CISH and Susceptibility to Infectious Diseases
Open accessAbstract
BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS: Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bacteremia, tuberculosis, and severe malaria) in blood samples from 8402 persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam. We had previously tested 20 other immune-related genes in one or more of these sample collections. RESULTS: We observed associations between variant alleles of multiple CISH polymorphisms and increased susceptibility to each infectious disease in each of the study populations. When all five single-nucleotide polymorphisms (SNPs) (at positions -639, -292, -163, +1320, and +3415 [all relative to CISH]) within the CISH-associated locus were considered together in a multiple-SNP score, we found an association between CISH genetic variants and susceptibility to bacteremia, malaria, and tuberculosis (P=3.8x10(-11) for all comparisons), with -292 accounting for most of the association signal (P=4.58x10(-7)). Peripheral-blood mononuclear cells obtained from adult subjects carrying the -292 variant, as compared with wild-type cells, showed a muted response to the stimulation of interleukin-2 production--that is, 25 to 40% less CISH expression. CONCLUSIONS: Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens, suggesting that negative regulators of cytokine signaling have a role in immunity against various infectious diseases. The overall risk of one of these infectious diseases was increased by at least 18% among persons carrying the variant CISH alleles.
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A recent GWAS identified multiple polymorphisms in CISH that were associated with increased susceptibility to bacteremia, tuberculosis, and severe malaria in persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam.
“A recent GWAS identified multiple polymorphisms in cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a SOCS family member that controls IL-2 signaling, that were associated with increased susceptibility to bacteremia, tuberculosis, and severe malaria in persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam (77).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [77]
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Update on the Application of Interleukin-2 in the Treatment of Renal Cell Carcinoma
McDermott, D. F. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1872 · Cited by 63 · see citing works
RetractedHaploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,754 · see citing works
Self-citationWacholder, S., Chanock, S. J., García‐Closas, M., ghormli, L. K. E., & Rothman, N. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh075 · Cited by 1,743 · see citing works
Common West African HLA antigens are associated with protection from severe malaria
Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,554 · see citing works
Self-citationInterleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,486 · see citing works
Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., & Lenardo, M. J. (2007) · Nature Immunology · doi:10.1038/ni1536 · Cited by 1,277 · see citing works
Toll-Like Receptor Signaling Pathways
Barton, G. M., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1085536 · Cited by 1,270 · see citing works
Annane, D., Bellissant, É., & Cavaillon, J. (2005) · The Lancet · doi:10.1016/s0140-6736(04)17667-8 · Cited by 1,209 · see citing works
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144 · see citing works
Indicators of Life-Threatening Malaria in African Children
Marsh, K., Forster, D., Waruiru, C., Mwangi, I., Winstanley, M., Marsh, V., Newton, C. R. J. C., Winstanley, P., Warn, P. A., Peshu, N. M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322102 · Cited by 1,093 · see citing works
Self-citationBacteremia among Children Admitted to a Rural Hospital in Kenya
Berkley, J. A., Lowe, B. S., Mwangi, I., Williams, T., Bauni, E., Mwarumba, S., Ngetsa, C., Slack, M. P. E., Njenga, S., Hart, C. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa040275 · Cited by 851 · see citing works
Self-citationGenetic and Environmental Influences on Premature Death in Adult Adoptees
Sørensen, T. I. A., Nielsen, G. G., Andersen, P. K., & Teasdale, T. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181202 · Cited by 823 · see citing works
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., & Miyajima, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07281.x · Cited by 751 · see citing works
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature reviews. Immunology · doi:10.1038/nri2189 · Cited by 746 · see citing works
Cundell, D. R., Gerard, N. P., Gerard, C. J., Idänpään‐Heikkilä, I., & TUOMANEN, E. I. (1995) · Nature · doi:10.1038/377435a0 · Cited by 741 · see citing works
Regulatory T cells: friend or foe in immunity to infection?
