Fracture risk and zoledronic acid therapy in men with osteoporosis
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BACKGROUND: Fractures in men are a major health issue, and data on the antifracture efficacy of therapies for osteoporosis in men are limited. We studied the effect of zoledronic acid on fracture risk among men with osteoporosis. METHODS: In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1199 men with primary or hypogonadism-associated osteoporosis who were 50 to 85 years of age to receive an intravenous infusion of zoledronic acid (5 mg) or placebo at baseline and at 12 months. Participants received daily calcium and vitamin D supplementation. The primary end point was the proportion of participants with one or more new morphometric vertebral fractures over a period of 24 months. RESULTS: The rate of any new morphometric vertebral fracture was 1.6% in the zoledronic acid group and 4.9% in the placebo group over the 24-month period, representing a 67% risk reduction with zoledronic acid (relative risk, 0.33; 95% confidence interval, 0.16 to 0.70; P=0.002). As compared with men who received placebo, men who received zoledronic acid had fewer moderate-to-severe vertebral fractures (P=0.03) and less height loss (P=0.002). Fewer participants who received zoledronic acid had clinical vertebral or nonvertebral fractures, although this difference did not reach significance because of the small number of fractures. Bone mineral density was higher and bone-turnover markers were lower in the men who received zoledronic acid (P<0.05 for both comparisons). Results were similar in men with low serum levels of total testosterone. The zoledronic acid and placebo groups did not differ significantly with respect to the incidence of death (2.6% and 2.9%, respectively) or serious adverse events (25.3% and 25.2%). CONCLUSIONS: Zoledronic acid treatment was associated with a significantly reduced risk of vertebral fracture among men with osteoporosis. (Funded by Novartis Pharma; ClinicalTrials.gov number, NCT00439647.).
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In 1199 men with osteoporosis, zoledronic acid decreased vertebral fracture risk by 67%, irrespective of baseline testosterone.
“In 1199 men with osteoporosis, zoledronic acid decreased vertebral fracture risk by 67%, irrespective of baseline testosterone (48).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [48]
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Cites
Prediction of Creatinine Clearance from Serum Creatinine
Cockcroft, D. W., & Gault, H. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000180580 · Cited by 15,291 · see citing works
Cook, R. J., Dickens, B. M., & Fathalla, M. F. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199241323.003.0025 · Cited by 10,813 · see citing works
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
Johnell, O., & Kanis, J. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0172-4 · Cited by 4,770 · see citing works
Vertebral fracture assessment using a semiquantitative technique
Genant, H. K., Wu, C. Y., van Kuijk, C., & Nevitt, M. C. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650080915 · Cited by 3,691 · see citing works
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
Cummings, S. R., Martin, J. S., McClung, M. R., Siris, E. S., Eastell, R., Reid, I. R., Delmas, P., Zoog, H. B., Austin, M., Wang, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809493 · Cited by 3,489 · see citing works
Self-citationOnce-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis
Black, D. M., Delmas, P. D., Eastell, R., Reid, I. R., Boonen, S., Cauley, J. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067312 · Cited by 2,986 · see citing works
Self-citationLiberman, U. A., Weiss, S. R., Bröll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J. A., Downs, R. W., Dequeker, J., Favus, M. J., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511303332201 · Cited by 2,276 · see citing works
