Cited by 6,873HIV/AIDS Research and InterventionsHIV Research and TreatmentHIV/AIDS drug development and treatment

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Prevention of HIV-1 infection with early antiretroviral therapy.

Open access

Cohen, Myron S., Chen, Ying Q., McCauley, Marybeth, Gamble, Theresa, Hosseinipour, Mina C., Kumarasamy, Nagalingeswaran, Hakim, James G., Kumwenda, Johnstone, Grinsztejn, Beatriz, Pilotto, Jose H.S., Godbole, Sheela V., Mehendale, Sanjay, Chariyalertsak, Suwat, Santos, Breno R., Mayer, Kenneth H., Hoffman, Irving F., Eshleman, Susan H., Piwowar-Manning, Estelle, Wang, Lei, Makhema, Joseph, Mills, Lisa A., de Bruyn, Guy, Sanne, Ian, Eron, Joseph, Gallant, Joel, Havlir, Diane, Swindells, Susan, Ribaudo, Heather, Elharrar, Vanessa, Burns, David, Taha, Taha E., Nielsen-Saines, Karin, Celentano, David, Essex, Max, Fleming, Thomas R.·2011·New England Journal of Medicine

DOI 10.1056/nejmoa1105243PMC PMC3200068

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS: In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1-infected subjects with CD4 counts between 350 and 550 cells per cubic millimeter were randomly assigned in a 1:1 ratio to receive antiretroviral therapy either immediately (early therapy) or after a decline in the CD4 count or the onset of HIV-1-related symptoms (delayed therapy). The primary prevention end point was linked HIV-1 transmission in HIV-1-negative partners. The primary clinical end point was the earliest occurrence of pulmonary tuberculosis, severe bacterial infection, a World Health Organization stage 4 event, or death. RESULTS: As of February 21, 2011, a total of 39 HIV-1 transmissions were observed (incidence rate, 1.2 per 100 person-years; 95% confidence interval [CI], 0.9 to 1.7); of these, 28 were virologically linked to the infected partner (incidence rate, 0.9 per 100 person-years, 95% CI, 0.6 to 1.3). Of the 28 linked transmissions, only 1 occurred in the early-therapy group (hazard ratio, 0.04; 95% CI, 0.01 to 0.27; P<0.001). Subjects receiving early therapy had fewer treatment end points (hazard ratio, 0.59; 95% CI, 0.40 to 0.88; P=0.01). CONCLUSIONS: The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1105243

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Self-citation
Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
Quinn, T. C., Wawer, M. J., Sewankambo, N. K., Serwadda, D., Li, C., Wabwire‐Mangen, F., Meehan, M. O., Lutalo, T., & Gray, R. H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003303421303 · Cited by 2,990
Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model
Granich, R., Gilks, C. F., Dye, C., Cock, K. M. D., & Williams, B. G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61697-9 · Cited by 1,987
Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda.
Wawer, M. J., Gray, R. H., Sewankambo, N. K., Serwadda, D., Li, X., Laeyendecker, O., Kiwanuka, N., Kigozi, G., Kiddugavu, M., Lutalo, T., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/429411 · Cited by 1,258
Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries
Braitstein, P. K. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68337-2 · Cited by 1,106
Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival
Kitahata, M. M., Gange, S. J., Abraham, A. G., Merriman, B., Saag, M. S., Justice, A. C., Hogg, R. S., Deeks, S. G., Eron, J. J., Brooks, J. T., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807252 · Cited by 1,105
Self-citation
Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
Donnell, D. J., Baeten, J. M., Kiarie, J. N., Thomas, K. K., Stevens, W. S., Cohen, C. R., McIntyre, J. A., Lingappa, J. R., & Celum, C. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60705-2 · Cited by 970
Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study
Montaner, J. S., Lima, V. D., Barrios, R., Yip, B., Wood, E., Kerr, T., Shannon, K., Harrigan, P. R., Hogg, R. S., Daly, P., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60936-1 · Cited by 780
Decreases in Community Viral Load Are Accompanied by Reductions in New HIV Infections in San Francisco
Das, M., Chu, P. L., Santos, G., Scheer, S., Vittinghoff, E., McFarland, W., & Colfax, G. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011068 · Cited by 771
Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies
Sterne, J. A. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60612-7 · Cited by 748

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 1

Smith K, 2011, Curr Opin HIV AIDS, 6, 315

Sorted by citations

Items 101–200 of 1,024

HIV infection
Bekker, L., Beyrer, C., Mgodi, N. M., Lewin, S. R., Delany‐Moretlwe, S., Taiwo, B., Masters, M. C., & Lazarus, J. V. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00452-3 · Cited by 289
Infection with hepatitis B and C virus in Europe: a systematic review of prevalence and cost-effectiveness of screening
Hahné, S. J. M., Veldhuijzen, I. K., Wiessing, L. G., Lim, T.-A., Salminen, M. O., & van de Laar, M. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-181 · Cited by 245
Quality and quantity
McKinnon, L. R., & Kaul, R. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283504941 · Cited by 245
The Effect of Same-Day Observed Initiation of Antiretroviral Therapy on HIV Viral Load and Treatment Outcomes in a US Public Health Setting
Pilcher, C. D., Ospina-Norvell, C., Dasgupta, A., Jones, D., Hartogensis, W., Torres, S. R., Calderon, F., DeMicco, E., Geng, E. H., Gandhi, M., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001134 · Cited by 244
Self-citation
Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective
Fraser, C., Lythgoe, K., Leventhal, G. E., Shirreff, G., Hollingsworth, T. D., Alizon, S., & Bonhoeffer, S. (2014) · Science · doi:10.1126/science.1243727 · Cited by 247
A systematic review of adherence to oral pre-exposure prophylaxis for HIV – how can we improve uptake and adherence?