Mills, K. H. G. (2004) · Nature reviews. Immunology · doi:10.1038/nri1485 · Cited by 702 · see citing works
Tishkoff, S. A., Varkonyi, R., Cahinhinan, N., Abbes, S., Argyropoulos, G., Destro-Bisol, G., Drousiotou, A., Dangerfield, B., Lefranc, G., Loiselet, J., et al. (2001) · Science · doi:10.1126/science.1061573 · Cited by 630 · see citing works
Handbook of Statistical Genetics
Balding, D., Bishop, M., & Cannings, C. (2004) · Wiley eBooks · doi:10.1002/0470022620 · Cited by 619 · see citing works
Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells
Moriggl, R., Topham, D. J., Teglund, S., Sexl, V., McKay, C., Wang, D., Hoffmeyer, A., van Deursen, J., Sangster, M. Y., Bunting, K. D., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80025-4 · Cited by 546 · see citing works
Matsumoto, A., Masuhara, M., Mitsui, K., Yokouchi, M., Ohtsubo, M., Misawa, H., Miyajima, A., & Yoshimura, A. (1997) · Blood · doi:10.1182/blood.v89.9.3148 · Cited by 528 · see citing works
Susceptibility to leprosy is associated with PARK2 and PACRG
Mira, M. T., Alcaïs, A., Thuc, N. V., Moraes, M. O., Flumeri, C. D., Thai, V. H., Phuong, M. C., Hương, N. T., Ba, N. N., Khoa, P. X., et al. (2004) · Nature · doi:10.1038/nature02326 · Cited by 467 · see citing works
Lyke, K. E., Burges, R., Cissoko, Y., Sangaré, L., Dao, M., Diarra, I., Kone, A. K., Harley, R., Plowe, C. V., Doumbo, O. K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5630-5637.2004 · Cited by 434 · see citing works
Khor, C. C., Chapman, S. J., Vannberg, F. O., Dunne, A., Murphy, C., Ling, E. Y. S., Frodsham, A. J., Walley, A. J., Kyrieleis, O. J. P., Khan, A. R., et al. (2007) · Nature Genetics · doi:10.1038/ng1976 · Cited by 431 · see citing works
Self-citationKovacs, J. A., Baseler, M., Dewar, R. J., Vogel, S. E., Davey, R. T., Falloon, J., Polis, M. A., WALKER, R. E., Stevens, R. A., Salzman, N. P., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320904 · Cited by 422 · see citing works
Kovacs, J. A., Vogel, S. E., Albert, J. M., Falloon, J., Davey, R. T., WALKER, R. E., Polis, M. A., Spooner, K., Metcalf, J. A., Baseler, M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351803 · Cited by 420 · see citing works
Kovanen, P., & Leonard, W. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00203.x · Cited by 409 · see citing works
Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Barreiro, L. B., Ben‐Ali, M., Quach, H., Laval, G., Patin, É., Pickrell, J. K., Bouchier, C., Tichit, M., Neyrolles, O., Gicquel, B., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000562 · Cited by 392 · see citing works
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Yamanouchi, J., Rainbow, D., Serra, P., Howlett, S., Hunter, K. M. D., Garner, V. E. S., González-Muñoz, A., Clark, J., Veijola, R., Cubbon, R. M., et al. (2007) · Nature Genetics · doi:10.1038/ng1958 · Cited by 367 · see citing works
Summerfield, J. A., Sumiya, M., Levin, M., & TURNER, M. W. (1997) · BMJ · doi:10.1136/bmj.314.7089.1229 · Cited by 362 · see citing works
The implications of structured 5′ untranslated regions on translation and disease
Pickering, B. M., & Willis, A. E. (2005) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2004.11.006 · Cited by 339 · see citing works
Puck, J. M., Deschênes, S. M., Porter, J. C., Dutra, A. S., Brown, C. J., Willard, H. F., & Henthorn, P. S. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.8.1099 · Cited by 297 · see citing works
Immune evasion by Mycobacterium tuberculosis: living with the enemy
Flynn, J. L., & Chan, J. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00075-x · Cited by 281 · see citing works
Nakajima, H., Liu, X.-W., Wynshaw-Boris, A. J., Rosenthal, L. A., Imada, K., Finbloom, D. S., Hennighausen, L. G., & Leonard, W. J. (1997) · Immunity · doi:10.1016/s1074-7613(00)80389-1 · Cited by 274 · see citing works
Matsumoto, A., Seki, Y., Kubo, M., Ohtsuka, S., Suzuki, A., Hayashi, I., Tsuji, K., Nakahata, T., Okabe, M., Yamada, S., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6396 · Cited by 265 · see citing works
Interleukin‐2 in the development and control of inflammatory disease
Hoyer, K. K., Dooms, H., Barron, L., & Abbas, A. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00697.x · Cited by 259 · see citing works
Ovacs, J. O. A. K., Ogel, S. U. V., Lbert, M. A., et al. (1996) · Cited by 210 · see citing works
Host factors in the pathogenesis of HIV disease
Cohen, O. J., Kinter, A. L., & Fauci, A. S. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01005.x · Cited by 194 · see citing works
Hawn, T. R., Dunstan, S. J., Thwaites, G. E., Simmons, C. P., Thương, N. T. T., Lan, N. T. N., Quy, H. T., Chau, T. T. H., Hieu, N. T., Rodrigues, S. D., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/507907 · Cited by 176 · see citing works