Zoledronic Acid and Clinical Fractures and Mortality after Hip Fracture
Lyles, K. W., Colón-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa074941 · Cited by 2,003 · see citing works
Self-citationMortality after all major types of osteoporotic fracture in men and women: an observational study
Nguyen, T. V., Schneider, D. L., Sambrook, P. N., & Eisman, J. A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09075-8 · Cited by 1,926 · see citing works
Reginster, J.-Y., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., et al. (2000) · Osteoporosis International · doi:10.1007/s001980050010 · Cited by 1,580 · see citing works
Meta-analysis: Excess Mortality After Hip Fracture Among Older Women and Men
Haentjens, P., Magaziner, J., Colon-Emeric, C. S., Vanderschueren, D., Milisen, K., Velkeniers, B., & Boonen, S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-6-201003160-00008 · Cited by 1,409 · see citing works
Prevalence of low femoral bone density in older U.S. women from NHANES III
Looker, A. C., Johnston, C. C., Wahner, H. W., Dunn, W. L., Calvo, M. S., Harris, T. B., Heyse, S. P., & Lindsay, R. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100517 · Cited by 1,379 · see citing works
Denosumab in men receiving androgen-deprivation therapy for prostate cancer
Smith, M. R., Egerdie, B., Toriz, N. H., Feldman, R., Tammela, T. L. J., Saad, F., Heracek, J., Szwedowski, M., Ke, C., Kupic, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809003 · Cited by 1,140 · see citing works
Prevalence of Low Femoral Bone Density in Older U.S. Adults from NHANES III
Looker, A. C., ORWOLL, E. S., Johnston, C. C., Lindsay, R., Wahner, H. W., Dunn, W. L., Calvo, M. S., Harris, T. B., & Heyse, S. P. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1761 · Cited by 1,052 · see citing works
Alendronate for the Treatment of Osteoporosis in Men
ORWOLL, E. S., Ettinger, M. P., Weiss, S. R., Miller, P. D., Kendler, D. L., Graham, J., Adami, S., Weber, K., Lorenc, R. S., Pietschmann, P., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008313430902 · Cited by 974 · see citing works
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867 · see citing works
Black, D. M., Arden, N., Palermo, L., Pearson, J., & Cummings, S. R. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.5.821 · Cited by 792 · see citing works
ORWOLL, E. S., Scheele, W. H., Paul, S., Adámi, S., Syversen, U., Díez‐Pérez, A., Kaufman, J.-M., Clancy, A., & Gaich, G. A. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.1.9 · Cited by 773 · see citing works
Delmas, P. D., Genant, H. K., Crans, G., Stock, J. L., Wong, M., Siris, E. S., & Adachi, J. D. (2003) · Bone · doi:10.1016/s8756-3282(03)00241-2 · Cited by 533 · see citing works
Screening for Osteoporosis: U.S. Preventive Services Task Force Recommendation Statement
U.S. Preventive Services Task Force* (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-5-201103010-00307 · Cited by 436 · see citing works
Summarizing historical information on controls in clinical trials
Neuenschwander, B. E., Capkun-Niggli, G., Branson, M., & Spiegelhalter, D. J. (2010) · Clinical Trials · doi:10.1177/1740774509356002 · Cited by 398 · see citing works
Lunt, M., O’Neill, T. W., Felsenberg, D., REEVE, J., Kanis, J. А., Cooper, C. C., & Silman, A. J. (2003) · Bone · doi:10.1016/s8756-3282(03)00248-5 · Cited by 213 · see citing works
Boonen, S., ORWOLL, E. S., Wenderoth, D., Stoner, K. J., Eusebio, R. A., & Delmas, P. D. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081214 · Cited by 192 · see citing works
ORWOLL, E. S., Miller, P. D., Adachi, J. D., Brown, J. P., Adler, R. A., Kendler, D. L., Bucci-Rechtweg, C. M., Readie, A., Mesenbrink, P. G., & Weinstein, R. S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.119 · Cited by 185 · see citing works
The near absence of osteoporosis treatment in older men with fractures