Sidebottom, D. B., Ekström, A. M., & Strömdahl, S. K. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3463-4 · Cited by 258
Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models
Eaton, J. W., Menzies, N. A., Stover, J., Cambiano, V., Chindelevitch, L., Cori, A., Hontelez, J. A. C., Humair, S., Kerr, C. C., Klein, D. J., et al. (2013) · The Lancet Global Health · doi:10.1016/s2214-109x(13)70172-4 · Cited by 241
Combination HIV prevention for female sex workers: what is the evidence?
Bekker, L., Johnson, L. F., Cowan, F. M., Overs, C., Besada, D., Hillier, S. L., & Cates, W. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60974-0 · Cited by 245
The Cost-Effectiveness of Preexposure Prophylaxis for HIV Prevention in the United States in Men Who Have Sex With Men
Juusola, J. L., Brandeau, M. L., Owens, D. K., & Bendavid, E. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-8-201204170-00001 · Cited by 247
Interventions to improve adherence to antiretroviral therapy
Chaiyachati, K. H., Ogbuoji, O., Price, M., Suthar, A. B., Negussie, E. K., & Bärnighausen, T. (2014) · AIDS · doi:10.1097/qad.0000000000000252 · Cited by 235
Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts
Hocqueloux, L., Avettand-Fènoël, V., Jacquot, S., Prazuck, T., Legac, É., Mélard, A., Niang, M., Mille, C., Moal, G. L., Viard, J., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks533 · Cited by 235
Regression discontinuity designs are underutilized in medicine, epidemiology, and public health: a review of current and best practice
Moscoe, E., Bor, J. H., & Bärnighausen, T. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2014.06.021 · Cited by 233
The evolving epidemiology of HIV/AIDS
Cock, K. M. D., Jaffe, H. W., & Curran, J. W. (2012) · AIDS · doi:10.1097/qad.0b013e328354622a · Cited by 251
An action agenda for HIV and sex workers
Beyrer, C., Crago, A.-L., Bekker, L., Butler, J., Shannon, K., Kerrigan, D. L., Decker, M. R., Baral, S., Poteat, T., Wirtz, A. L., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60933-8 · Cited by 228
What Is Required to End the AIDS Epidemic as a Public Health Threat by 2030? The Cost and Impact of the Fast-Track Approach
Stover, J., Bollinger, L. A., Izazola, J. A., Loures, L., DeLay, P., Ghys, P. D., & Fast Track modeling working group (2016) · PLoS ONE · doi:10.1371/journal.pone.0154893 · Cited by 231
I Can See Clearly Now: Using Active Visualisation to Improve Adherence to ART and PrEP
Jones, A. S. K., & Petrie, K. J. (2016) · AIDS and Behavior · doi:10.1007/s10461-016-1611-7 · Cited by 229
Botswana's progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey
Gaolathe, T., Wirth, K. E., Holme, M. P., Makhema, J. M., Moyo, S. M., Chakalisa, U. A., Yankinda, E. K., Lei, Q., Mmalane, M. O., Novitsky, V., et al. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)00037-0 · Cited by 225
Self-citation
Incidence of gonorrhea and chlamydia following human immunodeficiency virus preexposure prophylaxis among men who have sex with men: a modeling study.
