Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

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Items 101–200 of 1,000

  1. Effect of rituximab on human in vivo antibody immune responses
    Mark D. Pescovitz, Troy R. Torgerson, Hans D. Ochs, Elizabeth Ocheltree, Paula McGee, Heidi J Krause-Steinrauf, John M. Lachin, Jennifer D. Canniff, Carla J. Greenbaum, Kevan C. Herold et al. · 2011 · Journal of Allergy and Clinical Immunology
  2. Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes
    McLaughlin, Kerry A., Richardson, Carolyn C., Ravishankar, Aarthi, Brigatti, Cristina, Liberati, Daniela, Lampasona, Vito, Piemonti, Lorenzo, Morgan, Diana, Feltbower, Richard G., Christie, Michael R. · 2016 · Diabetes
  3. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis
    H. Benjamin Larman, Uri Laserson, Luís Querol, Katrijn Verhaeghen, Nicole L. Solimini, George Jing Xu, Paul L. Klarenbeek, George McDonald Church, David A. Hafler, Robert M. Plenge et al. · 2013 · Journal of Autoimmunity
  4. Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies
    Tyyne Viisanen, Emmi‐Leena Ihantola, Kirsti Näntö‐Salonen, Heikki Hyöty, Noora Nurminen, Jenni Selvenius, Auni Juutilainen, Leena Moilanen, Jussi Pihlajamäki, Riitta Veijola et al. · 2016 · Diabetes
  5. Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model
    Daniela Carlos, Frederico R. C. Costa, Camila A. Pereira, Fernanda A. Rocha, Juliana Navarro Ueda Yaochite, Gabriela Gonçalves de Oliveira, Fernando Silva Carneiro, Rita C. Tostes, Simone Gusmão Ramos, Dario S. Zamboni et al. · 2017 · Frontiers in Immunology
  6. Prediction and Prevention of Type 1 Diabetes
    Marina Primavera, Cosimo Giannini, Francesco Chiarelli · 2020 · Frontiers in Endocrinology
  7. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells
    Andrew Getahun, Nicole A. Beavers, Sandy R. Larson, Mark Jay Shlomchik, John C. Cambier · 2016 · The Journal of Experimental Medicine
  8. Immune therapy in type 1 diabetes mellitus
    Åke Lernmark, Helena Elding Larsson · 2013 · Nature Reviews Endocrinology
  9. Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
    Jay S. Skyler, Camillo Ricordi · 2010 · Diabetes
  10. Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens
    Sonja Kleffel, Andrea Vergani, Sara Tezza, Moufida Ben Nasr, Monika A. Niewczas, Florence Susan Wong, Roberto Bassi, Francesca D’Addio, Tobias Schatton, Reza Abdi et al. · 2014 · Diabetes
  11. Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes
    George S. Eisenbarth · 2010 · Diabetes
  12. Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade
    Vitaly G. Ablamunits, Octavian Henegariu, Jakob Bondo Hansen, Lynn Opare-Addo, Paula Preston‐Hurlburt, Pere Santamaría, Thomas R Mandrup-Poulsen, Kevan C. Herold · 2011 · Diabetes
  13. Restoring the balance: immunotherapeutic combinations for autoimmune disease
    Dawn Elaine Smilek, Mario R. Ehlers, Gerald T. Nepom · 2014 · Disease Models & Mechanisms
  14. Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients
    Mia J. Smith, Thomas Alexander Packard, Shannon K. O’Neill, Carole Henry, Min Huang, Lisa Fitzgerald-Miller, Daniel F. Stowell, Rochelle M. Hinman, Patrick C. Wilson, Peter A. Gottlieb et al. · 2014 · Diabetes