Feldstein, A. C., Nichols, G. A., ORWOLL, E. S., Elmer, P. J., Smith, D. H., Herson, M., & Aickin, M. G. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1950-0 · Cited by 139 · see citing works
Efficacy and safety of monthly ibandronate in men with low bone density
ORWOLL, E. S., Binkley, N., Lewiecki, E. M., Gruntmanis, U., Fries, M. A., & Dašić, G. (2010) · Bone · doi:10.1016/j.bone.2009.12.034 · Cited by 100 · see citing works
Roerholt, C., Eiken, P., & Abrahamsen, B. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0651-x · Cited by 83 · see citing works
Osteoporosis and vertebral fractures in men aged 60–74 years
Frost, M., Wraae, K., Abrahamsen, B., Høiberg, M., Hagen, C., Andersen, M., & Brixen, K. (2012) · Age and Ageing · doi:10.1093/ageing/afr170 · Cited by 46 · see citing works
Severity of vertebral fracture and risk of hip fracture: a nested case–control study
Puisto, V., Heliövaara, M., Impivaara, O., Jalanko, T., Kröger, H., Knekt, P., Aromaa, A. J., Rissanen, H. A., & Helenius, I. J. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1195-4 · Cited by 35 · see citing works
Hilner, J. E., Perdue, L., Sides, E. G., Pierce, J. J., Wägner, A. M., Aldrich, A., Loth, A., Albret, L., Wagenknecht, L. E., Nierras, C. R., et al. (2010) · Clinical Trials · doi:10.1177/1740774510373497 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khan, A. A., Morrison, A. D., Hanley, D. A., Felsenberg, D., McCauley, L. K., O’Ryan, F., Reid, I. R., Ruggiero, S. L., Taguchi, A., Tetradis, S., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2405 · Cited by 1,360 · see citing works
UK clinical guideline for the prevention and treatment of osteoporosis
The National Osteoporosis Guideline Group (NOGG), Compston, J. E., Cooper, A., Cooper, C. C., Gittoes, N. J. L., Gregson, C. L., Harvey, N. C., Hope, S., Kanis, J. А., McCloskey, E. V., et al. (2017) · Archives of Osteoporosis · doi:10.1007/s11657-017-0324-5 · Cited by 837 · see citing works
Qaseem, A., Forciea, M. A., McLean, R. M., Denberg, T. D., & for the Clinical Guidelines Committee of the American College of Physicians* (2017) · Annals of Internal Medicine · doi:10.7326/m15-1361 · Cited by 676 · see citing works
Adler, R. A., Fuleihan, G. E., Bauer, D. C., Camacho, P. M., Clarke, B. L., Clines, G. A., Compston, J. E., Drake, M. T., Edwards, B. J.-A., Favus, M. J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2708 · Cited by 679 · see citing works
Screening for Osteoporosis to Prevent Fractures
US Preventive Services Task Force, Curry, S. J., Krist, A. H., Owens, D. K., Barry, M. J., Caughey, A. B., Davidson, K. W., Doubeni, C. A., Epling, J. W., Kemper, A. R., et al. (2018) · JAMA · doi:10.1001/jama.2018.7498 · Cited by 668 · see citing works
UK clinical guideline for the prevention and treatment of osteoporosis
Gregson, C. L., Armstrong, D. J., Bowden, J., Cooper, C., Edwards, J., Gittoes, N. J. L., Harvey, N., Kanis, J., Leyland, S., Low, R., et al. (2022) · Archives of Osteoporosis · doi:10.1007/s11657-022-01061-5 · Cited by 593 · see citing works
Rezvan, P. H., Lee, K. J., & Simpson, J. (2015) · BMC Medical Research Methodology · doi:10.1186/s12874-015-0022-1 · Cited by 421 · see citing works
Change in Bone Density and Reduction in Fracture Risk: A Meta-Regression of Published Trials
Bouxsein, M., Eastell, R., Lui, L., Wu, L., de Papp, A. E., Grauer, A., Marín, F., Cauley, J. A., Bauer, D. C., Black, D. M., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3641 · Cited by 355 · see citing works
Lewiecki, E. M., Blicharski, T., Goemaere, S., Lippuner, K., Meisner, P. D., Miller, P. D., Miyauchi, A., Maddox, J., Chen, L., & Horlait, S. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02163 · Cited by 332 · see citing works
Sex Steroid Actions in Male Bone
Vanderschueren, D., Laurent, M. R., Claessens, F., Gielen, E., Lagerquist, M. K., Vandenput, L., Börjesson, A. E., & Ohlsson, C. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1024 · Cited by 327 · see citing works
