The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Radical Prostatectomy versus Observation for Localized Prostate Cancer
Open accessAbstract
BACKGROUND: The effectiveness of surgery versus observation for men with localized prostate cancer detected by means of prostate-specific antigen (PSA) testing is not known. METHODS: From November 1994 through January 2002, we randomly assigned 731 men with localized prostate cancer (mean age, 67 years; median PSA value, 7.8 ng per milliliter) to radical prostatectomy or observation and followed them through January 2010. The primary outcome was all-cause mortality; the secondary outcome was prostate-cancer mortality. RESULTS: During the median follow-up of 10.0 years, 171 of 364 men (47.0%) assigned to radical prostatectomy died, as compared with 183 of 367 (49.9%) assigned to observation (hazard ratio, 0.88; 95% confidence interval [CI], 0.71 to 1.08; P=0.22; absolute risk reduction, 2.9 percentage points). Among men assigned to radical prostatectomy, 21 (5.8%) died from prostate cancer or treatment, as compared with 31 men (8.4%) assigned to observation (hazard ratio, 0.63; 95% CI, 0.36 to 1.09; P=0.09; absolute risk reduction, 2.6 percentage points). The effect of treatment on all-cause and prostate-cancer mortality did not differ according to age, race, coexisting conditions, self-reported performance status, or histologic features of the tumor. Radical prostatectomy was associated with reduced all-cause mortality among men with a PSA value greater than 10 ng per milliliter (P=0.04 for interaction) and possibly among those with intermediate-risk or high-risk tumors (P=0.07 for interaction). Adverse events within 30 days after surgery occurred in 21.4% of men, including one death. CONCLUSIONS: Among men with localized prostate cancer detected during the early era of PSA testing, radical prostatectomy did not significantly reduce all-cause or prostate-cancer mortality, as compared with observation, through at least 12 years of follow-up. Absolute differences were less than 3 percentage points. (Funded by the Department of Veterans Affairs Cooperative Studies Program and others; PIVOT ClinicalTrials.gov number, NCT00007644.).
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Autonomic nerve development contributes to prostate cancer progression
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Ankerst, D. P., Hoefler, J., Bock, S., Goodman, P. J., Vickers, A., Hernandez, J., Sokoll, L. J., Sanda, M. G., Wei, J. T., Leach, R. J., et al. (2014) · Urology · doi:10.1016/j.urology.2014.02.035 · Cited by 236
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Drabovich, A. P., Saraon, P., Drabovich, M., Karakosta, T. D., Dimitromanolakis, A., Hyndman, M. E., Jarvi, K., & Diamandis, E. P. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001612 · Cited by 40
A surveillance system to assess the need for updating systematic reviews
Ahmadzai, N., Newberry, S. J., Maglione, M. A., Tsertsvadze, A., Ansari, M. T., Hempel, S., Motala, A., Tsouros, S., Schneider Chafen, J. J., Shanman, R., et al. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-104 · Cited by 33
Drabovich, A. P., Saraon, P., Drabovich, M., Karakosta, T. D., Dimitromanolakis, A., Hyndman, M. E., Jarvi, K., & Diamandis, E. P. (2017) · doi:10.1101/120873
Metadata
- Authors
- Wilt, T. J., Brawer, M. K., Jones, K. M., Barry, M. J., Aronson, W. J., Fox, S., Gingrich, J. R., Wei, J. T., Gilhooly, P., Grob, B. M., Nsouli, I., Iyer, P., Cartagena, R., Snider, G., Roehrborn, C., Sharifi, R., Blank, W., Pandya, P., Andriole, G. L., Culkin, D., & Wheeler, T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-07-19
- Volume
- 367
- Issue
- 3
- Pages
- 203-213
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2110569728
- Cited by
- 1,770
- References
- 1
- FWCI
- 185.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
