The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Beyond Malaria — Causes of Fever in Outpatient Tanzanian Children
Open accessAbstract
BACKGROUND: As the incidence of malaria diminishes, a better understanding of nonmalarial fever is important for effective management of illness in children. In this study, we explored the spectrum of causes of fever in African children. METHODS: We recruited children younger than 10 years of age with a temperature of 38°C or higher at two outpatient clinics--one rural and one urban--in Tanzania. Medical histories were obtained and clinical examinations conducted by means of systematic procedures. Blood and nasopharyngeal specimens were collected to perform rapid diagnostic tests, serologic tests, culture, and molecular tests for potential pathogens causing acute fever. Final diagnoses were determined with the use of algorithms and a set of prespecified criteria. RESULTS: Analyses of data derived from clinical presentation and from 25,743 laboratory investigations yielded 1232 diagnoses. Of 1005 children (22.6% of whom had multiple diagnoses), 62.2% had an acute respiratory infection; 5.0% of these infections were radiologically confirmed pneumonia. A systemic bacterial, viral, or parasitic infection other than malaria or typhoid fever was found in 13.3% of children, nasopharyngeal viral infection (without respiratory symptoms or signs) in 11.9%, malaria in 10.5%, gastroenteritis in 10.3%, urinary tract infection in 5.9%, typhoid fever in 3.7%, skin or mucosal infection in 1.5%, and meningitis in 0.2%. The cause of fever was undetermined in 3.2% of the children. A total of 70.5% of the children had viral disease, 22.0% had bacterial disease, and 10.9% had parasitic disease. CONCLUSIONS: These results provide a description of the numerous causes of fever in African children in two representative settings. Evidence of a viral process was found more commonly than evidence of a bacterial or parasitic process. (Funded by the Swiss National Science Foundation and others.).
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Cites
A new world malaria map: Plasmodium falciparum endemicity in 2010
Gething, P. W., Patil, A. P., Smith, D. L., Guerra, C. A., Elyazar, I. R., Johnston, G. L., Tatem, A. J., & Hay, S. I. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-378 · Cited by 1,146
Bacteremia among Children Admitted to a Rural Hospital in Kenya
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Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
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Cited by
Fleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548
Access to pathology and laboratory medicine services: a crucial gap
Wilson, M. L., Fleming, K. A., Kuti, M. A., Looi, L. M., Lago, N., & Ru, K. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30458-6 · Cited by 444
Drug-resistant enteric fever worldwide, 1990 to 2018: a systematic review and meta-analysis
Browne, A. J., Kashef Hamadani, B. H., Kumaran, E. A. P., Rao, P., Longbottom, J., Harriss, E., Moore, C. E., Dunachie, S., Basnyat, B., Baker, S., et al. (2020) · BMC Medicine · doi:10.1186/s12916-019-1443-1 · Cited by 396
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Lewnard, J. A., Charani, E., Gleason, A., Hsu, L. Y., Khan, W. A., Karkey, A., Chandler, C. I. R., Mashe, T., Khan, E. A., Bulabula, A. N. H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00862-6 · Cited by 220
Metadata
- Authors
- D'Acremont, V., Kilowoko, M., Kyungu, E., Philipina, S., Sangu, W., Kahama-Maro, J., Lengeler, C., Cherpillod, P., Kaiser, L., & Genton, B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-02-27
- Volume
- 370
- Issue
- 9
- Pages
- 809-817
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2126383097
- Cited by
- 444
- References
- 31
- FWCI
- 36.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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