Ayers, C. K., Kansagara, D. L., Lazur, B. H., Fu, R. F., Kwon, A., & Harrod, C. S. (2023) · Annals of Internal Medicine · doi:10.7326/m22-0684 · Cited by 294 · see citing works
Long-term and sequential treatment for osteoporosis
Foessl, I., Dimai, H. P., & Obermayer-Pietsch, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00866-9 · Cited by 273 · see citing works
Guidelines for the diagnosis, prevention and management of osteoporosis
Rossini, M., Adámi, S., Bertoldo, F., Diacinti, D., Gatti, D., Giannini, S., Giusti, A., Malavolta, N., Minisola, S., Osella, G., et al. (2016) · Reumatismo · doi:10.4081/reumatismo.2016.870 · Cited by 277 · see citing works
Comparative Effectiveness of Pharmacologic Treatments to Prevent Fractures
Crandall, C. J., Newberry, S. J., Diamant, A. L., Lim, Y.-W., Gellad, W. F., Booth, M. J., Motala, A., & Shekelle, P. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0317 · Cited by 257 · see citing works
Grossmann, M., & Matsumoto, A. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3580 · Cited by 246 · see citing works
Osteoporosis in Men: A Review of an Underestimated Bone Condition
Rinonapoli, G., Ruggiero, C., Meccariello, L., Bisaccia, M., Ceccarini, P., & Caraffa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042105 · Cited by 252 · see citing works
National incidence of traumatic fractures in China: a retrospective survey of 512 187 individuals
Chen, W., Lv, H., Liu, S., Liu, B., Zhu, Y., Chen, X., Yang, G., Liu, L., Zhang, T., Wang, H., et al. (2017) · The Lancet Global Health · doi:10.1016/s2214-109x(17)30222-x · Cited by 244 · see citing works
Qaseem, A., Hicks, L. A., Etxeandia‐Ikobaltzeta, I., Shamliyan, T., & Cooney, T. G. (2023) · Annals of Internal Medicine · doi:10.7326/m22-1034 · Cited by 244 · see citing works
Vilaca, T., Eastell, R., & Schini, M. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00012-2 · Cited by 221 · see citing works
Overview of treatment approaches to osteoporosis
Langdahl, B. L. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15024 · Cited by 214 · see citing works
Screening to Prevent Osteoporotic Fractures
Viswanathan, M., Reddy, S., Berkman, N. D., Cullen, K., Middleton, J. C., Nicholson, W. K., & Kahwati, L. C. (2018) · JAMA · doi:10.1001/jama.2018.6537 · Cited by 208 · see citing works
The clinical epidemiology of male osteoporosis: a review of the recent literature
Nelson, R. E., Willson, T. M., Nelson, S. D., Newbold, J., & LaFleur, J. (2015) · Clinical Epidemiology · doi:10.2147/clep.s40966 · Cited by 191 · see citing works
Bisphosphonates for the prevention and treatment of osteoporosis
Maraka, S., & Kennel, K. A. (2015) · BMJ · doi:10.1136/bmj.h3783 · Cited by 178 · see citing works
Screening for Osteoporosis to Prevent Fractures
US Preventive Services Task Force, Nicholson, W. K., Silverstein, M., Wong, J. B., Chelmow, D. P., Coker, T. R., Davis, E. M., Jaén, C. R., Krousel-Wood, M. A., Lee, S., et al. (2025) · JAMA · doi:10.1001/jama.2024.27154 · Cited by 163 · see citing works
Muscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment
Colón, C. J. P., Molina-Vicenty, I. L., Frontera-Rodríguez, M., García-Ferré, A., Rivera, B. P., Cintrón-Vélez, G., & Frontera-Rodríguez, S. (2018) · Journal of Biomedicine · doi:10.7150/jbm.23390 · Cited by 150 · see citing works
Golds, G., Houdek, D., & Arnason, T. (2017) · International Journal of Endocrinology · doi:10.1155/2017/4602129 · Cited by 150 · see citing works
Safety issues with bisphosphonate therapy for osteoporosis
Suresh, E., Pazianas, M., & Abrahamsen, B. (2013) · Rheumatology · doi:10.1093/rheumatology/ket236 · Cited by 140 · see citing works
Evidence-Based Guideline for the management of osteoporosis in men
Fuggle, N. R., Beaudart, C., Bruyère, O., Abrahamsen, B., Al‐Daghri, N. M., Burlet, N., Chandran, M., Rosa, M. M., Cortet, B., Demonceau, C., et al. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01094-9 · Cited by 139 · see citing works
Diagnosis and Management of Osteoporosis.