Jenness, S. M., Weiss, K. M., Goodreau, S. M., Gift, T., Chesson, H., Hoover, K. W., Smith, D. K., Liu, A. Y., Sullivan, P. S., & Rosenberg, E. S. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix439 · Cited by 224
British HIV Association guidelines for the treatment of HIV ‐1‐positive adults with antiretroviral therapy 2012
Writing Group, Williams, I. G., Churchill, D. R., Anderson, J., Boffito, M., Bower, M., Cairns, G., Cwynarski, K., Edwards, S., Fidler, S. J., et al. (2012) · HIV Medicine · doi:10.1111/j.1468-1293.2012.01029.x · Cited by 225
Resilience as a Research Framework and as a Cornerstone of Prevention Research for Gay and Bisexual Men: Theory and Evidence
Herrick, A. L., Stall, R. D., Goldhammer, H., Egan, J. E., & Mayer, K. H. (2013) · AIDS and Behavior · doi:10.1007/s10461-012-0384-x · Cited by 236
Self-citation
The global response to HIV in men who have sex with men
Beyrer, C., Baral, S., Collins, C., Richardson, E. T., Sullivan, P. S., Sánchez, J., Trapence, G., Katabira, E., Kazatchkine, M. D., Ryan, O., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30781-4 · Cited by 223
Self-citation
Research for Universal Health Coverage
Dye, C., Reeder, J. C., & Terry, R. F. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006971 · Cited by 241
Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis
Tan, D. H. S., Hull, M., Yoong, D., Tremblay, C. L., O’Byrne, P., Thomas, R., Kille, J., Baril, J.-G., Cox, J., Giguère, P., et al. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.170494 · Cited by 221
HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes, R., Ayles, H., Beyers, N., Sabapathy, K., Floyd, S., Shanaube, K., Bock, P., Griffith, S., Moore, A. T., Watson‐Jones, D., et al. (2014) · Trials · doi:10.1186/1745-6215-15-57 · Cited by 220
Screening for HIV Infection
US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M. D., Caughey, A. B., Curry, S. J., Doubeni, C. A., Epling, J. W., et al. (2019) · JAMA · doi:10.1001/jama.2019.6587 · Cited by 221
HIV-1 Latency in Monocytes/Macrophages
Kumar, A., Abbas, W., & Herbein, G. (2014) · Viruses · doi:10.3390/v6041837 · Cited by 214
Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing
Xiao, M., Tian, F., Liu, X., Zhou, Q., Pan, J., Luo, Z., Yang, M., & Yi, C. (2022) · Advanced Science · doi:10.1002/advs.202105904 · Cited by 225
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study
Henrich, T. J., Hatano, H., Bacon, O., Hogan, L. E., Rutishauser, R. L., Hill, A. L., Kearney, M. F., Anderson, E. M., Buchbinder, S., Cohen, S. E., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002417 · Cited by 224
Homelessness, unstable housing, and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis
Arum, C., Fraser, H., Artenie, A. A., Bivegete, S., Trickey, A., Alary, M., Astemborski, J. A., Iversen, J., Lim, A. G., MacGregor, L., et al. (2021) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00013-x · Cited by 217
Increased HIV Incidence in Men Who Have Sex with Men Despite High Levels of ART-Induced Viral Suppression: Analysis of an Extensively Documented Epidemic
Phillips, A. N., Cambiano, V., Nakagawa, F., Brown, A. E., Lampe, F. C., Rodger, A. J., Miners, A. H., Elford, J., Hart, G. J., Johnson, A. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055312 · Cited by 215
Access to antiretroviral treatment in South Africa, 2004 - 2011
Johnson, L. F. (2012) · Southern African Journal of HIV Medicine · doi:10.4102/sajhivmed.v13i1.156 · Cited by 213
Integrated Delivery of Antiretroviral Treatment and Pre-exposure Prophylaxis to HIV-1–Serodiscordant Couples: A Prospective Implementation Study in Kenya and Uganda
Baeten, J. M., Heffron, R. A., Kidoguchi, L., Mugo, N., Katabira, E. T., Bukusi, E. A., Asiimwe, S. B., Haberer, J. E., Morton, J. F., Ngure, K., et al. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002099 · Cited by 217
HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa
Havlir, D. V., Balzer, L. B., Charlebois, E. D., Clark, T. D., Kwarisiima, D., Ayieko, J., Kabami, J., Sang, N., Liegler, T. J., Chamie, G., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1809866 · Cited by 212
Self-citation
Association Between Efavirenz as Initial Therapy for HIV-1 Infection and Increased Risk for Suicidal Ideation or Attempted or Completed Suicide
