patients with pancreatic cancer, making it an imperfect test to distinguish between these two conditions.
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Cites
High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
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Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome
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Cited by
Shimosegawa, T., Chari, S. T., Frulloni, L., Kamisawa, T., Kawa, S., Mino-Kenudson, M., Kim, M.-H., Klöppel, G., Lerch, M. M., Löhr, M., et al. (2011) · Pancreas · doi:10.1097/mpa.0b013e3182142fd2 · Cited by 1,526
Self-citationVariations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
Farrell, J. J., Zhang, L., Zhou, H., Chia, D., Elashoff, D., Akin, D., Paster, B. J., Joshipura, K., & Wong, D. T. W. (2012) · Gut · doi:10.1136/gutjnl-2011-300784 · Cited by 662
Primary sclerosing cholangitis
Hirschfield, G. M., Karlsen, T. H., Lindor, K. D., & Adams, D. H. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60096-3 · Cited by 592
Braganza, J. M., Lee, S. H., McCloy, R. F., & McMahon, M. J. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61852-1 · Cited by 469
Pathogenesis of cholestatic liver disease and therapeutic approaches
Hirschfield, G. M., Heathcote, E. J., & Gershwin, M. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.004 · Cited by 287
Metadata
- Authors
- Frulloni, L., Lunardi, C., Simone, R., Dolcino, M., Scattolini, C., Falconi, M., Benini, L., Vantini, I., Corrocher, R., & Puccetti, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-11-26
- Volume
- 361
- Issue
- 22
- Pages
- 2135-2142
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2152013192
- Cited by
- 355
- References
- 20
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Frulloni, L., Lunardi, C., Simone, R., Dolcino, M., Scattolini, C., Falconi, M., Benini, L., Vantini, I., Corrocher, R., & Puccetti, A. (2009). Identification of a Novel Antibody Associated with Autoimmune Pancreatitis. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0903068
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