Jeremiah, M. P., Unwin, B., Greenawald, M. H., & Casiano, V. E. (2015) · PubMed · Cited by 130 · see citing works
Ebeling, P. R. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328362164d · Cited by 127 · see citing works
Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis
Belaya, Z. E., Belova, K. Y., Biryukova, E. V., Dedov, I. I., Dzeranova, L. K., Drapkina, O. M., Dreval', A. V., Dubovitskaya, Т. A., Dudinskaya, Е. N., Ershova, O. B., et al. (2021) · Osteoporosis and Bone Diseases · doi:10.14341/osteo12930 · Cited by 134 · see citing works
Renal safety in patients treated with bisphosphonates for osteoporosis: A review
Miller, P. D., Jamal, S. A., Evenepoel, P., Eastell, R., & Boonen, S. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2058 · Cited by 112 · see citing works
The 2024 UK clinical guideline for the prevention and treatment of osteoporosis
Gregson, C. L., Armstrong, D., Avgerinou, C., Bowden, J., Cooper, C. C., Douglas, L., Edwards, J., Gittoes, N. J. L., Harvey, N. C., Kanis, J. A., et al. (2025) · Archives of Osteoporosis · doi:10.1007/s11657-025-01588-3 · Cited by 127 · see citing works
Treatment of osteoporosis in men
Kaufman, J., Reginster, J.-Y., Boonen, S., Brandi, M. L., Cooper, C. C., Dere, W. H., Devogelaer, J.-P., Díez‐Pérez, A., Kanis, J. А., McCloskey, E. V., et al. (2012) · Bone · doi:10.1016/j.bone.2012.11.018 · Cited by 109 · see citing works
Adler, R. A. (2014) · Bone Research · doi:10.1038/boneres.2014.1 · Cited by 109 · see citing works
Tea and bone health: steps forward in translational nutrition
Shen, C., Chyu, M., & Wang, J.-S. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058255 · Cited by 100 · see citing works
The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis
Byun, J.-H., Jang, S., Lee, S., Park, S., Yoon, H. K., Yoon, B., & Ha, Y. (2017) · Journal of Bone Metabolism · doi:10.11005/jbm.2017.24.1.37 · Cited by 97 · see citing works
Association Between Drug Treatments for Patients With Osteoporosis and Overall Mortality Rates
Cummings, S. R., Lui, L., Eastell, R., & Allen, I. E. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.2779 · Cited by 97 · see citing works
Zoledronic Acid (Reclast®, Aclasta®): A Review in Osteoporosis
Dhillon, S. (2016) · Drugs · doi:10.1007/s40265-016-0662-4 · Cited by 96 · see citing works
Management of osteoporosis of the oldest old
Rizzoli, R., Branco, J., Brandi, M. L., Boonen, S., Bruyère, O., Cacoub, P., Cooper, C. C., Díez‐Pérez, A., Duder, J., Fielding, R. A., et al. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2755-9 · Cited by 93 · see citing works
EAA clinical guideline on management of bone health in the andrological outpatient clinic
Rochira, V., Antonio, L., & Vanderschueren, D. (2018) · Andrology · doi:10.1111/andr.12470 · Cited by 89 · see citing works
Androgens and prostate cancer; pathogenesis and deprivation therapy
Grossmann, M., Cheung, A. S., & Zajac, J. D. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.001 · Cited by 89 · see citing works
Zhou, J., Ma, X., Wang, T., & Zhai, S. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3654-z · Cited by 84 · see citing works
Li, F., Sun, X., Ma, J., Ma, X., Zhao, B., Zhang, Y., Tian, P., Li, Y., & Han, Z. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.117 · Cited by 82 · see citing works
Osteoporosis Treatment Efficacy for Men: A Systematic Review and Meta‐Analysis
Nayak, S., & Greenspan, S. L. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14668 · Cited by 80 · see citing works
Sanderson, J., James, M. M., Stevens, J., Goka, E., Wong, R., Campbell, F., Selby, P. L., Gittoes, N. J. L., & Davis, S. (2016) · Bone · doi:10.1016/j.bone.2016.05.013 · Cited by 76 · see citing works
Osteoporosis treatment: current drugs and future developments
Chen, Y.-J., Jia, L.-H., Han, T.-H., Zhao, Z.-H., Yang, J., Xiao, J.-P., Yang, H.-J., & Yang, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1456796 · Cited by 96 · see citing works
Nakamura, T., Fukunaga, M., Nakano, T., Kishimoto, H., Ito, M., Hagino, H., Sone, T., Taguchi, A., Tanaka, S., Ohashi, M., et al. (2016) · Osteoporosis International · doi:10.1007/s00198-016-3736-y · Cited by 78 · see citing works