Mollan, K. R., Smurzynski, M., Eron, J. J., Daar, E. S., Campbell, T., Sax, P. E., Gulick, R. M., Na, L., O'Keefe, L. R., Robertson, K. R., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0293 · Cited by 217
Self-citation
Trends in the use of oral emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis against HIV infection, United States, 2012–2017
Sullivan, P. S., Mera, R. M., Mouhanna, F., Pembleton, E. S., Guest, J. L., Jones, J. S., Castel, A. D., Yeung, H., Kramer, M. R., McCallister, S. H., et al. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.06.009 · Cited by 218
Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society–USA Panel
Günthard, H. F., Cálvez, V., Paredes, R., Pillay, D., Shafer, R. W., Wensing, A. M. J., Jacobsen, D. M., & Richman, D. D. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy463 · Cited by 209
Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis
Kanters, S., Vitória, M., Doherty, M. C., Socias, M. E., Ford, N. P., Forrest, J. I., Popoff, E., Bansback, N. J., Nsanzimana, S., Thorlund, K., et al. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)30091-1 · Cited by 210
Factors impacting antiretroviral therapy adherence among human immunodeficiency virus–positive adolescents in Sub-Saharan Africa: a systematic review
Ammon, N., Mason, S., & Corkery, J. (2018) · Public Health · doi:10.1016/j.puhe.2017.12.010 · Cited by 209
Tenofovir Alafenamide Vs. Tenofovir Disoproxil Fumarate in Single Tablet Regimens for Initial HIV-1 Therapy
Sax, P. E., Zolopa, A. R., Brar, I., Elion, R., Ortiz, R., Post, F. A., Wang, H., Callebaut, C., Martin, H., Fordyce, M. W., et al. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000225 · Cited by 206
The cascade of HIV care in British Columbia, Canada, 1996–2011: a population-based retrospective cohort study
Nosyk, B., Montaner, J. S. G., Colley, G., Lima, V. D., Chan, K., Heath, K., Yip, B., Samji, H., Gilbert, M., Barrios, R., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70254-8 · Cited by 206
Prevention of transmission of HIV, hepatitis B virus, hepatitis C virus, and tuberculosis in prisoners
Kamarulzaman, A., Reid, S. E., Schwitters, A. M., Wiessing, L. G., El‐Bassel, N., Dolan, K. A., Moazen, B., Wirtz, A. L., Verster, A. D., & Altice, F. L. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30769-3 · Cited by 205
Sexual Risk Behaviors and Acceptability of HIV Pre-Exposure Prophylaxis Among HIV-Negative Gay and Bisexual Men in Serodiscordant Relationships: A Mixed Methods Study
Brooks, R. A., Landovitz, R. J., Kaplan, R. L., Lieber, E., Lee, S., & Barkley, T. W. (2011) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0283 · Cited by 212
Trends in CD4 Count at Presentation to Care and Treatment Initiation in Sub-Saharan Africa, 2002–2013: A Meta-analysis
Siedner, M. J., Ng, C., Bassett, I. V., Katz, I. T., Bangsberg, D. R., & Tsai, A. C. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu1137 · Cited by 201
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses
Joseph, S., Swanstrom, R. I., Kashuba, A. D. M., & Cohen, M. S. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3471 · Cited by 197
Self-citation
Does Food Insecurity Undermine Adherence to Antiretroviral Therapy? A Systematic Review
Singer, A. W., Weiser, S. D., & McCoy, S. I. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0873-1 · Cited by 200
Can Money Prevent the Spread of HIV? A Review of Cash Payments for HIV Prevention
Pettifor, A. E., MacPhail, C. L., Nguyen, N., & Rosenberg, M. S. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0240-z · Cited by 200
Voluntary counseling and testing (VCT) for changing HIV-related risk behavior in developing countries
Fonner, V. A., Denison, J. A., Kennedy, C. E., O’Reilly, K., & Sweat, M. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001224.pub4 · Cited by 208
Four decades of HIV/AIDS - much accomplished, much to do
Fauci, A. S., & Lane, H. C. (2020) · New England Journal of Medicine · doi:10.1056/nejmp1916753 · Cited by 199
Incidence of Opportunistic Infections and the Impact of Antiretroviral Therapy Among HIV-Infected Adults in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis
Low, A., Gavriilidis, G., Larke, N. L., B-Lajoie, M.-R., Drouin, O., Stover, J., Muhe, L. M., & Easterbrook, P. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw125 · Cited by 198
Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder.