  15. Immune therapy for type 1 diabetes mellitus—what is unique about anti-CD3 antibodies?
    Lucienne Chatenoud · 2010 · Nature Reviews Endocrinology
  16. Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies
    Kamal D. Puri, Michael R. Gold · 2012 · Frontiers in Immunology
  17. Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes
    Ilse Ekman, Emmi‐Leena Ihantola, Tyyne Viisanen, Deepak A. Rao, Kirsti Näntö‐Salonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Tuure T. Kinnunen · 2019 · Diabetologia
  18. Life and death of β cells in Type 1 diabetes: A comprehensive review
    Nicholas S. Wilcox, Jinxiu Rui, Matthias Hebrok, Kevan C. Herold · 2016 · Journal of Autoimmunity
  19. Diabetogenic T lymphocytes in human Type 1 diabetes
    Roep, Bart O, Peakman, Mark · 2011 · Current Opinion in Immunology
  20. TGF-β–Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism
    Anping Xu, Ya Liu, Weiqian Chen, Julie Wang, Youqiu Xue, Feng Huang, Liming Rong, Jin Lin, Dahai Liu, Mei Yan et al. · 2016 · The Journal of Immunology
  21. Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
    Lars Krogvold, Anna Wiberg, Bjørn Edwin, Trond A Buanes, Frode Lars Jahnsen, Kristian Folkvord Hanssen, Erik N. V. Larsson, Olle Korsgren, Oskar Skog, Knut Dahl‐Jørgensen · 2015 · Diabetologia
  22. Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes
    M. Pietropaolo, Roberto Towns, George S. Eisenbarth · 2012 · Cold Spring Harbor Perspectives in Medicine
  23. Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report
    Diane K. Wherrett, Jane L. Chiang, Alan M. Delamater, Linda Anne DiMeglio, Stephen Eric Gitelman, Peter A. Gottlieb, Kevan C. Herold, Daniel J. Lovell, Trevor John Orchard, Christopher M. Ryan et al. · 2015 · Diabetes Care
  24. Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial
    Kurt Griffin, Paul A. Thompson, Michael Everett Gottschalk, Jennifer H. Kyllo, Alex Rabinovitch · 2014 · The Lancet Diabetes & Endocrinology
  25. Rituximab does not reset defective early B cell tolerance checkpoints
    Nicolas Chamberlain, Christopher Massad, Tyler Oe, Tineke Cantaert, Kevan C. Herold, Eric Meffre, the Type 1 Diabetes TrialNet Pathway to Prevention Study Group · 2015 · Journal of Clinical Investigation
  26. Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline
    Tihamer Orban, Craig A. Beam, Ping Xu, Keith Moore, Qi Jiang, Jun Deng, Sarah Müller, Peter A. Gottlieb, Lisa M. Spain, Mark Peakman et al. · 2014 · Diabetes
  27. Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes
    Frank Waldron-Lynch, Kevan C. Herold · 2011 · Nature Reviews Drug Discovery
  28. Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial
    Stephen Eric Gitelman, Peter A. Gottlieb, Eric I. Felner, Steven Matthew Willi, Lynda K. Fisher, Antoinette Moran, Michael Everett Gottschalk, Wayne V. Moore, Ashley Pinckney, Lynette Keyes-Elstein et al. · 2016 · Diabetologia
  29. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
    Morten Lundh, Dan Ploug Christensen, Mette Damgaard Nielsen, Sarah J. Richardson, Mattias Salling Dahllöf, Tine Skovgaard, Jens Berthelsen, Charles Anthony Dinarello, Andrea Stevenazzi, Paolo Mascagni et al. · 2012 · Diabetologia
  30. CXCR1/2 Inhibition Blocks and Reverses Type 1 Diabetes in Mice
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  31. Evolution of Ectopic Lymphoid Neogenesis and In Situ Autoantibody Production in Autoimmune Nonobese Diabetic Mice: Cellular and Molecular Characterization of Tertiary Lymphoid Structures in Pancreatic Islets
    Elisa Astorri, Michele Bombardieri, Silvia Gabba, Mark Peakman, Paolo Pozzilli, Costantino Pitzalis · 2010 · The Journal of Immunology
  32. The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
    Allison L. Bayer, Alberto Pugliese, Thomas R. Malek · 2013 · Immunologic Research
  33. Thinking bedside at the bench: the NOD mouse model of T1DM
    James Christopher Reed, Kevan C. Herold · 2015 · Nature Reviews Endocrinology
  34. Rituximab Selectively Suppresses Specific Islet Antibodies
    Liping Yu, Kevan C. Herold, Heidi J Krause-Steinrauf, Paula L. McGee, Brian N. Bundy, Alberto Pugliese, Jeff Krischer, George S. Eisenbarth, for the Type 1 Diabetes TrialNet Anti-CD20 Study Group · 2011 · Diabetes