Davis, S., James, M. M., Sanderson, J., Stevens, J., Goka, E., Rawdin, A., Sadler, S., Wong, R., Campbell, F., Stevenson, M., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20780 · Cited by 76 · see citing works
Cianferotti, L., Bertoldo, F., Carini, M., Kanis, J. А., Lapini, A., Longo, N., Martorana, G. E., Mirone, V. G., Reginster, J., Rizzoli, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17980 · Cited by 73 · see citing works
Osteoporosis Diagnosis in Men: The T-Score Controversy Revisited
Binkley, N., Adler, R. A., & Bilezikian, J. P. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0242-z · Cited by 73 · see citing works
Adler, R. A. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.05.007 · Cited by 73 · see citing works
Bandeira, L., Silva, B. C. C., & Bilezikian, J. P. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000563 · Cited by 83 · see citing works
Management of Osteoporosis in Men: A Narrative Review
Vescini, F., Chiodini, I., Falchetti, A., Palermo, A., Salcuni, A. S., Bonadonna, S., Geronimo, V. D., Cesareo, R., Giovanelli, L., Brigo, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413640 · Cited by 68 · see citing works
González-Macı́as, J., del Pino‐Montes, J., Olmos, J. M., & Nogués, X. (2015) · Revista Clínica Española · doi:10.1016/j.rce.2015.08.003 · Cited by 64 · see citing works
Effects of bisphosphonates on osteoporosis: Focus on zoledronate
Oryan, A., & Sahvieh, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118681 · Cited by 58 · see citing works
Walsh, J., & Eastell, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.171 · Cited by 56 · see citing works
Ganmaa, D., Enkhmaa, D., Erdenebileg, N., Sukhbaatar, S., Tumur‐Ochir, K., & Manson, J. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13399 · Cited by 57 · see citing works
Kendler, D. L., Compston, J. E., CAREY, J. J., Wu, C., Ibrahim, A., & Lewiecki, E. M. (2019) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2019.07.010 · Cited by 53 · see citing works
Osteoporosis in older men: Recent advances in pathophysiology and treatment
Laurent, M. R., Gielen, E., Claessens, F., Boonen, S., & Vanderschueren, D. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.04.010 · Cited by 51 · see citing works
Porcelli, T., Maffezzoni, F., Pezzaioli, L. C., Delbarba, A., Cappelli, C., & Ferlin, A. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0034 · Cited by 51 · see citing works
Biochemical Markers of Bone Turnover in Osteoporosis
Szulc, P., Bauer, D. C., & Eastell, R. (2013) · Wiley eBooks · doi:10.1002/9781118453926.ch35 · Cited by 51 · see citing works
Wu, H., Sun, Z., Tong, L., Wang, Y., Yan, H., & Sun, Z. (2021) · Archives of Osteoporosis · doi:10.1007/s11657-021-01016-2 · Cited by 50 · see citing works
Efficacy of osteoporosis pharmacological treatments in men: a systematic review and meta-analysis
Beaudart, C., Demonceau, C., Sabico, S., Veronese, N., Cooper, C. C., Harvey, N. C., Fuggle, N. R., Bruyère, O., Rizzoli, R., & Reginster, J. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02478-9 · Cited by 50 · see citing works
Quality of Osteoporosis Care of Older Medicare Recipients with Fragility Fractures: 2006 to 2010
Liu, S. K., Munson, J. C., Bell, J., Zaha, R. L., Mecchella, J. N., Tosteson, A. N. A., & Morden, N. E. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12507 · Cited by 50 · see citing works
Treatment of primary osteoporosis in men
Bianchi, G., & Giusti, A. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s44057 · Cited by 53 · see citing works
The Efficacy and Safety of Abaloparatide-SC in Men With Osteoporosis: A Randomized Clinical Trial
Czerwinski, E. J., Cardona, J., Plebanski, R., Recknor, C. P., Vokes, T., Saag, K. G., Binkley, N., Lewiecki, E. M., Adachi, J. D., Knychas, D., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4719 · Cited by 49 · see citing works
Zoledronic Acid in Osteoporosis Secondary to Mastocytosis
Rossini, M., Zanotti, R., Viapiana, O., Tripi, G., Idolazzi, L., Biondan, M., Orsolini, G., Bonadonna, P., Adami, S., & Gatti, D. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.06.015 · Cited by 48 · see citing works
Recovery From SIADH-Associated Osteoporosis: A Case Report