Self-citationInterleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells
Dooms, H., Wolslegel, K., Lin, P. W., & Abbas, A. K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062381 · Cited by 170 · see citing works
Signaling from the IL-2 receptor to the nucleus
Lin, J., & Leonard, W. J. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00021-x · Cited by 158 · see citing works
Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity
André, S., Tough, D. F., Lacroix‐Desmazes, S., Kaveri, S. V., & Bayry, J. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080987 · Cited by 135 · see citing works
The immunology of malaria infection
Plebanski, M., & Hill, A. V. S. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00117-5 · Cited by 129 · see citing works
Self-citationAman, M. J., Migone, T., Sasaki, A. T., Ascherman, D. P., Zhu, M., Soldaini, E., Imada, K., Miyajima, A., Yoshimura, A., & Leonard, W. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30266 · Cited by 116 · see citing works
Transcriptional regulation of Th2 cell differentiation
Zhu, J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2009.114 · Cited by 78 · see citing works
Analysis of IL10 haplotypic associations with severe malaria
Wilson, J. N., Rockett, K. A., Jallow, M., Pinder, M., Sisay-Joof, F., Newport, M. J., Newton, J. L., & Kwiatkowski, D. P. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364227 · Cited by 60 · see citing works
Self-citationTang, N. L. S., Fan, H. P. Y., Chang, K. C., Ching, J. K. L., Kong, K., Yew, W. W., Kam, K. M., Leung, C. C., Tam, C. M., Blackwell, J. M., et al. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.06.006 · Cited by 59 · see citing works
Self-citationTHE IMMUNOLOGY OF TUBERCULOSIS
Daniel, T. M. (1980) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00067-8 · Cited by 55 · see citing works
Lienhardt, C. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.11.1066 · Cited by 52 · see citing works
Self-citationJin, P., Wang, E., Provenzano, M., Deola, S., Selleri, S., Ren, J., Voiculescu, S. E., Stroncek, D. F., Panelli, M. C., & Marincola, F. M. (2006) · Journal of Translational Medicine · doi:10.1186/1479-5876-4-26 · Cited by 50 · see citing works
Chistiakov, D. A., Voronova, N. V., & Chistiakov, P. A. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.03.002 · Cited by 45 · see citing works
Tang, N. L. S., Chan, P. K. S., Hui, D. S. C., To, K., Zhang, W., Chan, F. K. L., Sung, J. J. �., & Lo, Y. M. D. (2007) · Nature Genetics · doi:10.1038/ng0607-691 · Cited by 28 · see citing works
Self-citationUchida, K., Yoshimura, A., Inazawa, J., Yanagisawa, K., Osada, H., Masuda, A., Saito, T., Takahashi, T., Miyajima, A., & Takahashi, T. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134658 · Cited by 27 · see citing works
Crampin, A. C., Mwinuka, V., Malema, S., Glynn, J. R., & Fine, P. (2001) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(01)90009-4 · Cited by 19 · see citing works
Self-citationNakajima, Y., Tsuge, I., Kondo, Y., Komatsubara, R., Hirata, N., Kakami, M., Kato, M., Kurahashi, H., Urisu, A., & Asano, Y. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03030.x · Cited by 12 · see citing works
Barzilai, A. (2000) · PubMed · Cited by 6 · see citing works
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1 of the 58 references couldn’t be matched to a known paper.
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Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works
Human genetic susceptibility to infectious disease
Chapman, S. J., & Hill, A. V. S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3114 · Cited by 499 · see citing works
Self-citationHuang, Z., Blum, R. H., Bernareggi, D., Ask, E. H., Wu, Z., Hoel, H. J., Meng, Z., Wu, C., Guan, K., Malmberg, K., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.05.008 · Cited by 349 · see citing works
Characterization of whole-genome autosomal differences of DNA methylation between men and women
Singmann, P., Shem‐Tov, D., Wahl, S., Grallert, H., Fiorito, G., Shin, S.-Y., Schramm, K., Wolf, P., Kunze, S., Baran, Y., et al. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0035-3 · Cited by 224 · see citing works
Negative Regulation of Cytokine Signaling in ImmunityPreprint
Yoshimura, A., Ito, M., Chikuma, S., Akanuma, T., & Nakatsukasa, H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028571 · Cited by 199 · see citing works
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance
Palmer, D. C., Guittard, G. C., Franco, Z., Crompton, J. G., Eil, R. L., Patel, S. J., Ji, Y., van Panhuys, N., Klebanoff, C. A., Sukumar, M., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150304 · Cited by 192 · see citing works
SOCS proteins in development and disease.