  35. Changing the landscape for type 1 diabetes: the first step to prevention
    Dayan, Colin M, Korah, Maria, Tatovic, Danijela, Bundy, Brian N, Herold, Kevan C · 2019 · The Lancet
  36. Prevention and Reversal of Type 1 Diabetes—Past Challenges and Future Opportunities
    Jay S. Skyler · 2015 · Diabetes Care
  37. Galectin-9 and T Cell Immunoglobulin Mucin-3 Pathway Is a Therapeutic Target for Type 1 Diabetes
    Motoko Kanzaki, Jun Wada, Koichi Sugiyama, Atsuko Nakatsuka, Sanae Teshigawara, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Jun Eguchi et al. · 2011 · Endocrinology
  38. Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model
    Jamal S. Lewis, Joshua Michael Stewart, Gregory P. Marshall, Matthew R. Carstens, Ying Zhang, Natalia V. Dolgova, Chang‐Qing Xia, Todd M. Brusko, Clive Henry Wasserfall, Michael J Clare-Salzler et al. · 2019 · ACS Biomaterials Science & Engineering
  39. Innate inflammation in type 1 diabetes
    Susanne M. Cabrera, Angela M. Henschel, Martin J. Hessner · 2015 · Translational research
  40. Understanding and preventing type 1 diabetes through the unique working model of TrialNet
    Manuela Battaglia, Mark Stuart Anderson, Jane Hoyt Buckner, Susan Michelle Geyer, Peter A. Gottlieb, Thomas W. H. Kay, Åke Lernmark, Sarah Müller, Alberto Pugliese, Bart O. Roep et al. · 2017 · Diabetologia
  41. The Long and Winding Road to Understanding and Conquering Type 1 Diabetes
    Pere Santamaría · 2010 · Immunity
  42. Increased T Cell Proliferative Responses to Islet Antigens Identify Clinical Responders to Anti-CD20 Monoclonal Antibody (Rituximab) Therapy in Type 1 Diabetes
    Kevan C. Herold, Mark D. Pescovitz, Paula McGee, Heidi J Krause-Steinrauf, Lisa M. Spain, Kasia Bourcier, Adam L. Asare, Zhugong Liu, John M. Lachin, H. M. Dosch et al. · 2011 · The Journal of Immunology
  43. Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes
    Polly J. Bingley, Diane K. Wherrett, Ann Shultz, Lisa E. Rafkin, Mark A. Atkinson, Carla J. Greenbaum · 2018 · Diabetes Care
  44. The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
    Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, MARIA JOSE REDONDO, Carmella Evans‐Molina · 2018 · Current Diabetes Reports
  45. Immune Therapy and β-Cell Death in Type 1 Diabetes
    Jasmin Lebastchi, Songyan Deng, Amir H. Lebastchi, Isabel Beshar, Stephen Eric Gitelman, Steven Matthew Willi, Peter A. Gottlieb, Eitan M. Akirav, Jeffrey A. Bluestone, Kevan C. Herold · 2013 · Diabetes
  46. Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens
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  47. Combination immunotherapies for type 1 diabetes mellitus
    Paolo Pozzilli, Ernesto Maddaloni, Raffaella Buzzetti · 2015 · Nature Reviews Endocrinology
  48. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial
    Johnny Ludvigsson, M. Hjorth, Mikael Chéramy, Stina Axelsson, M. Pihl, Gun Forsander, Nils-Osten Nilsson, B.-O. Samuelsson, T. Wood, Jan Åman et al. · 2010 · Diabetologia
  49. Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity
    Liping Yu, Fran Dong, Dongmei Miao, Alexandra Fouts, Janet M. Wenzlau, Andrea K. Steck · 2013 · Diabetes Care
  50. Type 1 Diabetes
    Åke Lernmark, Shehab Alshiekh · 2016 · Elsevier eBooks
  51. Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes
    Yoko Mullen · 2017 · Pancreas
  52. The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes
    Ningwen Tai, Florence Susan Wong, Wen Li · 2016 · Journal of Autoimmunity
  53. Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes
    Kathryn Sumpter, Soumya Adhikari, Ellen K. Grishman, Perrin C. White · 2011 · Pediatric Diabetes
  54. Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10
    Avijit Ray, Bonnie N. Dittel · 2017 · Journal of Clinical Medicine
  55. Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1 in juvenile diabetes
    Ciriana Orabona, Giada Mondanelli, Maria Teresa Pallotta, Agostinho Carvalho, Elisa Albini, Francesca Fallarino, Carmine Vacca, Claudia Volpi, Maria Laura Belladonna, Maria Giulia Berioli et al. · 2018 · JCI Insight
  56. Islet inflammation in human type 1 diabetes mellitus