Sejling, A., Thorsteinsson, A., Pedersen‐Bjergaard, U., & Eiken, P. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1572 · Cited by 47 · see citing works
Sun, K., Li, R., Jiang, W., Sun, Y., & Li, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.050 · Cited by 47 · see citing works
Screening for Osteoporosis to Prevent Fractures
Kahwati, L. C., Kistler, C. E., Booth, G., Sathe, N. A., Gordon, R. D., Okah, E. D., Wines, R., & Viswanathan, M. (2025) · JAMA · doi:10.1001/jama.2024.21653 · Cited by 45 · see citing works
Yeap, B. B., Page, S. T., & Grossmann, M. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30416-3 · Cited by 43 · see citing works
Malle, O., Borgström, F., Fahrleitner‐Pammer, A., Svedbom, A., Dimai, S. V., & Dimai, H. P. (2019) · Bone · doi:10.1016/j.bone.2019.115071 · Cited by 43 · see citing works
Vescini, F., Attanasio, R., Balestrieri, A., Bandeira, F. A. F., Bonadonna, S., Camozzi, V., Cassibba, S., Cesareo, R., Chiodini, I., Francucci, C. M., et al. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0434-8 · Cited by 43 · see citing works
Bone Microarchitecture in Transgender Adults: A Cross-Sectional Study
Bretherton, I., Ghasem-Zadeh, A., Leemaqz, S., Seeman, E., Wang, X., McFarlane, T., Spanos, C., Grossmann, M., Zajac, J. D., & Cheung, A. S. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4497 · Cited by 41 · see citing works
Gates, M., Pillay, J., Nuspl, M., Wingert, A., Vandermeer, B., & Hartling, L. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02181-w · Cited by 46 · see citing works
Misra, M., Singhal, V., Carmine, B. J., Bose, A., Kelsey, M. M., Stanford, F. C., Bram, J., Aidlen, J. T., Inge, T. H., Bouxsein, M., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115290 · Cited by 41 · see citing works
Ip, T., Cheung, S.-K. W., Cheung, S.-K. W., Cheung, T.-C., Choi, T.-C., Chow, S.-L. E., Kan, S.-Y. A., Kung, W. C. A., Lee, K.-K., Leung, K. L. F., et al. (2013) · PubMed · Cited by 41 · see citing works
The efficacy of 3D printing-assisted surgery for traumatic fracture: a meta-analysis
Xiong, L., Li, X., Li, H., Chen, Z., & Xiao, T. (2019) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2019-136482 · Cited by 40 · see citing works
Black, D. M., Reid, I. R., Napoli, N., Ewing, S. K., Shiraki, M., Nakamura, T., Takeuchi, Y., Schafer, A. L., Kim, T. Y., & Cauley, J. A. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4434 · Cited by 39 · see citing works
Androgens Inhibit the Osteogenic Response to Mechanical Loading in Adult Male Mice
Sinnesael, M., Laurent, M. R., Jardí, F., Dubois, V., Deboel, L., Delisser, P., Behets, G. J. S., D’Haese, P. C., Carmeliet, G., Claessens, F., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1673 · Cited by 38 · see citing works
Causes, consequences, and treatment of osteoporosis in men
Banu, J. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s46101 · Cited by 39 · see citing works
Promoting mobility and healthy aging in men: a narrative review
Ebeling, P. R., Cicuttini, F., Scott, D. S., & Jones, G. (2019) · Osteoporosis International · doi:10.1007/s00198-019-05080-w · Cited by 38 · see citing works
Benefits of Bisphosphonate Therapy: Beyond the Skeleton
Billington, E. O., & Reid, I. R. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00612-4 · Cited by 38 · see citing works
Male Osteoporosis in the Elderly
D’Amelio, P., & Isaia, G. C. (2015) · International Journal of Endocrinology · doi:10.1155/2015/907689 · Cited by 37 · see citing works
Practical guidance for the use of bisphosphonates in osteoporosis
Compston, J. E. (2020) · Bone · doi:10.1016/j.bone.2020.115330 · Cited by 39 · see citing works
David, K., Narinx, N., Antonio, L., Evenepoel, P., Claessens, F., Decallonne, B., & Vanderschueren, D. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09738-5 · Cited by 36 · see citing works
Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
ORWOLL, E. S., & KLEIN, R. F. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50044-6 · Cited by 35 · see citing works
Kim, J. Y., Kim, Y.-K., Choi, M. K., Oh, J., Kwak, H. B., & Kim, J.-J. (2012) · Journal of Bone Metabolism · doi:10.11005/jbm.2012.19.2.121 · Cited by 34 · see citing works