Trengove, M. C., & Ward, A. C. (2013) · Europe PMC (PubMed Central) · Cited by 185 · see citing works
SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer
Sobah, M. L., Liongue, C., & Ward, A. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.727987 · Cited by 171 · see citing works
Role of Interleukin 6 in Innate Immunity to Mycobacterium tuberculosis Infection
Martinez, A. N., Mehra, S., & Kaushal, D. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit037 · Cited by 167 · see citing works
An atlas of genetic scores to predict multi-omic traits
Xu, Y., Ritchie, S. C., Liang, Y., Timmers, P. R. H. J., Pietzner, M., Lannelongue, L., Lambert, S. A., Tahir, U. A., May-Wilson, S., Foguet, C., et al. (2023) · Nature · doi:10.1038/s41586-023-05844-9 · Cited by 143 · see citing works
Jarvis, J. P., Scheinfeldt, L. B., Soi, S., Lambert, C., Omberg, L., Ferwerda, B., Froment, A., Bodo, J.-M., Beggs, W., Hoffman, G., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002641 · Cited by 139 · see citing works
Galectin-9 Functionally Impairs Natural Killer Cells in Humans and Mice
Golden‐Mason, L., McMahan, R. H., Strong, M., Reisdorph, R. M., Mahaffey, S. B., Palmer, B. E., Cheng, L., Kulesza, C. A., Hirashima, M., Niki, T., et al. (2013) · Journal of Virology · doi:10.1128/jvi.01085-12 · Cited by 137 · see citing works
Evolution, revolution and heresy in the genetics of infectious disease susceptibility
Hill, A. V. S. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0275 · Cited by 128 · see citing works
Self-citationDNA methylation-based variation between human populations
Kader, F., & Ghai, M. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1264-2 · Cited by 121 · see citing works
Klouwenberg, P. M. C. K., Ong, D. S. Y., Bonten, M. J. M., & Cremer, O. L. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2549-5 · Cited by 113 · see citing works
Ito, S., Bollard, C. M., Carlsten, M., Melenhorst, J. J., Biancotto, A., Wang, E., Chen, J., Kotliarov, Y., Cheung, F., Xie, Z., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.50 · Cited by 112 · see citing works
Sex disparity in cancer: roles of microRNAs and related functional players
Carè, A., Bellenghi, M., Matarrese, P., Gabriele, L., Salvioli, S., & Malorni, W. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0051-x · Cited by 104 · see citing works
SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review
Duncan, S. A., Baganizi, D. R., Sahu, R., Singh, S. R., & Dennis, V. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02431 · Cited by 103 · see citing works
Genetic susceptibility to invasive Salmonella disease
Gilchrist, J. J., MacLennan, C. A., & Hill, A. V. S. (2015) · Nature reviews. Immunology · doi:10.1038/nri3858 · Cited by 97 · see citing works
Self-citationThe epigenomic landscape of African rainforest hunter-gatherers and farmers
Fagny, M., Patin, É., MacIsaac, J. L., Rotival, M., Flutre, T., Jones, M. J., Siddle, K. J., Quach, H., Harmant, C., McEwen, L. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms10047 · Cited by 94 · see citing works
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling
Queval, C. J., Song, O., Carralot, J., Saliou, J., Bongiovanni, A., Deloison, G., Deboosère, N., Jouny, S., Iantomasi, R., Delorme, V., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.101 · Cited by 94 · see citing works
Localization of adaptive variants in human genomes using averaged one-dependence estimation
Sugden, L. A., Atkinson, E. G., Fischer, A. P., Rong, S., Henn, B. M., & Ramachandran, S. (2018) · Nature Communications · doi:10.1038/s41467-018-03100-7 · Cited by 88 · see citing works
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SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis
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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Palmer, D. C., Webber, B. R., Patel, Y. K., Johnson, M. J., Kariya, C. M., Lahr, W. S., Parkhurst, M. R., Gartner, J. J., Prickett, T. D., Lowery, F. J., et al. (2022) · Med · doi:10.1016/j.medj.2022.07.008 · Cited by 81 · see citing works