Letendre, S. L. (2011) · PubMed · Cited by 196
Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa
Croome, N., Ahluwalia, M., Hughes, L. D., & Abas, M. (2017) · AIDS · doi:10.1097/qad.0000000000001416 · Cited by 215
Effectiveness of a Peer Navigation Intervention to Sustain Viral Suppression Among HIV-Positive Men and Transgender Women Released From Jail
Cunningham, W. E., Weiss, R. E., Nakazono, T. T., Malek, M. A., SHOPTAW, S. J., Ettner, S. L., & Harawa, N. T. (2018) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2018.0150 · Cited by 198
Impact of the Centers for Disease Control's HIV Preexposure Prophylaxis Guidelines for Men Who Have Sex With Men in the United States
Jenness, S. M., Goodreau, S. M., Rosenberg, E. S., Beylerian, E. N., Hoover, K. W., Smith, D. K., & Sullivan, P. S. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw223 · Cited by 203
Ending the HIV/AIDS Pandemic1
Eisinger, R. W., & Fauci, A. S. (2018) · Emerging infectious diseases · doi:10.3201/eid2403.171797 · Cited by 206
Engaging Men in Prevention and Care for HIV/AIDS in Africa
Mills, E. J., Beyrer, C., Birungi, J., & Dybul, M. R. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001167 · Cited by 192
The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review
Vagenas, P., Azar, M. M., Copenhaver, M. M., Springer, S. A., Molina, P. E., & Altice, F. L. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-015-0285-5 · Cited by 193
Higher Quality Communication and Relationships Are Associated With Improved Patient Engagement in HIV Care
Flickinger, T., Saha, S., Moore, R. D., & Beach, M. C. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318295b86a · Cited by 188
HIV/AIDS in the Southern USA: A disproportionate epidemic
Reif, S., Whetten, K., Wilson, E., McAllaster, C., Pence, B. W., LeGrand, S., & Gong, W. (2013) · AIDS Care · doi:10.1080/09540121.2013.824535 · Cited by 188
Beyond the Distinction Between Biomedical and Social Dimensions of HIV Prevention Through the Lens of a Social Public Health
Kippax, S. C., & Stephenson, N. (2012) · American Journal of Public Health · doi:10.2105/ajph.2011.300594 · Cited by 199
Response to the AIDS Pandemic — A Global Health Model
Piot, P. K., & Quinn, T. C. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1201533 · Cited by 196
Systematic Review of HIV Transmission between Heterosexual Serodiscordant Couples where the HIV-Positive Partner Is Fully Suppressed on Antiretroviral Therapy
Loutfy, M. R., Wu, W., Letchumanan, M., Bondy, L., Antoniou, T., Margolese, S. L., Zhang, Y., Rueda, S., McGee, F., Peck, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055747 · Cited by 193
Are We Prepped for Preexposure Prophylaxis (PrEP)? Provider Opinions on the Real-World Use of PrEP in the United States and Canada
Karris, M., Beekmann, S. E., Mehta, S., Anderson, C. M., & Polgreen, P. M. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit796 · Cited by 197
HIV/AIDS: trends in the Middle East and North Africa region
Gökengin, D., Doroudi, F., Tohme, J., Collins, B., & Madani, N. (2016) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2015.11.008 · Cited by 183
Using HIV Networks to Inform Real Time Prevention Interventions
Little, S. J., Pond, S. L. K., Anderson, C. M., Young, J. A., Wertheim, J. O., Mehta, S. R., May, S. J., & Smith, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098443 · Cited by 182
Adult antiretroviral therapy guidelines 2017
Meintjes, G., Moorhouse, M. A., Carmona, S., Davies, N., Dlamini, S. K., van Vuuren, C., Manzini, T. C., Mathe, M., Moosa, M. S., Nash, J., et al. (2017) · Southern African Journal of HIV Medicine · doi:10.4102/sajhivmed.v18i1.776 · Cited by 182
Improving antiretroviral therapy adherence in resource‐limited settings at scale: a discussion of interventions and recommendations
Haberer, J. E., Sabin, L., Amico, K. R., Orrell, C., Galárraga, O., Tsai, A. C., Vreeman, R., Wilson, I. B., Sam-Agudu, N. A., Blaschke, T. F., et al. (2017) · Journal of the International AIDS Society · doi:10.7448/ias.20.1.21371 · Cited by 192
Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy
Kredo, T., Adeniyi, F. B., Bateganya, M. H., & Pienaar, E. D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007331.pub3 · Cited by 181