    Noel G. Morgan, Pia Leete, Alan K. Foulis, Sarah J. Richardson · 2014 · IUBMB Life
  57. Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
    Johnny Ludvigsson, Annelie Carlsson, A. Deli, Gun Forsander, Sten Anders Ivarsson, Ingrid Skelton Kockum, Bengt Lindblad, Claude Marcus, Åke Lernmark, Ulf Samuelsson · 2013 · Diabetes Research and Clinical Practice
  58. Prediction and prevention of Type 1 diabetes mellitus
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  59. Progress in immune-based therapies for type 1 diabetes
    Matthias von Herrath, Mark Peakman, Bart O. Roep · 2013 · Clinical & Experimental Immunology
  60. Kinetics of the Post-Onset Decline in Zinc Transporter 8 Autoantibodies in Type 1 Diabetic Human Subjects
    Janet M. Wenzlau, Melanie Walter, Thomas J. Gardner, Lisa M. Frisch, Liping Yu, George S. Eisenbarth, Anette‐Gabriele Ziegler, Howard W. Davidson, John C. Hutton · 2010 · The Journal of Clinical Endocrinology & Metabolism
  61. Durable preservation of antiviral antibodies after CD19-directed chimeric antigen receptor T-cell immunotherapy
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  62. GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients
    Maria Hjorth, Stina Axelsson, Anna Rydén, Maria Faresjö, Johnny Ludvigsson, Rosaura Casas · 2010 · Clinical Immunology
  63. Therapeutic Antibodies in Medicine
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  64. Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα
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  65. Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
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  66. Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies
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  68. B cells as effectors and regulators of autoimmunity
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  69. Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
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  70. Anti-cytokine therapies in T1D: Concepts and strategies
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  71. Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
    Diego Ize-Ludlow, Yaima Luzardo Lightfoot, Matthew Parker, Song Xue, Clive Henry Wasserfall, Michael J. Haller, Desmond Schatz, Dorothy J. Becker, Mark A. Atkinson, Clayton E. Mathews · 2011 · Diabetes
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  73. Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes
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  74. On the Etiology of Type 1 Diabetes
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  75. T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review
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  76. B cell depletion therapy exacerbates murine primary biliary cirrhosis
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  77. Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease
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  81. Endoplasmic reticulum stress in beta cells and autoimmune diabetes
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  88. B Cell-Targeted Therapies for Systemic Lupus Erythematosus
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  90. Developing a vaccine for type 1 diabetes by targeting coxsackievirus B
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  93. C-peptide and metabolic outcomes in trials of disease modifying therapy in new-onset type 1 diabetes: an individual participant meta-analysis
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  94. IL-2 therapy in type 1 diabetes: “Trials” and tribulations
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  95. Reduced antibody formation after influenza vaccination in patients with neuromyelitis optica spectrum disorder treated with rituximab
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  96. Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
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  99. Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse
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  100. IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes
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