Carroll, R. K., Shelburne, S. A., Olsen, R. J., Suber, B., Sahasrabhojane, P. V., Kumaraswami, M., Beres, S. B., Shea, P. R., Flores, A. R., & Musser, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45169 · Cited by 75 · see citing works
Cornes, B. K., Khor, C. C., Nongpiur, M. E., Xu, L., Tay, W.-T., Zheng, Y., Lavanya, R., Li, Y., Wu, R., Sim, X., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr463 · Cited by 74 · see citing works
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Transcriptome sequencing of the choroid plexus in schizophrenia
Kim, S., Hwang, Y., Lee, D., & Webster, M. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.229 · Cited by 67 · see citing works
Community-acquired pneumonia in children
Cardinale, F., Cappiello, A. R., Mastrototaro, M. F., Pignatelli, M., & Esposito, S. (2013) · Early Human Development · doi:10.1016/j.earlhumdev.2013.07.023 · Cited by 64 · see citing works
Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach
Skibsted, S., Bhasin, M., Aird, W. C., & Shapiro, N. I. (2013) · Critical Care · doi:10.1186/cc12693 · Cited by 60 · see citing works
Shelburne, S. A., Ajami, N. J., Chibucos, M. C., Beird, H. C., Tarrand, J. J., Galloway-Peña, J., Albert, N. D., Chemaly, R. F., Ghantoji, S. S., Marsh, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139851 · Cited by 59 · see citing works
The Role of Suppressors of Cytokine Signalling in Human Neoplasms
Sasi, W., Sharma, A. K., & Mokbel, K. (2014) · Molecular Biology International · doi:10.1155/2014/630797 · Cited by 58 · see citing works
CISH is induced during DC development and regulates DC‐mediated CTL activation
Miah, M. A., Yoon, C., Kim, J., Jang, J., Seong, Y., & Bae, Y. (2011) · European Journal of Immunology · doi:10.1002/eji.201141846 · Cited by 56 · see citing works
SOCS proteins in infectious diseases of mammals
Delgado-Ortega, M., Marc, D., Dupont, J., Trapp, S., Berri, M., & Meurens, F. (2012) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2012.11.008 · Cited by 56 · see citing works
The PIRO (predisposition, insult, response, organ dysfunction) model
Marshall, J. C. (2013) · Virulence · doi:10.4161/viru.26908 · Cited by 52 · see citing works
Coordinated Changes in DNA Methylation in Antigen-Specific Memory CD4 T Cells
Hashimoto, S.-I., Ogoshi, K., Sasaki, A., Abe, J., Qü, W., Nakatani, Y., Ahsan, B., Oshima, K., Shand, F. H. W., Ametani, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202267 · Cited by 51 · see citing works
Qiu, J., Cheng, Z., Jiang, Z., Gan, L., Zhang, Z., & Xie, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105490 · Cited by 49 · see citing works
Vasunilashorn, S. M., Finch, C. E., Crimmins, E. M., Vikman, S. A., Stieglitz, J., Gurven, M., Kaplan, H. S., & Allayee, H. (2011) · Biodemography and Social Biology · doi:10.1080/19485565.2011.564475 · Cited by 48 · see citing works
Surfactant Protein B Gene Polymorphism Is Associated With Severe Influenza
To, K. K., Zhou, J., Song, Y., Hung, I. F., Ip, W. C., Cheng, Z., Chan, A., Kao, R. Y. T., Wu, A. K. L., Chau, S. K., et al. (2013) · CHEST Journal · doi:10.1378/chest.13-1651 · Cited by 47 · see citing works
The Role of Host Genetics (and Genomics) in Tuberculosis
Naranbhai, V. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0011-2016 · Cited by 45 · see citing works
Stowe, J., Andrews, N., Taylor, B., & Miller, E. (2009) · Vaccine · doi:10.1016/j.vaccine.2008.12.038 · Cited by 43 · see citing works
SOCS: negative regulators of cytokine signaling for immune tolerance
Yoshimura, A., Ito, M., Mise‐Omata, S., & Ando, M. (2021) · International Immunology · doi:10.1093/intimm/dxab055 · Cited by 37 · see citing works
Esteves, L. M., Bulhões, S. M., Branco, C. C., Melo-Mota, F., Paiva, C., Cabral, R. M., Vieira, M. L., & Mota‐Vieira, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108534 · Cited by 32 · see citing works
Yu, J., Zhang, B., Peng, L., Wu, C., Cao, H., Zhong, J. F., Hoffman, J. A., & Huang, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121911 · Cited by 31 · see citing works
Lakkavaram, A. L., Lundie, R. J., Do, H., Ward, A. C., & de Koning‐Ward, T. F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00702 · Cited by 29 · see citing works