The history of antiretroviral therapy and of its implementation in resource-limited areas of the world
Vella, S., Schwartländer, B., Sow, S. P., Eholié, S. P., & Murphy, R. L. (2012) · AIDS · doi:10.1097/qad.0b013e32835521a3 · Cited by 201
Substance Abuse, Violence, and HIV/AIDS (SAVA) Syndemic Effects on Viral Suppression Among HIV Positive Women of Color
Sullivan, K. A., Messer, L. C., & Quinlivan, E. B. (2015) · AIDS Patient Care and STDs · doi:10.1089/apc.2014.0278 · Cited by 174
Formulation and pharmacology of long-acting cabotegravir
Trezza, C., Ford, S. L., Spreen, W., Pan, R., & Piscitelli, S. (2015) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000168 · Cited by 179
Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding
Johnston, C., & Corey, L. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00043-15 · Cited by 186
The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa
Hontelez, J. A. C., de Vlas, S. J., Baltussen, R. M. P. M., Newell, M., Bakker, R., Tanser, F. C., Lurie, M. N., & Bärnighausen, T. (2012) · AIDS · doi:10.1097/qad.0b013e3283558526 · Cited by 175
Expanding ART for Treatment and Prevention of HIV in South Africa: Estimated Cost and Cost-Effectiveness 2011-2050
Granich, R., Kahn, J. G., Bennett, R., Holmes, C. B., Garg, N., Serenata, C. M., Sabin, M. L., Obermeyer, C. M., Mack, C. D. F., Williams, P. C. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030216 · Cited by 188
Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a Phase II study of cabotegravir + rilpivirine (LATTE-2) in the United States and Spain
Kerrigan, D. L., Mantsios, A. R., Górgolas, M., Montes, M., Pulido, F., Brinson, C. C., DeVente, J., Richmond, G. J., Beckham, S. W., Hammond, P., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190487 · Cited by 175
Beyond Core Indicators of Retention in HIV Care: Missed Clinic Visits Are Independently Associated With All-Cause Mortality
Mugavero, M. J., Westfall, A. O., Cole, S. R., Geng, E. H., Crane, H. M., Kitahata, M. M., Mathews, W. C., Napravnik, S., Eron, J. J., Moore, R. D., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu603 · Cited by 173
Self-citation
The Acceptability and Feasibility of an HIV Preexposure Prophylaxis (PrEP) Trial With Young Men Who Have Sex With Men
Hosek, S., Siberry, G. K., Bell, M., Lally, M., Kapogiannis, B. G., Green, K., Fernandez, M. I., Rutledge, B. N., Martinez, J., Garofalo, R., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182801081 · Cited by 177
The cost-effectiveness of harm reduction
Wilson, D. P., Donald, B., Shattock, A. J., Wilson, D. P., & Fraser‐Hurt, N. (2014) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2014.11.007 · Cited by 172
Retention in care during the first 3 years of antiretroviral therapy for women in Malawi's option B+ programme: an observational cohort study
Haas, A. D., Tenthani, L., Msukwa, M. T., Tal, K., Jahn, A., Gadabu, O. J., Spoerri, A., Chimbwandira, F. M., van Oosterhout, J. J., & Keiser, O. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)00008-4 · Cited by 173
Prevalence of Diagnosed and Undiagnosed HIV Infection--United States, 2008-2012.
Hall, H. I., An, Q., Tang, T., Song, R., Chen, M., Green, T., & Kang, J. (2015) · PubMed Central · Cited by 170
Persistent High Burden of Advanced HIV Disease Among Patients Seeking Care in South Africa’s National HIV Program: Data From a Nationwide Laboratory Cohort
Carmona, S., Bor, J. H., Nattey, C., Maughan‐Brown, B., Maskew, M., Fox, M. P., Glencross, D. K., Ford, N. P., & MacLeod, W. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy045 · Cited by 167
Effect of Optional Home Initiation of HIV Care Following HIV Self-testing on Antiretroviral Therapy Initiation Among Adults in Malawi
MacPherson, P., Lalloo, D. G., Webb, E. L., Maheswaran, H., Choko, A. T., Makombe, S. D., Butterworth, A. E., van Oosterhout, J. J., Desmond, N., Thindwa, D., et al. (2014) · JAMA · doi:10.1001/jama.2014.6493 · Cited by 167
Retention in Care of Adults and Adolescents Living With HIV in 13 US Areas
Hall, H. I., Gray, K. M., Tang, T., Li, J., Shouse, R. L., & Mermin, J. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318249fe90 · Cited by 168
Impact of an innovative approach to prevent mother-to-child transmission of HIV--Malawi, July 2011-September 2012.
