CoChat
Sign Up
Cited by 511Fatty Acid Research and HealthNutritional Studies and DietLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors

The Risk and Prevention Study Collaborative Group·2013·New England Journal of Medicine
DOI 10.1056/nejmoa1205409
Open this paper in CoChat — free account

Abstract

BACKGROUND: Trials have shown a beneficial effect of n-3 polyunsaturated fatty acids in patients with a previous myocardial infarction or heart failure. We evaluated the potential benefit of such therapy in patients with multiple cardiovascular risk factors or atherosclerotic vascular disease who had not had a myocardial infarction. METHODS: In this double-blind, placebo-controlled clinical trial, we enrolled a cohort of patients who were followed by a network of 860 general practitioners in Italy. Eligible patients were men and women with multiple cardiovascular risk factors or atherosclerotic vascular disease but not myocardial infarction. Patients were randomly assigned to n-3 fatty acids (1 g daily) or placebo (olive oil). The initially specified primary end point was the cumulative rate of death, nonfatal myocardial infarction, and nonfatal stroke. At 1 year, after the event rate was found to be lower than anticipated, the primary end point was revised as time to death from cardiovascular causes or admission to the hospital for cardiovascular causes. RESULTS: Of the 12,513 patients enrolled, 6244 were randomly assigned to n-3 fatty acids and 6269 to placebo. With a median of 5 years of follow-up, the primary end point occurred in 1478 of 12,505 patients included in the analysis (11.8%), of whom 733 of 6239 (11.7%) had received n-3 fatty acids and 745 of 6266 (11.9%) had received placebo (adjusted hazard ratio with n-3 fatty acids, 0.97; 95% confidence interval, 0.88 to 1.08; P=0.58). The same null results were observed for all the secondary end points. CONCLUSIONS: In a large general-practice cohort of patients with multiple cardiovascular risk factors, daily treatment with n-3 fatty acids did not reduce cardiovascular mortality and morbidity. (Funded by Società Prodotti Antibiotici and others; ClinicalTrials.gov number, NCT00317707.).

Overview

Integrity signals

Registry

Crossref · 10.1056/nejmoa1205409

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 12 references

Cited by

Sorted by citations

Items 501–511 of 511

Related

See all

Metadata

Authors
The Risk and Prevention Study Collaborative Group
Affiliations
Mario Negri Institute for Pharmacological Research (IT)
Corresponding author
The Risk and Prevention Study Collaborative Group
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2013-05-09
Volume
368
Issue
19
Pages
1800-1808
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1205409
OpenAlex
W2614282478
Cited by
510
References
12
Citations by year
2026: 10 · 2025: 14 · 2024: 22 · 2023: 27 · 2022: 31 · 2021: 27 · 2020: 48 · 2019: 33 · 2018: 39 · 2017: 45 · 2016: 45 · 2015: 52 · 2014: 79 · 2013: 38
FWCI
66.19
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
omega-3 fatty acids, omega-3 polyunsaturated fatty acids, cardiovascular risk factors, atherosclerosis, cardiovascular mortality, cardiovascular morbidity, myocardial infarction, stroke, olive oil placebo
MeSH terms
Aged, Cardiovascular Diseases, Double-Blind Method, Female, Hospitalization, Humans, Male, Middle Aged, Primary Prevention, Risk Factors, Fatty Acids, Omega-3, Proportional Hazards Models, Treatment Failure, Kaplan-Meier Estimate, General Practice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review