Sun, L., Jin, Y., Shen, C., Qi, H., Chu, P., Yin, Q.-Q., Li, J., Tian, J., Jiao, W., Xiao, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092020 · Cited by 26 · see citing works
Unravelling the druggability and immunological roles of the SOCS-family proteins
Lynch, D. M., Forrester, B., Webb, T., & Ciulli, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449397 · Cited by 25 · see citing works
The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation
Kumar, B., Field, N. S., Kim, D. D., Dar, A. A., Chen, Y., Suresh, A., Pastore, C., Hung, L., Porter, N., Sawada, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30437-x · Cited by 24 · see citing works
Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population
Wang, X., Tang, N. L. S., Leung, C. C., Kam, K. M., Yew, W. W., Tam, C. M., & Chan, C. Y. (2013) · Human Genetics · doi:10.1007/s00439-013-1282-7 · Cited by 24 · see citing works
Self-citationRosier, F., Brisebarre, A., Dupuis, C., Baaklini, S., Puthier, D., Brun, C., Pradel, L. C., Rihet, P., & Payen, D. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115852 · Cited by 23 · see citing works
Trends in programme budget expenditure
Jones, R. (2010) · British Journal of Healthcare Management · doi:10.12968/bjhc.2010.16.11.79645 · Cited by 22 · see citing works
Innate (General or Nonspecific) Host Defense Mechanisms
Dieffenbach, C. W., & Tramont, E. C. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00004-7 · Cited by 21 · see citing works
Low, Z. Y., Yip, A. J. W., Chow, V. T. K., & Lal, S. K. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2300 · Cited by 21 · see citing works
Hu, Z., Yang, J., Wu, Y., Guolian, X., Wang, Y., Yang, J. J. J., & Deng, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100826 · Cited by 20 · see citing works
LaRosa, S. P., & Opal, S. M. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.12.012 · Cited by 19 · see citing works
Yoshimura, A., Aki, D., & Ito, M. (2021) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.97.016 · Cited by 18 · see citing works
Zhao, L., Chu, H., Xu, X., Yue, J., Li, H., & Wang, M. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9733-2 · Cited by 18 · see citing works
Association of CISH -292A/T genetic variant with hepatitis B virus infection
Tong, H. V., Toàn, N. L., Song, L. H., Kremsner, P. G., Kun, J. F. J., & Velavan, T. P. (2011) · Immunogenetics · doi:10.1007/s00251-011-0584-y · Cited by 18 · see citing works
CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone
Kotas, M. E., Mroz, N. M., Koga, S., Liang, H.-E., Schroeder, A., Ricardo-González, R. R., Schneider, C., & Locksley, R. M. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00430-6 · Cited by 17 · see citing works
Role of Tumor Necrosis Factor-α in the Human Systemic Endotoxin-Induced Transcriptome
Scicluna, B. P., Veer, C. V. ′., Nieuwdorp, M., Felsmann, K., Wlotzka, B., Stroes, E. S. G., & van der Poll, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079051 · Cited by 17 · see citing works
Mboowa, G. (2014) · International Journal of Evolutionary Biology · doi:10.1155/2014/108291 · Cited by 16 · see citing works
Regulation of Embryonic Hematopoiesis by a Cytokine-Inducible SH2 Domain Homolog in Zebrafish
Lewis, R. S., Noor, S. M., Fraser, F. W., Sertori, R., Liongue, C., & Ward, A. C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301376 · Cited by 16 · see citing works
Ji, L., Xu, W.-N., Chai, P., Zheng, W., Qian, H., & Xu, J. (2014) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2014.10.006 · Cited by 15 · see citing works
Application of personalised medicine to solid tumours: opportunities and challenges
Ruiz, C. F., Tolnay, M., & Bubendorf, L. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13587 · Cited by 13 · see citing works
CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice
Carow, B., Gao, Y., Terán, G., Yang, X. O., Dong, C., Yoshimura, A., & Rottenberg, M. E. (2017) · Tuberculosis · doi:10.1016/j.tube.2017.09.007 · Cited by 13 · see citing works
Zechi‐Ceide, R. M., Rodrigues, M. G., Jehee, F. S., Kokitsu‐Nakata, N. M., Passos‐Bueno, M. R., & Guion‐Almeida, M. L. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35367 · Cited by 13 · see citing works