Chimbwandira, F. M., Mhango, E., Makombe, S. D., Midiani, D., Mwansambo, C. W., Njala, J., Chirwa, Z., Jahn, A., Schouten, E. J., Phelps, B. R., et al. (2013) · PubMed Central · Cited by 191
Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review and Meta-analysis
Ong, J. J., Baggaley, R. C., Wi, T. E., Tucker, J. D., Fu, H., Smith, M. K., Rafael, S., Anglade, V., Falconer, J., Ofori-Asenso, R., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.17134 · Cited by 173
Trends in AIDS Deaths, New Infections and ART Coverage in the Top 30 Countries with the Highest AIDS Mortality Burden; 1990–2013
Granich, R., Gupta, S., Hersh, B. S., Williams, B. G., Montaner, J. S. G., Young, B., & Zuniga, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131353 · Cited by 167
Evidence of an explosive epidemic of HIV infection in a cohort of men who have sex with men in Thailand
van Griensven, F., Thienkrua, W., McNicholl, J. M., Wimonsate, W., Chaikummao, S., Chonwattana, W., Varangrat, A., Sirivongrangson, P., Mock, P. A., Akarasewi, P., et al. (2012) · AIDS · doi:10.1097/qad.0b013e32835c546e · Cited by 170
Control and prevention of infectious diseases from a One Health perspective
Ellwanger, J. H., da Veiga, A. B. G., Kaminski, V. D. L., Valverde-Villegas, J. M., de Freitas, A. W. Q., & Chies, J. A. B. (2021) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2020-0256 · Cited by 200
Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies
Hamers, R. L., Sigaloff, K., Wensing, A. M. J., Wallis, C. L., Kityo, C. M., Siwale, M., Mandaliya, K. N., Ive, P., Botes, M. E., Wellington, M., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis254 · Cited by 166
Recruiting male partners for couple HIV testing and counselling in Malawi's option B+ programme: an unblinded randomised controlled trial
Rosenberg, N. E., Mtande, T. K., Saidi, F., Stanley, C., Jere, E., Paile, L., Kumwenda, K., Mofolo, I., Ng'ambi, W., Miller, W. C., et al. (2015) · The Lancet HIV · doi:10.1016/s2352-3018(15)00182-4 · Cited by 166
Self-citation
Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus
Salehi, B., Kumar, N. V. A., Şener, B., Sharifi‐Rad, M., Kılıç, M., Mahady, G. B., Vlaisavljević, S., Iriti, M., Kobarfard, F., Setzer, W. N., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051459 · Cited by 178
Trends in knowledge of HIV status and efficiency of HIV testing services in sub-Saharan Africa, 2000–20: a modelling study using survey and HIV testing programme data
Giguère, K., Eaton, J. W., Marsh, K., Johnson, L. F., Johnson, C., Ehui, E., Jahn, A., Wanyeki, I., Mbofana, F., Bakiono, F., et al. (2021) · The Lancet HIV · doi:10.1016/s2352-3018(20)30315-5 · Cited by 166
Service delivery interventions to improve adolescents' linkage, retention and adherence to antiretroviral therapy and HIV care
MacPherson, P., Munthali, C., Ferguson, J., Armstrong, A., Kranzer, K., Ferrand, R. A., & Ross, D. A. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12517 · Cited by 164
Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Bartenschlager, R. F. W., Baumert, T. F., Bukh, J., Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., et al. (2018) · Virus Research · doi:10.1016/j.virusres.2018.02.016 · Cited by 163
Concomitant Socioeconomic, Behavioral, and Biological Factors Associated with the Disproportionate HIV Infection Burden among Black Men Who Have Sex with Men in 6 U.S. Cities
Mayer, K. H., Wang, L., Koblin, B. A., Mannheimer, S., Magnus, M., del Rı́o, C., Buchbinder, S., Wilton, L., Cummings, V., Watson, C. C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087298 · Cited by 166
Self-citation
What has been achieved in HIV prevention, treatment and care for people who inject drugs, 2010–2012? A review of the six highest burden countries
Degenhardt, L. J., Mathers, B. M., Wirtz, A. L., Wolfe, D., Kamarulzaman, A., Carrieri, P., Strathdee, S. A., Malinowska-Sempruch, K., Kazatchkine, M. D., & Beyrer, C. (2013) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2013.08.004 · Cited by 163
Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS
Collins, L. M., Kugler, K. C., & Gwadz, M. V. (2015) · AIDS and Behavior · doi:10.1007/s10461-015-1145-4 · Cited by 166