Silverman, S. L., Agodoa, I., Kruse, M., Parthan, A., & ORWOLL, E. S. (2015) · Journal of Osteoporosis · doi:10.1155/2015/627631 · Cited by 34 · see citing works
Wu, Q. F., Nasoz, F., Jung, J.-Y., Bhattarai, B. D., & Han, M. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00734-y · Cited by 34 · see citing works
Jin, X., Zhu, L., Li, X., Jia, J., Zhang, Y., Sun, X., Ma, J., Liu, Z., & Ma, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6062 · Cited by 34 · see citing works
Anderson, M. S., Gendrano, I. N., Liu, C., Jeffers, S., Mahon, C., Mehta, A., Mostoller, K., Zajic, S. C., Morris, D., Lee, J., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1688 · Cited by 33 · see citing works
Gourlay, M. L., Ritter, V., Fine, J. P., Overman, R. A., Schousboe, J. T., Cawthon, P. M., ORWOLL, E. S., Nguyen, T. V., Lane, N. E., Cummings, S. R., et al. (2017) · Archives of Osteoporosis · doi:10.1007/s11657-017-0389-1 · Cited by 33 · see citing works
Idiopathic Osteoporosis in Men
Gennari, L., & Bilezikian, J. P. (2013) · Current Osteoporosis Reports · doi:10.1007/s11914-013-0164-1 · Cited by 32 · see citing works
New and developing pharmacotherapy for osteoporosis in men
Gennari, L., & Bilezikian, J. P. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1428559 · Cited by 34 · see citing works
Misof, B. M., Patsch, J., Roschger, P., Muschitz, C., Gamsjaeger, S., Paschalis, E. P., Prokop, E., Klaus Klaushofer, A., Pietschmann, P., & Resch, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2035 · Cited by 31 · see citing works
Randomized controlled trial of zoledronic acid for treatment of osteoporosis in women
Bai, H., Jing, D., Guo, A., & Yin, S. (2013) · Journal of International Medical Research · doi:10.1177/0300060513480917 · Cited by 31 · see citing works
Celiac Disease and Its Role in the Development of Metabolic Bone Disease
Micić, D., Rao, V. L., & Semrad, C. E. (2019) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2019.06.005 · Cited by 32 · see citing works
Management of comorbidities in haemophilia
Kempton, C. L., Makris, M., & Holme, P. A. (2020) · Haemophilia · doi:10.1111/hae.14013 · Cited by 31 · see citing works
- Authors
- Boonen, S., Reginster, J.-Y., Kaufman, J.-M., Lippuner, K., Zanchetta, J., Langdahl, B., Rizzoli, R., Lipschitz, S., Dimai, H. P., Witvrouw, R., Eriksen, E., Brixen, K., Russo, L., Claessens, F., Papanastasiou, P., Antunez, O., Su, G., Bucci-Rechtweg, C., Hruska, J., Incera, E., Vanderschueren, D., & Orwoll, E.
- Affiliations
- KU Leuven (BE)
- University of Liège (BE)
- Ghent University (BE)
- University of Bern (CH)
- Aarhus University Hospital (DK)
- Medical University of Graz (AT)
- Ziekenhuis Oost-Limburg (BE)
- University of Oslo (NO)
- University of Southern Denmark (DK)
- Novartis (Switzerland) (CH)
- Oregon Health & Science University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-11
- Volume
- 367
- Issue
- 18
- Pages
- 1714-1723
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2123816368
- Cited by
- 359
- References
- 30
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 23 · 2023: 21 · 2022: 25 · 2021: 25 · 2020: 26 · 2019: 24 · 2018: 30 · 2017: 21 · 2016: 28 · 2015: 23 · 2014: 29 · 2013: 36 · 2012: 5
- FWCI
- 32.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- BORIS (University Library Bern) (submittedVersion, other-oa)
- IRIS (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- U.S. Department of Justice
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Teva Pharmaceutical Industries
- Danone
- University of Bern
- Union Chimique Belge
- Daiichi-Sankyo
- Novo Nordisk
- Servier
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- zoledronic acid, male osteoporosis, vertebral fractures, fracture risk reduction, bisphosphonates, androgen deficiency, bone mineral density, bone turnover markers, height loss
- MeSH terms
- Zoledronic Acid, Aged, Aged, 80 and over, Analysis of Variance, Diphosphonates, Double-Blind Method, Humans, Hypogonadism, Imidazoles, Male, Middle Aged, Osteoporosis, Risk, Testosterone, Bone Density, Logistic Models, Spinal Fractures, Bone Density Conservation Agents
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