Wang, X., Ma, A., Han, X., Litifu, A., & Feng, X. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5800 · Cited by 12 · see citing works
Limper, M., de Kruif, M. D., Ajubi, N. E., van Zanten, A. P., Brandjes, D. P. M., Duits, A. J., & Gorp, E. C. M. V. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1150-5 · Cited by 11 · see citing works
Musimbi, Z. D., Rono, M. K., Otieno, J. R., Kibinge, N., Ochola‐Oyier, L. I., de Villiers, E. P., & Nduati, E. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-54083-4 · Cited by 11 · see citing works
Hu, X., Jiao, F., Deng, J., Zhou, Z., Chen, S., Liu, C., Liu, Z., & Guo, F. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad041 · Cited by 10 · see citing works
CIS and TGF ‐β regulatory pathways influence immunity to bacterial infection
McCulloch, T. R., Rossi, G. R., Schreuder, J., Belz, G. T., Wells, T. J., & Souza-Fonseca-Guimarães, F. (2022) · Immunology · doi:10.1111/imm.13516 · Cited by 10 · see citing works
Chen, G., Chen, J., Wu, J., Ren, X., Li, L., Lu, S., Cheng, T., Tan, L., Liu, M., Luo, Q., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.610605 · Cited by 10 · see citing works
Tremblay, B. L., Guénard, F., Lamarche, B., Përusse, L., & Vohl, M. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0639-5 · Cited by 9 · see citing works
Johnson, A. M., Barigye, R., & Saminathan, H. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2021.1908060 · Cited by 9 · see citing works
Zhang, A., Gu, W., Lu, H., Zeng, L., Zhang, L., Du, D., Hao, J., Wen, D., Wang, X., & Jiang, J. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13160 · Cited by 9 · see citing works
Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset
Tang, N. L. S., Wang, X., Chang, K. C., Chan, C.-Y., Szeto, N. W.-S., Huang, D., Wu, J., Lui, G. C.-Y., Leung, C. C., & Hui, M. (2018) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2018.12.014 · Cited by 9 · see citing works
Self-citationCISH and Susceptibility to Infectious Diseases
Khardori, N. M. (2010) · Yearbook of Medicine · doi:10.1016/s0084-3873(10)79671-1 · Cited by 9 · see citing works
Naser, W., Maymand, S., Dlugolenski, D. A., Basheer, F., & Ward, A. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612757 · Cited by 8 · see citing works
Xu, Z., Huang, G., Gong, W., Zhao, Y., Zhou, P., Zeng, Y., & He, F. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0008 · Cited by 8 · see citing works
Singh, A. K., Abhimanyu, A., Yadav, A. B., Sharma, S., Garg, R., Bose, M., & Misra, A. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.12 · Cited by 8 · see citing works
Naderi, M., Hashemi, M. M., Safdari, A., Bahari, G., & Taheri, M. (2016) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2016.05.003 · Cited by 8 · see citing works
Nutritional immunomodulation of Atlantic salmon response to Renibacterium salmoninarum bacterin
Emam, M., Eslamloo, K., Caballero‐Solares, A., Lorenz, E. K., Xue, X., Umasuthan, N., Gnanagobal, H., Santander, J., Taylor, R. G., Balder, R., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.931548 · Cited by 6 · see citing works
Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1
Adhikari, N., Billaud, M., Carlson, M., Lake, S. P., Montaniel, K. R. C., Staggs, R., Guan, W., Walek, D., Desir, S., Isakson, B. E., et al. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1831-3 · Cited by 6 · see citing works
Carter, T. C., Ye, Z., Ivacic, L., Budi, N., Rose, W., & Shukla, S. (2020) · Genes and Immunity · doi:10.1038/s41435-020-0101-0 · Cited by 6 · see citing works
Regulation of DC development and DC-mediated T-cell immunity via CISH
Miah, M. A., & Bae, Y. (2013) · OncoImmunology · doi:10.4161/onci.23404 · Cited by 6 · see citing works
Hütter, G., & Ganepola, S. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010241 · Cited by 6 · see citing works
Perkins, D. J., Were, T., Anyona, S. B., Hittner, J. B., Kempaiah, P., Davenport, G. C., & Ong’echa, J. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3961-5_8 · Cited by 6 · see citing works
Nelson, C. E., Kauffman, K. D., Osum, K. C., Sakai, S., Buchanan, J., Chanchu, J. M., Cohen, M., Laux, J., Dougi, I., Barrows, K. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114034 · Cited by 5 · see citing works
A 12-bp indel in the 3’UTR of porcine CISH gene associated with Landrace piglet diarrhea score
Niu, B., Chen, Z., Yao, D., Kou, M., Gao, X., Sun, Y., Yang, X., Wang, X., Di, S., Cai, J., et al. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.03.012 · Cited by 5 · see citing works
Skallerup, P., Thamsborg, S. M., Jørgensen, C. B., Mejer, H., Göring, H. H. H., Archibald, A. L., Fredholm, M., & Nejsum, P. L. (2015) · Veterinary Parasitology · doi:10.1016/j.vetpar.2015.03.014 · Cited by 5 · see citing works
CISHand Susceptibility to Infectious Diseases
Vani, J., Kaveri, S. V., & Bayry, J. (2010) · New England Journal of Medicine · doi:10.1056/nejmc1007642 · Cited by 5 · see citing works
Year in review 2010: Tuberculosis, pleural diseases, respiratory infections
Leung, C. C., Feller-Kopman, D. J., Niederman, M. S., & Spiro, S. G. (2011) · Respirology · doi:10.1111/j.1440-1843.2011.01940.x · Cited by 4 · see citing works
Self-citationSong, G., Rao, H., Feng, B., & Wei, L. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20132627 · Cited by 4 · see citing works
Porcel, J. M., Leung, C. C., Restrepo, M. I., & Lee, P. (2012) · Respirology · doi:10.1111/j.1440-1843.2012.02128.x · Cited by 4 · see citing works
Self-citationCarmichael, A., & Wills, M. R. (2013) · Medicine · doi:10.1016/j.mpmed.2013.08.006 · Cited by 4 · see citing works
CIS: the late-blooming eldest son
Yoshimura, A. (2013) · Nature Immunology · doi:10.1038/ni.2645 · Cited by 4 · see citing works
Terkawi, M. A., Takano, R., & Kato, K. (2018) · Journal of Immunology Research · doi:10.1155/2018/6709424 · Cited by 4 · see citing works
Naser, W., & Ward, A. C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1752876 · Cited by 3 · see citing works
Low, G. C. W. J. G. (2013) · Journal of Blood Disorders & Transfusion · doi:10.4172/2155-9864.1000156 · Cited by 3 · see citing works
- Authors
- Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D., Rautanen, A., Mills, T. C., Chang, K.-C., Kam, K.-M., Crampin, A. C., Ngwira, B., Leung, C.-C., Tam, C.-M., Chan, C.-Y., Sung, J. J. Y., Yew, W.-W., Toh, K.-Y., Tay, S. K. H., Kwiatkowski, D., Lienhardt, C., Hien, T.-T., Day, N. P., Peshu, N., Marsh, K., Maitland, K., Scott, J. A., Williams, T. N., Berkley, J. A., Floyd, S., Tang, N. L. S., Fine, P. E. M., Goh, D. L. M., & Hill, A. V. S.
- Affiliations
- Centre for Human Genetics (GB)
- Genome Institute of Singapore (SG)
- University of Oxford (GB)
- Singapore Institute for Clinical Sciences (SG)
- Kenya Medical Research Institute (KE)
- London School of Hygiene & Tropical Medicine (GB)
- ORCID
- Khor, Chiea C.
- Vannberg, Fredrik O.
- Chapman, Stephen J.
- Wong, Sunny H.
- Walley, Andrew J.
- Vukcevic, Damjan
- Crampin, Amelia C.
- Ngwira, Bagrey
- Sung, Joseph J.Y.
- Toh, Kai-Yee
- Tay, Stacey K.H.
- Kwiatkowski, Dominic
- Lienhardt, Christian
- Day, Nicholas P.
- Marsh, Kevin
- Maitland, Kathryn
- Scott, J. Anthony
- Williams, Thomas N.
- Berkley, James A.
- Floyd, Sian
- Tang, Nelson L.S.
- Fine, Paul E.M.
- Hill, Adrian V.S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-06-03
- Volume
- 362
- Issue
- 22
- Pages
- 2092-2101
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3646238
- OpenAlex
- W2142222423
- Cited by
- 136
- References
- 58
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 12 · 2013: 22 · 2012: 15
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Wellcome Trust (061089, 091758, 079828, 076934, 081835)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- CISH, suppressor of cytokine signaling, interleukin-2 signaling, bacteremia, tuberculosis, severe malaria, single nucleotide polymorphisms, cytokine signaling regulation, immune response, genetic association
- MeSH terms
- Adult, Child, Genotype, Humans, Interleukin-2, Malaria, Risk, Tuberculosis, Linkage Disequilibrium, Gene Expression, Odds Ratio, Case-Control Studies, Bacteremia, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Suppressor of Cytokine Signaling Proteins
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