Internalized Stigma, Social Distance, and Disclosure of HIV Seropositivity in Rural Uganda
Tsai, A. C., Bangsberg, D. R., Kegeles, S. M., Katz, I. T., Haberer, J. E., Muzoora, C. K., Kumbakumba, E., Hunt, P. W., Martin, J. N., & Weiser, S. D. (2013) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9514-6 · Cited by 161
Dramatic increase in HIV prevalence after scale-up of antiretroviral treatment
Zaidi, J., Grapsa, E., Tanser, F. C., Newell, M., & Bärnighausen, T. (2013) · AIDS · doi:10.1097/qad.0b013e328362e832 · Cited by 161
Changing Knowledge and Attitudes Towards HIV Treatment-as-Prevention and “Undetectable = Untransmittable”: A Systematic Review
Bor, J. H., Fischer, C. B., Modi, M., Richman, B., Kinker, C., King, R. L., Calabrese, S. K., Mokhele, I., Sineke, T., Zuma, T., et al. (2021) · AIDS and Behavior · doi:10.1007/s10461-021-03296-8 · Cited by 162
Self-citation
Immunodeficiency at the Start of Combination Antiretroviral Therapy in Low-, Middle-, and High-Income Countries
Collaborations, T. I. A. A. C. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182a39979 · Cited by 159

Authors: Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., Hakim, J. G., Kumwenda, J., Grinsztejn, B., Pilotto, J. H. S., Godbole, S. V., Mehendale, S., Chariyalertsak, S., Santos, B. R., Mayer, K. H., Hoffman, I. F., Eshleman, S. H., Piwowar-Manning, E., Wang, L., Makhema, J., Mills, L. A., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T. E., Nielsen-Saines, K., Celentano, D., Essex, M., & Fleming, T. R.
Affiliations: University of North Carolina at Chapel Hill (US)
Fred Hutch Cancer Center (US)
YR Gaitonde Centre for AIDS Research and Education (IN)
University of Zimbabwe (ZW)
Johns Hopkins University (US)
National AIDS Research Institute (IN)
Chiang Mai University (TH)
Fenway Health (US)
Harvard University (US)
Kenya Medical Research Institute (KE)
University of California, San Francisco (US)
University of Nebraska Medical Center (US)
National Institutes of Health (US)
University of Washington (US)
ORCID: Cohen, Myron S.
Chen, Ying Q.
Gamble, Theresa
Hosseinipour, Mina C.
Kumarasamy, Nagalingeswaran
Hakim, James G.
Kumwenda, Johnstone
Grinsztejn, Beatriz
Godbole, Sheela V.
Mehendale, Sanjay
Chariyalertsak, Suwat
Santos, Breno R.
Mayer, Kenneth H.
Hoffman, Irving F.
Eshleman, Susan H.
Wang, Lei
Makhema, Joseph
Mills, Lisa A.
Sanne, Ian
Eron, Joseph
Gallant, Joel
Havlir, Diane
Swindells, Susan
Ribaudo, Heather
Burns, David
Taha, Taha E.
Celentano, David
Essex, Max
Fleming, Thomas R.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2011-08-11
Volume: 365
Issue: 6
Pages: 493-505
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1105243
PMC: PMC3200068
OpenAlex: W2152505869
Cited by: 6,873
References: 35
Citations by year: 2026: 106 · 2025: 155 · 2024: 189 · 2023: 204 · 2022: 288 · 2021: 354 · 2020: 398 · 2019: 471 · 2018: 510 · 2017: 594 · 2016: 694 · 2015: 720 · 2014: 759 · 2013: 740 · 2012: 571
FWCI: 466.60
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
Funders: Abbott Laboratories
Bristol-Myers Squibb
Pfizer
GlaxoSmithKline
Sanofi
Gilead Sciences
ViiV Healthcare
Abbott Diagnostics
Sanofi Pasteur
National Institute of Allergy and Infectious Diseases (U01AI068617, U01AI068619, U01AI068613, K24AI051982, UM1AI068619, UM1AI069418, P30AI050410, UM1AI068613, UM1AI068617, P30AI027763)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD042854)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: HIV-1 prevention, early antiretroviral therapy, serodiscordant couples, sexual transmission of HIV, CD4 count, HIV-negative partners, tuberculosis, bacterial infection, AIDS mortality, HPTN 052
MeSH terms: Adolescent, Adult, Drug Therapy, Combination, Female, HIV Seropositivity, Humans, Male, Sexual Partners, HIV-1, HIV Infections, Proportional Hazards Models, Treatment Outcome, Disease Progression, Spouses, Disease Transmission, Infectious, Anti-Retroviral Agents, Kaplan-Meier Estimate, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prevention of HIV-1 infection with early antiretroviral therapy.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks